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1. 发明授权

US09186322B2 Platinum aggregates and process for producing the same 有权
标题翻译：铂集合体及其生产方法
公开(公告)号：US09186322B2
公开(公告)日：2015-11-17
申请号：US12027752
申请日：2008-02-07
申请人： Jin K. Lee , Brian S. Miller , Fangjun Wu , Lawrence T. Boni , Vladimir Malinin
发明人： Jin K. Lee , Brian S. Miller , Fangjun Wu , Lawrence T. Boni , Vladimir Malinin
IPC分类号： A61K9/127 , A61K9/00 , A61K31/28 , A61K33/24 , A61K47/48
CPC分类号： A61K9/127 , A61K9/0078 , A61K9/1277 , A61K31/28 , A61K33/24 , A61K47/544 , A61K47/554
摘要： One aspect of the disclosure relates to a new form of lipid-complexed active platinum compound, which allows for high concentrations of platinum compound in the composition. For example, the concentration of cisplatin in the composition is higher at room temperature, e.g., about greater than 1.2 mg/mL, compared to 1 mg/mL in aqueous solution. In one embodiment, the present invention is directed to a composition comprising a lipid-complexed active platinum compound, wherein the complex has a lipid to drug (L/D) ratio of less than about 1 by weight, e.g. about 0.10 to 1, wherein the lipid-complexed active platinum compound comprises at least one lipid and at least one active platinum compound. In other embodiments, wherein lipid-complexed active platinum compound has an average volume-weighted diameter of about 0.5 to about 20 microns. In still other embodiments, the composition further comprises a liposome. The liposome may comprise at least one lipid, and may further comprise at least one active platinum compound. The disclosure also relates to a pharmaceutical formulation comprising a lipid complexed active platinum compound and a pharmaceutically acceptable carrier or diluent. The pharmaceutical formulation may be formulated for inhalation or injection.
摘要翻译：本公开的一个方面涉及脂质复合的活性铂化合物的新形式，其允许组合物中高浓度的铂化合物。例如，与1mg / mL的水溶液相比，组合物中顺铂的浓度在室温较高，例如大于1.2mg / mL。在一个实施方案中，本发明涉及包含脂质复合的活性铂化合物的组合物，其中所述复合物具有小于约1重量比的脂质与药物（L / D）比例，例如。约0.10至1，其中所述脂质复合的活性铂化合物包含至少一种脂质和至少一种活性铂化合物。在其它实施方案中，其中脂质配合的活性铂化合物的平均体积加权直径为约0.5至约20微米。在其它实施方案中，组合物还包含脂质体。脂质体可以包含至少一种脂质，并且还可以包含至少一种活性铂化合物。本公开还涉及包含脂质复合的活性铂化合物和药学上可接受的载体或稀释剂的药物制剂。药物制剂可以配制用于吸入或注射。

2. 发明申请

US20100260829A1 Sustained Release of Antiinfectives 有权
标题翻译：持续释放抗感染药
公开(公告)号：US20100260829A1
公开(公告)日：2010-10-14
申请号：US12748756
申请日：2010-03-29
申请人： Lawrence Boni , Brian S. Miller , Vladimir Malinin , Xingong Li
发明人： Lawrence Boni , Brian S. Miller , Vladimir Malinin , Xingong Li
IPC分类号： A61K9/127 , A61K31/7036 , A61P31/04
CPC分类号： A61K47/28 , A61K9/0078 , A61K9/127 , A61K9/1277 , A61K31/407 , A61K31/4709 , A61K31/496 , A61K31/545 , A61K31/7036 , A61K31/704 , A61K45/06 , Y02A50/473
摘要： Provided are lipid antiinfective formulations substantially free of anionic lipids with a lipid to antiinfective ratio is about 1:1 to about 4:1, and a mean average diameter of less than about 1 μm. Also provided is a method of preparing a lipid antiinfective formulation comprising an infusion process. Also provided are lipid antiinfective formulations wherein the lipid to drug ratio is about 1:1 or less, about 0.75:1 or less, or about 0.50:1 or less prepared by an in line fusion process. The present invention also relates to a method of treating a patient with a pulmonary infection comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention. The present invention also relates to a method of treating a patient for cystic fibrosis comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention.
摘要翻译：提供基本上不含阴离子脂质的脂质抗感染制剂，其脂质与抗感染比为约1:1至约4:1，平均平均直径小于约1μm。还提供了制备包含输注方法的脂质抗感染制剂的方法。还提供了脂质抗感染制剂，其中通过在线融合方法制备的脂质与药物的比例为约1:1或更低，约0.75:1或更低，或约0.50:1或更低。本发明还涉及治疗患有肺部感染的患者的方法，其包括向患者施用治疗有效量的本发明的抗脂质抗感染药物。本发明还涉及一种治疗患者囊性纤维化的方法，其包括向患者施用治疗有效量的本发明的抗脂质抗感染制剂。

