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1. 发明授权

US5683667A Reactive tricalcium phosphate compositions 失效
标题翻译：活性磷酸三钙组合物
公开(公告)号：US5683667A
公开(公告)日：1997-11-04
申请号：US570237
申请日：1995-12-11
申请人： Mark Fulmer , Brent R. Constantz , Ira C. Ison , Bryan M. Barr
发明人： Mark Fulmer , Brent R. Constantz , Ira C. Ison , Bryan M. Barr
IPC分类号： A61L24/00 , A61F2/00 , A61L24/02 , A61L27/12 , C01B25/32 , C04B12/02 , C04B28/34
CPC分类号： C01B25/32 , A61L24/02 , A61L27/12 , C01B25/321 , C04B12/02 , C04B12/025 , C04B28/34 , C04B28/344 , C04B28/346 , A61F2310/00293 , C04B2111/00836
摘要： Methods for producing a room temperature stable, phase pure .alpha.-C.sub.3 P product, and compositions derived therefrom, are provided. In the subject method, a tricalcium phosphate source is heated to a temperature sufficient to convert substantially all of said tricalcium phosphate source to a substantially phase pure .alpha.-C.sub.3 P product. The temperature of the resultant product is rapidly cooled to a temperature below about 700.degree. C., resulting in a room temperature stable, reactive .alpha.-C.sub.3 P product. The resultant .alpha.-C.sub.3 P product may be milled to provide an .alpha.-C.sub.3 P composition which may find use in the preparation of calcium phosphate cements.
摘要翻译：提供了制备室温稳定的纯相α-C3P产物及其衍生物的方法。在本发明方法中，磷酸三钙源被加热到足以将基本上所有的所述磷酸三钙源转化为基本相纯α-C3P产物的温度。将所得产物的温度快速冷却至低于约700℃的温度，得到室温稳定的反应性α-C3P产物。所得到的α-C3P产物可以被研磨以提供可用于制备磷酸钙水泥的α-C3P组合物。

2. 发明授权

US6002065A Kits for preparing calcium phosphate minerals 失效
标题翻译：用于制备磷酸钙矿物的试剂盒
公开(公告)号：US6002065A
公开(公告)日：1999-12-14
申请号：US820126
申请日：1997-03-19
申请人： Brent R. Constantz , Mark T. Fulmer , Bryan M. Barr
发明人： Brent R. Constantz , Mark T. Fulmer , Bryan M. Barr
IPC分类号： A61F2/00 , A61L24/02 , A61L27/12 , A61F2/28
CPC分类号： A61L24/02 , A61K6/0038 , A61K6/033 , A61K6/0643 , A61K6/0668 , A61K6/0675 , A61L27/12 , A61F2310/00293 , Y10S623/923
摘要： Setting times of calcium phosphate cement compositions are enhanced by the addition of phosphate or carbonate lubricant compositions. Methods for preparing the cement compositions are provided.
摘要翻译：通过添加磷酸盐或碳酸盐润滑剂组合物可提高磷酸钙水泥组合物的凝固时间。提供了制备水泥组合物的方法。

