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1. 发明申请

US20220151930A1 WOUND SEALING POWDER 有权
公开(公告)号：US20220151930A1
公开(公告)日：2022-05-19
申请号：US17566255
申请日：2021-12-30
申请人： Biolife, L.L.C.
发明人： Kurt Vadelund , Talmadge Kelly Keene , Mark Travi
IPC分类号： A61K9/14 , A61P7/04 , A61P17/02 , A61B17/12 , A61K9/00
摘要： A wound sealing powder, method of making a wound sealing powder, and method of using a wound sealing powder to reduce blood flow from a wound are provided. Specifically, the wound sealing powder utilizes a particulate powder material of an effective amount of an insoluble cation exchange material wherein the majority of the particles in the powder have particle sizes of less than approximately 48 microns.

2. 发明授权

US09877728B2 Hemostatic device and method 有权
公开(公告)号：US09877728B2
公开(公告)日：2018-01-30
申请号：US15447712
申请日：2017-03-02
申请人： Biolife, L.L.C.
发明人： John Hen , Talmadge Kelly Keene , Mark Travi
IPC分类号： A61F13/40 , A61B17/12 , A61L24/06 , A61L24/02 , A61B17/00 , A61M25/02
CPC分类号： A61B17/12159 , A61B17/0057 , A61B17/12163 , A61B2017/00004 , A61B2017/12004 , A61B2017/12054 , A61F13/00 , A61F13/36 , A61F2013/00412 , A61F2013/00472 , A61L15/18 , A61L15/60 , A61L24/0015 , A61L24/02 , A61L24/06 , A61L2300/102 , A61L2300/418 , A61L2400/04 , A61M25/02 , A61M35/00 , A61M35/003 , A61M35/006 , C08L25/18
摘要： A hemostatic tablet preferably including potassium ferrate and a cation ion exchange resin pressure formed into a tablet for delivery to a bleeding wound. The tablet improves the rate of adhesion to a bleeding wound surface, and allows a significantly greater and more uniform pressure to be exerted by manual compression of the tablet on the wound site, as compared to that of a thin layer of scattered hemostatic powder. After the seal is formed from the interaction of blood or exudates with the immediate contacting surface of the tablet, the bulk of the unused tablet easily delaminates from the seal making clean up facile. If the unused portion of the tablet is not removed from the wound site, a reservoir of hemostatic dressing stops further bleeding and to provide antimicrobial protection and healing. The tablet may be applied to any surface orientation and take any shape and thickness possible.

3. 发明授权

US08961479B2 Hemostatic device and method 有权
公开(公告)号：US08961479B2
公开(公告)日：2015-02-24
申请号：US13847057
申请日：2013-03-19
申请人： Biolife, L.L.C.
发明人： John Hen , Talmadge Kelly Keene , Mark Travi
IPC分类号： A61M35/00 , A61D1/00 , A61L15/18 , A61F13/36 , A61F13/00 , A61B17/00
CPC分类号： A61B17/12159 , A61B17/0057 , A61B17/12163 , A61B2017/00004 , A61B2017/12004 , A61B2017/12054 , A61F13/00 , A61F13/36 , A61F2013/00412 , A61F2013/00472 , A61L15/18 , A61L15/60 , A61L24/0015 , A61L24/02 , A61L24/06 , A61L2300/102 , A61L2300/418 , A61L2400/04 , A61M25/02 , A61M35/00 , A61M35/003 , A61M35/006 , C08L25/18
摘要： A hemostatic tablet preferably including potassium ferrate and a cation ion exchange resin pressure formed into a tablet for delivery to a bleeding wound. The tablet improves the rate of adhesion to a bleeding wound surface, and allows a significantly greater and more uniform pressure to be exerted by manual compression of the tablet on the wound site, as compared to that of a thin layer of scattered hemostatic powder. After the seal is formed from the interaction of blood or exudates with the immediate contacting surface of the tablet, the bulk of the unused tablet easily delaminates from the seal making clean up facile. If the unused portion of the tablet is not removed from the wound site, a reservoir of hemostatic dressing stops further bleeding and to provide antimicrobial protection and healing. The tablet may be applied to any surface orientation and take any shape and thickness possible.

