专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08182816B2 Methods of treating cancer 失效
标题翻译：治疗癌症的方法
公开(公告)号：US08182816B2
公开(公告)日：2012-05-22
申请号：US12944338
申请日：2010-11-11
申请人： Francisco Sanchez-Madrid , Carlos-Martinez Alonso , David Sancho Madrid , Pablo Engel Rocamora , Enric Esplugues Artola , Javier Vega Ramos , Pilar Lauzurica Gomez
发明人： Francisco Sanchez-Madrid , Carlos-Martinez Alonso , David Sancho Madrid , Pablo Engel Rocamora , Enric Esplugues Artola , Javier Vega Ramos , Pilar Lauzurica Gomez
IPC分类号： A61K39/395
CPC分类号： C07K16/2851 , A61K2039/505 , C07K2317/76
摘要： Disclosed are methods of treating subjects having cancers including administering an effective amount of an early activation molecule agonist, antagonist or depletor, to the subject. Human monoclonal antibodies specific to the early activation molecules, and methods of use, are also disclosed.
摘要翻译：公开了治疗患有癌症的受试者的方法，包括向受试者施用有效量的早期活化分子激动剂，拮抗剂或抑制剂。还公开了对早期活化分子特异性的人单克隆抗体及其使用方法。

2. 发明申请

US20110165071A1 Methods Of Treating Cancer 失效
标题翻译：治疗癌症的方法
公开(公告)号：US20110165071A1
公开(公告)日：2011-07-07
申请号：US12944338
申请日：2010-11-11
申请人： Francisco Sanchez-Madrid , Carlos Martinez Alonso , David Sancho Madrid , Pablo Engel Rocamora , Enric Esplugues Artola , Javier Vega Ramos , Pilar Lauzurica Gómez
发明人： Francisco Sanchez-Madrid , Carlos Martinez Alonso , David Sancho Madrid , Pablo Engel Rocamora , Enric Esplugues Artola , Javier Vega Ramos , Pilar Lauzurica Gómez
IPC分类号： A61K39/395 , A61K51/00 , A61P35/00
CPC分类号： C07K16/2851 , A61K2039/505 , C07K2317/76
摘要： Disclosed are methods of treating subjects having cancers including administering an effective amount of an early activation molecule agonist, antagonist or depletor, to the subject. Human monoclonal antibodies specific to the early activation molecules, and methods of use, are also disclosed.
摘要翻译：公开了治疗患有癌症的受试者的方法，包括向受试者施用有效量的早期活化分子激动剂，拮抗剂或抑制剂。还公开了对早期活化分子特异性的人单克隆抗体及其使用方法。

3. 发明授权

US06495329B1 Method for determining cytokine receptor activation by the use of an antibody 失效
公开(公告)号：US06495329B1
公开(公告)日：2002-12-17
申请号：US09044154
申请日：1998-03-19
申请人： Carlos Martinez Alonso , José Mario Mellado Garcia , Leonor Kremer Baron , José Miguel Rodriguez Frade
发明人： Carlos Martinez Alonso , José Mario Mellado Garcia , Leonor Kremer Baron , José Miguel Rodriguez Frade
IPC分类号： G01N3353
摘要： The present invention relates to a method for determinating cytokine receptor, especially growth hormone receptor (GHR), activation, by the use of an antibody capable of discriminating between an activated and an inactive cytokine receptor conformation, especially GHR or growth hormone binding protein (GHBP) conformation, the method comprising: contacting the antibody and the cytokine receptor to form a complex, contacting a candidate ligand to the complex, measuring the antibody binding to inactive cytokine receptor and thereby discriminating between an activated and an inactive conformation. The invention also relates to an antibody directed to the hinge spanning subdomains I and II of the growth hormone receptor extracellular region and which is capable of discriminating between an activated and an inactive receptor conformation. The invention also relates to the use of the antibody for e.g. characterization of growth hormone receptor interactions and for screening for compounds stabilising die dimerization of GHR.

