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1. 发明授权

US09128107B2 Prognostic biomarkers for the progression of primary chronic kidney disease 有权
标题翻译：原发性慢性肾脏疾病进展的预后生物标志物
公开(公告)号：US09128107B2
公开(公告)日：2015-09-08
申请号：US13125631
申请日：2009-10-22
申请人： Joachim Struck , Benjamin Dieplinger , Thomas Muller , Barbara Kollerits , Florian Kronenberg
发明人： Joachim Struck , Benjamin Dieplinger , Thomas Muller , Barbara Kollerits , Florian Kronenberg
IPC分类号： G01N31/00 , G01N33/53 , G01N33/74
CPC分类号： G01N33/74 , G01N2333/58 , G01N2800/347
摘要： Subject of the present invention are assays and in vitro methods for prediction of the progression of primary chronic kidney disease (CKD) or for monitoring chronic kidney disease therapy comprising the determination of the level of ANP and/or ADM or its precursors or fragments thereof.
摘要翻译：本发明的主题是用于预测原发性慢性肾脏病（CKD）进展或用于监测慢性肾脏疾病治疗的测定和体外方法，包括测定ANP和/或ADM或其前体或其片段的水平。

2. 发明申请

US20120003752A1 Prognostic biomarkers for the progression of primary chronic kidney disease 有权
标题翻译：原发性慢性肾脏疾病进展的预后生物标志物
公开(公告)号：US20120003752A1
公开(公告)日：2012-01-05
申请号：US13125631
申请日：2009-10-22
申请人： Joachim Struck , Benjamin Dieplinger , Thomas Muller , Barbara Kollerits , Florian Kronenberg
发明人： Joachim Struck , Benjamin Dieplinger , Thomas Muller , Barbara Kollerits , Florian Kronenberg
IPC分类号： G01N33/566
CPC分类号： G01N33/74 , G01N2333/58 , G01N2800/347
摘要： Subject of the present invention are assays and in vitro methods for prediction of the progression of primary chronic kidney disease (CKD) or for monitoring chronic kidney disease therapy comprising the determination of the level of ANP and/or ADM or its precursors or fragments thereof.
摘要翻译：本发明的主题是用于预测原发性慢性肾脏病（CKD）进展或用于监测慢性肾脏疾病治疗的测定和体外方法，包括测定ANP和/或ADM或其前体或其片段的水平。

3. 发明授权

US08623607B2 Markers for chronic kidney disease 有权
标题翻译：慢性肾脏疾病的标志物
公开(公告)号：US08623607B2
公开(公告)日：2014-01-07
申请号：US13280719
申请日：2011-10-25
申请人： Florian Kronenberg , Barbara Kollerits , Danilo Fliser
发明人： Florian Kronenberg , Barbara Kollerits , Danilo Fliser
IPC分类号： G01N33/53
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/118
摘要： The present invention relates to a method for determining or predicting the progression of chronic kidney disease in a subject suspected of having chronic kidney disease, comprising determining the expression levels of at least one marker selected from (a) FGF23; and (b) adiponectin in a biological sample. Furthermore, the present invention relates to a use of a specific detection molecule for FGF23 or adiponectin for the preparation of a diagnostic composition for the detection of chronic kidney disease or the progression of chronic kidney diseases in a subject suspected to suffer from said disease. In particular, the present invention also provides for use of FGF23 and/or of adiponectin as an in vitro marker for the presence, absence or progression of a chronic kidney disease and kits comprising a specific detection molecule for FGF23 or a specific detection molecule for adiponectin for use in the method of the present invention.
摘要翻译：本发明涉及一种用于确定或预测疑似患有慢性肾脏疾病的受试者的慢性肾脏疾病进展的方法，包括确定选自（a）FGF23的至少一种标志物的表达水平; 和（b）生物样品中的脂联素。此外，本发明涉及用于FGF23或脂联素的特异性检测分子用于制备用于检测疑似患有所述疾病的受试者的慢性肾脏疾病或慢性肾脏疾病进展的诊断组合物的用途。特别地，本发明还提供使用FGF23和/或脂连蛋白作为慢性肾脏疾病的存在，不存在或进展的体外标记物，以及包含用于FGF23的特异性检测分子或脂联素特异性检测分子的试剂盒用于本发明的方法中。