4. 发明公开

US20230363767A1 COMPRESSION FORCE INDICATOR FOR ACHIEVING HEMOSTASIS 审中-公开
公开(公告)号：US20230363767A1
公开(公告)日：2023-11-16
申请号：US18078551
申请日：2022-12-09
申请人： Biolife, L.L.C.
发明人： Talmadge Kelly Keene , Kurt Vadelund
IPC分类号： A61B17/135
CPC分类号： A61B17/135 , A61B2017/12004
摘要： This present device is a compression force indicating device for use during hemostasis. The device may be held in contact or close contact with the skin with the hand, by a circumferential band, a clamp or other mechanism and provides compression force data feedback to the clinician.

5. 发明申请

US20180193011A1 Adaptive Devices and Methods for Endoscopic Wound Closures 审中-公开
公开(公告)号：US20180193011A1
公开(公告)日：2018-07-12
申请号：US15914282
申请日：2018-03-07
申请人： Biolife, L.L.C.
发明人： Talmadge Kelly Keene , John Tifton Fordham , Louis M. Guzzi , Charles E. Entenmann
IPC分类号： A61B17/00 , A61B10/04 , A61B90/00 , A61B90/30 , A61B17/22 , A61B17/04
CPC分类号： A61B17/00491 , A61B10/04 , A61B17/0057 , A61B90/361 , A61B2017/00296 , A61B2017/003 , A61B2017/00522 , A61B2017/00544 , A61B2017/00579 , A61B2017/00623 , A61B2017/0065 , A61B2017/00659 , A61B2017/00668 , A61B2017/00676 , A61B2017/00685 , A61B2017/00876 , A61B2017/0417 , A61B2017/22067 , A61B2090/306
摘要： This invention is directed to devices and methods for improving wound closures produced during endoscopic surgery. These methods are directed to delivering and applying a quantity of hemostatic agents in either powder, solid, liquid, or gel form onto an open wound produced e.g., by polyp removal, followed by the application of pressure. The method is implemented preferably using existing endoscopic equipment; however, modifications to existing endoscopic insertion tubes, application and tamping devices and endoscopic clips deployed from the distal end of the insertion tube during endoscopic surgery are also within the scope of this invention.

6. 发明授权

US09757412B2 Ferrate and povidone iodine (PI) composition 有权
公开(公告)号：US09757412B2
公开(公告)日：2017-09-12
申请号：US14446682
申请日：2014-07-30
申请人： Biolife, L.L.C.
发明人： Talmadge Kelley Keene , John Hen
IPC分类号： A61K31/79 , A61K33/26 , A61K47/00 , A61K9/00 , A61K9/14 , A61K33/24
CPC分类号： A61K31/79 , A61K9/0014 , A61K9/14 , A61K33/24 , A61K33/26 , A61K47/00
摘要： A composition and method useful in promoting hemostasis, absorbing ooze, and being antimicrobial with respect to an open wound. The composition broadly includes an antimicrobial agent, preferably povidone iodine, preferably a ferrate compound, and a cation ion exchange resin. This composition will destroy a biofilm which has formed over the open wound in providing a soluble iron compound, a cation chelation compound, and an active antimicrobial compound effective against planktonic microorganisms and biofilms. The antimicrobial agent is locked or sealed within the scab formed over the wound to maintain long-term positioning and anti-dilution of the antimicrobial over the wound.