3. 发明授权

US07449320B2 Truncated forms of pullulanase 有权
标题翻译：截短形式的支链淀粉酶
公开(公告)号：US07449320B2
公开(公告)日：2008-11-11
申请号：US09262126
申请日：1999-03-03
申请人： Brian S. Miller , Jayarama K. Shetty
发明人： Brian S. Miller , Jayarama K. Shetty
IPC分类号： C12N9/44 , D06M16/00 , C07K14/32 , C12P21/02
CPC分类号： C12N9/2457 , C12N9/2451 , C12N9/246 , C12Y302/01041 , C12Y302/01068
摘要： The present invention relates to modified pullulanases useful in the starch industry. The present invention provides methods for producing the modified pullulanase, enzymatic compositions comprising the modified pullulanase, and methods for the saccharification of starch comprising the use of the enzymatic compositions.
摘要翻译：本发明涉及可用于淀粉工业的改性支链淀粉酶。本发明提供了生产改性的支链淀粉酶的方法，包含改良的支链淀粉酶的酶组合物和包含使用酶组合物的淀粉糖化方法。

4. 发明申请

US20080223926A1 BIOMETRIC CONTROL OF EQUIPMENT 有权
标题翻译：设备生物量控制
公开(公告)号：US20080223926A1
公开(公告)日：2008-09-18
申请号：US12041194
申请日：2008-03-03
申请人： Brian S. Miller , Jack Vaughan , Oscar A. Ladriere , Gino DiSimone
发明人： Brian S. Miller , Jack Vaughan , Oscar A. Ladriere , Gino DiSimone
IPC分类号： G06K5/00
CPC分类号： G07C9/00158
摘要： An example apparatus for allowing operation of equipment by an authorized operator comprises a biometric scanner receiving a biometric input from an authorized operator, and transmitting an authorization signal. The apparatus may further includes a base station that allows the equipment to operate while the base station receives the authorization signal from the biometric scanner, and which prevents the equipment from operating shortly after the authorization signal is no longer received from the biometric scanner.
摘要翻译：用于允许授权操作者操作设备的示例性设备包括从授权操作者接收生物特征输入并发送授权信号的生物计量扫描器。该装置还可以包括基站，其允许设备在基站从生物测定扫描器接收到授权信号的同时进行操作，并且在从生物测定扫描器不再接收到授权信号之后，防止设备运行不久。

