专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07651996B2 Pharmaceutical compositions and methods for insulin treatment 有权
标题翻译：用于胰岛素治疗的药物组合物和方法
公开(公告)号：US07651996B2
公开(公告)日：2010-01-26
申请号：US11509417
申请日：2006-08-24
申请人： Robert J. Gyurik , Carl Reppucci
发明人： Robert J. Gyurik , Carl Reppucci
IPC分类号： A61K38/28 , A61K51/00 , A61M36/14
CPC分类号： A61K9/0019 , A61K9/0043 , A61K9/1075 , A61K38/28 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/34 , A61K47/44
摘要： Compositions and methods for treating a patient with insulin that combines insulin, a permeation enhancer, and a carrier that maintains an acidic pH, are disclosed.
摘要翻译：公开了用于治疗患有胰岛素的患者的组合物和方法，其结合胰岛素，渗透增强剂和保持酸性pH的载体。

2. 发明申请

US20080045447A1 Fibrilliform-free insulin composition 审中-公开
标题翻译：无纤维素的胰岛素组成
公开(公告)号：US20080045447A1
公开(公告)日：2008-02-21
申请号：US11811170
申请日：2007-06-08
申请人： Robert Gyurik , Carl Reppucci , Zhengmao Li
发明人： Robert Gyurik , Carl Reppucci , Zhengmao Li
IPC分类号： A61K38/28 , A61M11/00 , A61P3/08
CPC分类号： A61K38/28 , A61K9/0043 , A61K9/107 , A61K9/1075 , A61K47/02 , A61K47/08 , A61K47/12 , A61K47/22 , A61K47/26
摘要： Compositions and methods are disclosed for treating a patient with insulin, wherein a composition in a form suitable for nasal delivery to a patient comprises a therapeutically effective amount of insulin, a permeation enhancer, a liquid carrier, and an acid present in said composition in an amount sufficient to provide an acidic pH, but not greater than a pH of 4.5, said acid being selected from the group consisting of: monovalent inorganic acid(s), sulfuric acid, and acetic acid. Preferably the composition is essentially-free of citrate(s) and essentially-free of phosphate(s). The composition being thus designed with the intent to provide a composition that is essentially-free of fibrilliform (or beta-sheet) insulin polymorphs.
摘要翻译：公开了用于治疗患有胰岛素的患者的组合物和方法，其中适于鼻输给患者的形式的组合物包含治疗有效量的胰岛素，渗透增强剂，液体载体和存在于所述组合物中的酸足以提供酸性pH但不大于pH 4.5的量，所述酸选自：一价无机酸，硫酸和乙酸。优选地，组合物基本上不含柠檬酸盐，并且基本上不含磷酸盐。这样设计的组合物旨在提供基本上不含原纤维状（或β-片）胰岛素多晶型物的组合物。

3. 发明申请

US20090156464A1 Pharmaceutical Compositions and Methods for Insulin Treatment 审中-公开
标题翻译：胰岛素治疗的药物组合物和方法
公开(公告)号：US20090156464A1
公开(公告)日：2009-06-18
申请号：US12337924
申请日：2008-12-18
申请人： Robert J. Gyurik , Carl Reppucci
发明人： Robert J. Gyurik , Carl Reppucci
IPC分类号： A61K38/28
CPC分类号： A61K9/0019 , A61K9/0043 , A61K9/1075 , A61K38/28 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/34 , A61K47/44
摘要： Compositions and methods for treating a patient with insulin that combines insulin, a permeation enhancer, and a carrier that maintains an acidic pH, are disclosed.
摘要翻译：公开了用于治疗患有胰岛素的患者的组合物和方法，其结合胰岛素，渗透增强剂和保持酸性pH的载体。

