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1. 发明申请

US20230028224A1 Novel Topical Therapy 有权
公开(公告)号：US20230028224A1
公开(公告)日：2023-01-26
申请号：US17958289
申请日：2022-09-30
申请人： Bruce H. Levin
发明人： Bruce H. Levin
IPC分类号： G16H20/10
摘要： The present invention provides a method of patient care involving SPG blocking, pharmacotherapy or neuromodulation modalities.

2. 发明申请

US20200246620A1 Method And Device Of Treatment Of Abdominal And Pelvic Pain With Neuroaugmentation 审中-公开
公开(公告)号：US20200246620A1
公开(公告)日：2020-08-06
申请号：US16778942
申请日：2020-01-31
申请人： Bruce H. Levin
发明人： Bruce H. Levin
IPC分类号： A61N1/36
摘要： A method and device for treating a disorder by multiple points of stimulation.

3. 发明申请

US20190008819A1 Methods and Compositions Using Cetyl Myristoleate (CMO) In Medical Treatments 审中-公开
公开(公告)号：US20190008819A1
公开(公告)日：2019-01-10
申请号：US16028371
申请日：2018-07-05
申请人： Bruce H. Levin
发明人： Bruce H. Levin
IPC分类号： A61K31/231 , A61P25/02 , A61P25/06 , A61K9/70
摘要： A therapeutic method of alleviating the symptoms of failed back surgery syndrome, post laminectomy syndrome, post-surgery syndrome, sympathetic dystrophies, macular degenerations, complex regional pain syndrome, reflex sympathetic dystrophy and neuropathies by administering to the afflicted subject a therapeutically effective amount of cetyl myristoleate alone, or in combination with selective effective amount of aspirin, gabapentin, pregabalin, duloxetine, selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, neuroceuticals, Neurontin, Cymbalta, Lyrica, muscle relaxers, anti-depressants, nortriptyline, local anesthetics, and steroids.

4. 发明授权

US07799337B2 Method for directed intranasal administration of a composition 有权
标题翻译：鼻内给药组合物的方法
公开(公告)号：US07799337B2
公开(公告)日：2010-09-21
申请号：US10218138
申请日：2002-08-12
申请人： Bruce H. Levin
发明人： Bruce H. Levin
IPC分类号： A61F13/00 , A61N1/30 , A61M1/00
CPC分类号： A61N1/0551 , A61K9/0043 , A61K31/00 , A61K31/167 , A61K31/245 , A61K31/445 , A61K31/46 , A61K31/618 , A61K45/06 , A61M15/08 , A61M31/00 , A61M2205/075 , A61M2210/0618 , A61N1/0546 , A61N1/36075 , A61N5/00 , A61M2230/005
摘要： Methods, kits, apparatus, and compositions for inhibiting a cerebral neurovascular disorder, a muscular headache, or cerebral inflammation in a human patient are provided. The methods comprise intranasally administering to the patient a pharmaceutical composition comprising a local anesthetic, and preferably a long-acting local anesthetic ingredient. A composition useful for practicing the methods of the invention is described which comprises at least one local anesthetic in a pharmaceutically acceptable carrier, wherein the composition is formulated for intranasal delivery. Cerebral neurovascular disorders include migraine and cluster headache. Muscular headaches include tension headaches and muscle contraction headaches. A kit comprising the composition and an intranasal applicator and a method of systemically delivering a pharmaceutically active agent to an animal are also included in the invention. Apparatus for directed intranasal administration of the compositions of the invention and for performing the methods of the invention are also described.
摘要翻译：提供了用于抑制人类神经血管障碍，肌肉发酸痛或脑部炎症的方法，试剂盒，装置和组合物。所述方法包括向患者鼻内施用包含局部麻醉剂，优选长效局部麻醉剂成分的药物组合物。描述了可用于实施本发明方法的组合物，其包含在药学上可接受的载体中的至少一种局部麻醉剂，其中所述组合物被配制用于鼻内递送。脑神经血管疾病包括偏头痛和丛集性头痛。肌肉性头痛包括紧张性头痛和肌肉收缩性头痛。本发明还包括一种包含该组合物和鼻内施用器的试剂盒以及将药物活性剂全身递送至动物的方法。还描述了用于本发明组合物的定向鼻内施用和用于执行本发明的方法的装置。

5. 发明授权

US06432986B1 Compositions, kits, and methods for inhibiting cerebral neurovascular disorders and muscular headaches 失效
公开(公告)号：US06432986B1
公开(公告)日：2002-08-13
申请号：US09118615
申请日：1998-07-17
申请人： Bruce H. Levin
发明人： Bruce H. Levin
IPC分类号： A61K31445
摘要： Methods, kits, and compositions for inhibiting a cerebral neurovascular disorder or a muscular headache in a human patient are provided. The methods comprise intranasally administering to the patient a pharmaceutical composition comprising a local anesthetic, and preferably a long-acting local anesthetic ingredient. A composition useful for practicing the methods of the invention is described which comprises at least one local anesthetic in a pharmaceutically acceptable carrier, wherein the composition is formulated for intranasal delivery. Cerebral neurovascular disorders include migraine and cluster headache. Muscular headaches include tension headaches and muscle contraction headaches. A kit comprising the composition and an intranasal applicator and a method of systemically delivering a pharmaceutically active agent to an animal are also included in the invention.

