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    • 1. 发明授权
    • Homodyne receiver minimizing oscillator leakage
    • 零接收器可最大限度地减少振荡器泄漏
    • US5530929A
    • 1996-06-25
    • US303183
    • 1994-09-08
    • Bjorn LindqvistMartin Isberg
    • Bjorn LindqvistMartin Isberg
    • H04B1/40H03D1/22H04B1/10H04B1/30H04B1/26
    • H03D1/2245H04B1/30
    • A method and a device in a homodyne receiver including a local oscillator generating an oscillator signal at a frequency of f.sub.LO, a mixer, and a reception device for receiving an input signal having a frequency of f.sub.RF, the oscillator signal and the input signal being supplied to the mixer. The oscillator signal is supplied to a first processing unit to produce a first output signal having a frequency of M*f.sub.LO, where M is an integer value. The first output signal is supplied to a second processing unit to produce a second output signal having a frequency of M*f.sub.LO /N=f.sub.LO, where N is an integer number and M.noteq.N, and the mixer and the second processing unit are integrated to minimize leakage of signals being supplied to the mixer from the second processing unit.
    • 一种在零差接收机中的方法和装置,包括以fLO频率产生振荡器信号的本地振荡器,混频器和用于接收具有fRF频率的输入信号的接收装置,提供振荡器信号和输入信号 到搅拌机。 振荡器信号被提供给第一处理单元以产生具有M * fLO频率的第一输出信号,其中M是整数值。 第一输出信号被提供给第二处理单元以产生频率为M * fLO / N = fLO的第二输出信号,其中N是整数和M NOTEQUAL N,并且混频器和第二处理单元被集成 以最小化从第二处理单元提供给混合器的信号的泄漏。
    • 2. 发明申请
    • Methods for peptide and protein display in nucleic acid arrays
    • 肽和蛋白质显示在核酸阵列中的方法
    • US20060003314A1
    • 2006-01-05
    • US10507434
    • 2003-03-13
    • Bjorn Lindqvist
    • Bjorn Lindqvist
    • C12Q1/70C12Q1/68C12N15/74
    • C40B40/02C07K1/047C12N15/1037
    • Virus displayed peptides or proteins can be integrated and presented in a nucleic acid array format. The present invention makes it possible to generate naked nucleic acidvirion protein display complexes in which the individual nucleic acid template is freely and covalently linked to the very same virion proteins it coded for. This cis-capture of the virion proteins by its naked nucleic acid template makes it possible to use phage display libraries in combinatorial display array formats. This can be achieved by allowing the naked nucleic acid-virion protein display complexes to be deposited by nucleic acid hybridisation to their corresponding mRNA or cDNA which separately have been prepared and used for the fabrication of a nucleic acid array. The hybridisation step will therefore function as a ‘search engine’ and a ‘delivery robot’ by automatically positioning the protein to its own gene. The nucleic acid coded protein or peptide display arrays described here can be used in functional genomics, protenomics and in protein or peptide identfication of relevance for the exploration of therapeutic drugs as well as for search of new diagnostic procedures.
    • 病毒展示的肽或蛋白质可以整合并以核酸阵列形式存在。 本发明使得可以产生裸核酸丝氨酸蛋白显示复合物,其中各个核酸模板可自由并共价连接到与其编码的非常相同的病毒粒子蛋白。 通过其裸核酸模板对病毒粒子蛋白的顺式捕获使得可以以组合显示阵列格式使用噬菌体展示文库。 这可以通过使裸核酸 - 病毒粒子蛋白质显示复合物通过核酸杂交沉积到分别制备并用于制备核酸阵列的相应mRNA或cDNA来实现。 因此,杂交步骤将通过将蛋白质自动定位到其自身基因而起“搜索引擎”和“递送机器人”的作用。 本文描述的核酸编码的蛋白质或肽显示阵列可用于功能基因组学,蛋白质组学以及与治疗药物的探索相关的蛋白质或肽鉴定以及用于寻找新的诊断程序。