3. 发明授权

US5964932A Storage stable calcium phosphate cements 失效
标题翻译：储存稳定的磷酸钙水泥
公开(公告)号：US5964932A
公开(公告)日：1999-10-12
申请号：US111347
申请日：1998-07-07
申请人： Ira C. Ison , Mark T. Fulmer , Bryan M. Barr , Brent R. Constantz
发明人： Ira C. Ison , Mark T. Fulmer , Bryan M. Barr , Brent R. Constantz
IPC分类号： A61F2/00 , A61L27/12 , C04B12/02 , C04B20/10 , C04B28/34 , C04B40/06
CPC分类号： C04B20/107 , A61L27/12 , C04B12/025 , C04B20/1077 , C04B28/34 , C04B28/344 , C04B40/06 , A61F2310/00293 , C04B2111/00836 , Y10S623/901 , Y10T428/2949 , Y10T428/2991 , Y10T428/2993
摘要： Two component, storage stable apatitic cement compositions, as well as methods for their production, are provided. The dry component of subject apatitic cements comprises basic calcium source particles at least partially coated with a partially neutralized acidic calciumim phosphate. The dry component of subject compositions is prepared by combining basic calcium source particles with dissolved acidic phosphate in at least a partially aqueous medium, whereby the basic calcium source particles become partially coated with a partially neutralized acidic calcium phosphate. The reaction is terminated prior to completion of the reaction between the acidic phosphate and the basic calcium source by removing the available water from the reaction mixture. In a first mode, the subject cement may be produced by mechanically mixing an acidic phosphate source with basic calcium source particles in the presence of an aqueous solvent and stopping the reaction between the acid and base prior to completion. Alternatively, a phosphoric acid solution may be rapidly combined with a basic calcium phosphate particle slurry such that partially neutralized acidic calcium phosphate precipitates on the surface of the basic calcium phosphate particles.
摘要翻译：提供了两种组分的储存稳定的磷灰石水泥组合物，以及它们的生产方法。受试者磷灰石水泥的干组分包括至少部分涂覆有部分中和的酸性磷酸钙的碱性钙源颗粒。通过将碱性钙源颗粒与溶解的酸性磷酸盐在至少部分水性介质中组合来制备主体组合物的干组分，由此碱性钙源颗粒部分地涂覆有部分中和的酸性磷酸钙。在酸性磷酸盐和碱性钙源之间的反应完成之后，通过从反应混合物中除去可用的水来终止反应。在第一模式中，主体水泥可以通过在水性溶剂的存在下将酸性磷酸盐源与碱性钙源颗粒机械混合并在完成之前停止酸和碱之间的反应来制备。或者，磷酸溶液可以与碱性磷酸钙颗粒浆料快速组合，使得部分中和的酸性磷酸钙在碱性磷酸钙颗粒的表面上沉淀。

4. 发明授权

US5885540A Reactive tricalcium phosphate compositions 失效
标题翻译：活性磷酸三钙组合物
公开(公告)号：US5885540A
公开(公告)日：1999-03-23
申请号：US886239
申请日：1997-07-01
申请人： Mark Fulmer , Brent R. Constantz , Ira C. Ison , Bryan M. Barr
发明人： Mark Fulmer , Brent R. Constantz , Ira C. Ison , Bryan M. Barr
IPC分类号： A61L24/00 , A61F2/00 , A61L24/02 , A61L27/12 , C01B25/32 , C04B12/02 , C04B28/34
CPC分类号： C01B25/32 , A61L24/02 , A61L27/12 , C01B25/321 , C04B12/02 , C04B12/025 , C04B28/34 , C04B28/344 , C04B28/346 , A61F2310/00293 , C04B2111/00836
摘要： Methods for producing a room temperature stable, phase pure .alpha.-C.sub.3 P product, and compositions derived therefrom, are provided. In the subject method, a tricalcium phosphate source is heated to a temperature sufficient to convert substantially all of said tricalcium phosphate source to a substantially phase pure .alpha.-C.sub.3 P product. The temperature of the resultant product is rapidly cooled to a temperature below about 700.degree. C., resulting in a room temperature stable, reactive .alpha.-C.sub.3 P product. The resultant .alpha.-C.sub.3 P product may be milled to provide an .alpha.-C.sub.3 P composition which may find use in the preparation of calcium phosphate cements.
摘要翻译：提供了制备室温稳定的纯相α-C3P产物及其衍生物的方法。在本发明方法中，磷酸三钙源被加热到足以将基本上所有的所述磷酸三钙源转化为基本相纯α-C3P产物的温度。将所得产物的温度快速冷却至低于约700℃的温度，得到室温稳定的反应性α-C3P产物。所得到的α-C3P产物可以被研磨以提供可用于制备磷酸钙水泥的α-C3P组合物。