4. 发明申请

US20080107735A1 Macrocyclic formulations for transmembrane drug delivery 审中-公开
标题翻译：用于跨膜药物递送的大环制剂
公开(公告)号：US20080107735A1
公开(公告)日：2008-05-08
申请号：US11591788
申请日：2006-11-02
申请人： Robert J. Gyurik , Carl Reppucci
发明人： Robert J. Gyurik , Carl Reppucci
IPC分类号： A61K9/14
CPC分类号： A61K9/0014 , A61K47/10 , A61K47/22
摘要： Topically applied pharmaceutical products comprising (a) an active ingredient, (b) an organogel, and (c) a non-irritating permeation enhancer, are disclosed, along with and methods of use and formulations thereof. The topically applied products and methods are intended to be used to enhance any of the transdermal, subdermal, transmembrane, musculoskeletal, transungual, transonychial, and/or peronychial deliveries of a therapeutically effective amount of an active ingredient to a patient. The invention is particularly directed to topically applied pharmaceutical products for enhancing the delivery of a therapeutically effective amount of an active ingredient to a diseased or infected nail bed, nail matrix, and/or nail plate in the toenails or fingernails of a patient suffering from onychomycosis. The invention is also directed to delivery of an anti-inflammatory agent, preferably of the Cox-2 enzyme inhibitory class, topically to a site of soft tissue injury or discomfort.
摘要翻译：公开了包含（a）活性成分，（b）有机凝胶和（c）非刺激性渗透促进剂）的局部应用的药物产品，以及其使用方法和制剂。局部施用的产品和方法旨在用于增强患者的治疗有效量的活性成分的任何透皮，皮下，跨膜，肌肉骨骼，横断面，转基因和/或肛门周围递送。本发明特别涉及用于增强治疗有效量的活性成分向病患或受感染的甲床，指甲基质和/或指甲板在患有甲真菌病的患者的趾甲或指甲中的递送的药物产品。本发明还涉及将抗炎剂（优选为Cox-2酶抑制剂）局部递送至软组织损伤或不适的部位。

5. 发明申请

US20070265191A1 Pharmaceutical compositions and methods for peptide treatment 有权
标题翻译：药物组合物和肽治疗方法
公开(公告)号：US20070265191A1
公开(公告)日：2007-11-15
申请号：US11811304
申请日：2007-06-07
申请人： Robert Gyurik , Carl Reppucci
发明人： Robert Gyurik , Carl Reppucci
IPC分类号： A61K38/02 , A61P37/08
CPC分类号： A61K9/0043 , A61K9/08 , A61K9/107 , A61K9/1075 , A61K31/12 , A61K31/365 , A61K31/485 , A61K38/02 , A61K38/08 , A61K38/25 , A61K47/06 , A61K47/08 , A61K47/10 , A61K47/18 , A61K47/186 , A61K47/22 , A61K47/32 , A61K47/44 , Y10S514/937
摘要： Disclosed are compositions and methods for treating a patient with a pharmaceutically active agent other than insulin selected from the group consisting of peptides, peptidomimetics, and proteins, wherein the pharmaceutical composition is in the form of an emulsified nasal spray comprising: a macrocyclic permeation enhancer, a liquid carrier comprising water, and a therapeutically effective amount of a pharmaceutically active agent other than insulin selected from the group consisting of peptides, peptidomimetics, and proteins; wherein the macrocyclic permeation enhancer is a Hsieh enhancer emulsified in the liquid carrier; and wherein the Hsieh enhancer has the following structure: wherein X and Y are oxygen, sulfur or an imino group of the structure or ═N—R with the proviso that when Y is the imino group, X is an imino group, and when Y is sulfur, X is sulfur or an imino group, A is a group having the structure wherein X and Y are defined above, m and n are integers having a value from 1 to 20 and the sum of m+n is not greater than 25, p is an integer having a value of 0 or 1, q is an integer having a value of 0 or 1, r is an integer having a value of 0 or 1, and each of R, R1, R2, R3, R4, R5 and R6 is independently hydrogen or an alkyl group having from 1 to 6 carbon atoms which may be straight chained or branched provided that only one of R1 to R6 can be an alkyl group, with the proviso that when p, q and r have a value of 0 and Y is oxygen, m+n is at least 11, and with the further proviso that when X is an imino group, q is equal to 1, Y is oxygen, and p and r are 0, then m+n is at least 11.
摘要翻译：公开了用除了选自肽，肽模拟物和蛋白质的胰岛素以外的药物活性剂治疗患者的组合物和方法，其中所述药物组合物为乳化鼻喷雾剂的形式，其包含：大环渗透促进剂，包含水的液体载体和治疗有效量的选自肽，肽模拟物和蛋白质的胰岛素以外的药学活性剂; 其中所述大环渗透促进剂是在所述液体载体中乳化的Hsieh增强剂; 并且其中所述Hsieh增强剂具有以下结构：其中X和Y是结构中的氧，硫或亚氨基或-NR，条件是当Y是亚氨基时，X是亚氨基，当Y是硫时 X是硫或亚氨基，A是具有以上结构的基团，其中X和Y定义如上，m和n是具有1至20的整数，并且m + n的总和不大于25，p 是0或1的整数，q是0或1的整数，r是0或1的整数，R 1，R 1， R 2，R 3，R 4，R 5和R 6是独立地是氢或具有1至6个碳原子的烷基，其可以是直链或支链的，条件是R 1至R 6中只有一个可以是烷基，条件是当p，q和r的值为0，Y为氧时，m + n为至少11，另外条件是当X为亚氨基 gup等于1，Y为氧，p和r为0，则m + n为11以上。

