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1. 发明申请

US20120071658A1 PYRAZINO[2,3-b]PYRAZINE mTOR KINASE INHIBITOR FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY 有权
标题翻译：对于与mTOR / PI3K / AKT PATHWAY相关的肿瘤学指征和疾病的吡嗪并[2,3-b]吡嗪mTOR激酶抑制剂
公开(公告)号：US20120071658A1
公开(公告)日：2012-03-22
申请号：US13295533
申请日：2011-11-14
申请人： Sophie Perrin-Ninkovic , Roy L. Harris , John Sapienza , Graziella Shevlin , Patrick Papa , Branden Lee , Garrick Packard , Lida Tehrani , Jingjing Zhao , Jennifer Riggs , Jason Parnes , Deborah Mortensen , Weiming Xu , Loui Madakamutil , Kimberly Fultz , Rama K. Narla , Sabita Sankar , Jan Elsner
发明人： Sophie Perrin-Ninkovic , Roy L. Harris , John Sapienza , Graziella Shevlin , Patrick Papa , Branden Lee , Garrick Packard , Lida Tehrani , Jingjing Zhao , Jennifer Riggs , Jason Parnes , Deborah Mortensen , Weiming Xu , Loui Madakamutil , Kimberly Fultz , Rama K. Narla , Sabita Sankar , Jan Elsner
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , C07D241/20 , C07D471/04 , C07D471/14 , C07D487/10 , C07D487/14 , C07D498/14
摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.
摘要翻译：本文提供具有以下结构的杂芳基化合物：其中R 1 -R 4如本文所定义，包含有效量的杂芳基化合物的组合物以及用于治疗或预防癌症，炎症状况，免疫学条件，神经变性疾病，糖尿病，肥胖症，神经系统疾病疾病，年龄相关疾病或心血管疾病，包括向有需要的患者施用有效量的杂芳基化合物。

2. 发明申请

US20130005707A1 AMINOTRIAZOLOPYRIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH 审中-公开
标题翻译：氨基三唑基吡啶类，其组合物及其处理方法
公开(公告)号：US20130005707A1
公开(公告)日：2013-01-03
申请号：US13609412
申请日：2012-09-11
申请人： Sogole Bahmanyar , R.J. Bates , Kate Blease , Andrew Antony Calabrese , Thomas Oran Daniel , Mercedes Delgado , Jan Elsner , Paul Erdman , Bruce Fahr , Gregory Ferguson , Branden Lee , Lisa Nadolny , Garrick Packard , Patrick Papa , Veronique Plantevin-Krenitsky , Jennifer Riggs , Patricia Rohane , Sabita Sankar , John Sapienza , Yoshitaka Satoh , Victor Sloan , Randall Stevens , Lida Tehrani , Jayashree Tikhe , Eduardo Torres , Andrew Wallace , Brandon Wade Whitefield , Jingjing Zhao
发明人： Sogole Bahmanyar , R.J. Bates , Kate Blease , Andrew Antony Calabrese , Thomas Oran Daniel , Mercedes Delgado , Jan Elsner , Paul Erdman , Bruce Fahr , Gregory Ferguson , Branden Lee , Lisa Nadolny , Garrick Packard , Patrick Papa , Veronique Plantevin-Krenitsky , Jennifer Riggs , Patricia Rohane , Sabita Sankar , John Sapienza , Yoshitaka Satoh , Victor Sloan , Randall Stevens , Lida Tehrani , Jayashree Tikhe , Eduardo Torres , Andrew Wallace , Brandon Wade Whitefield , Jingjing Zhao
IPC分类号： A61K31/437 , A61K31/5377 , A61K31/506 , A61K31/4545 , A61K31/496 , A61K31/551 , A61P37/00 , A61P37/08 , A61P29/00 , A61P7/02 , A61P35/00 , A61P31/00 , A61P25/28 , A61P9/00 , A61P3/00 , A61P37/06 , A61P19/02 , A61P17/00 , A61P31/12 , A61P3/10 , A61P25/00 , A61P21/04 , A61P1/00 , A61P11/02 , A61P11/00 , A61P17/06 , A61P3/04 , A61P19/06 , A61P9/10 , C12N5/071 , A61K31/4709
CPC分类号： C07D471/04 , C07D519/00
摘要： Provided herein are Heteroaryl Compounds of formula (I): wherein R1 and R2 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing inflammatory conditions or cancer, and conditions treatable or preventable by inhibition of a kinase or a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a subject in need thereof.
摘要翻译：本文提供了式（I）的杂芳基化合物：其中R 1和R 2如本文所定义，包含有效量的杂芳基化合物的组合物和用于治疗或预防炎性病症或癌症的方法，以及可通过抑制激酶治疗或预防的病症或激酶途径，其包括向有需要的受试者施用有效量的杂芳基化合物。