4. 发明申请

US20110059015A1 VACCINE 审中-公开
标题翻译：疫苗
公开(公告)号：US20110059015A1
公开(公告)日：2011-03-10
申请号：US12210118
申请日：2008-09-12
申请人： José Luis Toran Garcia , Carlos Martinez Alonso
发明人： José Luis Toran Garcia , Carlos Martinez Alonso
IPC分类号： A61K49/00 , C07K16/10 , C07H21/00 , C12N15/63 , C12N5/10 , G01N33/53 , C07K2/00 , C07K7/08 , C07K7/06 , C07K14/00 , A61K39/00 , C12N7/04 , A61P31/18
CPC分类号： C07K16/1063 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/565
摘要： The application relates to antibodies and fragments capable of binding HIV-1 gp120 protein, nucleic acids encoding such proteins, to the use of such proteins to identify active compounds, and to the use of the compounds as vaccines.
摘要翻译：本申请涉及能够结合HIV-1 gp120蛋白的抗体和片段，编码此类蛋白质的核酸，使用此类蛋白质鉴定活性化合物，以及该化合物作为疫苗的用途。

5. 发明授权

US07867475B2 Immune regulation based on the depletion of CD69+ cells 失效
标题翻译：基于CD69 +细胞消耗的免疫调节
公开(公告)号：US07867475B2
公开(公告)日：2011-01-11
申请号：US10770639
申请日：2004-02-02
申请人： Francisco Sanchez-Madrid , Carlos Martinez Alonso , David Sancho Madrid , Pablo Engel Rocamora , Enric Esplugues Artola , Javier Vega Ramos , Pilar Lauzurica Gómez
发明人： Francisco Sanchez-Madrid , Carlos Martinez Alonso , David Sancho Madrid , Pablo Engel Rocamora , Enric Esplugues Artola , Javier Vega Ramos , Pilar Lauzurica Gómez
IPC分类号： A61K51/00
CPC分类号： C07K16/2851 , A61K2039/505 , C07K2317/76
摘要： Disclosed are methods of treating subjects having disorders or conditions characterized by an unwanted immune response including administering an effective amount of an early activation molecule agonist, antagonist or depletor, to the subject. Human monoclonal antibodies specific to the early activation molecules, and methods of use, are also disclosed.
摘要翻译：公开了治疗具有由不想要的免疫应答表征的疾病或病症的受试者的方法，包括向受试者施用有效量的早期活化分子激动剂，拮抗剂或抑制剂。还公开了对早期活化分子特异性的人单克隆抗体及其使用方法。

6. 发明授权

US06645723B2 Method for determining cytokine receptor activation by the use of an antibody 失效
标题翻译：通过使用抗体测定细胞因子受体活化的方法
公开(公告)号：US06645723B2
公开(公告)日：2003-11-11
申请号：US09044154
申请日：1998-03-19
申请人： Carlos Martinez Alonso , José Mario Mellado Garcia , Leonor Kremer Baron , José Miguel Rodriguez Frade
发明人： Carlos Martinez Alonso , José Mario Mellado Garcia , Leonor Kremer Baron , José Miguel Rodriguez Frade
IPC分类号： G01N3353
CPC分类号： G01N33/74 , C07K16/2869 , G01N2333/61 , G01N2333/715
摘要： The present invention relates to a method for determinating cytokine receptor, especially growth hormone receptor (GHR), activation, by the use of an antibody capable of discriminating between an activated and an inactive cytokine receptor conformation, especially GHR or growth hormone binding protein (GHBP) conformation, the method comprising: contacting the antibody and the cytokine receptor to form a complex, contacting a candidate ligand to the complex, measuring the antibody binding to inactive cytokine receptor and thereby discriminating between an activated and an inactive conformation. The invention also relates to an antibody directed to the hinge spanning subdomains I and II of the growth hormone receptor extracellular region and which is capable of discriminating between an activated and an inactive receptor conformation. The invention also relates to the use of the antibody for e.g. characterization of growth hormone receptor interactions and for screening for compounds stabilising die dimerization of GHR.
摘要翻译：本发明涉及通过使用能够区分活化和非活性细胞因子受体构象的抗体（特别是GHR或生长激素结合蛋白（GHBP））来确定细胞因子受体，特别是生长激素受体（GHR）的活化的方法）构型，所述方法包括：使抗体和细胞因子受体接触以形成复合物，使候选配体与复合物接触，测量与非活性细胞因子受体结合的抗体，从而区分活化和非活性构象。本发明还涉及针对跨越生长激素受体细胞外区域的亚结构域I和II的铰链的抗体，其能够区分活化和非活性受体构象。本发明还涉及抗体用于例如抗体的用途。生长激素受体相互作用的表征和用于筛选稳定GHR的二聚体化合物的化合物。

