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1. 发明授权

US09323872B2 Fibre optic network design method 有权
标题翻译：光纤网络设计方法
公开(公告)号：US09323872B2
公开(公告)日：2016-04-26
申请号：US13575342
申请日：2011-08-18
申请人： Michael Forbes , Benjamin Leslie Hollis
发明人： Michael Forbes , Benjamin Leslie Hollis
IPC分类号： G06F17/50 , H04L12/24
CPC分类号： G06F17/5009 , G06F17/509 , G06F2217/36 , H04L41/145
摘要： A system and method of designing a fiber optic network for a plurality of premises in a geographic area that has existing infrastructure is described. They include electronically receiving fiber optic network design inputs that include data indicative of a plurality of nodes in the fiber optic network and data indicative of arcs extending between said nodes in the fiber optic network based on allocated bandwidth for said premises in the geographic area, electronically receiving existing infrastructure design inputs comprising data indicative of said existing infrastructure that can be used as geographic locations for said nodes and said arcs in the fiber optic network, electronically generating design outputs by optimizing geographic locations of said nodes and said arcs in the fiber optic network using said fiber optic network design inputs and said existing infrastructure inputs, and electronically outputting the design outputs.
摘要翻译：描述了在具有现有基础设施的地理区域中为多个房屋设计光纤网络的系统和方法。它们包括电子地接收光纤网络设计输入，其包括指示光纤网络中的多个节点的数据，以及指示在光纤网络中的所述节点之间延伸的弧的数据，基于所述地理区域中的所述房屋的分配带宽，电子地接收现有的基础设施设计输入，包括指示所述现有基础设施的数据，所述现有基础设施可以用作光纤网络中的所述节点和所述弧的地理位置，通过优化所述节点和所述光纤网络中的所述弧的地理位置来电子地生成设计输出使用所述光纤网络设计输入和所述现有基础结构输入，并且电子地输出所述设计输出。

2. 发明授权

US2037137A Plant cultivation 失效
公开(公告)号：US2037137A
公开(公告)日：1936-04-14
申请号：US4824835
申请日：1935-11-04
申请人： ALEXANDER BENJAMIN LESLIE , HUGH HOWELL , CLIFTON HOWARD TRACY
发明人： LINCOLN LESLIE THOMAS
IPC分类号： A01G17/00
CPC分类号： A01G17/00

3. 发明授权

US08572001B2 Simultaneous vehicle routing, vehicle scheduling, and crew scheduling 有权
标题翻译：同时车辆路线，车辆调度和船员调度
公开(公告)号：US08572001B2
公开(公告)日：2013-10-29
申请号：US12099327
申请日：2008-04-08
申请人： Benjamin Leslie Hollis
发明人： Benjamin Leslie Hollis
IPC分类号： G06Q30/00 , G06Q10/00
CPC分类号： G06Q10/06 , G06Q10/06315
摘要： A method for generating a transportation plan. A set of transportation requests are identified. An initial transportation plan having a set of vehicle routes, a set of vehicle schedules, and a set of crew schedules that satisfy the set of transportation requests is created. A set of vehicle routes, a set of vehicle schedules, and a set of crew schedules are simultaneously modified repeatedly using a policy to generate a new transportation plan until an objective is met.
摘要翻译：一种生成运输计划的方法。确定一组运输请求。创建具有一组车辆路线，一组车辆时刻表和满足一组运输请求的一组船员表的初始运输计划。一套车辆路线，一组车辆时间表以及一组船员时间表同时通过政策重新进行修改，以生成新的交通计划，直到满足目标。

4. 发明申请

US20090239761A1 Protein arrays and uses thereof 审中-公开
标题翻译：蛋白质阵列及其用途
公开(公告)号：US20090239761A1
公开(公告)日：2009-09-24
申请号：US12291466
申请日：2008-11-10
申请人： Jonathan Michael Blackburn , Benjamin Leslie James Godber , Darren James Hart , Nicholas A. Bockett , Roland Kozlowski , Michael Dyson
发明人： Jonathan Michael Blackburn , Benjamin Leslie James Godber , Darren James Hart , Nicholas A. Bockett , Roland Kozlowski , Michael Dyson
IPC分类号： C40B30/04 , C40B40/10 , C40B50/06 , C40B50/00 , C40B30/00 , C12N9/00
CPC分类号： C12Q1/00 , B01J2219/00387 , B01J2219/00527 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00628 , B01J2219/00639 , B01J2219/00691 , B01J2219/00722 , B01J2219/00725 , C12Q1/26 , C12Q1/6837 , C40B30/04 , C40B40/06 , C40B40/10 , C40B60/14 , G01N2333/90209 , G01N2500/00
摘要： The inventors herein describe methods for the production of a functional human, animal, plant or microbe protein arrays and methods to assay for interactions between the proteins on the array with molecules of interest, for example, using such arrays to determine the in vitro metabolite profile of any drug. Such protein arrays can be used, for example, to assay, in a parallel fashion, the protein products of DNA sequences encoding drug metabolizing enzymes (DMES) to obtain a toxicology profile. Also described herein is a novel DME expression and purification strategy using detergents and not requiring an ultra-centrifugation step.
摘要翻译：本文的发明人描述了用于产生功能性人，动物，植物或微生物蛋白质阵列的方法和用于测定阵列上的蛋白质与感兴趣的分子之间的相互作用的方法，例如使用这样的阵列来确定体外代谢物谱的任何药物这样的蛋白质阵列可以用于例如以并行方式测定编码药物代谢酶（DMES）的DNA序列的蛋白质产物以获得毒理学谱。本文还描述了使用洗涤剂并且不需要超离心步骤的新型DME表达和纯化策略。

