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1. 发明授权

US08679182B2 Spacerless artificial disc replacements 有权
标题翻译：无间隔人造椎间盘置换术
公开(公告)号：US08679182B2
公开(公告)日：2014-03-25
申请号：US13597898
申请日：2012-08-29
申请人： Bret A. Ferree , David Tompkins
发明人： Bret A. Ferree , David Tompkins
IPC分类号： A61F2/44
CPC分类号： A61F2/4425 , A61F2/30767 , A61F2/442 , A61F2002/30092 , A61F2002/30301 , A61F2002/30311 , A61F2002/30528 , A61F2002/30878 , A61F2002/30884 , A61F2002/30934 , A61F2002/4631 , A61F2210/0014 , A61F2220/0025 , A61F2230/0095 , A61F2310/00011 , A61F2310/00023 , A61F2310/00029 , A61F2310/00203 , A61F2310/00239 , A61F2310/00293 , A61L27/04 , A61L27/10 , A61L2430/38
摘要： Spacerless artificial disc replacements (ADR) are disclosed. One preferred embodiment includes two saddle-shaped components to facilitate more normal spinal flexion, extension, and lateral bending while limit axial rotation, thereby protecting the facet joints and the annulus fibrosus (AF). Either or both of the superior and inferior components are made of a hard material such as chrome cobalt, titanium, or a ceramic including alumina, zirconia, or calcium phosphate. The articulating surfaces of the ADR are also preferably highly polished to reduce friction between the components. Metals, alloys or other materials with shape-memory characteristics may also prove beneficial.
摘要翻译：公开了无间隔人造椎间盘置换术（ADR）。一个优选实施例包括两个鞍形部件，以便限制轴向旋转，从而保护小关节和纤维环（AF），从而有助于更正常的脊柱弯曲，延伸和侧向弯曲。上下组分中的一个或两个均由硬质材料如铬钴，钛或包括氧化铝，氧化锆或磷酸钙的陶瓷制成。 ADR的铰接表面也优选地被高度抛光以减少部件之间的摩擦。具有形状记忆特性的金属，合金或其他材料也可能是有益的。

2. 发明申请

US20130226271A1 METHOD AND APPARATUS TO PROMOTE INFLAMMATION IN SPINAL TISSUES 审中-公开
标题翻译：促进脊髓组织炎症的方法和装置
公开(公告)号：US20130226271A1
公开(公告)日：2013-08-29
申请号：US13859965
申请日：2013-04-10
申请人： Bret A. Ferree
发明人： Bret A. Ferree
IPC分类号： A61F7/00
CPC分类号： A61F7/00 , A61B17/7061 , A61F2/4455 , A61F7/12 , A61F2002/2817 , A61F2002/30062 , A61F2002/3008 , A61F2002/30448 , A61F2002/30451 , A61F2002/30461 , A61F2002/30462 , A61F2002/30578 , A61F2002/30917 , A61F2002/30932 , A61F2002/4435 , A61F2002/449 , A61F2002/4495 , A61F2002/4651 , A61F2007/0024 , A61F2007/0071 , A61F2007/126
摘要： Apparatus for treating tissue, wherein the apparatus heats the tissue in a controlled manner so as to promote therapeutic inflammation in the tissue, whereby to augment healing of the tissue.
摘要翻译：用于处理组织的装置，其中所述装置以受控的方式加热组织，以便促进组织中的治疗性炎症，从而增加组织的愈合。

