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1. 发明授权

US5851670A In vivo-soluble composite particles comprising calcium phosphate 失效
标题翻译：包含磷酸钙的体内可溶性复合颗粒
公开(公告)号：US5851670A
公开(公告)日：1998-12-22
申请号：US790984
申请日：1997-01-29
申请人： Ayumi Mitoh , Tetsuro Ogawa
发明人： Ayumi Mitoh , Tetsuro Ogawa
IPC分类号： A61K9/00 , A61K9/16 , A61K9/18 , A61K9/50 , A61K47/02 , A61K47/30 , B32B5/16 , A01N59/26
CPC分类号： A61K9/501 , A61K9/1647 , A61K9/1652 , Y10T428/2991 , Y10T428/2998
摘要： In vivo-soluble composite particles involving a particle of a polymeric substance such as polylactic acid and the like soluble in a living body, having coated on a surface thereof, a calcium phosphate compound having a Ca/P ratio of about 1.0 to 2.0. The in vivo-soluble composite particles have a highly increased adsorptivity with regard to medicaments, antigens and others and also the in vivo-soluble composite particles can be dissolved or decomposed in the living body without producing a remainder in the body.
摘要翻译：涉及可溶于生物体的聚乳酸等聚合物质粒子的表面具有约1.0〜2.0的Ca / P比的磷酸钙化合物的体内可溶性复合粒子。体内可溶性复合粒子对于药物，抗原等具有高度增加的吸附性，并且体内可溶性复合颗粒可以在生物体中溶解或分解而不会在体内产生余留物。

2. 发明授权

US5736099A Test plates for agglutination test and production process thereof 失效
标题翻译：凝集试验用试验板及其制造方法
公开(公告)号：US5736099A
公开(公告)日：1998-04-07
申请号：US579584
申请日：1995-12-28
申请人： Tsuneo Hiraide , Tetsuro Ogawa , Ayumi Mitoh , Tadahiko Kitano , Mikio Nakayama
发明人： Tsuneo Hiraide , Tetsuro Ogawa , Ayumi Mitoh , Tadahiko Kitano , Mikio Nakayama
IPC分类号： A61B5/00 , A61B5/15 , G01N33/543 , G01N33/53
CPC分类号： G01N33/54366
摘要： A test plate for an agglutination test which comprises a plate with a plurality of wells formed thereon, each of the wells having adhered to a surface thereof a protein A and/or a protein G. The agglutination test plate, according to the present invention, when used in an agglutination test, can ensure a clear judgment concerning the formation of an agglutinative image or a non-agglutinative image, along with a good determination sensitivity. A process for the production of such an agglutination test plate is also provided.
摘要翻译：一种用于凝集试验的试验板，其包括在其上形成有多个孔的板，每个孔的表面粘附有蛋白A和/或蛋白G.根据本发明的凝集试验板，当用于凝集试验时，可以确保对凝集图像或非凝集图像的形成的清晰判断以及良好的测定灵敏度。还提供了生产这种凝集试验板的方法。

3. 发明授权

US5827669A Sheets, kits and methods for detecting antigens or antibodies 失效
标题翻译：用于检测抗原或抗体的片剂，试剂盒和方法
公开(公告)号：US5827669A
公开(公告)日：1998-10-27
申请号：US746485
申请日：1996-11-12
申请人： Mikio Nakayama , Tadahiko Kitano , Ayumi Mitoh , Tetsuro Ogawa , Tsuneo Hiraide
发明人： Mikio Nakayama , Tadahiko Kitano , Ayumi Mitoh , Tetsuro Ogawa , Tsuneo Hiraide
IPC分类号： G01N33/53 , G01N33/543 , G01N33/547 , G01N33/551
CPC分类号： G01N33/54306 , G01N33/54313 , Y10S435/969 , Y10S435/97 , Y10S435/975 , Y10S436/808
摘要： A detection sheet capable of detecting an antigen or antibody in a biological fluid with a high sensitivity in a simple operation, as well as a detection kit and detection method using the detection sheet. The detection sheet comprises (a) a fibrous aggregate with carried particles of a calcium phosphate compound having an average particle diameter of about 0.01 to 200 microns and a Ca/P ratio of about 1.0 to 2.0, and (b) an avidin, streptavidin or avidin derivative from which carbohydrates have been extracted immobilized on said calcium phosphate compound. After a biotinylated antigen or antibody is bonded to the immobilized avidin, streptavidin, or avidin derivative of the detection sheet, the detection sheet is contacted with a test solution to thereby bond an antigen or antibody of the test solution to the detection sheet. The detection sheet is then contacted with a solution of labeling compound capable of being specifically bonded to the antigen or antibody of said test solution to detect the thus labeled antigen-antibody complex.
摘要翻译：能够在简单的操作中能够以高灵敏度检测生物流体中的抗原或抗体的检测片以及使用检测片的检测试剂盒和检测方法。检测片包括（a）具有平均粒径为约0.01至200微米并且Ca / P比为约1.0至2.0的带有磷酸钙化合物的载体的纤维聚集体，和（b）抗生物素蛋白，链霉抗生物素蛋白或提取固定在所述磷酸钙化合物上的碳水化合物的抗生物素蛋白衍生物。将生物素化的抗原或抗体与检测片的固定化抗生物素蛋白，链亲和素或抗生物蛋白衍生物结合后，使检测片与测试溶液接触，从而将检测溶液的抗原或抗体与检测片结合。然后将检测片与能够与所述测试溶液的抗原或抗体特异性结合的标记化合物溶液接触，以检测如此标记的抗原 - 抗体复合物。

4. 发明授权

US6040196A Method of evaluating a testing element for antigens or antibodies 失效
标题翻译：评估抗原或抗体检测元件的方法
公开(公告)号：US6040196A
公开(公告)日：2000-03-21
申请号：US754647
申请日：1996-11-21
申请人： Ayumi Mitoh , Tsuneo Hiraide
发明人： Ayumi Mitoh , Tsuneo Hiraide
IPC分类号： G01N33/545 , G01N33/543 , G01N33/551 , G01N21/00 , G01N33/53 , A61L5/103
CPC分类号： G01N33/54386 , G01N33/551 , Y10S435/81 , Y10S435/97 , Y10S436/81
摘要： An evaluating method of a testing element having an immobilized antigen or antibody on an immobilizing carrier thereof, which immobilized antigen or antibody has yet to react with another antigen or antibody, which involves contacting the testing element with a solution containing an antibody or antigen reactive with the immobilized antigen or antibody, specifically binding a labelling compound to the reactive antibody or antigen to thereby cause a color-developing reaction of the labelling compound, and determining an amount of the antigen or antibody immobilized on the testing element as a function of a level of produced color. Using this evaluation method, a quantitative determination of the immobilized antigen or antibody can be carried out, and thus the performance of the testing element for antigens or antibodies can be evaluated.
摘要翻译：固定化抗原或抗体与其他抗原或抗体反应的固定化抗原或抗体的固定化抗原或抗体的检测元件的评价方法，其包括使检测元件与含有与固定化的抗原或抗体，特异性地将标记化合物结合到反应性抗体或抗原上，从而引起标记化合物的显色反应，并测定固定在测试元件上的抗原或抗体的量作为水平的函数的颜色。使用该评价方法，可以进行固定化的抗原或抗体的定量测定，因此可以评价抗原或抗体的检测元件的性能。

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