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1. 发明授权

US06593295B2 Long lasting insulinotropic peptides 失效
标题翻译：持久的促胰岛素肽
公开(公告)号：US06593295B2
公开(公告)日：2003-07-15
申请号：US09876388
申请日：2001-06-06
申请人： Dominique P. Bridon , Benoit L'Archeveque , Alan M. Ezrin , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
发明人： Dominique P. Bridon , Benoit L'Archeveque , Alan M. Ezrin , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
IPC分类号： A01N3718
CPC分类号： C07K14/005 , A61K38/00 , C07K14/605 , C12N2740/16122
摘要： Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates may be formed in vivo or ex vivo. The modified peptides are administered to treat humans with diabetes and other related diseases.
摘要翻译：公开了改进的促胰岛素肽。修饰的促胰岛素肽能够形成肽酶稳定的促胰岛素肽。修饰的促胰岛素肽能够与一种或多种血液成分形成共价键以形成缀合物。缀合物可以在体内或离体形成。施用修饰的肽以治疗患有糖尿病和其他相关疾病的人。

2. 发明授权

US06514500B1 Long lasting synthetic glucagon like peptide {GLP-!} 失效
标题翻译：持久的合成胰高血糖素如肽{GLP-！}
公开(公告)号：US06514500B1
公开(公告)日：2003-02-04
申请号：US09657332
申请日：2000-09-07
申请人： Dominique P. Bridon , Benoit L'Archeveque , Alan M. Ezrin , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
发明人： Dominique P. Bridon , Benoit L'Archeveque , Alan M. Ezrin , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
IPC分类号： A61K39385
CPC分类号： C07K14/005 , A61K38/00 , A61K47/643 , C07K14/57563 , C07K14/605 , C12N2740/16122
摘要： Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates may be formed in vivo or ex vivo. The modified peptides are administered to treat humans with diabetes and other related diseases.
摘要翻译：公开了改进的促胰岛素肽。修饰的促胰岛素肽能够形成肽酶稳定的促胰岛素肽。修饰的促胰岛素肽能够与一种或多种血液成分形成共价键以形成缀合物。缀合物可以在体内或离体形成。施用修饰的肽以治疗患有糖尿病和其他相关疾病的人。

3. 发明授权

US08080516B2 Long lasting synthetic exendin-4 peptide conjugates 失效
标题翻译：持久的合成毒蜥外泌肽-4肽缀合物
公开(公告)号：US08080516B2
公开(公告)日：2011-12-20
申请号：US11170967
申请日：2005-06-29
申请人： Dominique P. Bridon , Benoit L'Archeveque , Darren L. Holmes , Anouk LeBlanc , Serge St. Pierre
发明人： Dominique P. Bridon , Benoit L'Archeveque , Darren L. Holmes , Anouk LeBlanc , Serge St. Pierre
IPC分类号： A61K38/22
CPC分类号： C07K14/005 , A61K38/00 , A61K47/643 , C07K14/57563 , C07K14/605 , C12N2740/16122
摘要： Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates may be formed in vivo or ex vivo. The modified peptides are administered to treat humans with diabetes and other related diseases.
摘要翻译：公开了改进的促胰岛素肽。修饰的促胰岛素肽能够形成肽酶稳定的促胰岛素肽。修饰的促胰岛素肽能够与一种或多种血液成分形成共价键以形成缀合物。缀合物可以在体内或离体形成。施用修饰的肽以治疗患有糖尿病和其他相关疾病的人。

4. 发明授权

US06329336B1 Long lasting insulinotropic peptides 失效
标题翻译：持久的促胰岛素肽
公开(公告)号：US06329336B1
公开(公告)日：2001-12-11
申请号：US09623618
申请日：2000-09-05
申请人： Dominique P. Bridon , Benoit L'Archeveque , Alan M. Ezrin , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
发明人： Dominique P. Bridon , Benoit L'Archeveque , Alan M. Ezrin , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
IPC分类号： A01N3718
CPC分类号： C07K14/005 , A61K38/00 , C07K14/605 , C12N2740/16122
摘要： Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates may be formed in vivo or ex vivo. The modified peptides are administered to treat humans with diabetes and other related diseases.
摘要翻译：公开了改进的促胰岛素肽。修饰的促胰岛素肽能够形成肽酶稳定的促胰岛素肽。修饰的促胰岛素肽能够与一种或多种血液成分形成共价键以形成缀合物。缀合物可以在体内或离体形成。施用修饰的肽以治疗患有糖尿病和其他相关疾病的人。

