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1. 发明授权

US08888735B2 High shear application in medical therapy 有权
标题翻译：高剪切应用于医学治疗
公开(公告)号：US08888735B2
公开(公告)日：2014-11-18
申请号：US13082882
申请日：2011-04-08
申请人： Abbas Hassan , Rayford G. Anthony , Aziz Hassan
发明人： Abbas Hassan , Rayford G. Anthony , Aziz Hassan
IPC分类号： A61M5/00 , A61J3/00 , B01F7/00 , B01F13/10 , A61M5/142 , A61K9/00
CPC分类号： A61J3/00 , A61K9/0019 , A61M5/142 , B01F7/00766 , B01F7/008 , B01F13/1016
摘要： In this disclosure, a method is described wherein the method comprises mixing a therapeutic gas or a therapeutic liquid or a combination thereof and a liquid carrier in a high shear device to produce a dispersion; and administering the produced dispersion intravenously to a patient; wherein the produced dispersion contains nanobubbles of the therapeutic gas or droplets of the therapeutic liquid with a mean diameter of less than about 1.5 μm. In this disclosure, a system is also described wherein the system comprises a therapeutic gas source or a therapeutic liquid source or a combination thereof; a liquid carrier source; a high shear device (HSD) having an inlet, an outlet, at least one rotor, and at least one stator separated by a shear gap; and a pump configured to control the flow rate and residence time of a fluid passing through the high shear device.
摘要翻译：在本公开中，描述了一种方法，其中所述方法包括在高剪切装置中混合治疗气体或治疗液体或其组合和液体载体以产生分散体; 并将产生的分散体静脉内施用于患者; 其中所制备的分散体含有平均直径小于约1.5μm的治疗液体的治疗气体或液滴的纳米气泡。在本公开中，还描述了一种系统，其中系统包括治疗气体源或治疗液体源或其组合; 液体载体源; 具有入口，出口，至少一个转子和由剪切间隔分开的至少一个定子的高剪切装置（HSD）; 以及构造成控制通过高剪切装置的流体的流速和停留时间的泵。

2. 发明授权

US08729290B2 Method of making glycerol 有权
标题翻译：制备甘油的方法
公开(公告)号：US08729290B2
公开(公告)日：2014-05-20
申请号：US13584219
申请日：2012-08-13
申请人： Abbas Hassan , Ebrahim Bagherzadeh , Rayford Anthony , Gregory Borsinger , Aziz Hassan
发明人： Abbas Hassan , Ebrahim Bagherzadeh , Rayford Anthony , Gregory Borsinger , Aziz Hassan
IPC分类号： C07C261/00
CPC分类号： C07C29/04 , B01F7/00766 , B01F13/1013 , B01F13/1016 , B01J8/025 , B01J8/20 , B01J19/0066 , B01J19/1806 , B01J2219/00006 , B01J2219/00779 , C07C29/48 , C07C31/225
摘要： Method of producing glycerol that includes mixing a peroxide stream with an olefenic alcohol stream to form a feed stream; processing the feed stream in a high shear device to produce a high shear dispersion of peroxide and olefinic alcohol, wherein the high shear device is configured with a rotor and a stator separated by a shear gap; and contacting the high shear dispersion with a catalyst in a reactor to produce glycerol.
摘要翻译：制备甘油的方法，包括将过氧化物流与烯醇流混合以形成进料流; 在高剪切装置中处理进料流以产生过氧化物和烯烃的高剪切分散体，其中高剪切装置构造有由剪切间隙分开的转子和定子; 并将高剪切分散体与催化剂在反应器中接触以产生甘油。

