专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20160038769A1 NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS FOR THE MANAGEMENT OF PAIN 审中-公开
标题翻译：神经修复及相关系统及其治疗方法
公开(公告)号：US20160038769A1
公开(公告)日：2016-02-11
申请号：US14379874
申请日：2013-03-07
申请人： Carol SULLIVAN , MEDTRONIC ARDIAN LUXEMBOURG SARL
发明人： Carol SULLIVAN , Neil BARMAN , Dwayne Sonny YAMASAKI
IPC分类号： A61N7/00 , A61B18/02 , A61F7/12
CPC分类号： A61N7/00 , A61B5/02405 , A61B5/14503 , A61B5/4035 , A61B5/4824 , A61B18/0206 , A61B18/1492 , A61B2018/0022 , A61B2018/00345 , A61B2018/00434 , A61B2018/00791 , A61B2018/00839 , A61B2018/0212 , A61B2018/0262 , A61F7/12 , A61F7/123 , A61F2007/0056 , A61F2007/126 , A61N1/36021 , A61N2/008 , A61N7/02 , A61N7/022 , A61N2007/0026 , A61N2007/0043 , G06F19/3481 , G16H10/20 , G16H50/30 , Y02A90/22 , Y02A90/26
摘要： Methods for treating and managing pain in a patient with therapeutic neuromodulation and associated systems and methods are disclosed herein. Chronic or debilitating pain can be associated, for example, with a disease or condition of the abdominal or reproductive viscera. One aspect of the present technology is directed to methods that at least partially inhibit sympathetic neural activity in nerves proximate a target blood vessel of a diseased or damaged organ of a patient experiencing pain. Targeted sympathetic nerve activity can be modulated at least along afferent pathways which can improve a measurable parameter associated with the pain of the patient The modulation can be achieved, for example, using an intravascularly positioned catheter carrying a therapeutic assembly, e.g., a therapeutic assembly configured to use electrically-induced, thermally-induced, and/or chemically-induced approaches to modulate the target sympathetic nerve.
摘要翻译：用于治疗和治疗患有治疗性神经调节和相关系统和方法的患者的疼痛的方法在本文中公开。慢性或虚弱的疼痛可以与例如腹部或生殖内脏的疾病或病症有关。本技术的一个方面涉及至少部分地抑制经历疼痛的患者的患病或受损器官的目标血管附近的神经中的交感神经活动的方法。目标交感神经活动可以至少沿着可以改善与患者疼痛相关的可测量参数的传入途径调节。调节可以通过例如使用血管内定位的导管来实现，该导管携带治疗组件，例如治疗组件使用电诱导，热诱导和/或化学诱导的方法来调节目标交感神经。

2. 发明申请

US20230057437A1 NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS FOR THE MANAGEMENT OF PAIN 有权
公开(公告)号：US20230057437A1
公开(公告)日：2023-02-23
申请号：US18045556
申请日：2022-10-11
申请人： Carol Sullivan , Neil Barman , Dwayne S. Yamasaki
发明人： Carol Sullivan , Neil Barman , Dwayne S. Yamasaki
IPC分类号： G16H20/30 , A61N2/00 , A61B5/00 , G16H50/30 , G16H20/40 , A61B18/02 , A61F7/12 , A61N7/00
摘要： Methods for treating and managing pain in a patient with therapeutic neuromodulation and associated systems and methods are disclosed herein. Chronic or debilitating pain can be associated, for example, with a disease or condition of the abdominal or reproductive viscera. One aspect of the present technology is directed to methods that at least partially inhibit sympathetic neural activity in nerves proximate a target blood vessel of a diseased or damaged organ of a patient experiencing pain. Targeted sympathetic nerve activity can be modulated at least along afferent pathways which can improve a measurable parameter associated with the pain of the patient The modulation can be achieved, for example, using an intravascularly positioned catheter carrying a therapeutic assembly, e.g., a therapeutic assembly configured to use electrically-induced, thermally-induced, and/or chemically-induced approaches to modulate the target sympathetic nerve.