5. 发明申请

US20130346398A1 Method and System for Refining a Semantic Search on a Mobile Device 有权
标题翻译：在移动设备上精简语义搜索的方法和系统
公开(公告)号：US20130346398A1
公开(公告)日：2013-12-26
申请号：US13985120
申请日：2012-03-07
申请人： Benoit L'Archeveque , Mickael Camus , Denton Cockburn , Richard Pavy , Lise Rebout , Anthony Bryant
发明人： Benoit L'Archeveque , Mickael Camus , Denton Cockburn , Richard Pavy , Lise Rebout , Anthony Bryant
IPC分类号： G06F17/30
CPC分类号： G06F17/30941 , G06F17/30731
摘要： System and method are disclosed for refining a semantic search query through large quantities of dynamically created concept categories and their associated extracted values on a mobile device using only two filtering controls or buttons. The first filtering control is a Semantic Categorization Filter control and the second filtering control is a Semantic Categorization Selection control. The user queries a semantic search engine using text or voice controls. The results returned to the user imply the full scope of search results along with a dynamically created semantic categorization. The most relevant semantic categorization will be considered as the pre-selected category in the Semantic Categorization Filter control along with a list of possible dynamically created sub-categorizations and the Semantic Categorization Selection control will be pre-populated with other possible semantic categorizations of the result set.
摘要翻译：公开了系统和方法，用于通过使用仅两个过滤控制或按钮在移动设备上通过大量动态创建的概念类别及其相关联的提取值来精简语义搜索查询。第一个过滤控制是一个语义分类过滤器控件，第二个过滤控件是一个语义分类选择控件。用户使用文本或语音控件查询语义搜索引擎。返回给用户的结果意味着搜索结果的全部范围以及动态创建的语义分类。最相关的语义分类将被视为语义分类过滤器控件中的预先选择的类别以及可能的动态创建的子分类的列表，并且将使用结果的其他可能的语义分类预先填充语义分类选择控件组。

6. 发明申请

US20090075890A1 Long lasting synthetic exendin-4 peptide conjugates and methods of use thereof 审中-公开
标题翻译：持久的合成毒蜥外泌肽-4肽缀合物及其使用方法
公开(公告)号：US20090075890A1
公开(公告)日：2009-03-19
申请号：US12221553
申请日：2008-08-01
申请人： Dominique P. Bridon , Benoit L'Archeveque , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
发明人： Dominique P. Bridon , Benoit L'Archeveque , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
IPC分类号： A61K38/38 , C07K14/00 , C07K14/76 , A61P3/10 , A61P1/00 , A61K38/17
CPC分类号： C07K14/005 , A61K38/00 , A61K47/643 , C07K14/57563 , C07K14/605 , C12N2740/16122
摘要： Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates may be formed in vivo or ex vivo. The modified peptides are administered to treat humans with diabetes and other related diseases.
摘要翻译：公开了改进的促胰岛素肽。修饰的促胰岛素肽能够形成肽酶稳定的促胰岛素肽。修饰的促胰岛素肽能够与一种或多种血液成分形成共价键以形成缀合物。缀合物可以在体内或离体形成。施用修饰的肽以治疗患有糖尿病和其他相关疾病的人。

7. 发明申请

US20060058235A1 Long lasting synthetic glucagon like peptide (GLP-1) 失效
公开(公告)号：US20060058235A1
公开(公告)日：2006-03-16
申请号：US11215967
申请日：2005-08-30
申请人： Dominique Bridon , Benoit L'Archeveque , Alan Ezrin , Darren Holmes , Anouk Leblanc , Serge St. Pierre
发明人： Dominique Bridon , Benoit L'Archeveque , Alan Ezrin , Darren Holmes , Anouk Leblanc , Serge St. Pierre
IPC分类号： A61K38/22
CPC分类号： C07K14/005 , A61K38/00 , A61K47/643 , C07K14/57563 , C07K14/605 , C12N2740/16122
摘要： Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates may be formed in vivo or ex vivo. The modified peptides are administered to treat humans with diabetes and other related diseases.

