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1. 发明申请

US20080176946A1 FORMULATIONS FOR CANCER TREATMENT 审中-公开
标题翻译：癌症治疗配方
公开(公告)号：US20080176946A1
公开(公告)日：2008-07-24
申请号：US12015403
申请日：2008-01-16
申请人： Valeria s. Ossovskaya , Lingyun Li , Barry Sherman
发明人： Valeria s. Ossovskaya , Lingyun Li , Barry Sherman
IPC分类号： A61K31/165 , A61P31/12 , A61P35/04
CPC分类号： B82Y5/00 , A61K9/0019 , A61K9/1075 , A61K9/1635 , A61K9/1652 , A61K31/166 , A61K47/6951
摘要： The present invention provides compositions of matter, kits, and methods for use in treating cancer and viral conditions. In particular the invention provides for pharmaceutical compositions containing nitrobenzamide compounds that have enhanced solubility in aqueous solutions.
摘要翻译：本发明提供了用于治疗癌症和病毒病症的物质，试剂盒和方法的组合物。特别地，本发明提供含有在水溶液中具有增强的溶解度的硝基苯甲酰胺化合物的药物组合物。

2. 发明申请

US20060052389A1 Compositions and methods for enhancing analgesic potency of tramadol and attenuating its adverse side effects 审中-公开
公开(公告)号：US20060052389A1
公开(公告)日：2006-03-09
申请号：US10894349
申请日：2004-07-19
申请人： Stanley Crain , Ke-Fei Shen , Barry Sherman , Mary Remien , Remi Barbier , Nadav Friedmann
发明人： Stanley Crain , Ke-Fei Shen , Barry Sherman , Mary Remien , Remi Barbier , Nadav Friedmann
IPC分类号： A61K31/496 , A61K31/485
CPC分类号： A61K31/135 , A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K9/4866 , A61K9/5042 , A61K9/5084 , A61K31/00 , A61K31/445 , A61K31/455 , A61K31/485 , A61K2300/00
摘要： The invention generally relates to compositions and methods with tramadol and an opioid antagonist to enhance analgesic potency and/or attenuate one or more adverse effects of tramadol, including adverse side effect(s) in humans such as nausea, vomiting, dizziness, headache, sedation (somnolence) or pruritis. This invention relates to compositions and methods for selectively enhancing the analgesic potency of tramadol and simultaneously attenuating anti-analgesia, hyperalgesia, hyperexcitability, physical dependence and/or tolerance effects associated with the administration of tramadol. The methods of the present invention comprise administering to a subject an analgesic or subanalgesic amount of tramadol and an amount of excitatory opioid receptor antagonist such as naltrexone or nalmefene effective to enhance the analgesic potency of tramadol and attenuate the anti-analgesia, hyperalgesia, hyperexcitability, physical dependence and/or tolerance effects of tramadol.

3. 发明授权

US06765010B2 Compositions and methods for enhancing analgesic potency of tramadol and attenuating its adverse side effects 失效
标题翻译：用于增强曲马多镇痛效力并减弱其不良副作用的组合物和方法
公开(公告)号：US06765010B2
公开(公告)日：2004-07-20
申请号：US10095802
申请日：2002-03-12
申请人： Stanley M. Crain , Ke-Fei Shen , Barry Sherman , Mary Remien , Remi Barbier , Nadav Friedmann
发明人： Stanley M. Crain , Ke-Fei Shen , Barry Sherman , Mary Remien , Remi Barbier , Nadav Friedmann
IPC分类号： A61R3114
CPC分类号： A61K31/135 , A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K9/4866 , A61K9/5042 , A61K9/5084 , A61K31/00 , A61K31/445 , A61K31/455 , A61K31/485 , A61K2300/00
摘要： The invention generally relates to compositions and methods with tramadol and an opioid antagonist to enhance analgesic potency and/or attenuate one or more adverse effects of tramadol, including adverse side effect(s) in humans such as nausea, vomiting, dizziness, headache, sedation (somnolence) or pruritis. This invention relates to compositions and methods for selectively enhancing the analgesic potency of tramadol and simultaneously attenuating anti-analgesia, hyperalgesia, hyperexcitability, physical dependence and/or tolerance effects associated with the administration of tramadol. The methods of the present invention comprise administering to a subject an analgesic or subanalgesic amount of tramadol and an amount of excitatory opioid receptor antagonist such as naltrexone or nalmefene effective to enhance the analgesic potency of tramadol and attenuate the anti-analgesia, hyperalgesia, hyperexcitability, physical dependence and/or tolerance effects of tramadol.
摘要翻译：本发明一般涉及具有曲马多和阿片样物质拮抗剂以增强止痛效力和/或减弱曲马多的一种或多种副作用的组合物和方法，包括人类的不良副作用，例如恶心，呕吐，头晕，头痛，镇静（嗜睡）或瘙痒症。本发明涉及用于选择性增强曲马多镇痛效力的组合物和方法，并且同时减轻与施用曲马多相关的抗镇痛，痛觉过敏，过度兴奋，身体依赖和/或耐受性作用。本发明的方法包括对受试者施用止痛剂或亚麻痛剂量的曲马多和一定量的兴奋性阿片样物质受体拮抗剂如纳曲酮或纳美芬，其有效地增强曲马多的镇痛效力并减弱镇痛，痛觉过敏，兴奋性过高，曲马多的身体依赖和/或耐受性影响。