3. 发明授权

US08545831B2 Compositions and methods for treating a damaged cardiovascular element 失效
公开(公告)号：US08545831B2
公开(公告)日：2013-10-01
申请号：US11443594
申请日：2006-05-31
申请人： Josee Roy , Hezi-Yamit Ayala , Carol Sullivan , Mingfei Chen
发明人： Josee Roy , Hezi-Yamit Ayala , Carol Sullivan , Mingfei Chen
IPC分类号： A61K31/77
CPC分类号： A61K31/765 , A61K9/0014 , A61K9/0019 , A61K31/00 , A61K45/06 , A61K47/10 , A61L31/06 , A61L31/16 , A61L2300/402 , A61L2400/06 , C08L71/02
摘要： In the present invention, the applicants describe methods and compositions of treating damaged cardiovascular elements and cardiovascular conditions including hypotension, atherosclerotic lesions, vulnerable plaque, and acute myocardial infarct. The applicants demonstrate the ability of a biomembrane sealing agent to accumulate on the walls of damaged blood vessels and help improving mean arterial pressure following tissue injury. The applicants describe the use of formulations comprising at least one biomembrane sealing agent and one bioactive agent for prophylactic treatment such as they could be administered concurrently to an invasive therapeutic intervention or after the insult (i.e. post-injury or post-surgery). Alternatively, these methods and compositions could be used to reduce the severity of cardiovascular diseases after onset.

4. 发明申请

US20070142905A1 Medical devices to treat or inhibit restenosis 审中-公开
标题翻译：用于治疗或抑制再狭窄的医疗器械
公开(公告)号：US20070142905A1
公开(公告)日：2007-06-21
申请号：US11567821
申请日：2006-12-07
申请人： Ayala Hezi-Yamit , Carol Sullivan , Jennifer Wong
发明人： Ayala Hezi-Yamit , Carol Sullivan , Jennifer Wong
IPC分类号： A61F2/02 , A61F2/82
CPC分类号： A61L27/54 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/436
摘要： Implantable medical devices having anti-restenotic coatings are disclosed. Specifically, implantable medical devices having coatings of certain NF-kappaB inhibitors, particularly certain dialkyl fumarates, are disclosed. Dimethyl fumarate is a particularly preferred dialkyl fumarate. The anti-restenotic medical devices include stents, catheters, micro-particles, probes and vascular grafts. Intravascular stents are preferred medical devices. The medical devices can be coated using any method known in the art including compounding the dialkyl fumarate with a biocompatible polymer prior to applying the coating. Moreover, medical devices composed entirely of biocompatible polymer-dialkyl fumarate blends are disclosed. Additionally, medical devices having a coating comprising at least one dialkyl fumarate in combination with at least one additional therapeutic agent are also disclosed. Furthermore, related methods of using and making the anti-restenotic implantable devices are also disclosed.
摘要翻译：公开了具有抗再狭窄涂层的可植入医疗装置。具体地，公开了具有某些NF-κB抑制剂，特别是某些二烷基富马酸盐的包衣的可植入医疗器械。富马酸二甲酯是特别优选的富马酸二烷基酯。抗再狭窄医疗器械包括支架，导管，微粒，探针和血管移植物。血管内支架是优选的医疗装置。可以使用本领域已知的任何方法涂覆医疗装置，包括在施加涂层之前将富马酸二烷基酯与生物相容性聚合物混合。此外，公开了完全由生物相容性聚合物 - 富马酸二烷基酯混合物组成的医疗装置。此外，还公开了具有包含至少一种富马酸二烷基酯与至少一种另外的治疗剂组合的涂层的医疗装置。此外，还公开了使用和制备抗再狭窄植入式装置的相关方法。

