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1. 发明授权

US06180681B2 2-cyclopenten-1-one as an inducer of HSP70 失效
标题翻译： 2-环戊烯-1-酮作为HSP70的诱导剂
公开(公告)号：US06180681B2
公开(公告)日：2001-01-30
申请号：US09202553
申请日：1998-12-16
申请人： Carla Amici , Giuliano Elia , Enrico Garaci , Antonio Rossi , Maria Gabriella Santoro
发明人： Carla Amici , Giuliano Elia , Enrico Garaci , Antonio Rossi , Maria Gabriella Santoro
IPC分类号： A61K3112
CPC分类号： A61K31/122
摘要： The invention relates to 2-cyclopenten-1-one as an inducer of the heat shock protein HSP70 by activating the heat shock transcription factor HSF, and selectively inducing the transcription and translation of HSP70 in human cells. In particular, since a cytoprotective role of HSP70 during viral infection was previously shown, the invention refers to 2-cyclopenten-1-one and its pharmaceutically acceptable derivatives as inducers of HSP70 with antiviral activity. Treatment with 2-cyclopenten-1-one and its pharmaceutically acceptable derivatives causes a dose-dependent reduction of infectious virus yield during infection with vesicular stomatitis virus. The block of virus replication is due to inhibition of viral protein synthesis, associated with HSP70 synthesis.
摘要翻译：本发明涉及2-环戊烯-1-酮作为热休克蛋白HSP70的诱导剂，通过激活热休克转录因子HSF，并选择性诱导人细胞中HSP70的转录和翻译。特别地，由于先前已显示出病毒感染期间HSP70的细胞保护作用，所以本发明涉及2-环戊烯-1-酮及其药学上可接受的衍生物作为具有抗病毒活性的HSP70诱导剂。用2-环戊烯-1-酮及其药学上可接受的衍生物的治疗导致在水泡性口炎病毒感染期间感染性病毒产量的剂量依赖性降低。病毒复制的阻断是由于与HSP70合成相关的病毒蛋白合成的抑制。

2. 发明申请

US20050020687A1 Methods of treating inflammatory and viral disorders by administering cyclopentenone compounds 审中-公开
标题翻译：通过施用环戊烯酮化合物治疗炎性和病毒性疾病的方法
公开(公告)号：US20050020687A1
公开(公告)日：2005-01-27
申请号：US10742523
申请日：2003-12-19
申请人： Maria Santoro , Antonio Rossi , Giuliano Elia , Enrico Garaci , Carla Amici
发明人： Maria Santoro , Antonio Rossi , Giuliano Elia , Enrico Garaci , Carla Amici
IPC分类号： A61K31/00 , A61K31/122 , A61K31/557
CPC分类号： A61K31/122 , A61K31/00 , Y02A50/387 , Y02A50/389 , Y02A50/463
摘要： The present invention relates to methods and compositions for the treatment and/or prevention of diseases and disorders in humans, including cancer, inflammatory diseases or disorders, and infectious diseases. In particular, the present invention relates to methods and compositions comprising the administration of a cyclopentenone prostaglandin or a derivative thereof, which induces cytoprotective responses and inhibits NF-κB activation. The present invention further relates to pharmaceutical compositions containing cyclopentenone prostaglandins for the treatment and/or prevention of viral infection, inflammation, and/or cancer in humans.
摘要翻译：本发明涉及用于治疗和/或预防人类疾病和病症的方法和组合物，包括癌症，炎性疾病或病症和感染性疾病。特别地，本发明涉及包含施用环戊烯酮前列腺素或其衍生物的方法和组合物，其诱导细胞保护反应并抑制NF-κB活化。本发明还涉及含有环戊烯酮前列腺素用于治疗和/或预防人类病毒感染，炎症和/或癌症的药物组合物。

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