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1. 发明授权

US10017470B2 Treatment for lipodystrophy 有权
公开(公告)号：US10017470B2
公开(公告)日：2018-07-10
申请号：US13978791
申请日：2012-01-30
申请人： Dhiraj Gambhire , Rajendrakumar Hariprasad Jani , Bipin Pandey , Kaushik Sata , Himanshu Kothari , Pankaj Ramanbhai Patel
发明人： Dhiraj Gambhire , Rajendrakumar Hariprasad Jani , Bipin Pandey , Kaushik Sata , Himanshu Kothari , Pankaj Ramanbhai Patel
IPC分类号： C07D207/33 , A61K31/40 , C07D207/333 , A61K45/06 , A61K9/20
摘要： The present invention provides a therapeutic compound of formula (I) and their pharmaceutically acceptable salts for the prevention and treatment of lipodystrophy caused because of HIV infection or combination therapy of HIV-1 protease inhibitors (Pis) and/or reverse transcriptase inhibitors (nRTIs) by neutralizing lipohypertrophy, lipoatrophy and metabolic abnormalities in HIV patient.

2. 发明申请

US20140051856A1 NOVEL SALTS OF DPP-IV INHIBITOR 有权
标题翻译： DPP-IV抑制剂的新口服
公开(公告)号：US20140051856A1
公开(公告)日：2014-02-20
申请号：US14002541
申请日：2012-03-02
申请人： Bipin Pandey , Mayank Ghanshyambhai Dave , Himanshu M. Kothari , Bhavin Shriprasad Shukla
发明人： Bipin Pandey , Mayank Ghanshyambhai Dave , Himanshu M. Kothari , Bhavin Shriprasad Shukla
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention discloses new salts of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine i.e. gentisate, adipate and trifluoro acetic acid salts. The invention also describes the new. crystalline and amorphous forms of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine gentisate. The present invention also discloses novel crystalline salt form of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine hydrochloride and novel crystalline and amorphous salt forms of besylate and process for their preparation and isolation.
摘要翻译：本发明公开了（2R）-4-氧代-4- [3-（三氟甲基）-5,6-二氢[1,2,4] - 三唑并[4,3-a]吡嗪-7（8H ） - 基] -1-（2,4,5-三氟苯基）丁-2-胺，即龙胆酸，己二酸酯和三氟乙酸盐。本发明还描述了新的。（2R）-4-氧代-4- [3-（三氟甲基）-5,6-二氢[1,2,4] - 三唑并[4,3-a]吡嗪-7（8H） - 的结晶和无定形形式吡啶-2-基] -1-（2,4,5-三氟苯基）丁-2-胺龙胆酸盐。本发明还公开了（2R）-4-氧代-4- [3-（三氟甲基）-5,6-二氢[1,2,4]三唑并[4,3-a] 7（8H） - 基] -1-（2,4,5-三氟苯基）丁-2-胺盐酸盐和新型的结晶和无定形盐形式的苯磺酸盐及其制备和分离方法。

3. 发明授权

US08445685B2 Process to prepare pioglitazone via several novel intermediates 有权
公开(公告)号：US08445685B2
公开(公告)日：2013-05-21
申请号：US13305295
申请日：2011-11-28
申请人： Bipin Pandey , Vidya Bhushan Lohray , Braj Bhushan Lohray
发明人： Bipin Pandey , Vidya Bhushan Lohray , Braj Bhushan Lohray
IPC分类号： C07D417/12
CPC分类号： C07D213/30 , C07D213/34 , C07D417/12
摘要： A novel process for preparing thiazolidinediones, preferably Pioglitazone, as described. Also described are novel intermediates involved in its synthesis and process for their preparation and use in medicine.

4. 发明授权

US08173816B2 Process to prepare pioglitazone via several novel intermediates 有权
标题翻译：通过几种新型中间体制备吡格列酮的方法
公开(公告)号：US08173816B2
公开(公告)日：2012-05-08
申请号：US12896844
申请日：2010-10-02
申请人： Bipin Pandey , Vidya Bhushan Lohray , Braj Bhushan Lohray
发明人： Bipin Pandey , Vidya Bhushan Lohray , Braj Bhushan Lohray
IPC分类号： C07D417/12
CPC分类号： C07D213/30 , C07D213/34 , C07D417/12
摘要： A novel process for preparing thiazolidinediones, preferably Pioglitazone, as described. Also described are novel intermediates involved in its synthesis and process for their preparation and use in medicine.
摘要翻译：如所述制备噻唑烷二酮类，优选吡格列酮的新方法。还描述了涉及其合成的新型中间体及其在医药中的制备和应用的方法。

