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1. 发明授权

US3963440A Analysis system 失效
标题翻译：分析系统
公开(公告)号：US3963440A
公开(公告)日：1976-06-15
申请号：US483610
申请日：1974-06-27
申请人： Bernard Stein , Philip Spergel
发明人： Bernard Stein , Philip Spergel
IPC分类号： G01N33/49 , G01N27/38 , G01N27/416 , G01N33/483 , G01N33/487 , G01N35/00 , G01N27/00 , G01N31/00 , G01N33/16
CPC分类号： G01N35/00594 , G01N33/4925 , G01N2035/00435 , G01N35/00693
摘要： A blood analysis system comprises a tempering chamber in which a plurality of flow through measuring cells are disposed. A sensor electrode is associated with each cell. A sample flow path extends from an entrance port through a heater element, a first measuring cell, a control valve, a second measuring cell, a reference electrode interface, to a positive displacement pump. In standby condition, the entrance port is immersed in flush fluid and operation of the pump in such condition flows flush fluid through the entire sample path. Fluid access to either measuring cell is obtainable through the entrance port, auxiliary valve ports, or disconnectable conduits connected to the valve. The control valve is connected in the flow path between the two measuring cells, and in a first condition that control valve places the measuring cells in series fluid communication with the inlet port, and in a second condition isolates the measuring cells from one another so that the electrode systems associated with the two measuring cells may be calibrated concurrently and independently of one another.
摘要翻译：血液分析系统包括其中设置有多个流过测量单元的回火室。传感器电极与每个电池相关联。样品流路从入口通过加热元件，第一测量单元，控制阀，第二测量单元，参考电极接口延伸到正排量泵。在待机状态下，入口浸没在冲洗流体中，泵在这种状态下的运行通过整个采样路径冲洗流体。可以通过入口，辅助阀口或连接到阀门的可断开的导管获得流体到任一个测量池的通路。控制阀连接在两个测量单元之间的流路中，并且在控制阀将测量单元与入口串联流体连通的第一状态下，并且在第二状态下将测量单元彼此隔离使得与两个测量单元相关联的电极系统可以彼此同时且独立地校准。

2. 发明授权

US5937364A Automatic selection of statistical quality control procedures 失效
标题翻译：自动选择统计质量控制程序
公开(公告)号：US5937364A
公开(公告)日：1999-08-10
申请号：US643993
申请日：1996-05-07
申请人： James O. Westgard , Bernard Stein
发明人： James O. Westgard , Bernard Stein
IPC分类号： G06Q10/06 , G06Q20/20 , G01N21/25 , G06F15/18 , G06F17/50 , G06F19/00
CPC分类号： G06Q10/06 , G06Q10/06395 , G06Q20/202
摘要： Disclosed is a computer implemented method for automating the selection of an analytical statistical quality control (QC) procedure. Inputs of a quality requirement and observed performance characteristics of a method of measurement are initially provided, together with a database of theoretical operating characteristics of statistical QC procedures. An appropriate quality-planning algorithm (either analytical or clinical) which relates the quality requirement, the observed performance characteristics of the method of measurement, and the theoretical operating characteristics of statistical QC procedures is also provided. Using predetermined QC selection criteria and selection logic, a computer is programmed to automatically choosing, based on the quality requirement, observed method performance, and operating characteristic of candidate QC procedures, a subset of control rules and numbers of control measurements which satisfy selection criteria and selection logic. Also disclosed is a dynamic QC process for automatically changing the statistical QC procedure when there are changes in performance of a method of measurement. In this embodiment, real-time statistical estimates of the performance characteristics of a method are provided through on-line sampling with an analytical instrument and this data is used to automatically select a QC procedure.
摘要翻译：公开了一种用于使分析统计质量控制（QC）过程的选择自动化的计算机实现方法。最初提供质量要求的输入和测量方法的观察性能特征，以及统计QC程序的理论操作特性数据库。还提供了质量要求，观察到的测量方法的性能特征和统计QC程序的理论操作特性的适当的质量规划算法（分析或临床）。使用预定的QC选择标准和选择逻辑，计算机被编程为基于质量要求自动选择观察到的方法性能和候选QC过程的操作特性，控制规则的子集以及满足选择标准的控制测量数量，选择逻辑。还公开了当测量方法的性能发生变化时自动改变统计QC程序的动态QC过程。在本实施例中，通过使用分析仪器进行在线采样来提供方法的性能特征的实时统计估计，并且该数据用于自动选择QC过程。

3. 发明授权

US2528619A Electric lighter and dispenser for cigarettes 失效
标题翻译：电动打火机和香烟分配器
公开(公告)号：US2528619A
公开(公告)日：1950-11-07
申请号：US79100047
申请日：1947-12-11
申请人： BERNARD STEIN
发明人： BERNARD STEIN
IPC分类号： A24F15/10
CPC分类号： A24F15/10