5. 发明申请

US20070012323A1 Compositions and methods for treating a damaged cardiovascular element 失效
标题翻译：用于治疗受损的心血管元件的组合物和方法
公开(公告)号：US20070012323A1
公开(公告)日：2007-01-18
申请号：US11443594
申请日：2006-05-31
申请人： Josee Roy , Hezi-Yamit Ayala , Carol Sullivan , Mingfei Chen
发明人： Josee Roy , Hezi-Yamit Ayala , Carol Sullivan , Mingfei Chen
IPC分类号： A61B19/00
CPC分类号： A61K31/765 , A61K9/0014 , A61K9/0019 , A61K31/00 , A61K45/06 , A61K47/10 , A61L31/06 , A61L31/16 , A61L2300/402 , A61L2400/06 , C08L71/02
摘要： In the present invention, the applicants describe methods and compositions of treating damaged cardiovascular elements and cardiovascular conditions including hypotension, atherosclerotic lesions, vulnerable plaque, and acute myocardial infarct. The applicants demonstrate the ability of a biomembrane sealing agent to accumulate on the walls of damaged blood vessels and help improving mean arterial pressure following tissue injury. The applicants describe the use of formulations comprising at least one biomembrane sealing agent and one bioactive agent for prophylactic treatment such as they could be administered concurrently to an invasive therapeutic intervention or after the insult (i.e. post-injury or post-surgery). Alternatively, these methods and compositions could be used to reduce the severity of cardiovascular diseases after onset.
摘要翻译：在本发明中，申请人描述了治疗受损的心血管因子和心血管疾病的方法和组合物，包括低血压，动脉粥样硬化病变，易损斑块和急性心肌梗死。申请人证明了生物膜密封剂积聚在受损血管壁上的能力，有助于改善组织损伤后的平均动脉压。申请人描述了使用包含至少一种生物膜密封剂和一种用于预防性治疗的生物活性剂的制剂，例如它们可以同时施用于侵入性治疗干预或在侮辱之后（即损伤后或手术后）。或者，这些方法和组合物可用于降低发病后心血管疾病的严重性。

6. 发明申请

US20120315303A1 METHODS AND INTRAVASCULAR TREATMENT DEVICES USING PACLITAXEL FOR TREATMENT OF ATHEROSCLEROSIS 审中-公开
标题翻译：方法和使用PACLITAXEL治疗ATHEROSCLEROSIS的血管内治疗装置
公开(公告)号：US20120315303A1
公开(公告)日：2012-12-13
申请号：US13464902
申请日：2012-05-04
申请人： AYALA HEZI-YAMIT , SUSAN EDWARDS , CAROL SULLIVAN , OLUWASHOLA SHAKIRAT SULAIMON , LORI GARCIA , STEFAN TUNEV
发明人： AYALA HEZI-YAMIT , SUSAN EDWARDS , CAROL SULLIVAN , OLUWASHOLA SHAKIRAT SULAIMON , LORI GARCIA , STEFAN TUNEV
IPC分类号： A61K31/337 , A61K9/00 , A61K31/505 , A61K31/422 , A61K31/506 , A61M25/10 , A61K31/4439 , A61K31/421 , A61K31/517 , A61K31/7008 , A61K31/5377 , A61K31/41 , A61P9/10 , A61K31/426
CPC分类号： A61K31/337 , A61F2250/0067 , A61K45/06 , A61L29/16 , A61L31/16 , A61L2300/416 , A61L2300/422 , A61L2300/45 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61K2300/00
摘要： Methods and intravascular treatment devices for treating atherosclerosis are provided.
摘要翻译：提供了治疗动脉粥样硬化的方法和血管内治疗装置。

7. 发明申请

US20100137976A1 Systems and Methods for Treating Heart Tissue Via Localized Delivery of Parp Inhibitors 审中-公开
标题翻译：通过局部递送Parp抑制剂治疗心脏组织的系统和方法
公开(公告)号：US20100137976A1
公开(公告)日：2010-06-03
申请号：US12326609
申请日：2008-12-02
申请人： Carol Sullivan , Ayala Hezi-Yamit
发明人： Carol Sullivan , Ayala Hezi-Yamit
IPC分类号： A61K31/4985 , A61K31/52 , A61F2/82 , A61K31/7088 , A61K38/18 , A61K39/12 , A61K31/728 , A61K39/395 , A61K38/43 , A61P9/00
CPC分类号： A61K31/4453 , A61F2/82 , A61K9/0019 , A61K31/4745 , A61K31/4985 , A61K31/52 , A61K31/7088 , A61K31/728 , A61K38/00
摘要： The systems and methods of the present disclosure, in a broad aspect, provide for treatment of cardiac tissue via localized delivery of PARP inhibitors. These systems include a composition comprising at least one poly(ADP-ribose) polymerase (PARP) inhibitor; and at least one delivery device for introducing the composition into the cardiac tissue.
摘要翻译：在广泛的方面，本公开的系统和方法提供了通过PARP抑制剂的局部递送来治疗心脏组织。这些系统包括包含至少一种聚（ADP-核糖）聚合酶（PARP）抑制剂的组合物; 以及用于将组合物引入心脏组织的至少一个递送装置。