5. 发明申请

US20090221827A1 PROCESSES FOR THE PREPARATION OF DIFFERENT FORMS OF (S)-(+)-CLOPIDOGREL BESYLATE 失效
标题翻译：制备不同形式的（S） - （+） - 氯化碳酸酯的方法
公开(公告)号：US20090221827A1
公开(公告)日：2009-09-03
申请号：US12065386
申请日：2006-08-28
申请人： Braj Bhushan Lohray , Vidya Bhushan Lohray , Bipin Pandey , Mayank Ghanshyambhai Dave , Parind Narendra Dholakia
发明人： Braj Bhushan Lohray , Vidya Bhushan Lohray , Bipin Pandey , Mayank Ghanshyambhai Dave , Parind Narendra Dholakia
IPC分类号： C07D498/04
CPC分类号： C07D495/04
摘要： Disclosed herein are the improved processes for the preparation of different forms of (S)-(+)-Clopidogrel besylate, pharmaceutical compositions containing them and their use in medicine.
摘要翻译：本文公开了制备不同形式的（S） - （+） - 氯吡格雷苯磺酸盐的改进方法，含有它们的药物组合物及其在医学中的用途。

6. 发明授权

US07465801B2 Process to prepare pioglitazone via several novel intermediates 有权
标题翻译：通过几种新型中间体制备吡格列酮的方法
公开(公告)号：US07465801B2
公开(公告)日：2008-12-16
申请号：US10520166
申请日：2003-07-15
申请人： Bipin Pandey , Vidya Bhushan Lohray , Braj Bhushan Lohray
发明人： Bipin Pandey , Vidya Bhushan Lohray , Braj Bhushan Lohray
IPC分类号： C07D417/12
CPC分类号： C07D213/30 , C07D213/34 , C07D417/12
摘要： A novel process for preparing thiazolidinediones, preferably Pioglitazone, as described. Also described are novel intermediates involved in its synthesis and process for their preparation and use in medicine.
摘要翻译：如所述制备噻唑烷二酮类，优选吡格列酮的新方法。还描述了涉及其合成的新型中间体及其在医药中的制备和应用的方法。

7. 发明申请

US20080300282A1 Novel process to prepare pioglitazone via several novel intermediates 有权
标题翻译：通过几种新型中间体制备吡格列酮的新方法
公开(公告)号：US20080300282A1
公开(公告)日：2008-12-04
申请号：US12010473
申请日：2008-01-25
申请人： Bipin Pandey , Vidya Bhushan Lohray , Braj Bhushan Lohray
发明人： Bipin Pandey , Vidya Bhushan Lohray , Braj Bhushan Lohray
IPC分类号： A61K31/4439 , C07D417/12 , A61P3/04 , A61P3/10
CPC分类号： C07D213/30 , C07D213/34 , C07D417/12
摘要： A novel process for preparing thiazolidinediones, preferably Pioglitazone, as described. Also described are novel intermediates involved in its synthesis and process for their preparation and use in medicine.
摘要翻译：如所述制备噻唑烷二酮类，优选吡格列酮的新方法。还描述了涉及其合成的新型中间体及其在医药中的制备和应用的方法。

8. 发明申请

US20080004446A1 Novel process to prepare pioglitazone via several novel intermediates 有权
标题翻译：通过几种新型中间体制备吡格列酮的新方法
公开(公告)号：US20080004446A1
公开(公告)日：2008-01-03
申请号：US11896911
申请日：2007-09-06
申请人： Bipin Pandey , Vidya Lohray , Braj Lohray
发明人： Bipin Pandey , Vidya Lohray , Braj Lohray
IPC分类号： C07D417/12
CPC分类号： C07D213/30 , C07D213/34 , C07D417/12
摘要： A process for preparing thiazolidinediones, preferably pioglitazone, is described. Also described are intermediates involved in synthesizing thiazolidinediones, and processes for preparation and use in medicine.
摘要翻译：描述了制备噻唑烷二酮类，优选吡格列酮的方法。还描述了涉及合成噻唑烷二酮类的中间体，以及药物制备和应用的方法。

9. 发明申请

US20060167061A1 Novel process to prepare pioglitazone via several novel intermediates 有权
标题翻译：通过几种新型中间体制备吡格列酮的新方法
公开(公告)号：US20060167061A1
公开(公告)日：2006-07-27
申请号：US10520166
申请日：2003-07-15
申请人： Bipin Pandey , Vidya Lohray , Braj Lohray
发明人： Bipin Pandey , Vidya Lohray , Braj Lohray
IPC分类号： A61K31/4439 , C07D417/02
CPC分类号： C07D213/30 , C07D213/34 , C07D417/12
摘要： A novel process for preparing thiazolidinediones, preferably Pioglitazone, as described. Also described are novel intermediates involved in its synthesis and process for their preparation and use in medicine.
摘要翻译：如所述制备噻唑烷二酮类，优选吡格列酮的新方法。还描述了涉及其合成的新型中间体及其在医药中的制备和应用的方法。

10. 发明授权

US06635763B2 Process to prepare clopidogrel 有权
公开(公告)号：US06635763B2
公开(公告)日：2003-10-21
申请号：US10054101
申请日：2001-10-22
申请人： Bipin Pandey , Vidya Bhushan Lohray , Braj Bhushan Lohray
发明人： Bipin Pandey , Vidya Bhushan Lohray , Braj Bhushan Lohray
IPC分类号： C07D4704
CPC分类号： C07D495/04
摘要： The present invention relates to a process for the preparation of thieno[3,2-c]pyridine derivatives having pharmacologically significant anti-aggregating and anti-thrombotic properties.

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