3. 发明申请

US20130345472A1 METHOD AND SYSTEM FOR LIQUID PHASE REACTIONS USING HIGH SHEAR 有权
标题翻译：使用高剪切液相反应的方法和系统
公开(公告)号：US20130345472A1
公开(公告)日：2013-12-26
申请号：US13530032
申请日：2012-06-21
申请人： Abbas HASSAN , Aziz HASSAN , Rayford G. ANTHONY , Gregory BORSINGER
发明人： Abbas HASSAN , Aziz HASSAN , Rayford G. ANTHONY , Gregory BORSINGER
IPC分类号： C07B41/08 , C07B41/02 , C07C2/88 , B01J19/00
CPC分类号： C07B41/08 , B01F7/00766 , B01F13/1016 , B01J19/0066 , B01J19/1806 , B01J2219/00083 , C07B41/02 , C07C2/88 , C07C29/149 , C07C45/49 , C07C45/87 , C07C51/12 , C10G2/30 , C10G2/35 , C10G2/50 , C07C53/08 , C07C31/08 , C07C47/06 , C07C49/90
摘要： A method of reacting one or more components in a liquid phase to form an organic product, the method including feeding a carbon-based gas to a high shear device; feeding a hydrogen-based liquid medium to the high shear device; using the high shear device to form a dispersion comprising the carbon-based gas and the hydrogen-based liquid medium, wherein the dispersion comprises gas bubbles with a mean diameter of less than about 5 μm; introducing the dispersion into a reactor; and reacting the dispersion to produce the organic product.
摘要翻译：一种在液相中使一种或多种组分反应以形成有机产物的方法，所述方法包括将碳基气体进料到高剪切装置; 将氢基液体介质供给高剪切装置; 使用高剪切装置形成包含碳基气体和氢基液体介质的分散体，其中分散体包含平均直径小于约5μm的气泡; 将分散体引入反应器; 并使该分散体反应生成有机产物。

4. 发明授权

US08455706B2 Method of making linear alkylbenzenes 失效
标题翻译：制备直链烷基苯的方法
公开(公告)号：US08455706B2
公开(公告)日：2013-06-04
申请号：US13563894
申请日：2012-08-01
申请人： Abbas Hassan , Ebrahim Bagherzadeh , Rayford G. Anthony , Gregory Borsinger , Aziz Hassan
发明人： Abbas Hassan , Ebrahim Bagherzadeh , Rayford G. Anthony , Gregory Borsinger , Aziz Hassan
IPC分类号： C07C2/60 , C07C2/62
CPC分类号： B01J19/1806 , B01F7/00766 , B01F13/1013 , B01F13/1016 , B01J8/025 , B01J8/20 , B01J19/0066 , B01J2219/00006 , B01J2219/00779 , C07C2/68 , C07C2527/08 , C07C2527/10 , C07C15/107 , C07C15/02
摘要： A method of producing a linear alkylbenzene that includes introducing an olefin into an aromatic stream to form a mixture; processing the mixture in a shear device at a shear rate greater than about 20,000 s−1 to form a dispersion; and reacting the dispersion in the presence of a catalyst in a reactor vessel to form a linear alkylbenzene product stream, wherein the reactor vessel is maintained at a bulk reaction temperature in the range of about 0° C. to about 60° C.
摘要翻译：线性烷基苯的制备方法，其包括将烯烃引入到芳族物流中以形成混合物; 以大于约20,000s -1的剪切速率在剪切装置中处理混合物以形成分散体; 并在催化剂存在下在反应器容器中使分散体反应以形成直链烷基苯产物流，其中反应器容器保持在约0℃至约60℃的本体反应温度。

5. 发明申请

US20130133514A1 APPARATUS AND METHOD FOR GAS SEPARATION 有权
标题翻译：气体分离装置和方法
公开(公告)号：US20130133514A1
公开(公告)日：2013-05-30
申请号：US13568888
申请日：2012-08-07
申请人： Abbas Hassan , Rayford G. Anthony , Aziz Hassan
发明人： Abbas Hassan , Rayford G. Anthony , Aziz Hassan
IPC分类号： B01D45/14
CPC分类号： B01D53/24 , B01D45/14 , B01D53/22 , B01D59/20 , B01D63/06 , B01D2256/24 , B01D2257/102 , B01D2257/504 , B01D2313/18 , B04B5/08 , B04B7/08 , Y02C10/10
摘要： Herein disclosed is an apparatus that includes a porous rotor positioned about an axis of rotation and surrounding an interior space wherein the porous rotor comprises sintered metal or ceramic; an outer casing, wherein the outer casing and the porous rotor are separated by an annular space; and a motor configured for rotating the porous rotor about the axis of rotation.
摘要翻译：本文公开了一种装置，其包括围绕旋转轴定位并围绕内部空间的多孔转子，其中多孔转子包括烧结金属或陶瓷; 外壳，其中所述外壳和所述多孔转子由环形空间分开; 以及电动机，其构造成用于绕所述旋转轴线旋转所述多孔转子。