4. 发明申请

US20120238601A1 TREATMENT OF CANCER 审中-公开
标题翻译：治疗癌症
公开(公告)号：US20120238601A1
公开(公告)日：2012-09-20
申请号：US13323630
申请日：2011-12-12
申请人： Jerome MOORE , Bruce KEYT , John BURNIER , Barry SHERMAN , Max TOTROV , Valeria S. OSSOVSKAYA
发明人： Jerome MOORE , Bruce KEYT , John BURNIER , Barry SHERMAN , Max TOTROV , Valeria S. OSSOVSKAYA
IPC分类号： A61K31/166 , A61K31/472 , A61K31/426 , A61P35/00 , A61K31/421 , A61K31/381 , A61K31/404 , A61K31/197 , A61K31/4245
CPC分类号： C07C323/62 , C07C233/65 , C07C235/46 , C07C237/30 , C07C239/18
摘要： The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase, as well as providing formulations and modes of administering such compositions.
摘要翻译：本发明提供了用于治疗癌症的物质，试剂盒和方法的组合物。特别地，本发明提供了通过抑制聚-ADP-核糖聚合酶来治疗受试者的癌症的组合物和方法，以及提供施用这种组合物的制剂和模式。

5. 发明申请

US20090291924A1 Drug design for tubulin inhibitors, compositions, and methods of treatment thereof 审中-公开
公开(公告)号：US20090291924A1
公开(公告)日：2009-11-26
申请号：US12454802
申请日：2009-05-21
申请人： Valeria Ossovskaya , John Burnier , Barry Sherman , Max Totrov
发明人： Valeria Ossovskaya , John Burnier , Barry Sherman , Max Totrov
IPC分类号： A61K31/661 , G01N33/53 , G06G7/58 , A61K31/135 , A61K31/12 , A61K31/495 , C07C213/00 , C07C45/00 , A61P35/00 , A61P5/00 , A61P11/00 , A61P13/00 , A61P15/00
CPC分类号： A61K31/12 , A61K31/135 , A61K31/497 , A61K31/66 , G16B15/00 , G16C20/50
摘要： The present invention relates to a computer-assisted method of a designing of a tubulin inhibitor comprising: a) determining an interaction between a tubulin protein and a chemical known to bind the tubulin protein by evaluating a binding of the tubulin protein to the chemical known to bind the tubulin protein; b) based on the interaction, designing a candidate tubulin inhibitor; c) determining an interaction between the tubulin protein and the candidate tubulin inhibitor by evaluating a binding of the tubulin protein to the candidate tubulin inhibitor; and d) concluding that the candidate tubulin inhibitor inhibits the tubulin protein wherein the conclusion is based on the interaction of step c). The invention also provides compositions and methods of treatment of diseases with the candidate tubulin inhibitors.

