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1. 发明授权

US5762770A Electrochemical biosensor test strip 失效
标题翻译：电化学生物传感器试片
公开(公告)号：US5762770A
公开(公告)日：1998-06-09
申请号：US496939
申请日：1995-06-30
申请人： G. John Pritchard , Joseph E. Bateson , Brian S. Hill , Brian A. Heald , Scott E. Hubbard
发明人： G. John Pritchard , Joseph E. Bateson , Brian S. Hill , Brian A. Heald , Scott E. Hubbard
IPC分类号： G01N27/327 , C12Q1/00 , C12Q1/54
CPC分类号： C12Q1/00 , C12Q1/006
摘要： An electrochemical biosensor test strip that has a minimum volume blood sample requirement of about 9 microliters. The test strip has working and counter electrodes that are substantially the same size and made of the same electrically conducting material placed on a first insulating substrate. Overlaying the electrodes is a second insulating substrate, which includes a cutout portion that forms a reagent well. The cutout portion exposes a smaller area of the counter electrode than the working electrode. A reagent for analysis of an analyte substantially covers the exposed areas of working and counter electrodes in the reagent well. Overlaying the reagent well and affixed to the second insulating substrate is a spreading mesh that is impregnated with a surfactant. The small cutout portion of 4 millimeters by 4.2 millimeters, small mesh of 6 millimeters by 5.8 millimeters, and small amount of reagent, 4 microliters before drying, allow the test strip to analyze a whole blood sample of about 9 microliters.
摘要翻译：电化学生物传感器测试条具有约9微升的最小体积血液样本要求。测试条具有基本上相同尺寸并由放置在第一绝缘基板上的相同导电材料制成的工作对电极。覆盖电极是第二绝缘基板，其包括形成试剂的切口部分。切除部分暴露对电极的面积比工作电极的面积小。用于分析分析物的试剂基本上覆盖试剂阱中的工作和对电极的暴露区域。将试剂叠加并固定到第二绝缘基底上的是用表面活性剂浸渍的铺展网。 4毫米×4.2毫米的小切口部分，6毫米×5.8毫米的小网孔和少量试剂，干燥前4微升，允许测试条分析约9微升的全血样品。

2. 发明授权

US5997817A Electrochemical biosensor test strip 失效
标题翻译：电化学生物传感器试片
公开(公告)号：US5997817A
公开(公告)日：1999-12-07
申请号：US985840
申请日：1997-12-05
申请人： William F. Crismore , Nigel A. Surridge , Daniel R. McMinn , Richard J. Bodensteiner , Eric R. Diebold , R. Dale Delk , David W. Burke , Jiaxiong Jason Ho , Robert Kitchel Earl , Brian A. Heald
发明人： William F. Crismore , Nigel A. Surridge , Daniel R. McMinn , Richard J. Bodensteiner , Eric R. Diebold , R. Dale Delk , David W. Burke , Jiaxiong Jason Ho , Robert Kitchel Earl , Brian A. Heald
IPC分类号： G01N27/28 , C12M1/34 , C12Q1/00 , G01N27/00 , G01N27/02 , G01N27/30 , G01N27/327 , G01N27/416 , G01N33/487 , G01N33/543 , G01N33/66 , G01N33/48
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , Y10S435/817
摘要： An electrochemical biosensor test strip with four new features. The test strip includes an indentation for tactile feel as to the location of the strips sample application port. The sample application port leads to a capillary test chamber, which includes a test reagent. The wet reagent includes from about 0.2% by weight to about 2% by weight polyethylene oxide from about 100 kilodaltons to about 900 kilodaltons mean molecular weight, which makes the dried reagent more hydrophilic and sturdier to strip processing steps, such as mechanical punching, and to mechanical manipulation by the test strip user. The roof of the capillary test chamber includes a transparent or translucent window which operates as a "fill to here" line, thereby identifying when enough test sample (a liquid sample, such as blood) has been added to the test chamber to accurately perform a test. The test strip may further include a notch located at the sample application port. The notch reduces a phenomenon called "dose hesitation".
摘要翻译：一种具有四个新特征的电化学生物传感器测试条。测试条包括针对带样品应用端口的位置的触感的缩进。样品应用端口通向包括测试试剂的毛细管测试室。湿试剂包括约0.2重量％至约2重量％的聚环氧乙烷约100千道尔顿至约900千道尔顿的平均分子量，这使得干燥的试剂更具亲水性并且更坚固以进行剥离加工步骤，例如机械冲压，和由测试用户进行机械操作。毛细管测试室的屋顶包括透明或半透明的窗口，其作为“填充到这里”线，从而识别何时将足够的测试样品（液体样品，例如血液）添加到测试室以精确地执行测试。测试条还可以包括位于样品应用端口处的凹口。缺口减少了称为“剂量犹豫”的现象。