8. 发明申请

US20100092534A1 Combination Local Delivery Using a Stent 审中-公开
标题翻译：组合使用支架本地交付
公开(公告)号：US20100092534A1
公开(公告)日：2010-04-15
申请号：US12249576
申请日：2008-10-10
申请人： Ayala Hezi-Yamit , Iskender Matt Bilge , Jennifer Wong , Carol Sullivan , Natividad Vasquez
发明人： Ayala Hezi-Yamit , Iskender Matt Bilge , Jennifer Wong , Carol Sullivan , Natividad Vasquez
IPC分类号： A61F2/04 , A61K31/58 , A61K31/4355
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/416 , A61L2300/45
摘要： Described herein are implantable medical devices useful in treating vascular conditions such as restenosis. In one embodiment, stents are described in which a combination of bioactive agents is described for local delivery in the vasculature. The combination of bioactive agents comprises at least one compound capable of inhibiting smooth muscle cell proliferation and at least one compound capable of mitigating MCP- and/or TF induction. For example, a compound capable of inhibiting smooth muscle cell proliferation is a mTOR inhibitor and a compound capable of mitigating MCP-1 and/or TF induction is a corticosteroid.
摘要翻译：本文描述了可用于治疗诸如再狭窄的血管病变的可植入医疗装置。在一个实施方案中，描述了支架，其中描述了生物活性剂的组合用于脉管系统中的局部递送。生物活性剂的组合包含至少一种能够抑制平滑肌细胞增殖的化合物和至少一种能够减轻MCP-和/或TF诱导的化合物。例如，能够抑制平滑肌细胞增殖的化合物是mTOR抑制剂，能够缓解MCP-1和/或TF诱导的化合物是皮质类固醇。

9. 发明授权

US10737123B2 Neuromodulation and associated systems and methods for the management of pain 有权
公开(公告)号：US10737123B2
公开(公告)日：2020-08-11
申请号：US14379874
申请日：2013-03-07
申请人： MEDTRONIC ARDIAN LUXEMBOURG SARL , Carol Sullivan
发明人： Carol Sullivan , Neil Barman , Dwayne S. Yamasaki
IPC分类号： A61N7/00 , A61N2/00 , G06F19/00 , A61B5/00 , G16H50/30 , A61B18/02 , A61F7/12 , A61B5/145 , A61B18/00 , A61N7/02 , A61F7/00 , A61B5/024 , A61B18/14 , A61N1/36 , G16H10/20
摘要： Methods for treating and managing pain in a patient with therapeutic neuromodulation and associated systems and methods are disclosed herein. Chronic or debilitating pain can be associated, for example, with a disease or condition of the abdominal or reproductive viscera. One aspect of the present technology is directed to methods that at least partially inhibit sympathetic neural activity in nerves proximate a target blood vessel of a diseased or damaged organ of a patient experiencing pain. Targeted sympathetic nerve activity can be modulated at least along afferent pathways which can improve a measurable parameter associated with the pain of the patient The modulation can be achieved, for example, using an intravascularly positioned catheter carrying a therapeutic assembly, e.g., a therapeutic assembly configured to use electrically-induced, thermally-induced, and/or chemically-induced approaches to modulate the target sympathetic nerve.

10. 发明申请

US20130046283A1 METHODS AND INTRAVASCULAR TREATMENT DEVICES FOR TREATMENT OF ATHEROSCLEROSIS 审中-公开
标题翻译：用于治疗甲状腺功能亢进的方法和血管内治疗装置
公开(公告)号：US20130046283A1
公开(公告)日：2013-02-21
申请号：US13464907
申请日：2012-05-04
申请人： Ayala Hezi-Yamit , Susan Edwards , Carol Sullivan , Oluwashola Shakirat Sulaimon , Lori Garcia , Stefan Tunev
发明人： Ayala Hezi-Yamit , Susan Edwards , Carol Sullivan , Oluwashola Shakirat Sulaimon , Lori Garcia , Stefan Tunev
IPC分类号： A61K38/17 , A61M25/10 , A61K9/00 , A61P9/10 , A61K31/4375
CPC分类号： A61L29/16 , A61K31/4745 , A61K38/55 , A61K45/06 , A61L31/16 , A61L2300/252 , A61L2300/41 , A61L2300/416 , A61M2025/105 , A61K2300/00
摘要： Methods and intravascular treatment devices for treating atherosclerosis are provided.
摘要翻译：提供了治疗动脉粥样硬化的方法和血管内治疗装置。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式