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1. 发明授权

US5312836A Short chain triglycerides 失效
标题翻译：短链甘油三酯
公开(公告)号：US5312836A
公开(公告)日：1994-05-17
申请号：US774643
申请日：1991-10-11
申请人： Bruce R. Bistrian
发明人： Bruce R. Bistrian
IPC分类号： A23L1/30 , A61K31/22 , A61K31/23 , A61P3/00 , A61P3/06 , C11C3/02 , C11C3/10
CPC分类号： A61K31/22 , A23L33/12 , A61K31/23 , C11C3/02 , C11C3/10
摘要： A new class of synthetic triglycerides, those having at least one short-chain (C.sub.2 -C.sub.5) fatty acid on a glycerol backbone, has been developed. These synthetic triglycerides (or structured lipids) are particularly useful in treating patients with intestinal problems.
摘要翻译：已经开发了一类新的合成甘油三酯，即在甘油骨架上具有至少一个短链（C 2 -C 5）脂肪酸的甘油三酯。这些合成甘油三酯（或结构化脂质）特别可用于治疗肠道问题的患者。

2. 发明授权

US07150996B2 Stability assessment of dispersions and emulsions 有权
标题翻译：分散体和乳液的稳定性评估
公开(公告)号：US07150996B2
公开(公告)日：2006-12-19
申请号：US10606959
申请日：2003-06-27
申请人： David F. Nicoli , David F. Driscoll , Bruce R. Bistrian
发明人： David F. Nicoli , David F. Driscoll , Bruce R. Bistrian
IPC分类号： G01N33/00
CPC分类号： G01N33/03 , G01N15/1456 , G01N21/532 , G01N2015/0092 , G01N2015/1493 , G01N2203/0025 , Y10T436/2525
摘要： A method and apparatus for determining the stability of dispersions and emulsions accelerates the onset of significant particle agglomeration in a sample by stressing the sample by reducing the height of the interparticle potential energy barrier between the particles. This is achieved by adding one or more of three stress factors: changing the pH of the sample to reduce the surface charge on the particles; adding an adsorbing electrolyte so that ions of the appropriate charge are adsorbed onto the surfaces of the particles to reduce the net charge on the particles; and applying a monovalent, divalent, or trivalent salt to partially screen electrostatic repulsions between the charged particles. In a preferred embodiment, the increase in agglomeration is detected with single particle detection, such as SPOS, to generate a PSD from which a figure of merit is derived. Another embodiment detects turbidity or light scattering to generate a value X indicative of the extent of agglomeration.
摘要翻译：用于确定分散体和乳液的稳定性的方法和装置通过降低颗粒之间的颗粒间势能阻挡层的高度来加速样品的强度，加速了样品中显着的颗粒聚集的发生。这通过添加三种应力因子中的一种或多种来实现：改变样品的pH以减少颗粒上的表面电荷; 添加吸附电解质使得适当电荷的离子被吸附到颗粒表面上以减少颗粒上的净电荷; 并施加一价，二价或三价盐以部分地屏蔽带电粒子之间的静电排斥。在优选的实施方案中，通过单粒子检测（例如SPOS）检测聚集的增加以产生从其导出品质因数的PSD。另一个实施方案检测浊度或光散射以产生指示聚集程度的值X.