3. 再颁专利

USRE41309E1 Electrochemical biosensor test strip 有权
标题翻译：电化学生物传感器试片
公开(公告)号：USRE41309E1
公开(公告)日：2010-05-04
申请号：US10409721
申请日：2003-04-09
申请人： William F. Crismore , Nigel A. Surridge , Daniel R. McMinn , Richard J. Bodensteiner , Eric R. Diebold , R. Dale Delk , David W. Burke , Jiaxiong Jason Ho , Robert Kitchel Earl , Brian A. Heald
发明人： William F. Crismore , Nigel A. Surridge , Daniel R. McMinn , Richard J. Bodensteiner , Eric R. Diebold , R. Dale Delk , David W. Burke , Jiaxiong Jason Ho , Robert Kitchel Earl , Brian A. Heald
IPC分类号： G01N33/48
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , Y10S435/817
摘要： An electrochemical biosensor test strip with four new features. The test strip includes an indentation for tactile feel as to the location of the strips sample application port. The sample application port leads to a capillary test chamber, which includes a test reagent. The wet reagent includes from about 0.2% by weight to about 2% by weight polyethylene oxide from about 100 kilodaltons to about 900 kilodaltons mean molecular weight, which makes the dried reagent more hydrophilic and sturdier to strip processing steps, such as mechanical punching, and to mechanical manipulation by the test strip user. The roof of the capillary test chamber includes a transparent or translucent window which operates as a “fill to here” line, thereby identifying when enough test sample (a liquid sample, such as blood) has been added to the test chamber to accurately perform a test. The test strip may further include a notch located at the sample application port. The notch reduces a phenomenon called “dose hesitation”.
摘要翻译：一种具有四个新特征的电化学生物传感器测试条。测试条包括针对带样品应用端口的位置的触感的缩进。样品应用端口通向包括测试试剂的毛细管测试室。湿试剂包括约0.2重量％至约2重量％的聚环氧乙烷约100千道尔顿至约900千道尔顿的平均分子量，这使得干燥的试剂更具亲水性并且更坚固以进行剥离加工步骤，例如机械冲压，和由测试用户进行机械操作。毛细管测试室的屋顶包括透明或半透明的窗口，其作为“填充到这里”线，从而识别何时将足够的测试样品（液体样品，例如血液）添加到测试室以精确地执行测试。测试条还可以包括位于样品应用端口处的凹口。缺口减少了称为“剂量犹豫”的现象。

