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1. 发明申请

US20110300149A1 LJUNGAN VIRUS 审中-公开
标题翻译： LJUNGAN病毒
公开(公告)号：US20110300149A1
公开(公告)日：2011-12-08
申请号：US13141758
申请日：2009-12-23
申请人： Bo Niklasson , Conny Tolf , Michael Lindberg
发明人： Bo Niklasson , Conny Tolf , Michael Lindberg
IPC分类号： A61K39/125 , C07H21/02 , C07K14/085 , C12Q1/70 , A61K39/395 , A61P37/04 , A61P31/14 , A61P25/00 , A61P21/04 , A61P3/10 , A61P15/06 , A61P9/00 , A61K31/4245 , C07D413/12 , C12N7/00
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/125 , A61K2039/5258 , A61K2039/53 , C12N2770/32522 , C12N2770/32534
摘要： The present invention relates to a new group of Ljungan viruses, proteins expressed by the viruses, antibodies to the viruses and proteins, vaccines against the viruses, diagnostic kits for detecting the viruses, uses of the viruses, proteins, antibodies and vaccines in therapy, uses of the viruses, proteins, antibodies and vaccines in treating diseases caused by the viruses and methods of treatment for treating diseases caused by the viruses.
摘要翻译：本发明涉及新的一组Ljungan病毒，由病毒表达的蛋白质，病毒和蛋白质的抗体，针对病毒的疫苗，用于检测病毒的诊断试剂盒，病毒，蛋白质，抗体和疫苗在治疗中的用途，病毒，蛋白质，抗体和疫苗在治疗由病毒引起的疾病中的用途以及用于治疗由病毒引起的疾病的治疗方法。

2. 发明申请

US20110033418A1 TREATMENT OF DISEASES CAUSED BY VIRAL INFECTION 审中-公开
标题翻译：治疗由病毒感染引起的疾病
公开(公告)号：US20110033418A1
公开(公告)日：2011-02-10
申请号：US12817247
申请日：2010-06-17
申请人： Bo Niklasson
发明人： Bo Niklasson
IPC分类号： A61K38/21 , A61K39/42 , A61K31/7056 , A61P25/00 , A61P7/06 , A61P3/10
CPC分类号： A61K38/21 , A61K39/42 , C07K16/1009 , A61K2300/00
摘要： A method of prophylactic and/or therapeutic treatment of a mammal is provided for treating a disease that is caused by a Ljungan virus infection. The method comprises administration to the mammal of an antivirally effective amount of ribavirin or a derivative thereof effective against the Ljungan virus and pleconaril or a derivative thereof effective against the Ljungan virus to eliminate or inhibit proliferation of said virus in said mammal and at the same time prevent and/or treat said disease in said mammal. Also provided is a composition comprising ribavirin or a derivative thereof effective against a Ljungan virus and pleconaril or a derivative thereof effective against a Ljungan virus and a kit relating to this composition. Further, a method is provided for treating Ljungan virus infection comprising administering ribavirin or a derivative thereof effective against the Ljungan virus as well as a composition and a kit comprising ribavirin.
摘要翻译：提供了哺乳动物的预防和/或治疗性治疗方法，用于治疗由Ljungan病毒感染引起的疾病。该方法包括给予哺乳动物有效抵抗Ljungan病毒的Ljungan病毒和pleconaril或其衍生物对抗病毒有效量的利巴韦林或其衍生物，以有效抵抗Ljungan病毒以消除或抑制所述哺乳动物中所述病毒的增殖，同时预防和/或治疗所述哺乳动物的所述疾病。还提供了包含有效抵抗Ljungan病毒的Ljungan病毒和pleconaril或其衍生物的利巴韦林或其衍生物的组合物，以及与该组合物有关的试剂盒。此外，提供了治疗Ljungan病毒感染的方法，包括对Ljungan病毒施用有效的利巴韦林或其衍生物，以及包含利巴韦林的组合物和试剂盒。