3. 发明授权

US6074560A Use of an in-line filter in the preparation of total nutrient admixtures 失效
标题翻译：使用在线过滤器来制备总营养物质外加剂
公开(公告)号：US6074560A
公开(公告)日：2000-06-13
申请号：US781008
申请日：1997-01-09
申请人： David F. Driscoll , Bruce R. Bistrian
发明人： David F. Driscoll , Bruce R. Bistrian
IPC分类号： A61M5/165 , B01D61/14 , B01D39/00 , B01D61/00
CPC分类号： B01D61/147 , A61M5/165
摘要： A method for reducing the number lipid droplets having a diameter exceeding a preselected threshold in a nutritional emulsion has been developed. The method has the steps of passing the nutritional emulsion, under pressure, through a filter having a pore size smaller than the threshold. A filter having a mean pore size of about 1.2 .mu.m with a standard deviation of about 0.5 is sufficient to exclude lipid droplets having a diameter in excess of five .mu.m.
摘要翻译：已经开发了一种用于在营养乳液中减少具有超过预选阈值的直径的脂滴的数量的方法。该方法具有以下步骤：使营养乳液在压力下通过孔径小于阈值的过滤器。平均孔径约1.2μm，标准偏差约为0.5的过滤器足以排除直径超过5μm的脂滴。

4. 发明授权

US6020324A Glucan dietary additives 失效
标题翻译：葡聚糖饮食添加剂
公开(公告)号：US6020324A
公开(公告)日：2000-02-01
申请号：US675913
申请日：1991-04-26
申请人： Spiros Jamas , D. Davidson Easson, Jr. , Bruce R. Bistrian
发明人： Spiros Jamas , D. Davidson Easson, Jr. , Bruce R. Bistrian
IPC分类号： A23L1/054 , A23L1/308 , A01N43/04 , A01N37/00 , C07H1/00
CPC分类号： A23L33/21 , A23L29/271
摘要： Compositions useful in the treatment of dietary disorders, and as dietary additives to provide a source of fiber and of short chain fatty acids, to reduce the level of serum cholesterol and as bulking agents in humans and animals, as well as methods of use therefor are described. The compositions and methods are based on whole .beta.-glucans.
摘要翻译： PCT No.PCT / US89 / 04734 Sec。 371日期：1991年4月26日 102（e）日期1991年4月26日PCT提交1989年10月20日PCT公布。公开号WO90 / 04334 日期1990年5月3日可用于治疗饮食障碍的组合物，以及用作提供纤维和短链脂肪酸来源的膳食添加剂，用于降低血清胆固醇水平和作为人和动物中的填充剂的方法，以及方法描述其用途。组合物和方法基于整个β-葡聚糖。

5. 发明授权

US5968896A Nutritional supplement for preoperative feeding 失效
标题翻译：营养补充剂用于术前喂养
公开(公告)号：US5968896A
公开(公告)日：1999-10-19
申请号：US8156
申请日：1998-01-16
申请人： Stacey J. Bell , R. Armour Forse , Bruce R. Bistrian
发明人： Stacey J. Bell , R. Armour Forse , Bruce R. Bistrian
IPC分类号： A23L1/29 , A23L1/30 , A61K38/01 , A61K38/00 , A61K31/595 , A61K31/70 , A61K31/715
CPC分类号： A61K38/018 , A23L33/115 , A23L33/40 , A23V2002/00
摘要： A nutritional supplement is described comprising approximately from about 10 to about 75 grams carbohydrate; approximately from about 5 to about 50 grams protein; approximately from about 3 to about 30 grams fat; and therapeutic amount of antioxidant, for use in weight maintenance in individuals who will undergo major surgery to prevent or reduce postoperative complications.
摘要翻译：描述了营养补充剂，其包含约10至约75克碳水化合物; 约5至约50克蛋白质; 约3至约30克脂肪; 和治疗量的抗氧化剂，用于将进行大手术以防止或减少术后并发症的个体的体重维持。