4. 发明授权

US08465977B2 Method and apparatus for lighted test strip 有权
标题翻译：照明测试条的方法和设备
公开(公告)号：US08465977B2
公开(公告)日：2013-06-18
申请号：US12177328
申请日：2008-07-22
申请人： Abner David Joseph , Brian A. Heald
发明人： Abner David Joseph , Brian A. Heald
IPC分类号： G01N33/49
CPC分类号： G01N33/49 , A61B5/1455 , A61B10/0045 , C12Q1/006 , F21V33/0068 , G01N1/10 , G01N33/48785 , G01N33/52 , G01N33/66 , Y10T436/144444
摘要： A test strip with a sample chamber is secured to a meter. The sample chamber in the portion of the test strip that extends out of the meter is illuminated by transmitting light from a light source inside the meter internally through the test strip towards the sample chamber. By way of analogy, the test strip acts in a fashion similar to a fiber optic cable or optical wave guide by transmitting the light from the meter to the remotely located sample chamber that extends outside the meter. The user is then able to easily see the sample chamber of the test strip in dark conditions so that the user is able to readily align the sample chamber with the drop of fluid on the skin as well as view the sample chamber in order to ensure proper filling. The light also illuminates a test strip slot into which the test strip is inserted.
摘要翻译：带有样品室的测试条固定在仪表上。通过将来自仪器内部的光源的光透过测试条朝向样品室传送来自测量仪器外延的测试条部分中的样品室。通过类推，测试条以与光纤电缆或光波导相似的方式通过将来自仪表的光传输到延伸到仪表外部的位于远处的样品室。使用者然后能够在黑暗的条件下容易地看到测试条的样品室，使得用户能够容易地将样品室与皮肤上的一滴液体对准，并且观察样品室以确保适当填充。灯也照亮测试条插入的测试条槽。

5. 发明申请

US20100021342A1 METHOD AND APPARATUS FOR LIGHTED TEST STRIP 有权
标题翻译：用于照明测试条的方法和装置
公开(公告)号：US20100021342A1
公开(公告)日：2010-01-28
申请号：US12177328
申请日：2008-07-22
申请人： Abner David Joseph , Brian A. Heald
发明人： Abner David Joseph , Brian A. Heald
IPC分类号： G01N31/22 , A61B5/00
CPC分类号： G01N33/49 , A61B5/1455 , A61B10/0045 , C12Q1/006 , F21V33/0068 , G01N1/10 , G01N33/48785 , G01N33/52 , G01N33/66 , Y10T436/144444
摘要： A test strip with a sample chamber is secured to a meter. The sample chamber in the portion of the test strip that extends out of the meter is illuminated by transmitting light from a light source inside the meter internally through the test strip towards the sample chamber. By way of analogy, the test strip acts in a fashion similar to a fiber optic cable or optical wave guide by transmitting the light from the meter to the remotely located sample chamber that extends outside the meter. The user is then able to easily see the sample chamber of the test strip in dark conditions so that the user is able to readily align the sample chamber with the drop of fluid on the skin as well as view the sample chamber in order to ensure proper filling. The light also illuminates a test strip slot into which the test strip is inserted.
摘要翻译：带有样品室的测试条固定在仪表上。通过将来自仪器内部的光源的光透过测试条朝向样品室传送来自测量仪器外延的测试条部分中的样品室。通过类推，测试条以与光纤电缆或光波导相似的方式通过将来自仪表的光传输到延伸到仪表外部的位于远处的样品室。使用者然后能够在黑暗的条件下容易地看到测试条的样品室，使得用户能够容易地将样品室与皮肤上的一滴液体对准，并且观察样品室以确保适当填充。灯也照亮测试条插入的测试条槽。