3. 发明申请

US20050043648A1 Epicutaneous test plaster 有权
标题翻译：皮肤试验膏药
公开(公告)号：US20050043648A1
公开(公告)日：2005-02-24
申请号：US10501555
申请日：2003-01-16
申请人： Bo Niklasson
发明人： Bo Niklasson
IPC分类号： A61B5/103 , A61B10/00 , A61B5/00
CPC分类号： A61B5/441 , A61B5/411 , A61B10/0035
摘要： An epicutaneous test plaster, which is intended for removable adhesion to a skin portion of a person subjected to testing, has a flexible carrier (10) with a medical adhesive layer (12) and a number of test chambers (31). The test chambers contain a filter element (17) for absorption of allergen and are oriented with their opening directed away from the flexible carrier (10). A removable cover layer (27, 32) extends over all the test chambers and the carrier (10) and is removably secured to them by means of the adhesive layer (12) of the carrier. According to the invention, the test chambers (31) are formed as separate chambers, which are each separately fixed to the carrier and which are made up of a number of different sub-layers (13, 17, 19, 20, 24, 26).
摘要翻译：用于可拆卸地粘附到经受测试的人的皮肤部分的表皮试验膏具有带有医用粘合剂层（12）和多个测试室（31）的柔性载体（10）。测试室包含用于吸收变应原的过滤元件（17），并且其开口指向远离柔性载体（10）。可移除的覆盖层（27,32）在所有测试室和载体（10）上延伸，并且通过载体的粘合剂层（12）可移除地固定到它们。根据本发明，测试室（31）形成为分离的室，它们分别固定到载体上，并且由多个不同的子层（13,17,19,20,24,26 ）。

4. 发明申请

US20130043282A1 SYRINGE DISPENSER, STAND AND APPLICATION PLATE FOR SAID SYRINGE DISPENSER AND METHOD FOR ITS USE 有权
标题翻译：注射器分配器，用于标准分配器的支架和应用板及其使用方法
公开(公告)号：US20130043282A1
公开(公告)日：2013-02-21
申请号：US13639988
申请日：2011-04-19
申请人： Bo Niklasson
发明人： Bo Niklasson
IPC分类号： G01F11/00
CPC分类号： A61M5/31586 , A61M5/007 , A61M5/008 , A61M5/3137 , A61M2005/3139
摘要： A syringe dispenser may include a plunger having an outer threading, a barrel adapted to contain liquid or semisolid fluid or any other material to be dispensed and to receive the plunger, the plunger being movably attached to the barrel, and a nut having an inner threading. The nut may at least partly enclose the plunger and the barrel, such that the inner threading of the nut engages with the outer threading of the plunger. A stand, an application plate, and a method of dispensing a controlled and measurable amount of liquid or semisolid fluid from a syringe dispenser are also disclosed.
摘要翻译：注射器分配器可以包括具有外螺纹的柱塞，适于容纳液体或半固体流体或任何其它待分配材料并且接收柱塞的柱塞，柱塞可移动地附接到筒体，以及具有内螺纹的螺母。螺母可以至少部分地包围柱塞和筒体，使得螺母的内螺纹与柱塞的外螺纹啮合。还公开了一种支架，应用板以及从注射器分配器分配受控和可测量的液体或半固体流体的方法。

5. 发明申请

US20120027776A1 DIABETIC MODEL 审中-公开
标题翻译：糖尿病模型
公开(公告)号：US20120027776A1
公开(公告)日：2012-02-02
申请号：US12475704
申请日：2009-06-01
申请人： Bo Niklasson , Ake Lernmark
发明人： Bo Niklasson , Ake Lernmark
IPC分类号： A61K39/42 , C07K2/00 , A61P3/10 , A61K39/125 , A61K38/02 , A61P31/14 , C07H21/04 , C07K16/10
CPC分类号： A01K67/027 , G01N33/564 , G01N33/56983 , G01N2333/085 , G01N2333/46 , G01N2800/042
摘要： An isolated nucleic acid molecule is disclosed, including a nucleotide sequence selected from the nucleotide sequence of (a) Ljungan virus 87-012, (b) Ljungan virus 145SL, (c) Ljungan virus 174F, and (d) a fragment of nucleotide sequences (a)-(c). Also disclosed are polypeptides encoded by the isolated nucleic acid, which are useful in preparing vaccines and antibodies to prevent or inhibit conditions caused by Ljungan virus, including diabetes.
摘要翻译：公开了分离的核酸分子，其包括选自（a）Ljungan病毒87-012，（b）Ljungan病毒145SL，（c）Ljungan病毒174F的核苷酸序列的核苷酸序列，和（d）核苷酸序列的片段（a） - （c）。还公开了由分离的核酸编码的多肽，其可用于制备疫苗和抗体以预防或抑制由Ljungan病毒（包括糖尿病）引起的病症。

