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1. 发明授权

US06931754B2 Freeze-drying apparatus 失效
标题翻译：冷冻干燥装置
公开(公告)号：US06931754B2
公开(公告)日：2005-08-23
申请号：US10411006
申请日：2003-04-10
申请人： Bernd Sennhenn , Dietrich Gehrmann , Ariane Firus
发明人： Bernd Sennhenn , Dietrich Gehrmann , Ariane Firus
IPC分类号： F26B5/04 , A61L2/04 , F26B1/00 , F26B3/20 , F26B5/06 , F26B23/10 , F26B21/06
CPC分类号： F26B5/06
摘要： A drying unit for removing solvent from moist material, and a method for drying moist material with the drying unit. The unit comprises at least one drying chamber (23) having at least one stand plate (2) for holding vessels (3), which are filled with moist material, or flat layers of moist material, the drying chamber (23) being connected to a condenser (22) via a vapor passage (15), in which sublimed solvent can be separated out, the stand plates (2) being connected to a temperature-controlled heating/cooling circuit, the chamber (23) having heating/cooling plates (4) or (4′) which are connected to a second heat-transfer circuit, wherein the heating/cooling plates (4) or (4′) are substantially thermally isolated from the chamber wall (6).
摘要翻译：用于从潮湿材料中除去溶剂的干燥单元，以及用干燥单元干燥潮湿材料的方法。所述单元包括至少一个干燥室（23），所述干燥室具有至少一个用于保持容器（3）的支撑板（2），所述支架容器（3）被填充有潮湿材料或平坦的湿润材料层，所述干燥室（23）连接到经由蒸汽通道（15）的冷凝器（22），其中可以分离出升华溶剂，支架板（2）连接到温度控制的加热/冷却回路，所述腔室（23）具有加热/冷却板（4）或（4'），其连接到第二传热回路，其中所述加热/冷却板（4）或（4'）与所述室壁（6）基本上热隔离。

2. 发明授权

US06684524B1 Lyopohilization method 失效
标题翻译：除菌方法
公开(公告)号：US06684524B1
公开(公告)日：2004-02-03
申请号：US10048783
申请日：2002-02-01
申请人： Bernd Sennhenn , Martin Kramer
发明人： Bernd Sennhenn , Martin Kramer
IPC分类号： F26B506
CPC分类号： F26B5/06
摘要： The invention relates to a lyophilization method which comprises the following steps: reducing the pressure in the drying chamber until the onset of a visible crystallization of the solvent at a temperature in the drying chamber which is above the solidification point of the preparation; reducing the temperature in the drying chamber to a temperature which is below the solidification point of the preparation or is identical to it, until completion of the crystallization of the solvent, resulting in a frozen solvent; and sublimation of the frozen solvent by means of reduced pressure.
摘要翻译：本发明涉及一种冻干方法，包括以下步骤：降低干燥室中的压力，直至在干燥室中高于制剂固化点的温度下溶剂的可见结晶开始; 将干燥室中的温度降低到低于制剂固化点或与之相同的温度，直到溶剂结晶完成，导致冷冻溶剂; 并通过减压升华冷冻溶剂。

3. 发明授权

US06605255B2 Repinotan kit 失效
公开(公告)号：US06605255B2
公开(公告)日：2003-08-12
申请号：US09991222
申请日：2001-11-16
申请人： Werner Kroll , Ferdinand Rombout , Horst Weber , Maria-Luisa Rodriguez , Bernd Sennhenn , Rudolf Schohe-Loop
发明人： Werner Kroll , Ferdinand Rombout , Horst Weber , Maria-Luisa Rodriguez , Bernd Sennhenn , Rudolf Schohe-Loop
IPC分类号： G01N3352
CPC分类号： C07D417/12 , G01N33/94
摘要： The invention relates to a kit comprising a pharmaceutical composition containing repinotan or a physiologically acceptable salt of repinotan, and a means for the determination of the concentration of repinotan or its metabolites in body fluids, and also new pharmaceutical compositions containing repinotan or a physiologically acceptable salt of repinotan, and processes for their preparation.

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