5. 发明授权

US4291068A Method of making semiconductor photodetector with reduced time-constant 失效
标题翻译：制造时间常数降低的半导体光电探测器的方法
公开(公告)号：US4291068A
公开(公告)日：1981-09-22
申请号：US956315
申请日：1978-10-31
申请人： Terry L. Jones , Brian S. Miller
发明人： Terry L. Jones , Brian S. Miller
IPC分类号： G03F7/00 , H01J9/12 , B05D5/12 , H01L27/14 , H01L31/00
CPC分类号： G03F7/00 , H01J9/12
摘要： An insulating layer on the surface of a slab of photo-responsive semicondor material is treated to produce a pattern of projections or mesas. The treatment includes the steps of producing a mask on the insulating layer using electron-beam lithography, etching holes in the layer through the mask, stripping the mask, and finishing with the usual electrical conductors on the insulating layer. An alternate embodiment etches the surface of the slab to produce a scrabrous surface, then coats with aluminum oxide and electrical conductors.
摘要翻译：处理光响应半导体材料板的表面上的绝缘层，以产生突起或台面的图案。该处理包括使用电子束光刻在绝缘层上制造掩模的步骤，通过掩模蚀刻在该层中的孔，剥离掩模，以及用绝缘层上的通常电导体进行修整。替代实施例蚀刻板坯的表面以产生刮痕表面，然后涂覆氧化铝和电导体。

6. 发明申请

US20110159079A1 High Delivery Rates for Lipid Based Drug Formulations, and Methods of Treatment Thereof 审中-公开
标题翻译：基于脂质药物制剂的高递送率及其治疗方法
公开(公告)号：US20110159079A1
公开(公告)日：2011-06-30
申请号：US12983659
申请日：2011-01-03
申请人： Zhili Li , Lawrence T. Boni , Brian S. Miller , Vladimir Malinin , Xingong Li
发明人： Zhili Li , Lawrence T. Boni , Brian S. Miller , Vladimir Malinin , Xingong Li
IPC分类号： A61K9/127 , A61K47/44 , A61P31/00 , A61P11/00
CPC分类号： A61K9/0078 , A61K9/127 , A61K9/1617 , A61K9/5015 , A61K9/5123 , A61K31/7034 , A61K31/7036 , Y02A50/406 , Y02A50/473
摘要： Provided is a method of preparing lipid based drug formulations with low lipid/drug ratios using coacervation techniques. Also provided are methods of delivering such lipid based drug formulations at high delivery rates, and methods of treating patients with pulmonary diseases comprising administering such lipid based drug formulations.
摘要翻译：提供了使用凝聚技术制备具有低脂/药物比例的基于脂质的药物制剂的方法。还提供了以高递送速率递送这种基于脂质的药物制剂的方法，以及治疗患有肺部疾病的患者的方法，包括施用这种基于脂质的药物制剂。

7. 发明授权

US07718189B2 Sustained release of antiinfectives 有权
标题翻译：持续释放抗感染药
公开(公告)号：US07718189B2
公开(公告)日：2010-05-18
申请号：US11185448
申请日：2005-07-19
申请人： Lawrence T. Boni , Brian S. Miller , Vladimir Malinin , Xingong Li
发明人： Lawrence T. Boni , Brian S. Miller , Vladimir Malinin , Xingong Li
IPC分类号： A61K9/127
CPC分类号： A61K47/28 , A61K9/0078 , A61K9/127 , A61K9/1277 , A61K31/407 , A61K31/4709 , A61K31/496 , A61K31/545 , A61K31/7036 , A61K31/704 , A61K45/06 , Y02A50/473
摘要： Provided are lipid antiinfective formulations substantially free of anionic lipids with a lipid to antiinfective ratio is about 1:1 to about 4:1, and a mean average diameter of less than about 1 μm. Also provided is a method of preparing a lipid antiinfective formulation comprising an infusion process. Also provided are lipid antiinfective formulations wherein the lipid to drug ratio is about 1:1 or less, about 0.75:1 or less, or about 0.50:1 or less prepared by an in line fusion process. The present invention also relates to a method of treating a patient with a pulmonary infection comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention. The present invention also relates to a method of treating a patient for cystic fibrosis comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention.
摘要翻译：提供基本上不含阴离子脂质的脂质抗感染制剂，其脂质与抗感染比为约1:1至约4:1，平均平均直径小于约1μm。还提供了制备包含输注方法的脂质抗感染制剂的方法。还提供了脂质抗感染制剂，其中通过在线融合方法制备的脂质与药物的比例为约1:1或更低，约0.75:1或更低，或约0.50:1或更低。本发明还涉及治疗患有肺部感染的患者的方法，其包括向患者施用治疗有效量的本发明的抗脂质抗感染药物。本发明还涉及一种治疗患者囊性纤维化的方法，其包括向患者施用治疗有效量的本发明的抗脂质抗感染制剂。