6. 发明授权

US5902797A Nutritional supplement for use in the treatment of attention deficit 失效
标题翻译：营养补充剂用于治疗注意力缺陷
公开(公告)号：US5902797A
公开(公告)日：1999-05-11
申请号：US966829
申请日：1997-11-10
申请人： Stacey J. Bell , R. Armour Forse , Bruce R. Bistrian , Robert C. Jones
发明人： Stacey J. Bell , R. Armour Forse , Bruce R. Bistrian , Robert C. Jones
IPC分类号： A23L1/29 , A23L1/30 , A23L1/305 , A61K47/00
CPC分类号： A23L33/17 , A23L33/115 , A23L33/40 , A23V2002/00 , Y10S426/801 , Y10S426/808 , Y10S514/922 , Y10S514/948 , Y10S514/964
摘要： A nutritional supplement comprising approximately from about 5 to about 25 grams carbohydrate; approximately from about 1 to about 25 grams protein; and approximately from about 1 to about 10 grams fat, for use in treating low appetite that may result in weight loss, is described.
摘要翻译：包含约5至约25克碳水化合物的营养补充剂; 约1至约25克蛋白质; 和约1至约10克脂肪，用于治疗可能导致体重减轻的低食欲。

7. 发明授权

US5866555A Diabetic supplement bar 失效
公开(公告)号：US5866555A
公开(公告)日：1999-02-02
申请号：US815595
申请日：1997-03-12
申请人： Stacey J. Bell , Robert C. Jones , Bruce R. Bistrian , R. Armour Forse
发明人： Stacey J. Bell , Robert C. Jones , Bruce R. Bistrian , R. Armour Forse
IPC分类号： A23L1/29 , A23L1/30 , A23L1/305 , A61K31/715
CPC分类号： A23L33/17 , A23L33/00 , A23L33/115 , A23L33/40 , A23V2002/00
摘要： A novel diabetic supplement bar which includes about 10-60% by weight simple carbohydrate, about 1-25% by weight protein, about 2-40% by weight lipid and about 1-60%, preferably about 5-35% by weight complex carbohydrate. This formulation is particularly useful for the treatment or prevention of nighttime hypoglycemia in diabetic patients who require insulin injections.

8. 发明授权

US06210686B1 Dietary supplement and method for lowering risk of heart disease 失效
标题翻译：膳食补充剂和降低心脏病风险的方法
公开(公告)号：US06210686B1
公开(公告)日：2001-04-03
申请号：US09215353
申请日：1998-12-18
申请人： Stacey J. Bell , R. Armour Forse , Bruce R. Bistrian
发明人： Stacey J. Bell , R. Armour Forse , Bruce R. Bistrian
IPC分类号： A61K31355
CPC分类号： A61K31/435 , A23L33/21 , A23L33/40 , A23V2002/00 , A61K31/355 , A61K31/4415 , A61K31/495 , Y10S514/824 , Y10S514/904 , Y10S514/948 , A61K2300/00 , A23V2250/218 , A23V2250/7052 , A23V2250/706 , A23V2250/712 , A23V2250/5034 , A23V2250/5058
摘要： Yeast-derived fiber has been demonstrated, as described herein, to effectively improve the serum lipid profile in humans, when provided as a dietary supplement, without some of the disadvantages known to accompany dietary supplementation with oat fiber or psyllium fiber. Described herein are dietary supplements comprising yeast fiber, e.g., &bgr;-glucan or glucomannan, and further comprising folic acid or a salt thereof, vitamin B6, vitamin B12, and vitamin E. The dietary supplements of the invention can further comprise fats, carbohydrates and proteins, for example, and other ingredients added to formulate a food product. Such food products can be in the form, for example, of solid or semi-solid foods, such as food bars, pudding, or spreads. By including folate and vitamin B6, the dietary supplement provides a second benefit of suppressing the level of homocysteine in the blood. A third benefit is provided by the anti-oxidant properties of vitamin E, particularly the effect of preserving low density lipoproteins from oxidation. Further embodiments of the invention are methods for improving the serum lipid profile in a human, methods for lowering risk of heart disease, and methods for improving cardiovascular health in a human, comprising administering to the human a dietary supplement of the invention.
摘要翻译：如本文所述，已经证明了酵母衍生的纤维，当作为膳食补充剂提供时，有效地改善了人类的血清脂质谱，而没有已知的与燕麦纤维或欧车前纤维的膳食补充剂相关的一些缺点。本文描述的是包含酵母纤维例如β-葡聚糖或葡甘露聚糖并且还包含叶酸或其盐，维生素B6，维生素B12和维生素E的膳食补充剂。本发明的膳食补充剂还可以包含脂肪，碳水化合物和蛋白质，以及其它添加成分配食品的成分。这样的食品可以是例如固体或半固体食物，例如食物棒，布丁或散布物的形式。通过包括叶酸和维生素B6，膳食补充剂提供了抑制血液中同型半胱氨酸水平的第二个好处。维生素E的抗氧化性质，特别是保护低密度脂蛋白氧化的作用提供了第三个益处。本发明的其它实施方案是用于改善人类血清脂质分布的方法，用于降低心脏病风险的方法，以及改善人类心血管健康的方法，包括向人类施用本发明的膳食补充剂。