7. 发明申请

US20140341837A1 Ferrate and Povidone Iodine (PI) Composition 有权
标题翻译：铁酸盐和聚维酮碘（PI）组合物
公开(公告)号：US20140341837A1
公开(公告)日：2014-11-20
申请号：US14446682
申请日：2014-07-30
申请人： Biolife, L.L.C.
发明人： Talmadge Kelley Keene , John Hen
IPC分类号： A61K31/79
CPC分类号： A61K31/79 , A61K9/0014 , A61K9/14 , A61K33/24 , A61K33/26 , A61K47/00
摘要： A composition and method useful in promoting hemostasis, absorbing ooze, and being antimicrobial with respect to an open wound. The composition broadly includes an antimicrobial agent, preferably povidone iodine, preferably a ferrate compound, and a cation ion exchange resin. This composition will destroy a biofilm which has formed over the open wound in providing a soluble iron compound, a cation chelation compound, and an active antimicrobial compound effective against planktonic microorganisms and biofilms. The antimicrobial agent is locked or sealed within the scab formed over the wound to maintain long-term positioning and anti-dilution of the antimicrobial over the wound.
摘要翻译：用于促进止血，吸收渗透和对开放伤口进行抗菌的组合物和方法。组合物广泛地包括抗微生物剂，优选聚维酮碘，优选高铁酸盐化合物和阳离子交换树脂。该组合物将破坏在开放伤口上形成的生物膜，以提供可溶性铁化合物，阳离子螯合化合物和对浮游微生物和生物膜有效的活性抗微生物化合物。将抗微生物剂锁定或密封在伤口上形成的痂内，以保持抗菌剂在伤口上的长期定位和抗稀释。

8. 发明授权

US11554137B2 Composition and method for arresting blood flow and for forming a persistent microbial barrier 有权
公开(公告)号：US11554137B2
公开(公告)日：2023-01-17
申请号：US14147143
申请日：2014-01-03
申请人： Biolife, L.L.C.
发明人： John Hen , John Alfred Thompson , Talmadge Kelly Keene , Mark Travi
IPC分类号： A61K31/795 , B01J39/20 , B01J39/05
摘要： A composition and method useful in promoting healing of a bleeding wound site. The composition preferably includes a substantially anhydrous acid form of a cation exchange resin, which when applied over blood, provides an antimicrobial against planktonic microorganisms and biofilms in the wound. The resin is also capable, when applied in sufficient quantities, of providing a continuing and persistent antimicrobial against planktonic microorganisms and biofilms through dehydration and ion exchange with cations present in the blood and other body fluids. When the resin has a concentration of at least 26 mg/ml, it provides a >3 log reduction in biological activity of MRSA, MRSE and Pseudomonas aeruginosa.

9. 发明申请

US20220330949A1 COMPRESSION BALLOON WITH A RIGID FOOT FOR HEMOSTASIS 有权
公开(公告)号：US20220330949A1
公开(公告)日：2022-10-20
申请号：US17724318
申请日：2022-04-19
申请人： Biolife, L.L.C.
发明人： Talmadge Kelly Keene
IPC分类号： A61B17/135 , A61B17/132
摘要： This device is a combination of an expandable or inflatable bladder or balloon in conjunction with a rigid or semi-rigid skin contact surface or structure to reduce bleeding from a skin insertion wound site and a vascular wound site after a vascular intervention or surgical procedure is performed. The device may be held in contact or close contact with the skin by a circumferential band, a clamp or other mechanism and provides a more consistent and uniform surface area contact and compression force. The contact surface or foot provides a uniform surface area contact as compared to the ever-changing contact surface area from an inflatable bladder.

10. 发明申请

US20220313492A1 EXPANDABLE TAMPONADE 有权
公开(公告)号：US20220313492A1
公开(公告)日：2022-10-06
申请号：US17713902
申请日：2022-04-05
申请人： Biolife, L.L.C.
发明人： Talmadge Kelly Keene , John Tifton Fordham
IPC分类号： A61F13/00
摘要： A device designed to be packed into a wound that will expand to fill the voids of the wound to control bleeding is provided. The device is comprised of two or more individual pouches, linked together, and filled with an expandable material that will swell upon absorption of blood through the pouch walls.

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