3. 发明授权

US08110578B2 Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway 有权
标题翻译：吡嗪并[2,3-b]吡嗪mTOR激酶抑制剂用于肿瘤适应症和与mTOR / PI3K / Akt途径相关的疾病
公开(公告)号：US08110578B2
公开(公告)日：2012-02-07
申请号：US12605791
申请日：2009-10-26
申请人： Sophie Perrin-Ninkovic , Roy L. Harris , John Sapienza , Graziella Shevlin , Patrick Papa , Branden Lee , Garrick Packard , Lida Tehrani , Jingjing Zhao , Jennifer Riggs , Jason Parnes , Deborah Mortensen , Weiming Xu , Loui Madakamutil , Kimberly Fultz , Rama K. Narla , Sabita Sankar , Jan Elsner
发明人： Sophie Perrin-Ninkovic , Roy L. Harris , John Sapienza , Graziella Shevlin , Patrick Papa , Branden Lee , Garrick Packard , Lida Tehrani , Jingjing Zhao , Jennifer Riggs , Jason Parnes , Deborah Mortensen , Weiming Xu , Loui Madakamutil , Kimberly Fultz , Rama K. Narla , Sabita Sankar , Jan Elsner
IPC分类号： A61K31/497
CPC分类号： C07D487/04 , C07D241/20 , C07D471/04 , C07D471/14 , C07D487/10 , C07D487/14 , C07D498/14
摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.
摘要翻译：本文提供具有以下结构的杂芳基化合物：其中R 1 -R 4如本文所定义，包含有效量的杂芳基化合物的组合物以及用于治疗或预防癌症，炎症状况，免疫学条件，神经变性疾病，糖尿病，肥胖症，神经系统疾病疾病，年龄相关疾病或心血管疾病，包括向有需要的患者施用有效量的杂芳基化合物。

4. 外观设计

USD534937S1 Ceiling camera 有权
标题翻译：天花板相机
公开(公告)号：USD534937S1
公开(公告)日：2007-01-09
申请号：US29215905
申请日：2004-10-25
申请人： Branden Lee
设计人： Branden Lee

5. 发明申请

US20060092137A1 Portable electronic product 审中-公开
标题翻译：便携式电子产品
公开(公告)号：US20060092137A1
公开(公告)日：2006-05-04
申请号：US10976104
申请日：2004-10-27
申请人： Branden Lee
发明人： Branden Lee
IPC分类号： G09G5/00
CPC分类号： G06F3/04886 , G06F1/1626 , G06F1/169 , G06F3/03547
摘要： A portable electronic product comprising a main body, a display panel and a touch pad is provided. The main body comprises a top surface and a bottom surface, and the display panel is disposed on the top surface of the main body and electrically coupled thereto. Moreover, the touch pad is disposed on the bottom surface of the main body and electrically coupled thereto. Since the touch pad is disposed over the bottom surface of the main body, the display panel is not blocked while a user selects the functional options shown in the display panel. Furthermore, the user can control the portable electronic product without touching the display panel such that the damage of the display panel from frequent touching is avoided.
摘要翻译：提供一种包括主体，显示面板和触摸板的便携式电子产品。主体包括顶表面和底表面，并且显示面板设置在主体的顶表面上并与其电耦合。此外，触摸板设置在主体的底表面上并电耦合到主体。由于触摸板设置在主体的底表面上，所以当用户选择显示面板中所示的功能选项时，显示面板不被阻挡。此外，用户可以在不触摸显示面板的情况下控制便携式电子产品，从而避免了显示面板的频繁触摸的损坏。