6. 发明授权

US09669275B2 Divot repair apparatus 有权
公开(公告)号：US09669275B2
公开(公告)日：2017-06-06
申请号：US14963494
申请日：2015-12-09
申请人： Barry Sherman
发明人： Barry Sherman
IPC分类号： A63B57/50
CPC分类号： A63B57/50
摘要： A divot repair apparatus transports and dispenses fill material to fill and repair divots. The repair apparatus includes a hopper for holding the fill material, the hopper being adapted to be worn on the user's back; a conduit for dispensing the fill material from the hopper; and a valve assembly disposed in the conduit for controlling the flow of the fill material from the hopper. An outlet end of the conduit may include a smoothing tool for manipulating the fill material after it has been dispensed.

7. 发明申请

US20120004260A1 INHIBITION OF FATTY ACID SYNTHESIS BY IODO-NITROBENZAMIDE COMPOUNDS AND METHODS OF TREATMENT THEREOF 审中-公开
标题翻译：碘化亚硝酸盐化合物对脂肪酸合成的抑制作用及其处理方法
公开(公告)号：US20120004260A1
公开(公告)日：2012-01-05
申请号：US13169785
申请日：2011-06-27
申请人： Valeria Ossovskaya , Barry Sherman
发明人： Valeria Ossovskaya , Barry Sherman
IPC分类号： A61K31/166 , A61K31/47 , A61K31/404 , A61P35/00 , A61K31/42 , A61K31/4245 , A61K31/381 , A61P3/04 , A61K31/198 , A61K31/425
CPC分类号： A61K31/166 , A61K31/197 , A61K31/7012
摘要： The present invention relates to a method of treating a fatty acid synthesis related disease comprising administering to a patient in need thereof an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis, wherein the fatty acid synthesis related disease is obesity, diabetes, or cardiovascular disease. The present invention also relates to a method of treating a cancer in a subject comprising: (i) identifying a level of fatty acid in a sample from the subject, and (ii) administering an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis in the subject, wherein the administration is based on the level of fatty acid, thereby treating the cancer in the subject. The present invention further relates to a method of treating Her-2 related cancers by administering to a patient in need thereof an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis.
摘要翻译：本发明涉及一种治疗脂肪酸合成相关疾病的方法，包括向有需要的患者施用有效量的PARP抑制剂或其代谢物以抑制脂肪酸合成，其中所述脂肪酸合成相关疾病是肥胖症，糖尿病，或心血管疾病。本发明还涉及治疗受试者的癌症的方法，包括：（i）鉴定来自受试者的样品中的脂肪酸水平，和（ii）施用有效量的PARP抑制剂或其代谢物以抑制受试者中的脂肪酸合成，其中所述给药基于脂肪酸的水平，从而治疗受试者的癌症。本发明还涉及通过向有需要的患者施用有效量的PARP抑制剂或其代谢物来抑制脂肪酸合成来治疗Her-2相关癌症的方法。

8. 发明申请

US20080076778A1 METHODS FOR DESIGNING PARP INHIBITORS AND USES THEREOF 审中-公开
标题翻译：设计PARP抑制剂的方法及其用途
公开(公告)号：US20080076778A1
公开(公告)日：2008-03-27
申请号：US11850612
申请日：2007-09-05
申请人： Valeria Ossovskaya , John Burnier , Barry Sherman , Max Totrov
发明人： Valeria Ossovskaya , John Burnier , Barry Sherman , Max Totrov
IPC分类号： A61K31/37 , A61K31/4025 , A61K31/4178 , A61K31/4433 , A61K31/496 , A61P11/00 , A61P15/00 , A61P25/00 , A61P29/00 , A61P3/00 , A61P35/00 , A61P5/00 , C07D311/02 , C07D405/10 , G06G7/48
CPC分类号： A61K31/37 , A61K31/4025 , A61K31/4178 , A61K31/4433 , A61K31/496 , C07D311/14 , C07D405/06
摘要： The present invention relates to a computer-assisted method of a designing of a PARP inhibitor comprising: a) determining an interaction between a candidate PARP protein and a known PARP inhibitor by evaluating a binding of the PARP protein to the known PARP inhibitor; b) based on the interaction, designing a candidate PARP inhibitor; c) determining an interaction between the PARP protein and the candidate PARP inhibitor by evaluating a binding of the PARP protein to the candidate PARP inhibitor; and d) concluding that the candidate PARP inhibitor inhibits the PARP protein wherein the conclusion is based on the interaction of step c). The invention also provides methods for treatment of diseases with the candidate PARP inhibitors.
摘要翻译：本发明涉及一种设计PARP抑制剂的计算机辅助方法，包括：a）通过评估PARP蛋白与已知PARP抑制剂的结合来确定候选PARP蛋白和已知PARP抑制剂之间的相互作用; b）基于相互作用，设计候选PARP抑制剂; c）通过评估PARP蛋白与候选PARP抑制剂的结合来确定PARP蛋白和候选PARP抑制剂之间的相互作用; 和d）得出结论，候选PARP抑制剂抑制PARP蛋白，其中结论是基于步骤c）的相互作用。本发明还提供了用候选PARP抑制剂治疗疾病的方法。

