专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050059953A1 Apparatus for demineralizing osteoinductive bone 审中-公开
标题翻译：使骨骼软骨脱矿质的装置
公开(公告)号：US20050059953A1
公开(公告)日：2005-03-17
申请号：US10732799
申请日：2003-12-11
申请人： Barton Gaskins , Louis Ford , Debra Moore-Smith , Robert O'Leary , Anne Wilson , Lloyd Wolfinbarger
发明人： Barton Gaskins , Louis Ford , Debra Moore-Smith , Robert O'Leary , Anne Wilson , Lloyd Wolfinbarger
IPC分类号： A61K35/32 , A61M31/00
CPC分类号： A61L27/3683 , A61K35/32
摘要： The invention is directed to an apparatus for producing demineralized osteoinductive bone. The apparatus demineralizes bone by subjecting bone, including, for example, ground bone, bone cubes, chips, strips, or essentially intact bone, to either a rapid high volume pulsatile acidification wave process or to a rapid continuous acid demineralization process. The pulsatile acidification wave process includes subjecting bone to two or more rapid pulse/drain cycles in which one or more demineralizing acids is rapidly pulsed into a vessel containing bone, and after a desired period of time, is rapidly drained from the vessel. The continuous acid demineralization process includes subjecting bone to a continuous exchange of demineralizing acid solution in which the demineralizing acid solution is recirculated from the container holding the bone through an ion exchange media. Calcium and phosphate are thereby removed from the bone to produce a regenerated acid, and the regenerated acid is returned to the container holding the bone. Both processes allow bone to be rapidly demineralized to a precise and specific desired residual calcium level without sacrificing osteoinductivity.
摘要翻译：本发明涉及一种用于生产去矿物质的骨诱导骨的装置。该装置通过使骨骼（包括例如研磨骨，骨块，切片，条或基本上完整的骨）经受快速高体积的脉动酸化波过程或快速连续的酸脱矿过程来使骨骼软化矿物质。脉动酸化波过程包括使骨头进行两个或更多个快速的脉冲/排出循环，其中一个或多个软化酸迅速脉冲进入含有骨的容器中，并且在所需的时间段之后，迅速从容器中排出。连续酸性脱盐过程包括使骨头连续交换软化酸溶液，其中脱矿质酸溶液从容纳骨的容器通过离子交换介质再循环。因此，从骨中除去钙和磷酸盐以产生再生酸，再生酸返回到容纳骨的容器中。两种方法允许骨快速脱矿质至精确和特定的所需残留钙水平而不牺牲骨诱导能力。

IPRDB

热门服务

关于我们

友情链接

联系方式