8. 发明授权

US5062203A Method of making a flexible membrane circuit tester 失效
公开(公告)号：US5062203A
公开(公告)日：1991-11-05
申请号：US658805
申请日：1991-02-22
申请人： Brian S. Miller , David R. Kaplan
发明人： Brian S. Miller , David R. Kaplan
IPC分类号： G01R31/312
CPC分类号： G01R31/312 , Y10T29/49165
摘要： A pattern of electrodes, with electrical lead lines to the electrodes, arearried by a thin-film membrane mounted on a frame. The pattern corresponds to a test point pattern on a circuit to be tested. The lead lines go to edge connectors on the frame. In order to test a circuit, the membrane is pushed against the test points by air pressure, such that capacitive coupling occurs between the electrodes and the test points.

9. 发明授权

US4573627A Indium bump hybrid bonding method and system 失效
标题翻译：铟凸块混合键合方法及系统
公开(公告)号：US4573627A
公开(公告)日：1986-03-04
申请号：US684223
申请日：1984-12-20
申请人： Brian S. Miller , Aubrey J. Dunn
发明人： Brian S. Miller , Aubrey J. Dunn
IPC分类号： B23K20/02 , H01L21/98 , B23K20/00 , B23K31/02
CPC分类号： H01L25/50 , B23K20/02 , H01L2924/0002
摘要： In order to ensure total bonding together of two-dimensional arrays of inm bumps on circuit boards, additional bumps are placed on each board in a triangular pattern which contains the array of that board. Opposing sets of thrusters are used to move the boards and their bumps toward each other, after the arrays are aligned with the boards juxtaposed and substantially parallel to each other. As corresponding sets of additional bumps touch each other, the set of thrusters moving the boards at those points hold their positions, until all sets of additional bumps are in touch; all of the thrusters of at least one board are then simultaneously energized until a predetermined pressure is achieved between the boards.
摘要翻译：为了确保电路板上的铟凸块的二维阵列的全部结合在一起，附加的凸块以包含该板的阵列的三角形图案放置在每个板上。在将阵列与彼此并置并且基本上彼此平行的板对准之后，相反的推进器组被用于将板和它们的凸起朝向彼此移动。当相应的附加凸块相互接触时，在那些位置移动板的推进器组保持它们的位置，直到所有的附加凸块组合在一起; 然后至少一个板的所有推进器同时通电，直到板之间达到预定的压力。

10. 发明申请

US20100068257A1 Sustained Release of Antiinfectives 审中-公开
标题翻译：持续释放抗感染药
公开(公告)号：US20100068257A1
公开(公告)日：2010-03-18
申请号：US12424177
申请日：2009-04-15
申请人： Lawrence T. Boni , Brian S. Miller
发明人： Lawrence T. Boni , Brian S. Miller
IPC分类号： A61K9/127 , A61K31/70 , A61P11/00
摘要： Provided, among other things, is a method of treating or ameliorating pulmonary infection in a cystic fibrosis patient comprising pulmonary administration of an effective amount of a liposomal/complexed antiinfective to the patient, wherein the (i) administrated amount is 50% or less of the comparative free drug amount, or (ii) the dosing is once a day or less, or (iii) both.
摘要翻译：提供了一种治疗或改善囊性纤维化患者肺部感染的方法，包括向患者肺部施用有效量的脂质体/复合抗感染药，其中（i）给药量为50％或更少比较游离药物量，或（ii）给药是每天一次或更少，或（iii）两者。

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