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1. 发明申请

US20160083764A1 AN IMPROVED PROCESS FOR THE PREPARATION OF FIDAXOMICIN 审中-公开
标题翻译：改进FIDAXOMICIN的制备方法
公开(公告)号：US20160083764A1
公开(公告)日：2016-03-24
申请号：US14785696
申请日：2014-04-21
申请人： CONCORD BIOTECH LIMITED
发明人： Ankur Sudhir Vaid , Mitesh Jagdishkumar Patel , Dhimant Punjalal Mehta , Anand Mahadev Dhiman , Jayesh Chandubhai Patel , Traunkant Parshuram Sharma
IPC分类号： C12P19/58 , C07H17/08 , C12N1/20
CPC分类号： C12P19/58 , C07D407/14 , C07H17/08 , C12N1/20 , C12P19/62
摘要： The present invention provides an improved process for the preparation of fidaxomicin by culturing Actinoplanes deccanensis in the culture medium of the invention wherein the fidaxomicin is produced in a yield of greater than 500 mg/L broth. The present invention also provides a whole broth extraction process for the isolation of fidaxomicin from the fermentation broth. The present invention also provides fidaxomicin having purity of greater than 97% area by HPLC.
摘要翻译：本发明提供了一种通过在本发明的培养基中培养放线菌素来制备福多西菌素的改进方法，其中制备的大豆多糖以大于500mg / L肉汤的产量生产。本发明还提供了用于从发酵液中分离fidaxomicin的整个肉汤提取方法。本发明还提供通过HPLC纯度大于97％的Fidaxomicin。

2. 发明授权

US10294276B2 Process for isolation of romidepsin from fermentation broth and preparation of crystals of romidepsin 有权
公开(公告)号：US10294276B2
公开(公告)日：2019-05-21
申请号：US15123295
申请日：2015-03-02
申请人： Concord Biotech Limited
发明人： Ankur S. Vaid , Anand M. Dhiman , Traunkant P. Sharma
IPC分类号： C07K11/02 , C07K5/103
摘要： The present invention describes a process for isolation of romidepsin from fermentation broth and preparation of crystals of romidepsin. The process of the invention includes fewer purification steps and provides romidepsin having purity of greater than 99.5% area by HPLC. The process of the invention involves simple purification steps and hence, does not require multiple chromatographic purification steps to achieve desired quality of romidepsin. The process is advantageous over reported processes in terms of 99.5% pure yield, fast process, less expensive and less cumbersome as multiple chromatographic purification is not necessary to achieve desired quality. The process for the preparation of crystals of romidepsin provides advantages like simple steps and involves use of single solvent. The process is advantageous in terms of time, cost, and simplicity.

3. 发明申请

US20170073374A1 A PROCESS FOR ISOLATION PF ROMIDEPSIN FROM FERMENTATION BROTH AND PREPARATION OF CRYSTALS OF ROMIDEPSIN 审中-公开
标题翻译：从发酵丝中分离PF ROMIDEPSIN的方法和ROMIDEPSIN晶体的制备
公开(公告)号：US20170073374A1
公开(公告)日：2017-03-16
申请号：US15123295
申请日：2015-03-02
申请人： CONCORD BIOTECH LIMITED
发明人： ANKUR S. VAID , Anand M. DHIMAN , Traunkant P. SHARMA
IPC分类号： C07K11/02
CPC分类号： C07K11/02 , C07K5/101
摘要： The present invention describes a process for isolation of romidepsin from fermentation broth and preparation of crystals of romidepsin. The process of the invention includes fewer purification steps and provides romidepsin having purity of greater than 99.5% area by HPLC. The process of the invention involves simple purification steps and hence, does not require multiple chromatographic purification steps to achieve desired quality of romidepsin. The process is advantageous over reported processes in terms of 99.5% pure yield, fast process, less expensive and less cumbersome as multiple chromatographic purification is not necessary to achieve desired quality. The process for the preparation of crystals of romidepsin provides advantages like simple steps and involves use of single solvent. The process is advantageous in terms of time, cost, and simplicity.
摘要翻译：本发明描述了一种从发酵液中分离罗非西菌素的方法以及罗曲甜蛋白晶体的制备。本发明的方法包括较少的纯化步骤，并通过HPLC提供具有大于99.5％面积的纯度的罗曲非菌素。本发明的方法涉及简单的纯化步骤，因此，不需要多个色谱纯化步骤来达到所需的罗维菌素质量。该方法优于所报道的方法，其纯度为99.5％，快速加工，较便宜且较不麻烦，因为不需要多次色谱纯化来达到所需的质量。制备罗非曲汀晶体的方法提供了简单步骤的优点，并涉及使用单一溶剂。该方法在时间，成本和简单性方面是有利的。

4. 发明授权

US10119158B2 Process for the preparation of fidaxomicin 有权
公开(公告)号：US10119158B2
公开(公告)日：2018-11-06
申请号：US14785696
申请日：2014-04-21
申请人： CONCORD BIOTECH LIMITED
发明人： Ankur Sudhir Vaid , Mitesh Jagdishkumar Patel , Dhimant Punjalal Mehta , Anand Mahadev Dhiman , Jayesh Chandubhai Patel , Traunkant Parshuram Sharma
IPC分类号： C12P19/58 , C07D407/14 , C12P19/62 , C07H17/08 , C12N1/20
摘要： The present invention provides an improved process for the preparation of fidaxomicin by culturing Actinoplanes deccanensis in the culture medium of the invention wherein the fidaxomicin is produced in a yield of greater than 500 mg/L broth. The present invention also provides a whole broth extraction process for the isolation of fidaxomicin from the fermentation broth. The present invention also provides fidaxomicin having purity of greater than 97% area by HPLC.

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