9. 发明授权

US06143731A Glucan dietary additives 失效
标题翻译：葡聚糖饮食添加剂
公开(公告)号：US06143731A
公开(公告)日：2000-11-07
申请号：US361831
申请日：1999-07-27
申请人： Spiros Jamas , D. Davidson Easson, Jr. , Bruce R. Bistrian
发明人： Spiros Jamas , D. Davidson Easson, Jr. , Bruce R. Bistrian
IPC分类号： A23L1/054 , A23L1/308 , A01N43/04 , A01N37/00 , C12Q1/00
CPC分类号： A23L33/21 , A23L29/271 , Y10S435/94 , Y10S435/941 , Y10S435/942 , Y10S435/943
摘要： Compositions useful in the treatment of dietary disorders, and as dietary additives to provide a source of fiber and of short chain fatty acids, to reduce the level of serum cholesterol, increase HDL cholesterol levels and as bulking agents in humans and animals, as well as methods of use therefor are described. The compositions and methods are based on whole .beta.-glucans.
摘要翻译：用于治疗饮食障碍的组合物，以及用作提供纤维和短链脂肪酸来源的膳食添加剂，以降低血清胆固醇水平，增加HDL胆固醇水平以及作为人和动物中的填充剂，以及对其使用方法进行说明。组合物和方法基于整个β-葡聚糖。

10. 发明授权

US5114401A Method for central venous catheterization 失效
标题翻译：中央静电导引方法
公开(公告)号：US5114401A
公开(公告)日：1992-05-19
申请号：US483906
申请日：1990-02-23
申请人： Regina K. Stuart , Jeffrey A. Lowell , John K. Baxter, III , Bruce R. Bistrian , Scott Shikora
发明人： Regina K. Stuart , Jeffrey A. Lowell , John K. Baxter, III , Bruce R. Bistrian , Scott Shikora
IPC分类号： A61M25/00 , A61M25/01 , A61M25/095
CPC分类号： A61M25/01 , A61M25/0014 , A61M25/09 , A61M2025/0008 , A61M25/0169
摘要： Disclosed are an apparatus and methods for initial, or replacement, central venous catherization using a flexible guidewire with markings thereon and a substantially translucent non-thrombogenic catheter. In operation, the guidewire is inserted along a catheter positioned in a vein. The marks on the guidewire are then used to establish, and maintain as constant, the position of the guidewire. Next, the catheter already in the vein is removed by sliding it over the guidewire, and a new catheter is slipped over the guidewire into position. Once the new catheter is positioned, the guidewire is removed.
摘要翻译：公开了一种使用其上具有标记的柔性导丝和基本上半透明的非血栓形成导管来初始或替换中心静脉插管的装置和方法。在操作中，导丝沿着位于静脉中的导管插入。然后使用导丝上的标记来建立并维持导丝的位置并保持恒定。接下来，已经在静脉中的导管通过将其滑过导丝而被移除，并且将新的导管滑过导丝线就位。一旦新的导管被定位，则导线被移除。

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