6. 发明授权

US08507492B2 Pyrazino[2,3-b]pyrazine mTOR kinase inhibitor for oncology indications and diseases associated with the mTOR/PI3K/AKT pathway 有权
标题翻译：吡嗪并[2,3-b]吡嗪mTOR激酶抑制剂与mTOR / PI3K / AKT途径相关的肿瘤适应症和疾病
公开(公告)号：US08507492B2
公开(公告)日：2013-08-13
申请号：US13295513
申请日：2011-11-14
申请人： Sophie Perrin-Ninkovic , Roy L. Harris , John Sapienza , Graziella Shevlin , Patrick Papa , Branden Lee , Garrick Packard , Lida Tehrani , Jingjing Zhao , Jennifer Riggs , Jason Parnes , Deborah Mortensen , Weiming Xu , Loui Madakamutil , Kimberly Fultz , Rama K. Narla , Sabita Sankar , Jan Elsner
发明人： Sophie Perrin-Ninkovic , Roy L. Harris , John Sapienza , Graziella Shevlin , Patrick Papa , Branden Lee , Garrick Packard , Lida Tehrani , Jingjing Zhao , Jennifer Riggs , Jason Parnes , Deborah Mortensen , Weiming Xu , Loui Madakamutil , Kimberly Fultz , Rama K. Narla , Sabita Sankar , Jan Elsner
IPC分类号： A61K31/497
CPC分类号： C07D487/04 , C07D241/20 , C07D471/04 , C07D471/14 , C07D487/10 , C07D487/14 , C07D498/14
摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.
摘要翻译：本文提供具有以下结构的杂芳基化合物：其中R 1 -R 4如本文所定义，包含有效量的杂芳基化合物的组合物以及用于治疗或预防癌症，炎症状况，免疫学条件，神经变性疾病，糖尿病，肥胖症，神经系统疾病疾病，年龄相关疾病或心血管疾病，包括向有需要的患者施用有效量的杂芳基化合物。

7. 发明授权

US08492381B2 Pyrazino[2,3-b]pyrazine mTOR kinase inhibitor for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway 有权
标题翻译：吡嗪并[2,3-b]吡嗪mTOR激酶抑制剂与mTOR / PI3K / Akt途径相关的肿瘤适应症和疾病
公开(公告)号：US08492381B2
公开(公告)日：2013-07-23
申请号：US13295533
申请日：2011-11-14
申请人： Sophie Perrin-Ninkovic , Roy L. Harris , John Sapienza , Graziella Shevlin , Patrick Papa , Branden Lee , Garrick Packard , Lida Tehrani , Jingjing Zhao , Jennifer Riggs , Jason Parnes , Deborah Mortensen , Weiming Xu , Loui Madakamutil , Kimberly Fultz , Rama K. Narla , Sabita Sankar , Jan Elsner
发明人： Sophie Perrin-Ninkovic , Roy L. Harris , John Sapienza , Graziella Shevlin , Patrick Papa , Branden Lee , Garrick Packard , Lida Tehrani , Jingjing Zhao , Jennifer Riggs , Jason Parnes , Deborah Mortensen , Weiming Xu , Loui Madakamutil , Kimberly Fultz , Rama K. Narla , Sabita Sankar , Jan Elsner
IPC分类号： A61K31/497
CPC分类号： C07D487/04 , C07D241/20 , C07D471/04 , C07D471/14 , C07D487/10 , C07D487/14 , C07D498/14
摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.
摘要翻译：本文提供具有以下结构的杂芳基化合物：其中R 1 -R 4如本文所定义，包含有效量的杂芳基化合物的组合物以及用于治疗或预防癌症，炎症状况，免疫学条件，神经变性疾病，糖尿病，肥胖症，神经系统疾病疾病，年龄相关疾病或心血管疾病，包括向有需要的患者施用有效量的杂芳基化合物。

8. 发明授权

US08299056B2 Aminotriazolopyridines, compositions thereof, and methods of treatment therewith 有权
标题翻译：氨基三唑并吡啶类，其组合物及其处理方法
公开(公告)号：US08299056B2
公开(公告)日：2012-10-30
申请号：US12555018
申请日：2009-09-08
申请人： Sogole Bahmanyar , R.J. Bates , Kate Blease , Andrew Calabrese , Thomas Daniel , Mercedes Delgado , Jan Elsner , Paul Erdman , Bruce Fahr , Gregory Ferguson , Branden Lee , Lisa Nadolny , Garrick Packard , Patrick Papa , Veronique Plantevin-Krenitsky , Jennifer Riggs , Patricia Rohane , Sabita Sankar , John Sapienza , Yoshitaka Satoh , Victor Sloan , Randall Stevens , Lida Tehrani , Jayashree Tikhe , Eduardo Torres , Andrew Wallace , Brandon Wade Whitefield , Jingjing Zhao
发明人： Sogole Bahmanyar , R.J. Bates , Kate Blease , Andrew Calabrese , Thomas Daniel , Mercedes Delgado , Jan Elsner , Paul Erdman , Bruce Fahr , Gregory Ferguson , Branden Lee , Lisa Nadolny , Garrick Packard , Patrick Papa , Veronique Plantevin-Krenitsky , Jennifer Riggs , Patricia Rohane , Sabita Sankar , John Sapienza , Yoshitaka Satoh , Victor Sloan , Randall Stevens , Lida Tehrani , Jayashree Tikhe , Eduardo Torres , Andrew Wallace , Brandon Wade Whitefield , Jingjing Zhao
IPC分类号： A61K31/437 , A61K31/5377 , A61K31/497 , A61K31/55 , C07D471/02
CPC分类号： C07D471/04 , C07D519/00
摘要： Provided herein are Heteroaryl Compounds of formula (I): wherein R1 and R2 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing inflammatory conditions or cancer, and conditions treatable or preventable by inhibition of a kinase or a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a subject in need thereof.
摘要翻译：本文提供了式（I）的杂芳基化合物：其中R 1和R 2如本文所定义，包含有效量的杂芳基化合物的组合物和用于治疗或预防炎性病症或癌症的方法，以及可通过抑制激酶治疗或预防的病症或激酶途径，其包括向有需要的受试者施用有效量的杂芳基化合物。