6. 发明申请

US20140128379A1 NASAL FORMULATIONS OF BENZODIAZEPINE 审中-公开
标题翻译：苯并二氮吡啶的制备方法
公开(公告)号：US20140128379A1
公开(公告)日：2014-05-08
申请号：US14007153
申请日：2012-03-29
申请人： Nils Bergenhem , Carl Reppucci , Zhengmao Li
发明人： Nils Bergenhem , Carl Reppucci , Zhengmao Li
IPC分类号： A61K31/5513 , A61K9/00
CPC分类号： A61K31/5513 , A61K9/0043 , A61K31/365 , A61K31/551 , A61K31/5517 , A61K47/08 , A61K47/10
摘要： The present invention provides pharmaceutical compositions for intranasal delivery of a benzodiazepine. The composition may contain a therapeutically effective amount of a benzodiazepine or a pharmaceutically acceptable salt thereof, and a permeation enhancer. The permeation enhancer may be propylene glycol or a Hsieh permeation enhancer. The present compositions have excellent bioavailability. After administration of the present compositions, therapeutically effective plasma levels of the benzodiazepine may be achieved rapidly. The present pharmaceutical composition may be used to treat a patient suffering from anxiety, epilepsy, insomnia, agitation, seizures, muscular disorders, alcohol dependence, and drug withdrawal.
摘要翻译：本发明提供了用于鼻内递送苯二氮卓类药物的药物组合物。组合物可以含有治疗有效量的苯并二氮杂或其药学上可接受的盐和渗透促进剂。渗透促进剂可以是丙二醇或Hsieh渗透促进剂。本发明的组合物具有优异的生物利用度。在给予本发明组合物后，可以快速实现苯二氮卓类药物的治疗有效血浆水平。本发明的药物组合物可用于治疗患有焦虑，癫痫，失眠，激动，癫痫发作，肌肉障碍，酒精依赖和药物戒断的患者。

7. 发明申请

US20100144593A1 Pharmaceutical Compositions and Methods for Insulin Treatment 有权
标题翻译：胰岛素治疗的药物组合物和方法
公开(公告)号：US20100144593A1
公开(公告)日：2010-06-10
申请号：US12614335
申请日：2009-11-06
申请人： Robert J. Gyurik , Carl Reppucci
发明人： Robert J. Gyurik , Carl Reppucci
IPC分类号： A61K38/28 , A61P3/00
CPC分类号： A61K9/0019 , A61K9/0043 , A61K9/1075 , A61K38/28 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/34 , A61K47/44
摘要： Compositions and methods for treating a patient with insulin that combines insulin, a permeation enhancer, and a carrier that maintains an acidic pH, are disclosed.
摘要翻译：公开了用于治疗患有胰岛素的患者的组合物和方法，其结合胰岛素，渗透增强剂和保持酸性pH的载体。