4. 发明申请

US20100143951A1 NOVEL MARKERS FOR CHRONIC KIDNEY DISEASE 有权
标题翻译：慢性狂犬病的新标志
公开(公告)号：US20100143951A1
公开(公告)日：2010-06-10
申请号：US12523625
申请日：2008-01-21
申请人： Florian Kronenberg , Barbara Kollerits , Danilo Fliser
发明人： Florian Kronenberg , Barbara Kollerits , Danilo Fliser
IPC分类号： G01N33/53
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/118
摘要： The present invention relates to a method for the determination or prediction of the progression of chronic kidney disease in a subject suspected to suffer from chronic kidney disease, said method comprising the step of determining the expression levels of at least one marker selected from (a) FGF23; and (b) adiponectin in a biological sample. Furthermore, the present invention relates to a use of a specific detection molecule for FGF23 or use of a specific detection molecule for adiponectin for the preparation of a diagnostic composition for the detection of chronic kidney disease or the progression of chronic kidney diseases in a subject suspected to suffer from said disease. In particular, the present invention also provides for use of FGF23 and/or of adiponectin as an in vitro marker for the presence, absence or progression of a chronic kidney disease and kits comprising a specific detection molecule for FGF23 or a specific detection molecule for adiponectin for use in the method of the present invention.
摘要翻译：本发明涉及一种用于确定或预测疑似患有慢性肾脏疾病的受试者的慢性肾脏疾病进展的方法，所述方法包括确定选自（a）的至少一种标志物的表达水平的步骤， FGF23; 和（b）生物样品中的脂联素。此外，本发明涉及用于FGF23的特异性检测分子的用途或者用于脂联素的特异性检测分子的用途，用于制备用于检测受试者的慢性肾脏疾病或慢性肾脏疾病进展的诊断组合物患有所述疾病。特别地，本发明还提供使用FGF23和/或脂连蛋白作为慢性肾脏疾病的存在，不存在或进展的体外标记物，以及包含用于FGF23的特异性检测分子或脂联素特异性检测分子的试剂盒用于本发明的方法中。

5. 发明申请

US20120135428A1 NOVEL MARKERS FOR CHRONIC KIDNEY DISEASE 有权
标题翻译：慢性狂犬病的新标志
公开(公告)号：US20120135428A1
公开(公告)日：2012-05-31
申请号：US13280719
申请日：2011-10-25
申请人： Florian Kronenberg , Barbara Kollerits , Danilo Fliser
发明人： Florian Kronenberg , Barbara Kollerits , Danilo Fliser
IPC分类号： G01N33/566 , C07K16/22 , C07K16/26
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/118
摘要： The present invention relates to a method for determining the progression of chronic kidney disease in a subject suspected of having chronic kidney disease, comprising of determining the expression levels of at least one marker selected from (a) FGF23; and (b) adiponectin in a biological sample. Furthermore, the present invention relates to a use of a specific detection molecule for FGF23 or adiponectin for the preparation of a diagnostic composition for the detection of chronic kidney disease or the progression of chronic kidney diseases in a subject suspected to suffer from said disease. In particular, the present invention also provides for use of FGF23 and/or of adiponectin as an in vitro marker for the presence, absence or progression of a chronic kidney disease and kits comprising a specific detection molecule for FGF23 or a specific detection molecule for adiponectin for use in the method of the present invention.
摘要翻译：本发明涉及一种用于确定疑似患有慢性肾脏疾病的受试者的慢性肾脏疾病进展的方法，包括确定选自（a）FGF23的至少一种标志物的表达水平; 和（b）生物样品中的脂联素。此外，本发明涉及用于FGF23或脂联素的特异性检测分子用于制备用于检测疑似患有所述疾病的受试者的慢性肾脏疾病或慢性肾脏疾病进展的诊断组合物的用途。特别地，本发明还提供使用FGF23和/或脂连蛋白作为慢性肾脏疾病的存在，不存在或进展的体外标记物，以及包含用于FGF23的特异性检测分子或脂联素特异性检测分子的试剂盒用于本发明的方法中。

6. 发明授权

US08058015B2 Markers for chronic kidney disease 有权
标题翻译：慢性肾脏疾病的标志物
公开(公告)号：US08058015B2
公开(公告)日：2011-11-15
申请号：US12523625
申请日：2008-01-21
申请人： Florian Kronenberg , Barbara Kollerits , Danilo Fliser
发明人： Florian Kronenberg , Barbara Kollerits , Danilo Fliser
IPC分类号： G01N33/53
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/118
摘要： The present invention relates to a method for the determination or prediction of the progression of chronic kidney disease in a subject suspected to suffer from chronic kidney disease, said method comprising the step of determining the expression levels of at least one marker selected from (a) FGF23; and (b) adiponectin in a biological sample. Furthermore, the present invention relates to a use of a specific detection molecule for FGF23 or use of a specific detection molecule for adiponectin for the preparation of a diagnostic composition for the detection of chronic kidney disease or the progression of chronic kidney diseases in a subject suspected to suffer from said disease. In particular, the present invention also provides for use of FGF23 and/or of adiponectin as an in vitro marker for the presence, absence or progression of a chronic kidney disease and kits comprising a specific detection molecule for FGF23 or a specific detection molecule for adiponectin for use in the method of the present invention.
摘要翻译：本发明涉及一种用于确定或预测疑似患有慢性肾脏疾病的受试者的慢性肾脏疾病进展的方法，所述方法包括确定选自（a）的至少一种标志物的表达水平的步骤， FGF23; 和（b）生物样品中的脂联素。此外，本发明涉及用于FGF23的特异性检测分子的用途或者用于脂联素的特异性检测分子的用途，用于制备用于检测受试者的慢性肾脏疾病或慢性肾脏疾病进展的诊断组合物患有所述疾病。特别地，本发明还提供使用FGF23和/或脂连蛋白作为慢性肾脏疾病的存在，不存在或进展的体外标记物，以及包含用于FGF23的特异性检测分子或脂联素特异性检测分子的试剂盒用于本发明的方法中。

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