6. 发明授权

US08450539B2 High shear process for producing micronized waxes 有权
标题翻译：用于生产微粉化蜡的高剪切过程
公开(公告)号：US08450539B2
公开(公告)日：2013-05-28
申请号：US12613916
申请日：2009-11-06
申请人： Abbas Hassan , Aziz Hassan , Gregory G. Borsinger
发明人： Abbas Hassan , Aziz Hassan , Gregory G. Borsinger
IPC分类号： B01F7/00 , C08L91/06
CPC分类号： C07C67/04 , B01F3/0807 , B01F3/20 , B01F3/2078 , B01F5/0451 , B01F5/0463 , B01F5/0465 , B01F7/00766 , B01F13/1013 , B01F13/1016 , C07C2/06 , C07C67/00
摘要： A method and system for producing dispersed waxes, including a high shear mechanical device. In one embodiment, the method comprises forming a dispersion of wax globules in a carrier liquid in a high shear device prior to implementation in a waxy product. In another instance the system for producing waxy products comprises a high shear device for dispersing wax in a carrier liquid.
摘要翻译：用于生产分散蜡的方法和系统，包括高剪切机械装置。在一个实施方案中，该方法包括在蜡质产物中实施之前，在高剪切装置中的载体液体中形成蜡球的分散体。在另一个实例中，用于生产蜡质产品的系统包括用于将蜡分散在载体液体中的高剪切装置。

7. 发明授权

US08426653B2 Method of making chlorohydrins 有权
标题翻译：制备氯代醇的方法
公开(公告)号：US08426653B2
公开(公告)日：2013-04-23
申请号：US13455124
申请日：2012-04-24
申请人： Abbas Hassan , Ebrahim Bagherzadeh , Rayford G. Anthony , Gregory Borsinger , Aziz Hassan
发明人： Abbas Hassan , Ebrahim Bagherzadeh , Rayford G. Anthony , Gregory Borsinger , Aziz Hassan
IPC分类号： C07C29/64 , B01J10/10 , B01J14/00
CPC分类号： C07C29/66 , B01F7/00766 , B01F13/1013 , B01F13/1016 , C07C31/42
摘要： Methods and systems for the preparation of chlorohydrins are described herein. The method includes introducing a liquid stream into a high shear device, wherein the liquid stream has an aqueous phase; introducing a gas stream into the high shear device, wherein the gas stream has an olefin gas; forming a dispersion in the high shear device, the dispersion comprising gas bubbles dispersed in the liquid stream; and reacting at least a portion of the dispersion to produce chlorohydrin.
摘要翻译：本文描述了用于制备氯代醇的方法和系统。该方法包括将液体流引入高剪切装置，其中液体流具有水相; 将气流引入高剪切装置，其中气流具有烯烃气体; 在高剪切装置中形成分散体，所述分散体包含分散在液体流中的气泡; 并使至少一部分分散体反应以产生氯代醇。

8. 发明授权

US08371741B2 System and process for hydrodesulfurization, hydrodenitrogenation, or hydrofinishing 有权
标题翻译：加氢脱硫，加氢脱氮或加氢精制的系统和工艺
公开(公告)号：US08371741B2
公开(公告)日：2013-02-12
申请号：US13206322
申请日：2011-08-09
申请人： Abbas Hassan , Ebrahim Bagherzadeh , Rayford G. Anthony , Gregory Borsinger , Aziz Hassan
发明人： Abbas Hassan , Ebrahim Bagherzadeh , Rayford G. Anthony , Gregory Borsinger , Aziz Hassan
IPC分类号： B01J19/00
CPC分类号： B01F7/00766 , B01F3/04099 , B01F5/104 , B01F5/106 , B01F13/1013 , B01F13/1016 , C10G45/02 , C10G49/007 , C10G2300/1025 , C10G2300/1033 , C10G2300/104 , C10G2300/1044 , C10G2300/1051 , C10G2300/1055 , C10G2300/207 , C10G2300/4081 , C10G2400/02 , C10G2400/04 , C10G2400/08
摘要： A method for hydrodesulfurization by forming a dispersion comprising hydrogen-containing gas bubbles with a mean diameter of less than 1 micron dispersed in a liquid phase comprising sulfur-containing compounds. Desulfurizing a liquid stream comprising sulfur-containing compounds by subjecting a fluid mixture comprising hydrogen-containing gas and the liquid to a shear rate greater than 20,000 s−1 to produce a dispersion of hydrogen in a continuous phase of the liquid and introducing the dispersion into a fixed bed hydrodesulfurization reactor from which a reactor product is removed. Systems of apparatus for hydrodesulfurization are also presented.
摘要翻译：通过形成包含分散在包含含硫化合物的液相中的平均直径小于1微米的含氢气泡的分散体的加氢脱硫方法。通过使包含含氢气体和液体的流体混合物以大于20,000s -1的剪切速率经受包含含硫化合物的液体流，以在液体的连续相中产生氢的分散体并将该分散体引入固定床加氢脱硫反应器，从中除去反应器产物。还提出了加氢脱硫装置系统。

