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1. 发明申请

US20120053150A1 N-PYRAZOLYL CARBOXAMIDES AS CRAC CHANNEL INIHIBITORS 失效
标题翻译： N-吡唑啉羧酰胺作为CRAC通道启动子
公开(公告)号：US20120053150A1
公开(公告)日：2012-03-01
申请号：US13265037
申请日：2010-04-22
申请人： David George Allen , Diane Mary Coe , Anthony William James Cooper , Paul Martin Gore , David House , Stefan Senger , Steven Leslie Sollis , Sadie Vile , Caroline Wilson
发明人： David George Allen , Diane Mary Coe , Anthony William James Cooper , Paul Martin Gore , David House , Stefan Senger , Steven Leslie Sollis , Sadie Vile , Caroline Wilson
IPC分类号： A61K31/675 , C07D401/12 , C07D403/10 , C07D413/10 , C07D413/12 , C07D403/12 , C07F9/6503 , A61K31/415 , A61K31/4439 , A61K31/4245 , A61K31/422 , A61K31/513 , A61P11/06 , A61P29/00 , C07D231/40
CPC分类号： C07D231/40
摘要： The present invention relates to amide compounds, processes for their preparation, pharmaceutical compositions containing these compounds and to their use in the treatment of disorders, conditions or disorders such as allergic disorders, inflammatory disorders and disorders of the immune system.
摘要翻译：本发明涉及酰胺化合物，其制备方法，含有这些化合物的药物组合物及其用于治疗疾病，病症或病症如过敏性疾病，炎症性疾病和免疫系统疾病的用途。

2. 发明授权

US5897265A Ink Eraser 失效
标题翻译：墨水橡皮擦
公开(公告)号：US5897265A
公开(公告)日：1999-04-27
申请号：US852058
申请日：1997-05-06
申请人： Caroline Wilson
发明人： Caroline Wilson
IPC分类号： B43K8/02 , B43K27/08 , B43L19/00 , B43M11/08 , B43K27/10
CPC分类号： B43K27/08 , B43K8/02 , B43L19/0018 , B43M11/08
摘要： An ink eraser including an eraser housing defining a housing chamber and a nib opening; a first fibrous wick container positioned within the housing chamber; a first section of fibrous wicking material positioned within the fibrous wick container; a supply of erasing agent within the fibrous wick container, the erasing agent including a mixture of vinegar and an organic bleach; and a delivery nib having a wick contacting portion, a central portion and a delivery portion, the wick contacting portion being positioned within the fibrous wick container in contact with the first section of fibrous wicking, the central portion being disposed through the nib opening, the delivery portion extending exteriorly of the eraser housing. In a preferred embodiment the eraser housing further defines a fill opening and the ink eraser further includes a sealing cap. The sealing cap preferably defines a recharging port that is sealable by a reusable sealing device such as a screw in cap.
摘要翻译：一种墨擦拭器，包括限定容纳室和笔尖开口的橡皮擦外壳; 位于所述容纳室内的第一纤维芯容器; 定位在纤维吸芯容器内的纤维吸湿材料的第一部分; 在纤维吸芯容器内提供擦除剂，消除剂包括醋和有机漂白剂的混合物; 以及具有芯接触部分，中心部分和输送部分的输送笔尖，所述芯接触部分位于所述纤维芯容器内，与所述第一纤维芯吸部分接触，所述中心部分通过所述笔尖开口设置，输送部分延伸到橡皮擦外壳的外部。在优选实施例中，橡皮擦外壳进一步限定了一个填充开口，墨擦拭器还包括密封帽。密封盖优选地限定可由可重复使用的密封装置（例如螺旋盖）密封的再充电端口。

3. 发明授权

US08399436B2 N-pyrazolyl carboxamides as CRAC channel inhibitors 失效
标题翻译： N-吡唑基甲酰胺作为CRAC通道抑制剂
公开(公告)号：US08399436B2
公开(公告)日：2013-03-19
申请号：US13265037
申请日：2010-04-22
申请人： David George Allen , Diane Mary Coe , Anthony William James Cooper , Paul Martin Gore , David House , Stefan Senger , Steven Leslie Sollis , Sadie Vile , Caroline Wilson
发明人： David George Allen , Diane Mary Coe , Anthony William James Cooper , Paul Martin Gore , David House , Stefan Senger , Steven Leslie Sollis , Sadie Vile , Caroline Wilson
IPC分类号： A61K31/675 , A61K31/415 , A61K31/4439 , A61K31/4245 , A61K31/513 , A61P11/06 , C07D401/12 , C07D403/10 , C07D413/12
CPC分类号： C07D231/40
摘要： The present invention relates to amide compounds, processes for their preparation, pharmaceutical compositions containing these compounds and to their use in the treatment of disorders, conditions or disorders such as allergic disorders, inflammatory disorders and disorders of the immune system.
摘要翻译：本发明涉及酰胺化合物，其制备方法，含有这些化合物的药物组合物及其用于治疗疾病，病症或病症如过敏性疾病，炎症性疾病和免疫系统疾病的用途。

4. 发明申请

US20120058984A1 PYRIMIDINE DERIVATIVES USED AS ITK INHIBITORS 审中-公开
标题翻译：用作ITK抑制剂的吡咯烷酮衍生物
公开(公告)号：US20120058984A1
公开(公告)日：2012-03-08
申请号：US13257098
申请日：2010-03-15
申请人： Catherine Mary Alder , Ian Robert Baldwin , Nicholas Paul Barton , Amanda Jennifer Campbell , Aurelie Cecile Champigny , John David Harling , Aoife Caitriona Maxwell , Juliet Kay Simpson , Ian Edward David Smith , Christopher John Tame , Caroline Wilson , James Michael Woolven
发明人： Catherine Mary Alder , Ian Robert Baldwin , Nicholas Paul Barton , Amanda Jennifer Campbell , Aurelie Cecile Champigny , John David Harling , Aoife Caitriona Maxwell , Juliet Kay Simpson , Ian Edward David Smith , Christopher John Tame , Caroline Wilson , James Michael Woolven
IPC分类号： A61K31/506 , C07D417/14 , A61K31/5377 , A61K31/541 , A61P11/00 , A61P37/08 , A61P37/00 , A61P37/06 , A61P29/00 , A61P31/18 , A61P7/06 , A61P25/00 , A61P11/06 , A61P11/08 , A61P17/00 , A61P17/06 , A61P3/10 , A61P5/16 , A61P27/02 , A61P1/00 , C07D417/12
CPC分类号： C07D513/04 , C07D417/12 , C07D417/14
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular Itk activity.
摘要翻译：本发明涉及某些新化合物。具体地，本发明涉及式（I）的化合物及其盐。本发明的化合物是激酶活性的抑制剂，特别是Itk活性。

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