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2. 发明申请

US20080300391A1 Acid Mediated Deacylation of 6-0-Trichlorogalactosurcrose to Trich-Lorogalactosucrose 审中-公开
标题翻译： 6-0-三氯半乳糖的酸介导的脱酰基作用到三萜半乳糖
公开(公告)号：US20080300391A1
公开(公告)日：2008-12-04
申请号：US12083859
申请日：2006-10-17
申请人： Rakesh Ratnam , Sundeep Aurora , Batchu Chandrashekar , Anandangowda Patil
发明人： Rakesh Ratnam , Sundeep Aurora , Batchu Chandrashekar , Anandangowda Patil
IPC分类号： C07H1/00
CPC分类号： C07H1/00 , C07H1/06 , C07H5/02 , C07H13/04
摘要： A process is described for acid mediated deacylation of acyl derivatives of chlorinated sucrose compounds comprising generating a predominantly organic phase condition in a process stream requiring deacylation treatment but allowing an optimum quantity of water content which is capable of participating in a hydrolysis reaction; this objective being achieved for the said process stream by following steps of (a) adding to it alcoholic solvent in an amount such that water content of final reaction mixture is between about 5% to 0.5%, (b) adding acid chloride to the same (c) adjusting the pH to 4 by adding acetate buffer in a methanolic solution and, (d) stirring the reaction until deacylation is complete. This process can be integrated in a process for production of a chlorinated compound, involving use of dimethylformamide during the process, to achieve deacylation without decomposition of dimethylformamide as well as the chlorinated sucrose product.
摘要翻译：描述了用于酸介导的氯化蔗糖化合物的酰基衍生物的脱酰基的方法，其包括在需要脱酰基处理的工艺流中产生主要有机相条件，但允许最佳量的能够参与水解反应的水含量; 通过以下步骤（a）向醇溶剂中加入一定量使得最终反应混合物的水含量在约5％至0.5％之间的量，（b）向其中加入酰氯，（c）通过在甲醇溶液中加入乙酸盐缓冲液将pH调节至4，和（d）搅拌反应直到完全脱酰基化。该方法可以整合到生产氯化化合物的方法中，涉及在该方法中使用二甲基甲酰胺，以达到脱酰基化而不分解二甲基甲酰胺以及氯化蔗糖产物。

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