3. 发明授权

US08366772B2 Artificial disc replacements with natural kinematics 有权
标题翻译：人造盘替代与自然运动学
公开(公告)号：US08366772B2
公开(公告)日：2013-02-05
申请号：US10512515
申请日：2003-04-23
申请人： Bret A. Ferree , David Tompkins
发明人： Bret A. Ferree , David Tompkins
IPC分类号： A61F2/44
CPC分类号： A61F2/4425 , A61B17/86 , A61F2/30767 , A61F2/44 , A61F2002/30016 , A61F2002/3008 , A61F2002/30135 , A61F2002/302 , A61F2002/30245 , A61F2002/30301 , A61F2002/30324 , A61F2002/30327 , A61F2002/30507 , A61F2002/30518 , A61F2002/30563 , A61F2002/30578 , A61F2002/30604 , A61F2002/30616 , A61F2002/30632 , A61F2002/30649 , A61F2002/30769 , A61F2002/30841 , A61F2002/30878 , A61F2002/30884 , A61F2002/30919 , A61F2002/30934 , A61F2002/443 , A61F2002/448 , A61F2220/0025 , A61F2230/0004 , A61F2230/0065 , A61F2230/0071 , A61F2230/0095 , A61F2250/0019 , A61F2250/0039 , A61F2250/0098 , A61F2310/00023 , A61F2310/00029 , A61F2310/00179 , A61F2310/00203 , A61F2310/00239 , A61F2310/00293 , A61F2310/00395 , A61F2310/0058 , A61F2310/00592
摘要： This invention improves upon prior aft total disc replacements (TDRs) by more closely replicating the kinematics of a natural disc. The preferred embodiments feature two or more fixed centers of rotation (CORs) and an optional variable COR (VCOR) as the artificial disk replacement (ADR) translates from a fixed posterior COR that lies posterior to the COR of the TDR to facilitate normal disc motion. The use of two or more CORs allows more flexion and more extension than permitted by the facet joints and the artificial facet (AF). AF joint-like components may also be incorporated into the design to restrict excessive translation, rotation, and/or lateral bending.
摘要翻译：本发明通过更紧密地复制天然盘的运动学来改进先前的后总盘替换（TDR）。优选实施例具有两个或更多个固定的旋转中心（COR）和可选的可变的COR（VCOR），因为人造盘替换（ADR）从位于TDR的COR后面的固定的后COR转换，以便于正常的盘运动。使用两个或多个COR允许比小面关节和人造小面（AF）允许的更多的屈曲和更多的延伸。 AF关节部件也可以结合到设计中以限制过度的平移，旋转和/或横向弯曲。

4. 发明申请

US20120277766A1 APPARATUS AND METHODS FOR CLOSURE OF FISSURES IN THE ANULUS FIBROSIS 审中-公开
标题翻译：装置和方法，用于闭合眼睛的麻疹
公开(公告)号：US20120277766A1
公开(公告)日：2012-11-01
申请号：US13297789
申请日：2011-11-16
申请人： Bret A. Ferree
发明人： Bret A. Ferree
IPC分类号： A61B17/04
CPC分类号： A61F2/442 , A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/06166 , A61B2017/00261 , A61B2017/00349 , A61B2017/00867 , A61B2017/0403 , A61B2017/0409 , A61B2017/0414 , A61B2017/0417 , A61B2017/0427 , A61B2017/0438 , A61B2017/047 , A61B2017/0472 , A61B2017/06042 , A61F2002/30062 , A61F2002/30092 , A61F2002/4435 , A61F2310/00023
摘要： Apparatus for repairing a defect in an anulus fibrosis surrounding an intradiscal space, the apparatus comprising a first surgical instrument having a distal end adapted for penetration through an annulus fibrosis on one side of a defect in the annulus fibrosis such that the distal end of the first surgical instrument enters into an intradiscal space; a flexible longitudinal fixation component temporarily coupled to the distal end of the first surgical instrument; and a second surgical instrument having a distal end adapted for penetration through an annulus fibrosis on the other side of a defect in the annulus fibrosis or through a defect in the annulus fibrosis, the distal end of the second surgical instrument including a device for capturing the flexible longitudinal fixation component within an intradiscal space and pulling the flexible longitudinal fixation component so as to repair the defect.
摘要翻译：用于修复围绕椎间盘内空间的环状纤维化中的缺陷的装置，该装置包括第一手术器械，其具有适于穿过环状纤维化中的缺损的一侧上的环状纤维化的远端，使得第一手术器械进入一个椎间盘内空间; 柔性的纵向固定部件临时联接到第一外科器械的远端; 以及第二外科器械，其具有适于穿过环状纤维化中的缺陷的另一侧上的环状纤维化或通过环状纤维化中的缺陷的远端，第二手术器械的远端包括用于捕获弹性纵向固定部件在椎间盘内空间内并拉动柔性纵向固定部件，以修复缺损。