6. 发明授权

US11266800B2 Nasal delivery device and methods of use 有权
公开(公告)号：US11266800B2
公开(公告)日：2022-03-08
申请号：US16186396
申请日：2018-11-09
申请人： Bruce H. Levin
发明人： Bruce H. Levin
IPC分类号： A61M15/08 , A61M15/00 , A61M11/00
摘要： The present invention provides a drug delivery system that includes a housing configured to contain one or more dispensers. Each dispenser includes an activation mechanism, a nozzle configured to direct the medicament to a predetermined area in the nasal passageway. The nozzles may be configured to create a spray pattern that is about 50-degrees to direct the delivery of a medicament to the sphenopalatine ganglion.

7. 发明申请

US20190333619A1 Monitoring System for Drug Distribution 审中-公开
公开(公告)号：US20190333619A1
公开(公告)日：2019-10-31
申请号：US16509288
申请日：2019-07-11
申请人： Bruce H. Levin
发明人： Bruce H. Levin
IPC分类号： G16H20/10 , G06Q50/26
摘要： A system for tracking one or more drugs comprising a central database adapted to track a drug through its lifecycle from point of manufacture to use by a patient. The system is further adapted to recognize inconsistencies or patterns indicating illicit or improper use of a drug.

8. 发明申请

US20190217025A1 Medical Instruments 审中-公开
公开(公告)号：US20190217025A1
公开(公告)日：2019-07-18
申请号：US16247515
申请日：2019-01-14
申请人： Bruce H. Levin
发明人： Bruce H. Levin
IPC分类号： A61M11/00 , A61M15/00 , A61M15/08
CPC分类号： A61M11/003 , A61M11/007 , A61M11/008 , A61M15/009 , A61M15/08 , A61M16/16 , A61M25/0074 , A61M2202/048 , A61M2202/30 , A61M2206/20
摘要： The present invention provides various medical instruments for delivery of nasal medication. It provides devices for influencing fluid flow around and/or inside a device. It also provides improved drug delivery systems to administer a desired dosage to the nasal epithelia, SPG, or a predetermined area.

9. 发明申请

US20190216684A1 HIPPA Compliant Monitoring System For Drug Distribution And Decreasing Drug Diversion 审中-公开
公开(公告)号：US20190216684A1
公开(公告)日：2019-07-18
申请号：US16247514
申请日：2019-01-14
申请人： Bruce H. Levin
发明人： Bruce H. Levin
IPC分类号： A61J3/00 , G06Q50/28 , A61B5/00 , G16H20/10
CPC分类号： A61J3/007 , A61B5/4833 , A61J2200/30 , A61J2200/70 , A61J2205/60 , G06Q10/0833 , G06Q10/087 , G06Q50/28 , G07G1/0045 , G08B13/2417 , G16H10/60 , G16H20/10
摘要： The present invention provides a HIPPA compliant monitoring system for drug distribution and decreasing drug diversion. Incorporating electromagnetic tag technology, such as RF ID and other applicable technology, a system is provided to track movements of a dispensed drug, from the manufacturer to the end use. A central unit processes information received from a number of different tracking units, stores such information and processes the information with pre-determined conditions including but not limited to drug abuse, diversion, and other compliance related events. Once an abnormal event is detected by the central unit, an alert may be sent to the authorities or relevant personnel. The system also includes a one or multilevel authentication code system, to further ensure the protection of a patient's privacy during the tracking process, and to make the system HIPPA compliant.

10. 发明申请

US20180256867A1 Nasal Delivery Device and Methods of Use 审中-公开
公开(公告)号：US20180256867A1
公开(公告)日：2018-09-13
申请号：US15915046
申请日：2018-03-07
申请人： Bruce H. Levin
发明人： Bruce H. Levin
IPC分类号： A61M31/00 , A61M11/00 , A61M11/02
CPC分类号： A61M31/00 , A61M11/007 , A61M11/008 , A61M11/02 , A61M15/08 , A61M2207/00 , A61M2210/0618 , B05B1/14 , B05B11/0035
摘要： A drug delivery system includes flexible and interchangeable nozzle and tip. In one embodiment, the present invention relates to a medical device for intranasal delivery of a medicament. The present invention effectively delivers an appropriate amount of medicament to the designated surface area. In one other embodiment., the present invention ensures that a complete dosage of the medicament is delivered, especially to specific areas in the nasal cavity such as the rear of the nasal cavity where the SPG is located.

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