8. 发明申请

US20080045446A1 Insulin composition 失效
标题翻译：胰岛素组成
公开(公告)号：US20080045446A1
公开(公告)日：2008-02-21
申请号：US11811169
申请日：2007-06-08
申请人： Robert Gyurik , Carl Reppucci
发明人： Robert Gyurik , Carl Reppucci
IPC分类号： A61K38/28 , A61P3/00
CPC分类号： A61K38/28 , A61K9/0043 , A61K9/107 , A61K9/1075 , A61K47/02 , A61K47/08 , A61K47/12 , A61K47/22 , A61K47/26
摘要： Pharmaceutical compositions for nasal administration to humans, or to warm-blooded animals, comprise: (A) a therapeutically effective amount of insulin; (B) a permeation enhancer; and (C) a liquid carrier; the compositions being further comprised of, or characterized by, any, or each, of: (D) a combination of non-ionic surfactants; wherein the combination of non-ionic surfactants comprises: (i) at least one fatty acid ester of a sugar or sugar alcohol and (ii) at least one pegylated fatty acid ester of a sugar or sugar alcohol; (E) an acidic pH, but no greater than a pH of 4.5; and (F) an osmolality of
摘要翻译：用于鼻给予人或温血动物的药物组合物包含：（A）治疗有效量的胰岛素; （B）渗透促进剂; 和（C）液体载体; 所述组合物进一步由下列组分组成：或（ii）非离子表面活性剂的组合; 其中非离子表面活性剂的组合包括：（i）糖或糖醇的至少一种脂肪酸酯和（ii）糖或糖醇的至少一种聚乙二醇化脂肪酸酯; （E）酸性pH，但不大于pH 4.5; 和（F）<200mOsmol / Kg H2O的重量克分子渗透压浓度。

9. 发明授权

US07244703B2 Pharmaceutical compositions and methods for peptide treatment 有权
标题翻译：药物组合物和肽治疗方法
公开(公告)号：US07244703B2
公开(公告)日：2007-07-17
申请号：US10895465
申请日：2004-03-05
申请人： Robert J. Gyurik , Carl Reppucci
发明人： Robert J. Gyurik , Carl Reppucci
IPC分类号： A61K38/02 , A61K91/07
CPC分类号： A61K9/0043 , A61K9/08 , A61K9/107 , A61K9/1075 , A61K31/12 , A61K31/365 , A61K31/485 , A61K38/02 , A61K38/08 , A61K38/25 , A61K47/06 , A61K47/08 , A61K47/10 , A61K47/18 , A61K47/186 , A61K47/22 , A61K47/32 , A61K47/44 , Y10S514/937
摘要： Compositions and methods for treating a patient with a pharmaceutically active peptide that combines a pharmaceutically active peptide, a permeation enhancer, and a carrier, are disclosed.
摘要翻译：公开了用药物活性肽，渗透促进剂和载体组合的药物活性肽治疗患者的组合物和方法。

10. 发明授权

US08044020B2 Pharmaceutical compositions and methods for insulin treatment 有权
标题翻译：用于胰岛素治疗的药物组合物和方法
公开(公告)号：US08044020B2
公开(公告)日：2011-10-25
申请号：US12614335
申请日：2009-11-06
申请人： Robert J. Gyurik , Carl Reppucci
发明人： Robert J. Gyurik , Carl Reppucci
IPC分类号： A61K38/00 , A61K47/00 , A61K38/28 , A61K51/00
CPC分类号： A61K9/0019 , A61K9/0043 , A61K9/1075 , A61K38/28 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/34 , A61K47/44
摘要： Compositions and methods for treating a patient with insulin that combines insulin, a permeation enhancer, and a carrier that maintains an acidic pH, are disclosed.
摘要翻译：公开了用于治疗患有胰岛素的患者的组合物和方法，其结合胰岛素，渗透增强剂和保持酸性pH的载体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式