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1. 发明授权

US06242238B1 Isolated nucleic acid molecule encoding mammalian endoglucuronidase and uses therefor 失效
标题翻译：分离的核酸分子编码哺乳动物内糖葡萄糖醛酸酶，并用于此
公开(公告)号：US06242238B1
公开(公告)日：2001-06-05
申请号：US09181336
申请日：1998-10-28
申请人： Craig Geoffrey Freeman , Mark Darren Hulett , Christopher Richard Parish , Brenton James Hamdorf
发明人： Craig Geoffrey Freeman , Mark Darren Hulett , Christopher Richard Parish , Brenton James Hamdorf
IPC分类号： C12N924
CPC分类号： C12Y302/01166 , A61K38/00 , C12N9/2402
摘要： The present invention relates to isolated or recombinant mammalian endoglucuronidase enzymes, polypeptides and peptides, in particular human, murine and rat heparanases, genetic sequences encoding same and uses therefor, for example in the determination and characterisation of chemical compounds, proteins, polypeptides, small molecules and macromolecules capable of inhibiting metastasis, angiogenesis, angioplasty-induced restenosis, atherosclerosis, inflammation, promote wound healing and otherwise modulate physiological processes involving heparanase cleavage of heparan sulphate. The invention further relates to a method of altering, modifying or otherwise modulating the level of expression of mammalian heparanase in a cell. A further aspect of the invention relates to immunoreactive molecules capable of binding to and/or inhibiting mammalian heparanase, in particular monoclonal antibodies. A still further aspect of the invention contemplates the use of heparanase as an agent to promote the processes of wound healing.
摘要翻译：本发明涉及分离的或重组的哺乳动物内葡萄糖醛酸酶，多肽和肽，特别是人，鼠和大鼠肝素酶，编码它们的遗传序列和用途，例如在化学化合物，蛋白质，多肽，小分子的测定和表征中和能够抑制转移，血管生成，血管成形术诱导的再狭窄，动脉粥样硬化，炎症，促进伤口愈合并且否则调节涉及肝素硫酸乙酰肝素酶切割的生理过程的大分子。本发明还涉及改变，修饰或以其他方式调节细胞中哺乳动物肝素酶的表达水平的方法。本发明的另一方面涉及能够结合和/或抑制哺乳动物肝素酶，特别是单克隆抗体的免疫反应性分子。本发明的另一方面考虑使用乙酰肝素酶作为促进伤口愈合过程的药剂。

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