4. 发明授权

US4373812A Cuvette assembly 失效
标题翻译：比色柜总成
公开(公告)号：US4373812A
公开(公告)日：1983-02-15
申请号：US247351
申请日：1981-03-25
申请人： Bernard Stein , Hamid Keramaty , Romas A. Brickus
发明人： Bernard Stein , Hamid Keramaty , Romas A. Brickus
IPC分类号： G01N21/07
CPC分类号： G01N21/07
摘要： An improved analytical cuvette assembly includes structure defining a first chamber region that has a loading port through which a first reaction component is introduced for storage, structure defining a second chamber region having a loading port through which a second reaction component is introduced for storage, and barrier structure between the first and second chamber regions that has a crest portion that defines the lower edge of a transfer passage between the two chamber regions. The second chamber region includes an analysis region where the reaction product resulting from mixture of the two reaction components is subjected to analysis. Each chamber region is defined by opposed planar side wall surfaces and a planar base wall surface, and capillary flow inhibiting structure extends from the crest of the barrier structure along the intersection between a planar surface portion of the barrier structure and the side wall surface and along at least a portion of the intersection of the side wall surfaces and the base surface.
摘要翻译：改进的分析反应杯组件包括限定第一室区域的结构，所述第一室区域具有装载端口，通过所述装载端口引入第一反应组分用于储存，结构限定具有加载端口的第二室区域，第二反应组分通过该装载端口被引入以供存储; 所述第一和第二室区域之间的阻挡结构具有限定两个室区域之间的传送通道的下边缘的波峰部分。第二室区域包括其中由两个反应组分的混合物产生的反应产物进行分析的分析区域。每个室区域由相对的平面侧壁表面和平面底壁表面限定，并且毛细管阻流结构沿着屏障结构的平坦表面部分和侧壁表面之间的交叉部分从阻挡结构的顶部延伸所述侧壁面与所述基面的交点的至少一部分。

5. 发明授权

US4314970A Analysis system 失效
标题翻译：分析系统
公开(公告)号：US4314970A
公开(公告)日：1982-02-09
申请号：US181814
申请日：1980-08-27
申请人： Bernard Stein , Richard A. Granoff
发明人： Bernard Stein , Richard A. Granoff
IPC分类号： B04B5/04 , G01N21/07 , G01N21/09
CPC分类号： G01N21/07 , B04B5/0407
摘要： A multicuvette rotor assembly for use in a clinical chemistry analyzer of the centrifugal type includes a body member that defines a circumferential array of spaced radially extending recesses, with a divider member in each recess to define a first chamber and a second chamber radial outward from said first chamber; and a ring member that has a mating reference surface seated on an annular reference surface of the body member, with the inner peripheral surface of the ring member located outwardly of the middle of the second chambers. A circumferential array of first optical windows is bonded to the ring member, the lower surface of each first optical window being parallel to the mating reference surface; and a circumferential array of second optical windows is bonded to the base of the body member in alignment with the first optical windows such that each pair of opposed aligned surfaces of corresponding first and second optical windows are parallel to one another and define an optical path of precise and stable path length. A cover member has sealing surfaces that mate with the edges of the recesses of the base member and the inner peripheral lip of the ring member to provide a continuous seal of the recesses to retain reagent and sample material to be analyzed within the recesses.
摘要翻译：用于离心式的临床化学分析仪的多单元转子组件包括限定周向阵列的间隔开的径向延伸的凹部的本体构件，在每个凹部中具有分隔构件，以限定第一腔室和从所述第二腔室向外径向的第二腔室第一室以及环构件，其具有安置在主体构件的环形基准表面上的配合基准表面，环构件的内周表面位于第二室的中间的外侧。第一光学窗口的圆周阵列结合到环形构件，每个第一光学窗口的下表面平行于配合参考表面; 并且第二光学窗口的圆周阵列与第一光学窗口对准地接合到主体构件的基部，使得对应的第一和第二光学窗口的每对相对的对准表面彼此平行并且限定光路的光路精确稳定的路径长度。盖构件具有与基部构件的凹部的边缘和环构件的内周边缘配合的密封表面，以提供凹部的连续密封，以保持待在凹槽内分析的试剂和样品材料。

6. 发明授权

US3949615A Analysis apparatus 失效
标题翻译：分析仪
公开(公告)号：US3949615A
公开(公告)日：1976-04-13
申请号：US469080
申请日：1974-05-13
申请人： Bernard Stein , Gustav H. Dreier
发明人： Bernard Stein , Gustav H. Dreier
IPC分类号： G01N33/48 , B08B9/032 , G01N35/10 , G01N1/14
CPC分类号： G01N35/1004
摘要： A flush system for electrochemical analysis apparatus comprising a reservoir of flush solution, a flush chamber connected thereto and open at the top, and a sample entrance (probe) arranged for movement between an immersed position in the flush chamber and a sampling position removed from the flush chamber.
摘要翻译：一种用于电化学分析装置的冲洗系统，包括：冲洗溶液储存器，与其连接并在顶部开口的冲洗室;以及样品入口（探针），布置成用于在冲洗室中的浸入位置与从该冲洗腔中取出的取样位置之间移动冲洗室。

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