5. 发明授权

US5846312A Storage stable calcium phosphate cements 失效
公开(公告)号：US5846312A
公开(公告)日：1998-12-08
申请号：US886238
申请日：1997-07-01
申请人： Ira C. Ison , Mark T. Fulmer , Bryan M. Barr , Brent R. Constantz
发明人： Ira C. Ison , Mark T. Fulmer , Bryan M. Barr , Brent R. Constantz
IPC分类号： A61F2/00 , A61L27/12 , C04B12/02 , C04B20/10 , C04B28/34 , C04B40/06
CPC分类号： C04B20/107 , A61L27/12 , C04B12/025 , C04B20/1077 , C04B28/34 , C04B28/344 , C04B40/06 , A61F2310/00293 , C04B2111/00836 , Y10S623/901 , Y10T428/2949 , Y10T428/2991 , Y10T428/2993
摘要： Two component, storage stable apatitic cement compositions, as well as methods for their production, are provided. The dry component of subject apatitic cements comprises basic calcium source particles at least partially coated with a partially neutralized acidic calcium phosphate. The dry component of subject compositions is prepared by combining basic calcium source particles with dissolved acidic phosphate in at least a partially aqueous medium, whereby the basic calcium source particles become partially coated with a partially neutralized acidic calcium phosphate. The reaction is terminated prior to completion of the reaction between the acidic phosphate and the basic calcium source by removing the available water from the reaction mixture. In a first mode, the subject cement may be produced by mechanically mixing an acidic phosphate source with basic calcium source particles in the presence of an aqueous solvent and stopping the reaction between the acid and base prior to completion. Alternatively, a phosphoric acid solution may be rapidly combined with a basic calcium phosphate particle slurry such that partially neutralized acidic calcium phosphate precipitates on the surface of the basic calcium phosphate particles.

6. 发明授权

US5820632A Prepared calcium phosphate composition and method 失效
标题翻译：制备磷酸钙组合物及方法
公开(公告)号：US5820632A
公开(公告)日：1998-10-13
申请号：US221646
申请日：1994-04-01
申请人： Brent R. Constantz , Mark T. Fulmer , Bryan M. Barr
发明人： Brent R. Constantz , Mark T. Fulmer , Bryan M. Barr
IPC分类号： A61K47/02 , A61F2/00 , A61F2/02 , A61F2/28 , A61K6/033 , A61L24/02 , A61L27/00 , A61L27/12 , A61L27/46 , A61L27/50 , A61L27/58 , C01B25/16 , C01B25/32 , C01B25/455 , C01B15/16
CPC分类号： A61K6/033 , A61K6/0023 , A61K6/0038 , A61K6/0085 , A61K6/0643 , A61K6/0668 , A61K6/0675 , A61L24/02 , A61L27/12 , A61L27/46 , A61L27/50 , A61L27/58 , C01B25/16 , C01B25/32 , C01B25/322 , C01B25/327 , C01B25/455 , A61F2002/2817 , A61F2002/30062 , A61F2210/0004 , A61F2310/00293 , Y10S623/901
摘要： Setting times of calcium phosphate cement compositions are enhanced by the addition of phosphate or carbonate lubricant compositions. Methods for preparing the cement compositions are provided.
摘要翻译：通过添加磷酸盐或碳酸盐润滑剂组合物可提高磷酸钙水泥组合物的凝固时间。提供了制备水泥组合物的方法。