6. 发明授权

US07442380B2 Treatment of diseases caused by viral infection 有权
标题翻译：治疗由病毒感染引起的疾病
公开(公告)号：US07442380B2
公开(公告)日：2008-10-28
申请号：US11209467
申请日：2005-08-22
申请人： Bo Niklasson
发明人： Bo Niklasson
IPC分类号： A61K39/42 , A61K39/00 , A61K39/125 , A61K31/33 , A61K39/118
CPC分类号： A61K38/21 , A61K31/4245 , C07K16/1009 , A61K2300/00
摘要： A method of prophylactic and/or therapeutic treatment of a mammal for a disease that is caused by a Ljungan virus infection, such as Myocarditis, Cardiomyopathia, Guillain Barré Syndrome, and Diabetes Mellitus, Multiple Sclerosis, Chronic Fatigue Syndrome, Myasthenia Gravis, Amyothrophic Lateral Sclerosis, Dermatomyositis, Polymyositis, Spontaneous Abortion, Intrauterine Death, Preeclampsia, Sudden Infant Death Syndrome, Bell's (facial) paralysis, Addison's disease, and Pernicious anemia, is described. An antiviral compound effective against a Ljungan virus, such as a compound effective against a picornavirus, e.g. Pleconaril or a derivative thereof, is used for the preparation of a medicament for the treatment of a disease in a mammal that is caused by a Ljungan virus infection, to eliminate or inhibit proliferation of the virus in the mammal and at the same time prevent and/or treat the disease in the mammal. A composition for treatment of a mammal for a disease caused by Ljungan virus infection including an antiviral compound, antiserum, and an interferon. A method of treatment of a mammal for a disease caused by a Ljungan virus infection.
摘要翻译：用于由Ljungan病毒感染引起的疾病的哺乳动物的预防和/或治疗方法，例如心肌炎，心肌病，格列尔巴利综合征和糖尿病，多发性硬化症，慢性疲劳综合征，重症肌无力肌营养不良描述了硬化症，皮肌炎，多发性肌炎，自发性流产，子宫内死亡，先兆子痫，突发性婴儿死亡综合征，贝尔（面部）麻痹，艾迪生病和恶性贫血。对Ljungan病毒有效的抗病毒化合物，例如对微小核糖核酸病毒有效的化合物。普朗菌素或其衍生物用于制备用于治疗由Ljungan病毒感染引起的哺乳动物疾病的药物，以消除或抑制哺乳动物中病毒的增殖，同时预防和 /或治疗哺乳动物的疾病。用于治疗由Ljungan病毒感染引起的疾病的哺乳动物的组合物，包括抗病毒化合物，抗血清和干扰素。一种治疗由Ljungan病毒感染引起的疾病的哺乳动物的方法。

7. 发明申请

US20050233311A1 Family of picornaviruses 审中-公开
标题翻译：小核糖核酸病毒家族
公开(公告)号：US20050233311A1
公开(公告)日：2005-10-20
申请号：US10512392
申请日：2003-04-23
申请人： Michael Lindberg , Susanne Johansson , Bo Niklasson
发明人： Michael Lindberg , Susanne Johansson , Bo Niklasson
IPC分类号： C07H21/04 , C07K14/085 , C07K16/10 , C12N7/00 , C12N15/41 , C12Q1/70
CPC分类号： C07K14/005 , A61K2039/505 , A61K2039/5252 , A61K2039/5254 , C07K16/1009 , C12N7/00 , C12N2770/32021 , C12N2770/32022
摘要： The present invention relates to a new family of viruses within the Picornavirus family. The present invention also relates to an isolated nucleic acid from said virus or fragments of said nucleic acid. The present invention also relates to an isolated protein of said virus or an immunogenic fragment thereof. The invention also relates to antibodies or antigen-binding fragments of such antibodies directed against said virus. The present invention also relates to diagnostic kits. The present invention also relates to a method of detecting the presence of said virus in a subject suspected of having a viral infection.
摘要翻译：本发明涉及微小RNA病毒家族内新病毒家族。本发明还涉及来自所述病毒的分离的核酸或所述核酸的片段。本发明还涉及所述病毒的分离蛋白或其免疫原性片段。本发明还涉及针对所述病毒的这种抗体的抗体或抗原结合片段。本发明还涉及诊断试剂盒。本发明还涉及检测疑似患有病毒感染的受试者中所述病毒存在的方法。

