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1. 发明授权

US11464844B2 Methods and compositions using highly conserved pneumococcal surface proteins 有权
公开(公告)号：US11464844B2
公开(公告)日：2022-10-11
申请号：US16688545
申请日：2019-11-19
申请人： Boston Medical Center Corporation
发明人： Richard N. Goldstein
IPC分类号： A61K39/09 , A61P31/04 , A61K39/00
摘要： Cold spot genes of S. pneumoniae are disclosed that encode surface proteins that are universally conserved among known strains and have exceptionally low incidence of allelic variation. Cold spot polypeptides encoded by the genes that are antigenic on the S. pneumoniae cells on which they are expressed are candidates for immunogenic compositions capable of eliciting antibodies able to react with all or nearly all strains of S. pneumoniae, thus providing an improvement over currently available S. pneumoniae vaccines that protect inoculated individuals against a maximum of about 23 of the 94 or so known serotypes of S. pneumonia.

2. 发明授权

US11375918B2 White matter fibrography by synthetic magnetic resonance imaging 有权
公开(公告)号：US11375918B2
公开(公告)日：2022-07-05
申请号：US17104787
申请日：2020-11-25
申请人： BOSTON MEDICAL CENTER CORPORATION , TRUSTEES OF BOSTON UNIVERSITY
发明人： Hernan Jara , Ryan McNaughton
IPC分类号： G01V3/00 , A61B5/055 , G01R33/56 , A61B5/00 , G01R33/563 , G01R33/48 , G01R33/483 , G06T7/00 , G06T11/00 , G01R33/50
摘要： Methods of characterizing the brain of a subject, comprising: (a) performing a multispectral multislice magnetic resonance scan on the brain of a subject, (b) storing image data indicative of a plurality of magnetic resonance weightings of each of a plurality of slices of the brain of the subject to provide directly acquired images, (c) processing the directly acquired images to generate a plurality of quantitative maps of the brain indicative of a plurality of qMRI parameters of the subject, (d) constructing a plurality of magnetic resonance images indicative of white matter structure from the quantitative maps, and (e) generating a spatial entropy map of the brain of the subject from the plurality of magnetic resonance images; and/or generating a myelin water map of the brain of the subject from the plurality of magnetic resonance images.

3. 发明申请

US20210121263A1 TISSUE MARKERS 有权
公开(公告)号：US20210121263A1
公开(公告)日：2021-04-29
申请号：US17120950
申请日：2020-12-14
申请人： TRUSTEES OF BOSTON UNIVERSITY , BOSTON MEDICAL CENTER CORPORATION
发明人： Mark W. GRINSTAFF , Boris Nicolas BLOCH , Jonah KAPLAN
IPC分类号： A61B90/00 , A61M31/00
摘要： The inventions provided herein relate to tissue markers and uses thereof, e.g., to mark a target tissue site (e.g., a biopsy site in a breast tissue) or to produce a cell scaffold. The tissue markers described herein are designed to be resistant to fast migration (e.g., immediate migration after implantation through a needle track) and slow migration (e.g., over an extended period of time) upon implantation at a target tissue site (e.g., a biopsy site in a breast tissue), without using an adhesive. Additionally or alternatively, the tissue markers described herein can be readily detectable by at least one imaging modality, e.g., but not limited to magnetic resonance imaging, X-ray imaging, ultrasound imaging, or a combination thereof.

4. 发明申请

US20200157212A1 ANTI-ROBO2 ANTIBODIES, COMPOSITIONS, METHODS AND USES THEREOF 审中-公开
公开(公告)号：US20200157212A1
公开(公告)日：2020-05-21
申请号：US16614701
申请日：2018-06-08
申请人： Pfizer Inc. , Boston Medical Center Corporation
发明人： Stephen Berasi , Janet Elizabeth Buhlmann , Eric M. Bennett , Nathan Higginson-Scott , Huilan Gao , Zong Sean Juo , Stefano V. Gulla , Christine Huard , Sreekumar R. Kodangattil , Jian Li , Weining Lu , Xueping Fan , David J. Salant
IPC分类号： C07K16/28 , A61P13/12 , C12N15/85
摘要： The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to ROBO2, as well as uses, and methods thereof.