7. 发明授权

US5683496A Storage stable calcium phosphate cements 失效
标题翻译：储存稳定的磷酸钙水泥
公开(公告)号：US5683496A
公开(公告)日：1997-11-04
申请号：US645573
申请日：1996-05-14
申请人： Ira C. Ison , Mark T. Fulmer , Bryan M. Barr , Brent R. Constantz
发明人： Ira C. Ison , Mark T. Fulmer , Bryan M. Barr , Brent R. Constantz
IPC分类号： A61F2/00 , A61L27/12 , C04B12/02 , C04B20/10 , C04B28/34 , C04B40/06
CPC分类号： C04B20/107 , A61L27/12 , C04B12/025 , C04B20/1077 , C04B28/34 , C04B28/344 , C04B40/06 , A61F2310/00293 , C04B2111/00836 , Y10S623/901 , Y10T428/2949 , Y10T428/2991 , Y10T428/2993
摘要： Two component, storage stable apatitic cement compositions, as well as methods for their production, are provided. The dry component of subject apatitic cements comprises basic calcium source particles at least partially coated with a partially neutralized acidic calcium phosphate. The dry component of subject compositions is prepared by combining basic calcium source particles with dissolved acidic phosphate in at least a partially aqueous medium, whereby the basic calcium source particles become partially coated with a partially neutralized acidic calcium phosphate. The reaction is terminated prior to completion of the reaction between the acidic phosphate and the basic calcium source by removing the available water from the reaction mixture. In a first mode, the subject cement may be produced by mechanically mixing an acidic phosphate source with basic calcium source particles in the presence of an aqueous solvent and stopping the reaction between the acid and base prior to completion. Alternatively, a phosphoric acid solution may be rapidly combined with a basic calcium phosphate particle slurry such that partially neutralized acidic calcium phosphate precipitates on the surface of the basic calcium phosphate particles.
摘要翻译：提供了两种组分的储存稳定的磷灰石水泥组合物，以及它们的生产方法。受试者磷灰石水泥的干组分包括至少部分涂覆有部分中和的酸性磷酸钙的碱性钙源颗粒。通过将碱性钙源颗粒与溶解的酸性磷酸盐在至少部分水性介质中组合来制备主体组合物的干组分，由此碱性钙源颗粒部分地涂覆有部分中和的酸性磷酸钙。在酸性磷酸盐和碱性钙源之间的反应完成之后，通过从反应混合物中除去可用的水来终止反应。在第一模式中，主体水泥可以通过在水性溶剂的存在下将酸性磷酸盐源与碱性钙源颗粒机械混合并在完成之前停止酸和碱之间的反应来制备。或者，磷酸溶液可以与碱性磷酸钙颗粒浆料快速组合，使得部分中和的酸性磷酸钙在碱性磷酸钙颗粒的表面上沉淀。

8. 发明授权

US5496399A Storage stable calcium phosphate cements 失效
公开(公告)号：US5496399A
公开(公告)日：1996-03-05
申请号：US294325
申请日：1994-08-23
申请人： Ira C. Ison , Mark T. Fulmer , Bryan M. Barr , Brent R. Constantz
发明人： Ira C. Ison , Mark T. Fulmer , Bryan M. Barr , Brent R. Constantz
IPC分类号： A61F2/00 , A61L27/12 , C04B12/02 , C04B20/10 , C04B28/34 , C04B40/06
CPC分类号： C04B20/107 , A61L27/12 , C04B12/025 , C04B20/1077 , C04B28/34 , C04B28/344 , C04B40/06 , A61F2310/00293 , C04B2111/00836 , Y10S623/901 , Y10T428/2949 , Y10T428/2991 , Y10T428/2993
摘要： Two component, storage stable apatitic cement compositions, as well as methods for their production, are provided. The dry component of subject apatitic cements comprises basic calcium source particles at least partially coated with a partially neutralized acidic calcium phosphate. The dry component of subject compositions is prepared by combining basic calcium source particles with dissolved acidic phosphate in at least a partially aqueous medium, whereby the basic calcium source particles become partially coated with a partially neutralized acidic calcium phosphate. The reaction is terminated prior to completion of the reaction between the acidic phosphate and the basic calcium source by removing the available water from the reaction mixture. In a first mode, the subject cement may be produced by mechanically mixing an acidic phosphate source with basic calcium source particles in the presence of an aqueous solvent and stopping the reaction between the acid and base prior to completion. Alternatively, a phosphoric acid solution may be rapidly combined with a basic calcium phosphate particle slurry such that partially neutralized acidic calcium phosphate precipitates on the surface of the basic calcium phosphate particles.

