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1. 发明授权

US06223128B1 DNA sequence assembly system 失效
标题翻译： DNA序列组装系统
公开(公告)号：US06223128B1
公开(公告)日：2001-04-24
申请号：US09106370
申请日：1998-06-29
申请人： Carolyn F. Allex , Jude W Shavlik , Frederick R. Blattner
发明人： Carolyn F. Allex , Jude W Shavlik , Frederick R. Blattner
IPC分类号： G01N3348
CPC分类号： G06F19/22
摘要： A computerized method is described for assembling DNA sequence determined for small DNA fragments, called fragment reads, into larger fragments of DNA sequence called contigs. The method used makes a table of occurrences or counts for each mer appearing in any of the fragment reads and then picks from among those mers specific mers to use as mer tags. Following checking, the mer tags are used to assemble fragment reads into contigs. A feature of this method is that the processing time necessary to perform this process on a computer varies linearly with the number of fragment reads rather than with the square or cube of the number of fragment reads.
摘要翻译：描述了一种计算机化方法，用于将针对称为片段读取的小DNA片段确定的DNA序列组装成称为重叠群的DNA序列的更大片段。所使用的方法使得在每个片段读取中出现的每个词典的出现或计数表，然后从这些特定的词典中选择用作mer标签。检查之后，mer标签用于将片段读取组合到重叠群中。该方法的一个特点是在计算机上执行此过程所需的处理时间与片段读取次数呈线性关系，而不是片段读取次数的平方或立方。

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