5. 发明申请

US20120136444A1 TWO-COMPONENT ARTIFICIAL DISC REPLACEMENTS 有权
标题翻译：双组分人造椎间盘置换术
公开(公告)号：US20120136444A1
公开(公告)日：2012-05-31
申请号：US13251928
申请日：2011-10-03
申请人： Bret A. Ferree
发明人： Bret A. Ferree
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61F2/30767 , A61F2/4425 , A61F2002/3008 , A61F2002/30507 , A61F2002/30563 , A61F2002/30578 , A61F2002/30604 , A61F2002/30649 , A61F2002/30769 , A61F2002/30841 , A61F2002/30884 , A61F2002/30919 , A61F2002/443 , A61F2220/0025 , A61F2250/0098 , A61F2310/00023 , A61F2310/00029 , A61F2310/00203 , A61F2310/00239 , A61F2310/00293
摘要： Artificial disc replacements (ADRs) and total disc replacements (TDRs) are based upon two, directly articulating components, resulting in a restricted-motion system that better approximates more normal spinal flexion, extension, and lateral bending. One component may have a concave articulating surface, and the other a convex articulating surface. The radius of curvature of the articulating surface may be smaller in the anterior-to-posterior direction of the ADR than the radius of curvature of the articulating surface in the left-to-right direction of the ADR. Both components are preferably made of a hard material and are highly polished to reduce friction.
摘要翻译：人造椎间盘置换术（ADR）和总椎间盘置换术（TDR）基于两个直接关节部件，导致限制运动系统更好地接近更正常的脊柱弯曲，伸展和侧向弯曲。一个部件可以具有凹形的铰接表面，而另一个部件可以具有凸形的铰接表面。关节表面的曲率半径在ADR的前后方向可能比ADR的左右方向上的关节表面的曲率半径小。这两个部件优选地由硬质材料制成并被高度抛光以减少摩擦。

6. 发明申请

US20110218573A1 METHODS AND APPARATUS FOR ANULUS REPAIR 有权
标题翻译：用于神经修复的方法和装置
公开(公告)号：US20110218573A1
公开(公告)日：2011-09-08
申请号：US13128417
申请日：2009-11-25
申请人： Bret A. Ferree
发明人： Bret A. Ferree
IPC分类号： A61B17/70 , A61B17/04 , A61B17/86
CPC分类号： A61F2/44 , A61B17/7032 , A61B17/7053 , A61B17/7062 , A61B17/7067 , A61B17/7076 , A61B17/8861 , A61F2/4611 , A61F2002/30451 , A61F2002/30461 , A61F2002/30604 , A61F2002/4435 , A61F2002/4495 , A61F2220/0058 , A61F2220/0075
摘要： Apparatus, systems and methods are used to repair, reconstruct and/or replace spinal features. A flexible longitudinal fixation component such a suture is passed around or through a portion of a spine, with the end sections of the component either being attached to one another or coupled to at least one bone implant. The bone implant may be a bone anchor or may form part of a pedicle screw assembly. The flexible longitudinal fixation component may pass through an anulus fibrosis (AF) and at least one intra-aperture component situated within a void or defect in an AF. The intra-aperture component may be composed of a porous mesh, allograft tissue or xenograft tissue. The intra-aperture component preferably includes one or more proximal-to-distal channels facilitating the intentional initial passage of nucleus pulposis (NP) tissue while preventing the extrusion of the NP long term.
摘要翻译：装置，系统和方法用于修复，重建和/或替代脊柱特征。柔性纵向固定部件如缝合线绕或穿过脊柱的一部分，部件的端部部分彼此附接或联接至至少一个骨植入物。骨植入物可以是骨锚或者可以形成椎弓根螺钉组件的一部分。灵活的纵向固定组件可以通过位于AF中的空隙或缺陷内的环状纤维化（AF）和至少一个孔内组件。孔内组件可以由多孔网，同种异体移植组织或异种移植组织组成。孔内部件优选地包括一个或多个近端至远端通道，其有助于髓核组织（NP）组织的有意的初始通过，同时防止NP长期挤压。