9. 发明授权

US6053970A Storage stable calcium phosphate cements 有权
标题翻译：储存稳定的磷酸钙水泥
公开(公告)号：US6053970A
公开(公告)日：2000-04-25
申请号：US345984
申请日：1999-06-30
申请人： Ira C. Ison , Mark T. Fulmer , Bryan M. Barr , Brent R. Constantz
发明人： Ira C. Ison , Mark T. Fulmer , Bryan M. Barr , Brent R. Constantz
IPC分类号： A61F2/00 , A61L27/12 , C04B12/02 , C04B20/10 , C04B28/34 , C04B40/06
CPC分类号： C04B20/107 , A61L27/12 , C04B12/025 , C04B20/1077 , C04B28/34 , C04B28/344 , C04B40/06 , A61F2310/00293 , C04B2111/00836 , Y10S623/901 , Y10T428/2949 , Y10T428/2991 , Y10T428/2993
摘要： Two component, storage stable apatitic cement compositions, as well as methods for their production, are provided. The dry component of subject apatitic cements comprises basic calcium source particles at least partially coated with a partially neutralized acidic calcium phosphate. The dry component of subject compositions is prepared by combining basic calcium source particles with dissolved acidic phosphate in at least a partially aqueous medium, whereby the basic calcium source particles become partially coated with a partially neutralized acidic calcium phosphate. The reaction is terminated prior to completion of the reaction between the acidic phosphate and the basic calcium source by removing the available water from the reaction mixture. In a first mode, the subject cement may be produced by mechanically mixing an acidic phosphate source with basic calcium source particles in the presence of an aqueous solvent and stopping the reaction between the acid and base prior to completion. Alternatively, a phosphoric acid solution may be rapidly combined with a basic calcium phosphate particle slurry such that partially neutralized acidic calcium phosphate precipitates on the surface of the basic calcium phosphate particles.
摘要翻译：提供了两种组分的储存稳定的磷灰石水泥组合物，以及它们的生产方法。受试者磷灰石水泥的干组分包括至少部分涂覆有部分中和的酸性磷酸钙的碱性钙源颗粒。通过将碱性钙源颗粒与溶解的酸性磷酸盐在至少部分水性介质中组合来制备主体组合物的干组分，由此碱性钙源颗粒部分地涂覆有部分中和的酸性磷酸钙。在酸性磷酸盐和碱性钙源之间的反应完成之后，通过从反应混合物中除去可用的水来终止反应。在第一模式中，主体水泥可以通过在水性溶剂的存在下将酸性磷酸盐源与碱性钙源颗粒机械混合并在完成之前停止酸和碱之间的反应来制备。或者，磷酸溶液可以与碱性磷酸钙颗粒浆料快速组合，使得部分中和的酸性磷酸钙在碱性磷酸钙颗粒的表面上沉淀。

10. 发明授权

US5782971A Calcium phosphate cements comprising amorophous calcium phosphate 失效
标题翻译：含磷酸钙的磷酸钙粘合剂
公开(公告)号：US5782971A
公开(公告)日：1998-07-21
申请号：US821021
申请日：1997-03-19
申请人： Brent R. Constantz , Bryan M. Barr
发明人： Brent R. Constantz , Bryan M. Barr
IPC分类号： A61F2/00 , A61L24/02 , A61L27/12 , A61L27/46 , A61L27/50 , A61L27/58 , C04B12/02 , C01B25/32
CPC分类号： C04B28/34 , A61K6/0038 , A61K6/033 , A61K6/0643 , A61K6/0668 , A61K6/0675 , A61L24/02 , A61L27/12 , A61L27/46 , A61L27/50 , A61L27/58 , A61F2310/00293 , C04B2111/00836
摘要： Calcium phosphate cements are provided. The subject cements comprise amorphous calcium phosphate, at least one additional calcium source, usually an additional calcium phosphate, and a liquid component, such as a physiologically acceptable lubricant. Upon combination of the cement components, a flowable composition capable of setting in vivo into a solid calcium phosphate mineral product, such as hydroxyapatite, is produced. The subject cement compositions find use in a variety of applications, including the treatment of injured or compromised hard tissue.
摘要翻译：提供磷酸钙水泥。受试者水泥包括无定形磷酸钙，至少一种另外的钙源，通常是另外的磷酸钙，以及液体组分，例如生理上可接受的润滑剂。通过水泥组分的组合，可以制备能够体内固化成固体磷酸钙矿物产物如羟基磷灰石的可流动组合物。主题水泥组合物可用于各种应用，包括治疗受损或受损的硬组织。

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