7. 发明授权

US5945296A Monoclonal antibody 失效
标题翻译：单克隆抗体
公开(公告)号：US5945296A
公开(公告)日：1999-08-31
申请号：US828300
申请日：1997-03-28
申请人： Yngve Elof Hansson , Leonor Kremer Baron , Carlos Martinez Alonso , Jose Mario Mellado Garcia , Jose Miguel Rodriguez Frade
发明人： Yngve Elof Hansson , Leonor Kremer Baron , Carlos Martinez Alonso , Jose Mario Mellado Garcia , Jose Miguel Rodriguez Frade
IPC分类号： C07K16/26 , G01N33/74 , G01N33/53
CPC分类号： C07K16/26 , G01N33/74 , C07K2317/73 , G01N2333/61
摘要： The invention relates to monoclonal antibody capable of specific binding to the molecular weight of 20 kDa variant of human growth hormone. This monoclonal antibody has no substantial binding to hGH of molecular weight 22 kDa. The invention also relates to the use of this monoclonal antibody for measurement of hGH 20K, especially in body fluids. The antibodies can be used for detection and quantification of hGH 20K, especially in serum.
摘要翻译：本发明涉及能够特异性结合人生长激素的20kDa变体的分子量的单克隆抗体。该单克隆抗体与分子量22kDa的hGH没有实质性结合。本发明还涉及该单克隆抗体用于测量hGH 20K，特别是在体液中的用途。抗体可用于检测和定量hGH 20K，特别是在血清中。

8. 发明授权

US5776947A Use of quinoline-3-carboxamide compounds for inhibiting the production of tumor necrosis factor (TNF) and/or for the treatment of septic shock 失效
标题翻译：使用喹啉-3-甲酰胺化合物抑制肿瘤坏死因子（TNF）的产生和/或用于治疗败血性休克
公开(公告)号：US5776947A
公开(公告)日：1998-07-07
申请号：US586857
申请日：1996-05-20
申请人： Guido Peter Kroemer , JoseAngel Gonzalo , Carlos Martinez Alonso , Terje Kalland
发明人： Guido Peter Kroemer , JoseAngel Gonzalo , Carlos Martinez Alonso , Terje Kalland
IPC分类号： A61K31/47 , A61K31/4704 , A61P31/04 , A61P35/00 , C07D215/54 , C07D215/56
CPC分类号： C07D215/56 , A61K31/47 , A61K31/4704 , C07D215/54
摘要： The use of a quinoline-3-carboxamide compound comprising structure (I), optionally with substituents for the hydrogen atoms shown (H.sup.1-9), and a salt of compound (I) where (a) ---- represents that there are two conjugated double bonds between the atoms comprised by the dashed line, (b) X.sub.1 and X.sub.2 are separately selected form an oxygen atom or an NH.sup.9 group, said X.sub.1 and X.sub.2 being bound by a single bond to the ring when attached to H.sup.7 or H.sup.8 and by a double bond when not bound to H.sup.7 or H.sup.8, (c) H.sup.1-9 ; are hydrogens with the provision that H.sup.9 is only present when at least one of X.sub.1 and X.sub.2 is the NH.sup.9 group, (d) H.sup.7 and H.sup.8 are hydrogens that are attached to different atoms selected among X.sub.1, X.sub.2 and the nitrogen atom (N) in the quinoline ring, for the manufacture of a composition intended for inhibiting the production of tumor necrosis factor TNF in a living body and/or the treatment of septic shock in a living body.
摘要翻译： PCT No.PCT / SE94 / 00565 Sec。 371日期：1996年5月20日 102（e）日期1996年5月20日PCT提交1994年6月10日PCT公布。第WO95 / 03051号公报日期：1995年2月2日使用包含结构（I）的喹啉-3-甲酰胺化合物，任选地具有（H1-9）所示的氢原子的取代基和化合物（I）的盐，其中（a） - - 表示在由虚线包含的原子之间存在两个共轭双键，（b）X1和X2分别选自氧原子或NH9基团，所述X1和X2通过单键与环结合，连接于H7或H8，当不与H7或H8键合时为双键，（c）H1-9; 是氢，其条件是当X1和X2中的至少一个是NH9基团时，H9仅存在，（d）H7和H8是连接到选自X1，X2和氮原子（N）中的不同原子上的氢，喹啉环，用于制造用于抑制活体中肿瘤坏死因子TNF产生的组合物和/或在活体中治疗败血性休克。