8. 发明授权

US08231879B2 Treatment of diseases caused by viral infection 失效
标题翻译：治疗由病毒感染引起的疾病
公开(公告)号：US08231879B2
公开(公告)日：2012-07-31
申请号：US12143904
申请日：2008-06-23
申请人： Bo Niklasson
发明人： Bo Niklasson
IPC分类号： A61K39/42 , A61K39/00 , A61K39/125 , A61K31/33
CPC分类号： A61K38/21 , A61K31/4245 , C07K16/1009 , A61K2300/00
摘要： A method of prophylactic and/or therapeutic treatment of a mammal for a disease that is caused by a Ljungan virus infection, such as Myocarditis, Cardiomyopathia, Guillain Barre Syndrome, and Diabetes Mellitus, Multiple Sclerosis, Chronic Fatigue Syndrome, Myasthenia Gravis, Amyotrophic Lateral Sclerosis, Dermatomyositis, Polymyositis, Spontaneous Abortion, Intrauterine Death, Preeclampsia, Sudden infant Death Syndrome, Bell's (facial) paralysis, Addison's disease, and Pernicious anemia, is described. An antiviral compound effective against a Ljungan virus, such as a compound effective against a picornavirus, e.g. Pleconaril or a derivative thereof, is used for the preparation of a medicament for the treatment of a disease in a mammal that is caused by a Ljungan virus infection, to eliminate or inhibit proliferation of the virus in the mammal and at the same time prevent and/or treat the disease in the mammal. A composition for treatment of a mammal for a disease caused by Ljungan virus infection including an antiviral compound, antiserum, and an interferon. A method of treatment of a mammal for a disease caused by a Ljungan virus infection.
摘要翻译：用于由Ljungan病毒感染引起的哺乳动物的预防和/或治疗性治疗方法，例如心肌炎，心肌病，格兰巴利综合征和糖尿病，多发性硬化症，慢性疲劳综合征，重症肌无力肌营养不良描述了硬化症，皮肌炎，多发性肌炎，自发性流产，子宫内死亡，先兆子痫，突发性婴儿死亡综合征，贝尔（面部）麻痹，艾迪生病和恶性贫血。对Ljungan病毒有效的抗病毒化合物，例如对微小核糖核酸病毒有效的化合物。普朗菌素或其衍生物用于制备用于治疗由Ljungan病毒感染引起的哺乳动物疾病的药物，以消除或抑制哺乳动物中病毒的增殖，同时预防和 /或治疗哺乳动物的疾病。用于治疗由Ljungan病毒感染引起的疾病的哺乳动物的组合物，包括抗病毒化合物，抗血清和干扰素。一种治疗由Ljungan病毒感染引起的疾病的哺乳动物的方法。

