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    • 4. 发明申请
    • Method and Apparatus for Affinity of Users to Application Servers
    • 用户对应用服务器的亲和度的方法和装置
    • US20080195754A1
    • 2008-08-14
    • US12099499
    • 2008-04-08
    • Gennaro A. CuomoMichael L. FraenkelBrian K. Martin
    • Gennaro A. CuomoMichael L. FraenkelBrian K. Martin
    • G06F15/173
    • H04L12/66Y10S707/99937
    • A method and apparatus route hypertext protocol requests to one of a plurality of application servers, which share a database through a backend database management system. The application servers store session data in the database. Hence, if a subsequent request is routed to a different application server, the session data is available through the backend database management system. One or more web servers perform routing of requests to the application server. When a request is received that is accompanied by a session ID, routing is performed by utilizing a hash function on the session ID. The resulting hash value is mapped to an application server. A hash function on a session ID will always result in the same hash value; therefore, the request will always be routed to the same application server. However, if an application server is non-functional, a new hash based on the previous hash is computed until a functional application server is selected.
    • 方法和装置将超文本协议请求路由到通过后端数据库管理系统共享数据库的多个应用服务器之一。 应用程序服务器将会话数据存储在数据库中。 因此,如果后续请求被路由到不同的应用服务器,则会话数据可通过后台数据库管理系统获得。 一个或多个Web服务器执行请求到应用服务器的路由。 当接收到伴随有会话ID的请求时,通过利用会话ID上的散列函数来执行路由。 生成的哈希值映射到应用程序服务器。 会话ID上的散列函数将始终导致相同的散列值; 因此,请求将始终路由到同一应用程序服务器。 然而,如果应用服务器是非功能的,则计算出基于前一个散列的新散列,直到选择功能应用服务器为止。
    • 5. 发明授权
    • Non-invasive technique for enabling distributed computing applications to exploit distributed fragment caching and assembly
    • 非侵入性技术使分布式计算应用程序能够利用分布式片段缓存和组装
    • US07177900B2
    • 2007-02-13
    • US10368694
    • 2003-02-19
    • Steven D. ImsBrian K. MartinThomas F. McElroyBrad B. Topol
    • Steven D. ImsBrian K. MartinThomas F. McElroyBrad B. Topol
    • G06F15/16
    • G06F17/30902
    • Methods, systems, computer program products, and methods of doing business by caching dynamic content fragments in a distributed cache and assembling requested content using these fragments. The disclosed techniques are non-invasive, and enable the benefits of distributed fragment caching to be extended to more applications, without regard to the programming model used when designing the application. An application developer specifies dependencies among content creating components (or, in alternative embodiments, it may be possible to infer this information), and if one of these components may be called upon to generate a content fragment dynamically, correlator data is programmatically created and attached to a message that references the component. A subsequent content generation request to the component then automatically carries the correlator data, and that data is programmatically restored.
    • 方法,系统,计算机程序产品和通过在分布式缓存中缓存动态内容片段进行业务的方法,并使用这些片段组装所请求的内容。 所公开的技术是非侵入性的,并且使分布式片段缓存的优点能够扩展到更多的应用,而不考虑在设计应用时使用的编程模型。 应用程序开发人员指定内容创建组件之间的依赖关系(或在替代实施例中,可以推断该信息),并且如果这些组件中的一个可被动态地生成内容片段,则相关器数据被编程地创建并附加 引用组件的消息。 然后,向组件的后续内容生成请求自动携带相关器数据,并且该数据被编程地恢复。
    • 6. 发明授权
    • Methods and modified cells for the treatment of cancer
    • 用于治疗癌症的方法和修饰细胞
    • US06844188B1
    • 2005-01-18
    • US09288837
    • 1999-04-08
    • Gene H. MacDonaldBrian K. MartinRobert E. JohnstonJenny P.-Y. Ting
    • Gene H. MacDonaldBrian K. MartinRobert E. JohnstonJenny P.-Y. Ting
    • A61K39/00C12N15/86A61K48/00C07H21/04C12N15/09
    • A61K39/0011A61K2039/5254A61K2039/5256A61K2039/5258
    • The present invention provides methods of preventing and/or treating cancers (including tumors). In one preferred embodiment, the invention is practiced to induce regression of an existing cancer or tumor and/or to prevent metastasis and/or to prevent growth of metastatic nodules. In other preferred embodiments, the invention may be used as a prophylaxis to prevent the development of primary cancers through a childhood or adult vaccination program against specific tumor antigens for cancers with high incidences. In an alternate preferred embodiment, the present invention provides methods of establishing an immune response against a universal artificial tumor antigen through a childhood or adult vaccine program, thus providing a long-term immune response that can be utilized at any point to treat any cancer which develops later in life. The present invention also provides cancer and tumor cells stably expressing an artificial antigen, preferably an artificial cell-surface antigen.
    • 本发明提供了预防和/或治疗癌症(包括肿瘤)的方法。 在一个优选实施方案中,实施本发明以诱导现有癌症或肿瘤的消退和/或预防转移和/或预防转移性结节的生长。 在其它优选实施方案中,本发明可用作预防通过针对具有高发生率的癌症的特异性肿瘤抗原的儿童或成人免疫接种程序来预防原发性癌症的发展。 在替代的优选实施方案中,本发明提供了通过儿童或成人疫苗程序建立针对通用人造肿瘤抗原的免疫应答的方法,从而提供可以在任何时候用于治疗任何癌症的任何癌症的长期免疫应答 在后期发展。 本发明还提供稳定表达人造抗原,优选人造细胞表面抗原的癌细胞和肿瘤细胞。
    • 8. 发明授权
    • State machine for accessing a stealth firewall
    • 用于访问隐形防火墙的状态机
    • US07207061B2
    • 2007-04-17
    • US09944996
    • 2001-08-31
    • Brian K. Martin
    • Brian K. Martin
    • G06F9/00
    • H04L63/0254H04L63/029
    • A stealth firewall. The stealth firewall can include a first network interface to an external network; a second network interface to an internal network; a packet filter for restricting access to the internal network, the packet filter ignoring requests from the external network to access the internal network; and, a state machine. Importantly, the state machine can be pre-configured to transition across one or more internal states conditioned upon receiving particular requests to access the internal network. The state machine further can include at least one state transition reachable through a pre-specified sequence of states which causes the packet filter to permit access to the internal network.
    • 隐形防火墙 隐形防火墙可以包括到外部网络的第一网络接口; 到内部网络的第二网络接口; 用于限制对内部网络的访问的分组过滤器,分组过滤器忽略来自外部网络的访问内部网络的请求; 和状态机。 重要的是,状态机可以被预先配置成在接收到访问内部网络的特定请求的条件下经过一个或多个内部状态转换。 状态机还可以包括通过预先指定的状态序列可达到的至少一个状态转换,这使得分组过滤器允许访问内部网络。