9. 发明申请

US20110081292A1 Methods Of Treating Viral Hepatitis 审中-公开
标题翻译：治疗病毒性肝炎的方法
公开(公告)号：US20110081292A1
公开(公告)日：2011-04-07
申请号：US12944432
申请日：2010-11-11
申请人： Francisco Sanchez-Madrid , Carlos-Martinez Alonso , David Sancho Madrid , Pablo Engel Rocamora , Enric Esplugues Artola , Javier Vega Ramos , Pilar Lauzurica Gómez
发明人： Francisco Sanchez-Madrid , Carlos-Martinez Alonso , David Sancho Madrid , Pablo Engel Rocamora , Enric Esplugues Artola , Javier Vega Ramos , Pilar Lauzurica Gómez
IPC分类号： A61K51/10 , A61K39/395 , A61P31/14
CPC分类号： C07K16/2851 , A61K2039/505 , C07K2317/76
摘要： Disclosed are methods of treating viral hepatitis including administering an effective amount of an early activation molecule agonist, antagonist or depletor, to the subject. Human monoclonal antibodies specific to the early activation molecules, and methods of use, are also disclosed.
摘要翻译：公开了治疗病毒性肝炎的方法，包括向受试者施用有效量的早期活化分子激动剂，拮抗剂或deputor。还公开了对早期活化分子特异性的人单克隆抗体及其使用方法。

10. 发明申请

US20100227317A1 Method for the Molecular Diagnosis of Prostate Cancer and Kit for Implementing Same 审中-公开
标题翻译：前列腺癌分子诊断方法及其实施方法
公开(公告)号：US20100227317A1
公开(公告)日：2010-09-09
申请号：US12224061
申请日：2007-02-15
申请人： Timothy Thomson Okatsu , Raquel Bermudo Gascon , Angel Ramirez Ortiz , David Abia , Carlos Martinez Alonso , Pedro Luis Fernandez Ruiz , Berta Ferrer Fabrega , Elias Campo Guerri , Elisabet Rosell Vives
发明人： Timothy Thomson Okatsu , Raquel Bermudo Gascon , Angel Ramirez Ortiz , David Abia , Carlos Martinez Alonso , Pedro Luis Fernandez Ruiz , Berta Ferrer Fabrega , Elias Campo Guerri , Elisabet Rosell Vives
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57434 , C12Q1/6886 , C12Q2600/158 , Y02A90/26
摘要： The invention relates to a method for the molecular diagnosis of prostate cancer, comprising the in vitro analysis of the overexpression or underexpression of combinations of genes that can distinguish, with high statistical significance, tumorous prostate samples from non-tumorous prostate samples. The invention also relates to a kit for the molecular diagnosis of prostate cancer, which can perform the above-mentioned detection.
摘要翻译：本发明涉及用于分子诊断前列腺癌的方法，其包括能够以高统计学意义区分来自非肿瘤前列腺样品的肿瘤前列腺样品的基因组合的过表达或低表达的体外分析。本发明还涉及可以进行上述检测的用于前列腺癌分子诊断的试剂盒。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式