7. 发明授权

US07914553B2 Methods and apparatus for treating disc herniation and preventing the extrusion of interbody bone graft 有权
标题翻译：椎间盘突出症治疗方法及装置，防止椎体间移植物挤压
公开(公告)号：US07914553B2
公开(公告)日：2011-03-29
申请号：US11708101
申请日：2007-02-15
申请人： Bret A. Ferree
发明人： Bret A. Ferree
IPC分类号： A61B17/04 , A61B17/064
CPC分类号： A61B17/1671 , A61B2017/00261 , A61B2017/0256 , A61F2/2846 , A61F2/30742 , A61F2/30744 , A61F2/30965 , A61F2/441 , A61F2/442 , A61F2/4455 , A61F2/447 , A61F2/4601 , A61F2/4611 , A61F2002/2835 , A61F2002/30093 , A61F2002/30131 , A61F2002/30153 , A61F2002/302 , A61F2002/30224 , A61F2002/30235 , A61F2002/30271 , A61F2002/30283 , A61F2002/30329 , A61F2002/30433 , A61F2002/30441 , A61F2002/30461 , A61F2002/3052 , A61F2002/30538 , A61F2002/30556 , A61F2002/30565 , A61F2002/30576 , A61F2002/30579 , A61F2002/30589 , A61F2002/30626 , A61F2002/30677 , A61F2002/30774 , A61F2002/30777 , A61F2002/30784 , A61F2002/30787 , A61F2002/30828 , A61F2002/30909 , A61F2002/30975 , A61F2002/4435 , A61F2002/444 , A61F2002/4445 , A61F2002/445 , A61F2002/4475 , A61F2002/448 , A61F2002/4627 , A61F2002/4628 , A61F2210/0019 , A61F2220/0025 , A61F2220/0041 , A61F2220/0075 , A61F2230/0013 , A61F2230/0019 , A61F2230/0063 , A61F2230/0065 , A61F2230/0069 , A61F2230/0082 , A61F2250/0006 , A61F2250/0009 , A61F2250/0069 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61L27/3856 , A61L2430/38
摘要： Methods and apparatus for treating defects in the annulus fibrosis are described. The methods include providing first and second elongate fastening members, each having a first end and an anchor on the first end that is substantially transverse when deployed. The first end of the first and second elongate fastening members are positioned distal of the outer layer and at least one inner layer of the annulus fibrosis. The defect is then closed by interlocking the first and second elongate fastening members. Alternatively, second ends of the elongate fastening members may be linked, resulting in reducing the size of the opening of the defect. Devices having first and second elongate fastening members, each having a first end, a second end, and an anchor on the first end that is substantially transverse when deployed; and a connector that links the first and second elongate fastening members are also described.
摘要翻译：描述了用于治疗环状纤维化中的缺陷的方法和装置。所述方法包括提供第一和第二细长紧固构件，每个第一和第二细长紧固构件具有在第一端上的第一端和锚固件，其在展开时基本上横向。第一和第二细长紧固构件的第一端位于外层的远侧以及环状纤维化的至少一个内层。然后通过互锁第一和第二细长紧固构件来关闭缺陷。或者，细长紧固构件的第二端可以连接，从而减小缺陷开口的尺寸。具有第一和第二细长紧固构件的装置，每个具有第一端，第二端和在第一端上的锚固件，其在展开时基本上横向; 还描述了连接第一和第二细长紧固构件的连接器。