9. 发明申请

US20120059164A1 PYRAZINO[2,3-b]PYRAZINE mTOR KINASE INHIBITOR FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY 有权
公开(公告)号：US20120059164A1
公开(公告)日：2012-03-08
申请号：US13295513
申请日：2011-11-14
申请人： Sophie Perrin-Ninkovic , Roy L. Harris , John Sapienza , Graziella Shevlin , Patrick Papa , Branden Lee , Garrick Packard , Lida Tehrani , Jingjing Zhao , Jennifer Riggs , Jason Parnes , Deborah Mortensen , Weiming Xu , Loui Madakamutil , Kimberly Fultz , Rama K. Narla , Sabita Sankar , Jan Elsner
发明人： Sophie Perrin-Ninkovic , Roy L. Harris , John Sapienza , Graziella Shevlin , Patrick Papa , Branden Lee , Garrick Packard , Lida Tehrani , Jingjing Zhao , Jennifer Riggs , Jason Parnes , Deborah Mortensen , Weiming Xu , Loui Madakamutil , Kimberly Fultz , Rama K. Narla , Sabita Sankar , Jan Elsner
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , C07D241/20 , C07D471/04 , C07D471/14 , C07D487/10 , C07D487/14 , C07D498/14
摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

10. 发明申请

US20100216781A1 mTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY 有权
标题翻译：与mTOR / PI3K / AKT PATHWAY相关的肿瘤学指征和疾病的mTOR激酶抑制剂
公开(公告)号：US20100216781A1
公开(公告)日：2010-08-26
申请号：US12605791
申请日：2009-10-26
申请人： Sophie Perrin-Ninkovic , Roy L. Harris , John Sapienza , Graziella Shevlin , Patrick Papa , Branden Lee , Garrick Packard , Lida Tehrani , Jingjing Zhao , Jennifer Riggs , Jason Parnes , Deborah Mortensen , Weiming Xu , Loui Madakamutil , Kimberly Fultz , Rama K. Narla , Sabita Sankar , Jan Elsner
发明人： Sophie Perrin-Ninkovic , Roy L. Harris , John Sapienza , Graziella Shevlin , Patrick Papa , Branden Lee , Garrick Packard , Lida Tehrani , Jingjing Zhao , Jennifer Riggs , Jason Parnes , Deborah Mortensen , Weiming Xu , Loui Madakamutil , Kimberly Fultz , Rama K. Narla , Sabita Sankar , Jan Elsner
IPC分类号： A61K31/4985 , C07D487/04 , C07D487/10 , C07D498/14 , A61K31/5377 , A61K31/5383 , A61P35/00 , A61P29/00 , A61P37/00 , A61P25/00 , A61P3/10 , A61P3/04 , A61P9/00 , A61P19/02 , A61P11/00 , C12N9/99 , A61P1/00
CPC分类号： C07D487/04 , C07D241/20 , C07D471/04 , C07D471/14 , C07D487/10 , C07D487/14 , C07D498/14
摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.
摘要翻译：本文提供具有以下结构的杂芳基化合物：其中R 1 -R 4如本文所定义，包含有效量的杂芳基化合物的组合物以及用于治疗或预防癌症，炎症状况，免疫学条件，神经变性疾病，糖尿病，肥胖症，神经系统疾病疾病，年龄相关疾病或心血管疾病，包括向有需要的患者施用有效量的杂芳基化合物。

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