6. 发明授权

US06270637B1 Electrochemical biosensor test strip 有权
标题翻译：电化学生物传感器试片
公开(公告)号：US06270637B1
公开(公告)日：2001-08-07
申请号：US09386210
申请日：1999-08-31
申请人： William F. Crismore , Nigel A. Surridge , Daniel R. McMinn , Richard J. Bodensteiner , Eric R. Diebold , R. Dale Delk , David W. Burke , Jiaxiong Jason Ho , Robert Kitchel Earl , Brian A. Heald
发明人： William F. Crismore , Nigel A. Surridge , Daniel R. McMinn , Richard J. Bodensteiner , Eric R. Diebold , R. Dale Delk , David W. Burke , Jiaxiong Jason Ho , Robert Kitchel Earl , Brian A. Heald
IPC分类号： G01N2726
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , Y10S435/817
摘要： An electrochemical biosensor test strip with four new features. The test strip includes an indentation for tactile feel as to the location of the strips sample application port. The sample application port leads to a capillary test chamber, which includes a test reagent. The wet reagent includes from about 0.2% by weight to about 2% by weight polyethylene oxide from about 100 kilodaltons to about 900 kilodaltons mean molecular weight, which makes the dried reagent more hydrophilic and sturdier to strip processing steps, such as mechanical punching, and to mechanical manipulation by the test strip user. The roof of the capillary test chamber includes a transparent or translucent window which operates as a “fill to here” line, thereby identifying when enough test sample (a liquid sample, such as blood) has been added to the test chamber to accurately perform a test. The test strip may further include a notch located at the sample application port. The notch reduces a phenomenon called “dose hesitation”.
摘要翻译：一种具有四个新特征的电化学生物传感器测试条。测试条包括针对带样品应用端口的位置的触感的缩进。样品应用端口通向包括测试试剂的毛细管测试室。湿试剂包括约0.2重量％至约2重量％的聚环氧乙烷约100千道尔顿至约900千道尔顿的平均分子量，这使得干燥的试剂更具亲水性并且更坚固以进行剥离加工步骤，例如机械冲压，和由测试用户进行机械操作。毛细管测试室的屋顶包括透明或半透明的窗口，其作为“填充到这里”线，从而识别何时将足够的测试样品（液体样品，例如血液）添加到测试室以精确地执行测试。测试条还可以包括位于样品应用端口处的凹口。缺口减少了称为“剂量犹豫”的现象。

7. 发明授权

US5356782A Analytical test apparatus with on board negative and positive control 失效
标题翻译：带负载和正极控制的分析测试装置
公开(公告)号：US5356782A
公开(公告)日：1994-10-18
申请号：US940059
申请日：1992-09-03
申请人： David R. Moorman , David J. Ledden , David D. Webster , Brian A. Heald
发明人： David R. Moorman , David J. Ledden , David D. Webster , Brian A. Heald
IPC分类号： G01N31/22 , G01N21/77 , G01N33/52 , G01N33/543 , G01N33/558 , G01N37/00 , G01N33/53 , G01N33/50
CPC分类号： G01N33/558 , G01N33/54366 , Y10S435/805 , Y10S435/967 , Y10S435/97 , Y10S435/975
摘要： The invention is an apparatus useful in carrying out an analytical assay. The apparatus has a positive and negative control, as well as a site for determining the presence, amount, or lack of an analyte in a sample.
摘要翻译：本发明是可用于进行分析测定的装置。该装置具有阳性和阴性对照，以及用于确定样品中分析物的存在，量或缺乏的位点。

8. 发明授权

US06254736B1 Method of selectively increasing the hydrophilicity of a web 有权
标题翻译：选择性提高纤网亲水性的方法
公开(公告)号：US06254736B1
公开(公告)日：2001-07-03
申请号：US09386562
申请日：1999-08-31
申请人： Robert Kitchel Earl , Brian A. Heald
发明人： Robert Kitchel Earl , Brian A. Heald
IPC分类号： B01J1908
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , Y10S435/817
摘要： There is disclosed a method of selectively increasing the hydrophilicity of a web, such as a plastic glucose electrochemical test strip. The web is corona arc treated, and a film of water is selectively applied to the web where a reduction of the effect of the initial corona treatment is desired. The water is then removed by drying.
摘要翻译：公开了一种选择性地提高纤维网亲水性的方法，例如塑料葡萄糖电化学测试条。网被电晕处理，并且选择性地将水膜施加到幅材上，其中需要降低初始电晕处理的效果。然后通过干燥除去水。

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