5. 发明授权

US10575753B2 White matter fibrography by synthetic magnetic resonance imaging 有权
公开(公告)号：US10575753B2
公开(公告)日：2020-03-03
申请号：US16427324
申请日：2019-05-30
申请人： BOSTON MEDICAL CENTER CORPORATION
发明人： Hernan Jara
IPC分类号： A61B5/055 , G01R33/56 , A61B5/00 , G01R33/563 , G01R33/50
摘要： Methods of making a white matter fibrogram representing the connectome of the brain of a subject, comprising: (a) performing a multispectral multislice magnetic resonance scan on the brain of a subject, (b) storing image data indicative of a plurality of magnetic resonance weightings of each of a plurality of slices of the brain of the subject to provide directly acquired images, (c) processing the directly acquired images to generate a plurality of quantitative maps of the brain indicative of a plurality of qMRI parameters of the subject, (d) constructing a plurality of magnetic resonance images indicative of white matter structure from the quantitative maps, and (e) rendering a white matter fibrogram of the brain of the subject from the plurality of magnetic resonance images.

6. 发明申请

US20190377134A1 SYSTEMS AND METHODS FOR FIBER-BASED VISIBLE AND NEAR INFRARED OPTICAL COHERENCE TOMOGRAPHY 审中-公开
公开(公告)号：US20190377134A1
公开(公告)日：2019-12-12
申请号：US16433954
申请日：2019-06-06
申请人： BOSTON MEDICAL CENTER CORPORATION
发明人： Ji Yi , Weiye Song
IPC分类号： G02B6/293 , A61B3/10 , H04J14/02 , A61B5/00 , G01B9/02 , G01N21/359 , G01N21/47
摘要： A system for analyzing a tissue sample includes two wavelength-division multiplexers and a fiber coupler. The first wavelength-division multiplexer combines visible and near infrared electromagnetic radiation and directs the combined electromagnetic radiation to the fiber coupler. The fiber coupler emits a sample beam of visible and near infrared electromagnetic radiation toward a tissue sample, and a reference beam of visible and near infrared electromagnetic radiation toward a reference mirror. The sample beam reflects off the tissue sample back to the fiber coupler. The reference beam reflects off the reference mirror back to the fiber coupler. The fiber coupler combines the reflected sample and reference beams and directs the combined electromagnetic radiation to the second wavelength-division multiplexer. The second wavelength-division multiplexer sends visible electromagnetic radiation from the sample and reference beams to a first spectrometer, and near infrared electromagnetic radiation from the sample and reference beams to a second spectrometer.

7. 发明授权

US10390521B2 Parkinsons disease model and methods 有权
公开(公告)号：US10390521B2
公开(公告)日：2019-08-27
申请号：US15464047
申请日：2017-03-20
申请人： Boston Medical Center Corporation
发明人： Victoria Bolotina
IPC分类号： A01K67/027 , A61K38/46 , C12N5/0793 , C12N9/18 , G01N33/50 , C12N9/20 , A61K48/00
摘要： This application provides a novel mouse model (PLA2g6 KOEx2) in which genetic deletion of the N terminus of PLA2g6 results in a loss of dopaminergic (DA) neurons in substantia nigra (SN), and development of PD-like motor deficits that can be significantly improved by L-DOPA. Based in part on experimental results demonstrated with this model, this disclosure provides genetically modified animals and genetically modified animal cells that comprise a mutant allele of PLA2g6 and in which store-operated Ca2+ entry (SOCE) is impaired and ER Ca2+ stores are depleted. This disclosure also provides methods of screening a compound for an effect on the SOCE pathway and/or ER Ca2+ by administering the compound to such a genetically modified animal or genetically modified animal cell. This disclosure also provides methods of treating or preventing PD-related deficit(s) in an animal by characterizing a compound as a SOCE activator using the screening methods and then administering an effective amount of the compound to an animal. This disclosure also provides methods of restoring normal store-operated Ca2+ entry (SOCE) pathway and ER Ca2+ in a cell, comprising introducing a caspase-3 cleavage-resistant PLA2g6 protein into the cell. This disclosure also provides methods of treating or preventing a PD-related deficit(s) in an animal, comprising administering a caspase-3 cleavage-resistant PLA2g6 protein to the animal.