9. 发明授权

US07855277B2 Picornaviruses, vaccines and diagnostic kits 失效
标题翻译：微小RNA病毒，疫苗和诊断试剂盒
公开(公告)号：US07855277B2
公开(公告)日：2010-12-21
申请号：US11477709
申请日：2006-06-29
申请人： Bo Niklasson
发明人： Bo Niklasson
IPC分类号： C07K16/10 , C12Q1/70
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2770/32022 , G01N33/56983 , G01N2333/085
摘要： A new group of picornaviruses is disclosed. The picornaviruses of the invention comprise in the non-coding region of their viral genome a nucleotide sequence which corresponds to cDNA sequence (I) or homologous sequences having at least 75% homology to the SEQ ID NO:1, and they cause mammalian disease. Further aspects of the invention comprise a protein corresponding to a protein of the picornaviruses, antiserum or antibody directed against a protein of the picornaviruses, antigen comprising a protein of the picornaviruses, diagnostic kits, vaccines, use of the picornaviruses in medicaments, particularly for the treatment or prevention of Myocarditis, Cardiomyopathia, Guillain Barré Syndrome, and Diabetes Mellitus, Multiple Sclerosis, Chronic Fatigue Syndrome, Myasthenia Gravis, Amyothrophic Lateral Sclerosis, Dermatomyositis, Polymyositis, Spontaneous Abortion, and Sudden Infant Death Syndrome, and methods of treatment of diseases caused by the picornaviruses. SEQ ID NO: 1 (Ljungan 87-012)(I) AGTCTAGTCT TATCTTGTAT GTGTCCTGCA CTGAACTTGT TTCTGTCTCT 50 GGAGTGCTCT ACACTTCAGT AGGGGCTGTA CCCGGGCGGT CCCACTCTTC 100 ACAGGAATCT GCACAGGTGG CTTTCACCTC TGGACAGTGC ATTCCACACC 150 CGCTCCACGG TAGAAGATGA TGTGTGTCTT TGCTTOTGAA AAGCTTGTGA 200 AAATCGTGTG TAGGCGTAGC GGCTACTTGA GTGCCAGCGO ATTACCCCTA 250 GTGGTAACAC TAGC
摘要翻译：披露了一组新的小核糖核酸病毒。本发明的微小核糖核酸病毒在其病毒基因组的非编码区域中包含对应于cDNA序列（I）或与SEQ ID NO：1具有至少75％同源性的同源序列的核苷酸序列，并且它们引起哺乳动物疾病。本发明的其它方面包括对应于针对微小核糖核酸病毒蛋白质的微小核糖核酸病毒，抗血清或抗体的蛋白质的蛋白质，包含小核糖核酸病毒蛋白质的抗原，诊断试剂盒，疫苗，药物中微小核糖核酸病毒的用途，特别是治疗或预防心肌炎，心肌病，格林巴利综合征和糖尿病，多发性硬化症，慢性疲劳综合征，重症肌无力，肌营养不良性侧索硬化症，皮肌炎，多发性肌炎，自发性流产和突发性婴儿死亡综合征，以及引起的疾病的治疗方法由小核糖核酸病毒。 SEQ ID NO：1（永安河87-012）（I）AGTCTAGTCT TATCTTGTAT GTGTCCTGCA CTGAACTTGT TTCTGTCTCT 50 GGAGTGCTCT ACACTTCAGT AGGGGCTGTA CCCGGGCGGT CCCACTCTTC 100 ACAGGAATCT GCACAGGTGG CTTTCACCTC TGGACAGTGC ATTCCACACC 150 CGCTCCACGG TAGAAGATGA TGTGTGTCTT TGCTTOTGAA AAGCTTGTGA 200 AAATCGTGTG TAGGCGTAGC GGCTACTTGA GTGCCAGCGO ATTACCCCTA 250 GTGGTAACAC TAGC

10. 发明申请

US20070003573A1 Picornaviruses, vaccines and diagnostic kits 审中-公开
公开(公告)号：US20070003573A1
公开(公告)日：2007-01-04
申请号：US11448321
申请日：2006-06-07
申请人： Bo Niklasson
发明人： Bo Niklasson
IPC分类号： A61K39/395 , A61K39/12
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2770/32022 , G01N33/56983 , G01N2333/085
摘要： (I) SEQ ID NO: 1 (Ljungan 87-012) AGTCTAGTCT TATCTTGTAT GTGTCCTGCA CTGAACTTGT TTCTGT CTCT 50 GGAGTGCTCT ACACTTCAGT AGGGGCTGTA CCCGGGCGGT CCCACT CTTC 100 ACAGGAATCT GCACAGGTGG CTTTCACCTC TGGACAGTGC ATTCCA CACC 150 CGCTCCACGG TAGAAGATGA TGTGTGTCTT TGCTTGTGAA AAGCTT GTGA 200 AAATCGTGTG TAGGCGTAGC GGCTACTTGA GTGCCAGCGG ATTACC CCTA 250 GTGGTAACAC TAGC A new group of picornaviruses is disclosed. The picornaviruses of the invention comprise in the non-coding region of their viral genome a nucleotide sequence which corresponds to cDNA sequence (1) or homologous sequences having at least 75% homology to the SEQ ID NO:1, and they cause mammalian disease. Further aspects of the invention comprise a protein corresponding to a protein of the picornaviruses, antiserum or antibody directed against a protein of the picornaviruses, antigen comprising a protein of the picornaviruses, diagnostic kits, vaccines, use of the picornaviruses in medicaments, particularly for the treatment or prevention of Myocarditis, Cardiomyopathia, Guillain Barré Syndrome, and Diabetes Mellitus, Multiple Sclerosis, Chronic Fatigue Syndrome, Myasthenia Gravis, Amyothrophic Lateral Sclerosis, Dermatomyositis, Polymyositis, Spontaneous Abortion, and Sudden Infant Death Syndrome, and methods of treatment of diseases caused by the picornaviruses.

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