8. 发明申请

US20080311114A1 USE OF MORPHOGENIC PROTEINS TO TREAT HUMAN DISC DISEASE 审中-公开
标题翻译：使用多发性蛋白质治疗人类疾病
公开(公告)号：US20080311114A1
公开(公告)日：2008-12-18
申请号：US12196329
申请日：2008-08-22
申请人： Bret A. Ferree
发明人： Bret A. Ferree
IPC分类号： A61K38/16 , A61K39/395 , A61P19/00
CPC分类号： A61L27/54 , A61B2017/564 , A61F2/442 , A61F2002/444 , A61L27/227 , A61L2300/252 , A61L2300/414 , A61L2400/06 , A61L2430/38
摘要： Bone morphogenetic proteins (BMPs) are introduced into an affected intervertebral disc without the inclusion of disc cells. The inventions applies to all known and yet-to-be developed or discovered BMPs, including BMP-1, -2, -3, -4, -5, -6, -7, -8, -9, -10, . . . BMPn. The BMP(s) may be obtained from natural and/or recombinant sources. The BMP(s) may be introduced using any surgical technique, including percutaneous or laparoscopic approaches. As one delivery mechanism, a passageway may be formed through the annulus, with the substances then being introduced through the passageway. Alternatively, a carrier may be sewn or otherwise adhered to the inside or outside of the existing annulus using standard surgical procedures. Additional therapeutic substances such as culture medium, growth factors, differentiation factors, hydrogels, polymers, antibiotics, anti-inflammatory medications, or immunosuppressive medications could be introduced in conjunction with the BMP(s).
摘要翻译：将骨形态发生蛋白（BMP）引入受影响的椎间盘而不包括椎间盘细胞。本发明适用于所有已知且尚待开发或发现的BMP，包括BMP-1，-2，-3，-4，-5，-6，-7，-8，-9，-10。。。 BMPn。 BMP可以从天然和/或重组来源获得。可以使用任何手术技术（包括经皮或腹腔镜方法）引入BMP。作为一个输送机构，可以通过环形成通道，然后通过通道引入物质。或者，可以使用标准外科手术将载体缝合或以其他方式粘附到现有环的内部或外部。可以与BMP一起引入其它治疗物质，例如培养基，生长因子，分化因子，水凝胶，聚合物，抗生素，抗炎药物或免疫抑制药物。

9. 发明申请

US20080183296A1 MOBILE BEARING ARTIFICIAL DISC REPLACEMENT 审中-公开
标题翻译：移动轴承人工椎间盘置换术
公开(公告)号：US20080183296A1
公开(公告)日：2008-07-31
申请号：US12021926
申请日：2008-01-29
申请人： Bret A. Ferree
发明人： Bret A. Ferree
IPC分类号： A61F2/44
CPC分类号： A61F2/4425 , A61F2/4611 , A61F2002/30075 , A61F2002/30092 , A61F2002/30131 , A61F2002/30242 , A61F2002/30327 , A61F2002/30331 , A61F2002/30332 , A61F2002/30383 , A61F2002/30405 , A61F2002/30462 , A61F2002/30471 , A61F2002/30476 , A61F2002/30481 , A61F2002/30504 , A61F2002/30507 , A61F2002/30556 , A61F2002/30566 , A61F2002/30578 , A61F2002/30579 , A61F2002/30601 , A61F2002/30604 , A61F2002/3064 , A61F2002/30644 , A61F2002/30841 , A61F2002/30883 , A61F2002/30934 , A61F2002/443 , A61F2002/448 , A61F2002/4627 , A61F2002/4629 , A61F2210/0014 , A61F2210/0061 , A61F2220/0025 , A61F2220/0033 , A61F2220/0075 , A61F2220/0091 , A61F2230/0013 , A61F2230/0071 , A61F2250/0009 , A61F2250/0039 , A61F2310/00011 , A61F2310/00029 , A61F2310/00179
摘要： Artificial disc replacements (ADRs) use mobile spacers between vertebral endplates. In the preferred embodiment, spherical spacers are used between metal or ceramic plates placed over or in the endplates of the vertebrae. The spherical spacers may be made of metal, ceramics or polymers such as polyethylene. One or more of the bearings may be used in each disc replacement, and one or more disc replacements may be inserted into the disc space. The small bearings allow the preservation of the vertebral endplates. Although the preferred embodiment use mobile units preferably in the form of small spheres and two ADRs per level, alternatives are disclosed, wherein the mobile unit is non-spherical, including oblong shapes. Further alternative configurations include an elongated mobile bearing contained by interdigitating projections from superior and/or inferior endplates.
摘要翻译：人造椎间盘置换术（ADR）在椎骨终板之间使用移动间隔物。在优选实施例中，球形间隔物用于放置在椎骨终板上或其中的金属或陶瓷板之间。球形间隔件可以由金属，陶瓷或诸如聚乙烯的聚合物制成。可以在每个盘替换中使用一个或多个轴承，并且可以将一个或多个盘替换件插入到盘空间中。小轴承允许椎体终板的保存。虽然优选实施例使用优选地以小球体和每个级别的两个ADR的形式的移动单元，但是公开了替代方案，其中移动单元是非球形的，包括长方形形状。另外的替代构造包括通过从上和/或下端板的交叉突出物包含的细长移动轴承。

