专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20180325948A1 TUMOR ANTIGEN MODIFIED DENDRITIC CELLS 审中-公开
公开(公告)号：US20180325948A1
公开(公告)日：2018-11-15
申请号：US15351400
申请日：2016-11-14
申请人： Thomas ICHIM , JOSE JAVIER LOPEZ GONZALEZ , Santosh KESARI , Boris MINEV
发明人： Thomas ICHIM , JOSE JAVIER LOPEZ GONZALEZ , Santosh KESARI , Boris MINEV
IPC分类号： A61K35/15 , A61K39/00 , A61P35/00 , A61K38/03
CPC分类号： A61K35/15 , A61K38/03 , A61K39/001108 , A61K39/001109 , A61K39/001118 , A61K2039/572 , A61P35/00
摘要： Treatment of cancer is disclosed through administration of proteins or specific peptides that are uptaken by dendritic cells, wherein said dendritic cells as subsequently activated and administered, in vivo, in a matter eliciting monocyte or dendritic cell migration in order to allow uptake of said administrated proteins or peptides, followed by administration of a maturation signal in vivo. Alternatively said immature dendritic cells are grown ex vivo in an autologous or semiallogenenic manner derived utilizing conventional means and pulsed with tumor peptides disclosed herein and subsequently administered. In some embodiments of the invention said dendritic cells are treated with epigenetic modifiers to enhance antigen presentation. The invention provides for treatment of cancer through induction of anticancer immunity and/or immunity towards tumor associated blood vessels.

2. 发明申请

US20140087362A1 Methods for assessing effectiveness and monitoring oncolytic virus treatment 审中-公开
标题翻译：评估有效性和监测溶瘤病毒治疗的方法
公开(公告)号：US20140087362A1
公开(公告)日：2014-03-27
申请号：US13815727
申请日：2013-03-13
申请人： Aladar A. Szalay , Nanhai G. Chen , Huiqiang Wang , Melody Fells , Albert Roeder , Qian Zhang , Boris Minev
发明人： Aladar A. Szalay , Nanhai G. Chen , Huiqiang Wang , Melody Fells , Albert Roeder , Qian Zhang , Boris Minev
IPC分类号： C12Q1/70
CPC分类号： C12Q1/701 , A61K38/00 , C07K14/00 , C07K16/28 , C07K2317/34 , C07K2319/00 , C12N2710/24132 , C12N2710/24162 , C12N2710/24171 , G01N33/57496 , G01N2800/52
摘要： Diagnostic methods for in vivo and ex vivo detection of circulating tumor cells (CTCs) for the diagnosis and treatment of cancer are provided. The diagnostic methods employ oncolytic viruses alone or in combination with one or more tumor cell enrichment and/or detection methods. Combinations and kits for use in the practicing the methods also are provided.
摘要翻译：提供了用于诊断和治疗癌症的循环肿瘤细胞（CTC）的体内和体外检测的诊断方法。诊断方法单独使用溶瘤病毒或与一种或多种肿瘤细胞富集和/或检测方法组合使用。还提供了用于实施该方法的组合和试剂盒。

3. 发明申请

US20080044484A1 Use of polymeric nanoparticles for vaccine delivery 审中-公开
标题翻译：使用聚合物纳米粒子进行疫苗输送
公开(公告)号：US20080044484A1
公开(公告)日：2008-02-21
申请号：US11820753
申请日：2007-06-19
申请人： Boris Minev
发明人： Boris Minev
IPC分类号： C07K14/00 , A61K38/02 , A61K38/08 , A61K38/10 , C07K2/00 , C07K7/00 , A61K38/16 , A61K9/14 , A61P35/00
CPC分类号： C07K14/705 , A61K39/00 , C07K14/4748
摘要： The invention relates generally to the treatment and prevention of human cancer and viral diseases. More specifically, this invention relates to development of a new generation of vaccines that rely on eliciting cellular immune responses, specifically induction of cytotoxic T lymphocytes (CTL), against cancer cells and virus-infected cells via administration of a polymeric nanoparticle containing a vaccine comprising a fusion peptide or a modified peptide. Such a fusion peptide is composed of an insertion signal sequence and a peptide derived from a tumor antigen or a viral antigen, which improves antigen presentation and induces CTL with higher efficiency against cancer cells and virus-infected cells. An exemplary peptide utilized in the invention is Mart-1:27-35 peptide.
摘要翻译：本发明一般涉及人类癌症和病毒性疾病的治疗和预防。更具体地说，本发明涉及新一代疫苗的开发，所述新一代疫苗依赖于通过施用含有疫苗的聚合物纳米颗粒引发细胞免疫应答，特别是诱导细胞毒性T淋巴细胞（CTL），抗癌细胞和病毒感染细胞，所述聚合物纳米粒子包含融合肽或修饰肽。这样的融合肽由插入信号序列和衍生自肿瘤抗原或病毒抗原的肽组成，其改善抗原呈递并且诱导针对癌细胞和病毒感染细胞的更高效率的CTL。用于本发明的示例性肽是Mart-1：27-35肽。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式