8. 发明申请

US20090093408A1 Protection of exendin-4 peptides through conjugation 审中-公开
标题翻译：通过缀合保护毒蜥外泌肽-4肽
公开(公告)号：US20090093408A1
公开(公告)日：2009-04-09
申请号：US12221554
申请日：2008-08-01
申请人： Dominique P. Bridon , Benoit L'Archeveque , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
发明人： Dominique P. Bridon , Benoit L'Archeveque , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
IPC分类号： A61K38/16 , C07K14/00 , C07K14/76 , C07K14/765
CPC分类号： C07K14/57563 , A61K38/38 , A61K47/62 , A61K47/643
摘要： A method for protecting a peptide from peptidase activity in vivo, the peptide being composed of between 2 and 50 amino acids and having a C-terminus and an N-terminus and a C-terminus amino acid and an N-terminus amino acid is described. In the first step of the method, the peptide is modified by attaching a react group to the C-terminus amino acid, to the N-terminus amino acid, or to an amino acid located between the N-terminus and the C-terminus, such that the modified peptide is capable of forming a covalent bond in vivo with a reactive functionality on a blood component. In the next step, a covalent bond is formed between the reactive group and a reactive functionality on a blood component to form a peptide-blood component conjugate, thereby protecting said peptide from peptidase activity. The final step of the method involves the analyzing of the stability of the peptide-blood component conjugate to assess the protection of the peptide from peptidase activity.
摘要翻译：描述了一种在体内保护肽免受肽酶活性的方法，所述肽由2-50个氨基酸组成且具有C末端和N末端以及C末端氨基酸和N-末端氨基酸。在该方法的第一步中，通过将反应基团连接到C末端氨基酸，N末端氨基酸或位于N末端和C末端之间的氨基酸来修饰肽，使得修饰的肽能够在体内与血液成分上的反应性官能团形成共价键。在下一步骤中，在反应性基团和血液成分上的反应性官能团之间形成共价键以形成肽 - 血液成分缀合物，从而保护所述肽免受肽酶活性。该方法的最后步骤包括分析肽 - 血液成分缀合物的稳定性，以评估肽对肽酶活性的保护。

9. 发明申请

US20060009377A1 Long lasting synthetic glucagon like peptide (GLP-1) 失效
公开(公告)号：US20060009377A1
公开(公告)日：2006-01-12
申请号：US11170967
申请日：2005-06-29
申请人： Dominique Bridon , Benoit L'Archeveque , Alan Ezrin , Darren Holmes , Anouk Leblanc , Serge Pierre
发明人： Dominique Bridon , Benoit L'Archeveque , Alan Ezrin , Darren Holmes , Anouk Leblanc , Serge Pierre
IPC分类号： A61K38/27
CPC分类号： C07K14/005 , A61K38/00 , A61K47/643 , C07K14/57563 , C07K14/605 , C12N2740/16122
摘要： Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates may be formed in vivo or ex vivo. The modified peptides are administered to treat humans with diabetes and other related diseases.

10. 发明授权

US06887849B2 Long lasting synthetic glucagon-like peptide {GLP-1} 失效
标题翻译：长效合成胰高血糖素样肽（GLP-1）
公开(公告)号：US06887849B2
公开(公告)日：2005-05-03
申请号：US10288340
申请日：2002-11-04
申请人： Dominique P. Bridon , Benoit L'Archeveque , Alan M. Ezrin , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
发明人： Dominique P. Bridon , Benoit L'Archeveque , Alan M. Ezrin , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
IPC分类号： A61K38/00 , C07K14/16 , C07K14/605 , A61K38/16 , C07K17/00 , C07K17/02 , C07K17/06
CPC分类号： C07K14/005 , A61K38/00 , A61K47/643 , C07K14/57563 , C07K14/605 , C12N2740/16122
摘要： Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates may be formed in vivo or ex vivo. The modified peptides are administered to treat humans with diabetes and other related diseases.
摘要翻译：公开了改进的促胰岛素肽。修饰的促胰岛素肽能够形成肽酶稳定的促胰岛素肽。修饰的促胰岛素肽能够与一种或多种血液成分形成共价键以形成缀合物。缀合物可以在体内或离体形成。施用修饰的肽以治疗患有糖尿病和其他相关疾病的人。

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