8. 发明授权

US10337995B2 Systems and methods for oblique laser scanning 有权
公开(公告)号：US10337995B2
公开(公告)日：2019-07-02
申请号：US16005246
申请日：2018-06-11
申请人： BOSTON MEDICAL CENTER CORPORATION
发明人： Ji Yi
IPC分类号： G01N21/64 , G01J3/02 , G01J3/44 , G02B26/08 , G01N21/47 , G02B26/10 , A61B5/00 , G01B9/02 , G01N21/17
摘要： A method for constructing a three-dimensional image of a sample includes producing electromagnetic radiation and directing the produced electromagnetic radiation such that it is incident on the sample at an oblique angle. The incident electromagnetic radiation is scanned in discrete increments to a plurality of discrete locations along a first direction, and at each discrete location, scanned along a second direction orthogonal to the first direction. The sample reflects a first portion of the incident electromagnetic radiation and absorbs a second portion of the incident electromagnetic radiation, and emits electromagnetic radiation responsive to the absorption. A plurality of cross-sectional images is produced from the reflected electromagnetic radiation and the emitted electromagnetic radiation, and each cross-sectional image is modified to compensate for the oblique angle. The modified cross-sectional images are then combined to create a three-dimensional image of the sample.

9. 发明授权

US10258600B2 Aryl hydrocarbon receptor (AhR) modifiers as novel cancer therapeutics 有权
公开(公告)号：US10258600B2
公开(公告)日：2019-04-16
申请号：US15059911
申请日：2016-03-03
申请人： Trustees of Boston University , Northeastern University , Boston Medical Center Corporation
发明人： David H. Sherr , Michael Pollastri , Jennifer Schlezinger , Sarah Haigh Molina , Scott Schaus , Joshua Robert Giguere
IPC分类号： A61K31/352 , C07D311/22 , C07D407/04 , A61K31/35 , A61K45/06
摘要： Provided herein are novel agents that modulate AhR activity for use in therapeutic compositions and methods thereof for inhibiting cancer cell proliferation and tumor cell invasion and metastasis. The agents comprise AhR inhibitors or non-constitutive AhR agonists of Formula (I) and (II) for the inhibition of cancer cell growth and parameters that characterize tumor metastasis, such as tumor cell invasiveness.

10. 发明申请

US20190054120A1 COMPOSITIONS AND METHODS FOR ISOLATING AND ENRICHING IGM-PRODUCING CELLS AND USES THEREOF 审中-公开
公开(公告)号：US20190054120A1
公开(公告)日：2019-02-21
申请号：US16102905
申请日：2018-08-14
申请人： TRUSTEES OF BOSTON UNIVERSITY , BOSTON MEDICAL CENTER CORPORATION
发明人： Xuemei Zhong , Joyce Wong
IPC分类号： A61K35/17 , A61K47/24 , C12N5/0781 , C12N5/09 , A61K47/69 , C12N5/16
摘要： The technology described herein relates, at least in part, to compositions comprising and methods for isolating and enriching natural IgM-producing phagocytic B (NIMPAB) cells and methods of producing IgM antibodies using such cells, as well as uses of the antibodies produced by the methods for the prevention and treatment of diseases wherein immunotherapy with such natural IgM antibodies and their derivatives can be useful.

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