5. 发明申请

US20090254405A1 SIMULTANEOUS VEHICLE ROUTING, VEHICLE SCHEDULING, AND CREW SCHEDULING 有权
标题翻译：同步车辆路线，车辆调度和车辆调度
公开(公告)号：US20090254405A1
公开(公告)日：2009-10-08
申请号：US12099327
申请日：2008-04-08
申请人： Benjamin Leslie Hollis
发明人： Benjamin Leslie Hollis
IPC分类号： G06Q10/00
CPC分类号： G06Q10/06 , G06Q10/06315
摘要： A method for generating a transportation plan. A set of transportation requests are identified. An initial transportation plan having a set of vehicle routes, a set of vehicle schedules, and a set of crew schedules that satisfy the set of transportation requests is created. A set of vehicle routes, a set of vehicle schedules, and a set of crew schedules are simultaneously modified repeatedly using a policy to generate a new transportation plan until an objective is met.
摘要翻译：一种生成运输计划的方法。确定一组运输请求。创建具有一组车辆路线，一组车辆时刻表和满足一组运输请求的一组船员表的初始运输计划。一套车辆路线，一组车辆时间表以及一组船员时间表同时通过政策重新进行修改，以生成新的交通计划，直到满足目标。

6. 发明授权

US08739921B1 Sealing, absorbing, and decoupling speaker ring kit 失效
标题翻译：密封，吸收和去耦喇叭环套件
公开(公告)号：US08739921B1
公开(公告)日：2014-06-03
申请号：US13925774
申请日：2013-06-24
申请人： Benjamin Leslie Larson
发明人： Benjamin Leslie Larson
IPC分类号： H04R1/02
CPC分类号： H04R1/2896 , H04R2499/13
摘要： An acoustic system kit for a vehicle speaker and associated methods of installation and manufacture are disclosed. A drum of open-cell foam, preferably several inches thick, having a peel-and-stick pressure-sensitive adhesive backing is cut with two concentric circles to create an outer ring, and inner ring, and a core. The parts are sized to correspond in diameter, respectively, to the front edge, rear edge, and back disc of a particular size of speaker. The inner ring is cut circumferentially to reduce its height to a thin strip relative to the outer ring and drum. Using the pressure-sensitive adhesive, the core is affixed to the inside wall of vehicle door directly behind the door's speaker mount, the inner ring is affixed to the rear edge of a speaker to be installed, and the outer ring is affixed to front edge of the speaker. The speaker is then installed on its mount.
摘要翻译：公开了一种用于车辆扬声器的声学系统套件以及相关的安装和制造方法。用两个同心圆切割具有剥离和粘合压敏粘合剂背衬的开孔泡沫的鼓，优选几英寸厚，以形成外环，内环和芯。这些部件的尺寸分别对应于具体尺寸扬声器的前边缘，后边缘和后盘的直径。内环被圆周地切割以将其高度相对于外环和滚筒减小到薄带。使用压敏粘合剂，将芯固定在门的扬声器座的正后方的车门的内壁上，将内圈固定在要安装的扬声器的后缘，并将外圈固定在前缘的演讲者。然后将扬声器安装在其安装座上。

7. 发明授权

US3981441A Counters 失效
标题翻译：计数器
公开(公告)号：US3981441A
公开(公告)日：1976-09-21
申请号：US580721
申请日：1975-05-27
申请人： John Benjamin Leslie Walters
发明人： John Benjamin Leslie Walters
IPC分类号： G06M1/28 , G06M1/14 , G06M1/34 , G01C22/00 , G06C15/42
CPC分类号： G06M1/343 , G06M1/143
摘要： A counter comprises a body housing a set of discs which are freely rotatable on a sleeve and which have numerals on their peripheries. A series of drive plates are keyed to the sleeve and interleaved with the discs. At one end of the set of discs a spring-loaded collar also keyed to the sleeve urges the drive plates and discs into frictional engagement. The sleeve is rotatable with a reset wheel while the collar is driven by a star counting wheel through an orbital drive arrangement. The orbital drive arrangement may include a further collar having outwardly directed projections thereon which engage an abutment carried by a resilient arm, the abutment and projections restraining the further collar against rotation during counting. Each disc has a set of first abutments and a second abutment on its periphery. Spring blades engage the peripheries of the discs and have respective resilient stops thereon to engage the first abutments so as to oppose movement of the discs in a counting direction but to permit movement thereof in a reset direction. All the discs but one end disc are each provided with a resilient detent which is positioned in the path of movement of the second abutment. Each resilient detent is carried by the spring blade which mounts the resilient stop associated with an adjacent disc.
摘要翻译：计数器包括容纳一组可在套筒上自由旋转并且在其周边上具有数字的盘的主体。一系列驱动板被锁定到套筒上并与盘交错。在该组盘的一端，也与钥匙连接到套筒的弹簧加载的轴环推动驱动板和盘摩擦接合。当套圈由星形计数轮通过轨道驱动装置驱动时，套筒可以用复位轮旋转。轨道驱动装置可以包括另外的轴环，其上具有向外指向的突起，其接合由弹性臂承载的邻接件，所述抵靠和突起限制另外的轴环在计数期间防止旋转。每个盘具有一组第一基台和其周边上的第二基台。弹簧叶片接合盘的周边并且在其上具有相应的弹性止动件以接合第一邻接部，以抵抗盘在计数方向上的移动，但是允许其在复位方向上移动。所有的盘，但是一端盘都设置有弹性制动器，该止动件位于第二支座的移动路径中。每个弹性制动器由弹簧叶片承载，该弹簧刀片安装与相邻盘片相关联的弹性止动件。