9. 发明申请

US20080076737A1 DRUG DESIGN FOR TUBULIN INHIBITORS, COMPOSITIONS, AND METHODS OF TREATMENT THEREOF 失效
标题翻译：用于管状体抑制剂的药物设计，组合物及其处理方法
公开(公告)号：US20080076737A1
公开(公告)日：2008-03-27
申请号：US11850620
申请日：2007-09-05
申请人： Valeria Ossovskaya , John Burnier , Barry Sherman , Max Totrov
发明人： Valeria Ossovskaya , John Burnier , Barry Sherman , Max Totrov
IPC分类号： A61K31/12 , A61K31/135 , A61K31/497 , A61K31/66 , A61P43/00 , G06G7/48
CPC分类号： A61K31/12 , A61K31/135 , A61K31/497 , A61K31/66 , G06F19/16 , G06F19/706
摘要： The present invention relates to a computer-assisted method of a designing of a tubulin inhibitor comprising: a) determining an interaction between a tubulin protein and a chemical known to bind the tubulin protein by evaluating a binding of the tubulin protein to the chemical known to bind the tubulin protein; b) based on the interaction, designing a candidate tubulin inhibitor; c) determining an interaction between the tubulin protein and the candidate tubulin inhibitor by evaluating a binding of the tubulin protein to the candidate tubulin inhibitor; and d) concluding that the candidate tubulin inhibitor inhibits the tubulin protein wherein the conclusion is based on the interaction of step c). The invention also provides compositions and methods of treatment of diseases with the candidate tubulin inhibitors.
摘要翻译：本发明涉及一种设计微管蛋白抑制剂的计算机辅助方法，包括：a）通过评估微管蛋白与已知的化学物质的结合来确定微管蛋白与已知结合微管蛋白的化学物质之间的相互作用结合微管蛋白; b）基于相互作用，设计候选微管蛋白抑制剂; c）通过评估微管蛋白与候选微管蛋白抑制剂的结合来确定微管蛋白和候选微管蛋白抑制剂之间的相互作用; 和d）得出结论，候选微管蛋白抑制剂抑制微管蛋白，其中结论基于步骤c）的相互作用。本发明还提供了用候选微管蛋白抑制剂治疗疾病的组合物和方法。

10. 发明申请

US20160166899A1 DIVOT REPAIR APPARATUS 审中-公开
标题翻译： DIVOT修理设备
公开(公告)号：US20160166899A1
公开(公告)日：2016-06-16
申请号：US14963494
申请日：2015-12-09
申请人： Barry Sherman
发明人： Barry Sherman
IPC分类号： A63B57/50
CPC分类号： A63B57/50
摘要： A divot repair apparatus transports and dispenses fill material to fill and repair divots. The repair apparatus includes a hopper for holding the fill material, the hopper being adapted to be worn on the user's back; a conduit for dispensing the fill material from the hopper; and a valve assembly disposed in the conduit for controlling the flow of the fill material from the hopper. An outlet end of the conduit may include a smoothing tool for manipulating the fill material after it has been dispensed.
摘要翻译：修理装置运输和分配填充材料以填补和修理。修理装置包括用于保持填充材料的料斗，料斗适于佩戴在使用者的背部; 用于从料斗分配填充材料的导管; 以及设置在导管中的阀组件，用于控制填料从料斗的流动。导管的出口端可以包括用于在填充材料被分配之后操纵填充材料的平滑工具。

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