9. 发明申请

US20120330233A1 APPLYING SHEAR STRESS FOR DISEASE TREATMENT 有权
标题翻译：适用于疾病治疗的剪切应力
公开(公告)号：US20120330233A1
公开(公告)日：2012-12-27
申请号：US13558899
申请日：2012-07-26
申请人： Abbas Hassan , Rayford G. Anthony , Gregory G. Borsinger , Aziz Hassan
发明人： Abbas Hassan , Rayford G. Anthony , Gregory G. Borsinger , Aziz Hassan
IPC分类号： A61M37/00
CPC分类号： A61M5/142 , A61K9/0019 , A61M1/36 , A61M2206/16 , B01F7/00766
摘要： Herein disclosed is a system for applying shear stress ex-situ to a fluid. In some embodiments, the system comprises a shear device; and at least one device configured for intravenous administration of the fluid to a patient, the devices defining a fluid passage configured to be sterilized and maintained sterile during use, the fluid comprising at least one therapeutic fluid, blood, or a combination thereof. The shear device of the system is in fluid communication with the at least one device configured for intravenous administration of the fluid to a patient. Herein also disclosed is a method of preparing a fluid for intravenous administration to a patient.
摘要翻译：这里公开了一种用于将流体非原位施加剪切应力的系统。在一些实施例中，系统包括剪切装置; 以及至少一个被配置用于向患者静脉内施用流体的装置，所述装置限定被构造成在使用期间被灭菌并保持无菌的流体通道，所述流体包括至少一种治疗流体，血液或其组合。系统的剪切装置与至少一个被配置用于向患者静脉内施用流体的装置流体连通。本文还公开了制备用于静脉内施用给患者的流体的方法。

10. 发明申请

US20120309058A1 HIGH SHEAR PROCESS FOR DEXTROSE PRODUCTION 失效
标题翻译：用于食品生产的高剪切过程
公开(公告)号：US20120309058A1
公开(公告)日：2012-12-06
申请号：US13584250
申请日：2012-08-13
申请人： Abbas Hassan , Ebrahim Bagherzadeh , Rayford G. Anthony , Gregory Borsinger , Aziz Hassan
发明人： Abbas Hassan , Ebrahim Bagherzadeh , Rayford G. Anthony , Gregory Borsinger , Aziz Hassan
IPC分类号： C12P19/00 , C12M1/00 , C12P19/20 , C12P19/22 , C12P19/14
CPC分类号： C13K1/06 , A23L29/35 , C08B30/12
摘要： A method for producing starch hydrolysate that includes processing in a high shear device a hydrolytic solution having a component selected from the group consisting of acids, hydrolytic enzymes, and combinations thereof, and an aqueous starch solution to produce a dispersion, wherein the high shear device is configured with a rotor and a stator; and transferring the dispersion from the high shear device to a reactor from which a starch hydrolysate product comprising dextrose is removed, wherein the operating temperature within the reactor is maintained at a temperature of less than about 160° C.
摘要翻译：一种生产淀粉水解物的方法，包括在高剪切装置中加工具有选自酸，水解酶及其组合的组分的水解溶液和淀粉水溶液以产生分散体，其中所述高剪切装置配置有转子和定子; 并将分散体从高剪切装置转移到除去包含葡萄糖的淀粉水解物产物的反应器，其中反应器内的操作温度保持在小于约160℃的温度下

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