8. 发明申请

US20130289966A1 Fibre Optic Network Design Method 有权
标题翻译：光纤网络设计方法
公开(公告)号：US20130289966A1
公开(公告)日：2013-10-31
申请号：US13575342
申请日：2001-08-18
申请人： Michael Forbes , Benjamin Leslie Hollis
发明人： Michael Forbes , Benjamin Leslie Hollis
IPC分类号： G06F17/50
CPC分类号： G06F17/5009 , G06F17/509 , G06F2217/36 , H04L41/145
摘要： A system and method of designing a fibre optic network for a plurality of premises in a geographic area that has existing infrastructure is described. They include electronically receiving fibre optic network design inputs that include data indicative of a plurality of nodes in the fibre optic network and data indicative of arcs extending between said nodes in the fibre optic network based on allocated bandwidth for said premises in the geographic area, electronically receiving existing infrastructure design inputs comprising data indicative of said existing infrastructure that can be used as geographic locations for said nodes and said arcs in the fibre optic network, electronically generating design outputs by optimising geographic locations of said nodes and said arcs in the fibre optic network using said fibre optic network design inputs and said existing infrastructure inputs, and electronically outputting the design outputs.
摘要翻译：描述了在具有现有基础设施的地理区域中为多个房屋设计光纤网络的系统和方法。它们包括电子地接收光纤网络设计输入，其包括指示光纤网络中的多个节点的数据，以及指示在光纤网络中的所述节点之间延伸的弧的数据，基于所述地理区域中的所述房屋的分配带宽，电子地接收现有的基础设施设计输入，包括指示所述现有基础设施的数据，所述现有基础设施可以用作光纤网络中的所述节点和所述弧的地理位置，通过优化所述节点和所述光纤网络中的所述弧的地理位置来电子地生成设计输出使用所述光纤网络设计输入和所述现有基础结构输入，并且电子地输出所述设计输出。

9. 发明申请

US20050197511A1 Compounds and methods for treatment of cancer and modulation of programmed cell death for melanoma and other cancer cells 失效
标题翻译：用于治疗癌症的化合物和方法以及黑色素瘤和其他癌细胞程序性细胞死亡的调节
公开(公告)号：US20050197511A1
公开(公告)日：2005-09-08
申请号：US10976186
申请日：2004-10-27
申请人： Paul Hergenrother , Vitaliy Nesterenko , Karson Putt , Brittany Allen , Robin Dothager , Benjamin Leslie
发明人： Paul Hergenrother , Vitaliy Nesterenko , Karson Putt , Brittany Allen , Robin Dothager , Benjamin Leslie
IPC分类号： A61K20060101 , A61K31/165 , A61K31/704 , A61K31/7048 , C07C233/05 , C07C235/32
CPC分类号： C07C233/22 , C07B2200/07 , C07C233/11 , C07C233/18 , C07C233/31 , C07C233/40 , C07C233/44 , C07C233/51 , C07C235/34 , C07C235/36 , C07C235/38 , C07C271/16 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2603/74 , C40B30/06 , C40B40/04 , C40B50/08
摘要： Compounds and related methods for synthesis, and the use of compounds and combination therapies for the treatment of cancer and modulation of apoptosis in cells are disclosed. The generation of synthetic combinatorial libraries and the evaluation of library member compounds regarding induction of apoptosis selectively in cancer cells are disclosed. Compounds, methods of making the compounds, and therapeutic methods with application against breast cancer cells, melanoma cancer cells, colon cancer cells, and other cancer cells are described.
摘要翻译：公开了合成的化合物和相关方法，以及化合物和组合疗法在细胞治疗中的应用和细胞凋亡的调节。公开了合成组合文库的产生以及关于在癌细胞中选择性诱导凋亡的文库成员化合物的评估。描述了化合物，制备化合物的方法以及应用于乳腺癌细胞，黑素瘤癌细胞，结肠癌细胞和其它癌细胞的治疗方法。

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