10. 发明授权

US07273497B2 Methods for treating a defect in the annulus fibrosis 有权
标题翻译：治疗环状纤维化缺损的方法
公开(公告)号：US07273497B2
公开(公告)日：2007-09-25
申请号：US10630445
申请日：2003-07-30
申请人： Bret A. Ferree
发明人： Bret A. Ferree
IPC分类号： A61F2/44
CPC分类号： A61B17/1671 , A61B90/39 , A61B2017/00261 , A61B2017/0256 , A61F2/2846 , A61F2/30742 , A61F2/30744 , A61F2/30965 , A61F2/441 , A61F2/442 , A61F2/4455 , A61F2/447 , A61F2/4601 , A61F2/4611 , A61F2002/2835 , A61F2002/30093 , A61F2002/30131 , A61F2002/30153 , A61F2002/302 , A61F2002/30224 , A61F2002/30235 , A61F2002/30271 , A61F2002/30283 , A61F2002/30329 , A61F2002/30433 , A61F2002/30441 , A61F2002/30461 , A61F2002/3052 , A61F2002/30538 , A61F2002/30556 , A61F2002/30565 , A61F2002/30576 , A61F2002/30579 , A61F2002/30589 , A61F2002/30626 , A61F2002/30677 , A61F2002/30774 , A61F2002/30777 , A61F2002/30784 , A61F2002/30787 , A61F2002/30828 , A61F2002/30909 , A61F2002/30975 , A61F2002/4435 , A61F2002/444 , A61F2002/4445 , A61F2002/445 , A61F2002/4475 , A61F2002/448 , A61F2002/4627 , A61F2002/4628 , A61F2210/0019 , A61F2220/0025 , A61F2220/0041 , A61F2220/0075 , A61F2230/0013 , A61F2230/0019 , A61F2230/0063 , A61F2230/0065 , A61F2230/0069 , A61F2230/0082 , A61F2250/0006 , A61F2250/0009 , A61F2250/0069 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61L27/3856 , A61L2400/06 , A61L2430/38
摘要： Methods and apparatus for treating disc herniation provide a conformable device which assumes a first shape associated with insertion and a second shape or expanded shape to occlude the defect which typically follows partial discectomy. The device may take different forms, including patches sized to cover the defect, plugs adapted to fill the defect, or a mesh screen collapsed into an elongated form for the purposes of insertion, thereby minimizing the size of the requisite incision while avoiding delicate surrounding nerves. Such a configuration also permits the use of instrumentation to install the device, including, for example, a hollow tube or sheath adapted to hold the collapsed screen and a push rod to expel the collapsed device out of the sheath for use in occluding the disc defect. A device may further include one or more anchors to assist in permanently affixing the device with respect to the defect.
摘要翻译：用于治疗椎间盘突出症的方法和装置提供了一种适形装置，其采用与插入相关联的第一形状和第二形状或扩张形状以封闭通常在部分椎间盘切除术之后的缺损。该装置可以采取不同的形式，包括尺寸适于覆盖缺陷的贴片，适于填充缺陷的插塞或为了插入的目的而折叠成细长形状的网筛，从而最小化所需切口的尺寸，同时避免微妙的周围神经。这种构造还允许使用仪器来安装设备，包括例如适于保持塌缩的屏幕的中空管或护套和推杆，以将收缩的装置排出护套以用于阻塞盘缺陷。装置还可以包括一个或多个锚，以帮助永久性地将装置固定在缺陷上。

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