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1. 发明授权

US08808171B2 Endoscopy device and method for simultaneous observation of several zones of interest 有权
标题翻译：用于同时观察几个感兴趣区域的内窥镜检查装置和方法
公开(公告)号：US08808171B2
公开(公告)日：2014-08-19
申请号：US12300247
申请日：2007-05-11
申请人： Francois Lacombe , Bertrand Viellerobe , Nicolas Boularot , Francois Doussoux , Aymeric Perchant
发明人： Francois Lacombe , Bertrand Viellerobe , Nicolas Boularot , Francois Doussoux , Aymeric Perchant
IPC分类号： A61B1/06 , A61B1/00 , A61B1/04 , G02B23/26 , G02B6/06 , A61B5/00 , A61B1/313
CPC分类号： G02B23/26 , A61B1/00165 , A61B1/043 , A61B1/313 , A61B5/0068 , A61B5/0071 , A61B5/0075 , A61B5/0084 , G02B6/06
摘要： An endoscopy device includes several light guides (1, 2, 3), each light guide having one or more optical fibers. The light guides are coupled with a sweeping system (4) arranged to direct an excitation light beam in alternation in one of the fibers of the guides from the proximal end of the guide including the one of the fibers. In this way, the proximal ends of the guides may make use of the same sweeping system, whereas the distal ends of the guides may be installed simultaneously in different zones of interest of an object or animal (10) under study for an almost simultaneous observation of the zones of interest. The invention also relates to an endoscopy method used in a device according to the invention. A device and a method according to the invention may be applied to quasi-simultaneous reflectance, fluorescence, multi-photon imaging of several areas of interest.
摘要翻译：内窥镜检查装置包括若干个光导（1,2,3），每个光导具有一根或多根光纤。光导件与扫掠系统（4）耦合，所述清扫系统（4）被布置成从引导件的近端引导引导光纤中的一个纤维中的激发光束，所述光纤包括所述一个光纤。以这种方式，引导件的近端可以使用相同的扫掠系统，而引导件的远端可以同时安装在正在研究的几乎同时观察的物体或动物（10）的不同感兴趣的区域中的感兴趣区域。本发明还涉及在根据本发明的装置中使用的内窥镜检查方法。根据本发明的装置和方法可以应用于若干感兴趣区域的准同时反射，荧光，多光子成像。

2. 发明申请

US20100234686A1 ENDOSCOPY DEVICE AND METHOD FOR SIMULTANEOUS OBSERVATION OF SEVERAL ZONES OF INTEREST 有权
标题翻译：内窥镜装置和方法同时观察几个利益区域
公开(公告)号：US20100234686A1
公开(公告)日：2010-09-16
申请号：US12300247
申请日：2007-05-11
申请人： Francois Lacombe , Bertrand Viellerobe , Nicolas Boularot , Francois Doussoux , Aymeric Perchant
发明人： Francois Lacombe , Bertrand Viellerobe , Nicolas Boularot , Francois Doussoux , Aymeric Perchant
IPC分类号： A61B1/06 , G02B6/04
CPC分类号： G02B23/26 , A61B1/00165 , A61B1/043 , A61B1/313 , A61B5/0068 , A61B5/0071 , A61B5/0075 , A61B5/0084 , G02B6/06
摘要： An endoscopy device includes several light guides (1, 2, 3), each light guide having one or more optical fibres. The light guides are coupled with a sweeping system (4) arranged to direct an excitation light beam in alternation in one of the fibres of the guides from the proximal end of the guide including the one of the fibres. In this way, the proximal ends of the guides may make use of the same sweeping system, whereas the distal ends of the guides may be installed simultaneously in different zones of interest of an object or animal (10) under study for an almost simultaneous observation of the zones of interest. The invention also relates to an endoscopy method used in a device according to the invention. A device and a method according to the invention may be applied to quasi-simultaneous reflectance, fluorescence, multi-photon imaging of several areas of interest.
摘要翻译：内窥镜检查装置包括若干个光导（1,2,3），每个光导具有一根或多根光纤。光导件与扫掠系统（4）耦合，所述清扫系统（4）被布置成从引导件的近端引导引导光纤中的一个纤维中的激发光束，所述光纤包括所述一个光纤。以这种方式，引导件的近端可以使用相同的扫掠系统，而引导件的远端可以同时安装在正在研究的几乎同时观察的物体或动物（10）的不同感兴趣的区域中的感兴趣区域。本发明还涉及在根据本发明的装置中使用的内窥镜检查方法。根据本发明的装置和方法可以应用于若干感兴趣区域的准同时反射，荧光，多光子成像。

3. 发明申请

US20070273930A1 Method and system for super-resolution of confocal images acquired through an image guide, and device used for implementing such a method 有权
标题翻译：通过图像引导获取的共焦图像的超分辨率的方法和系统，以及用于实现这种方法的装置
公开(公告)号：US20070273930A1
公开(公告)日：2007-11-29
申请号：US10585083
申请日：2004-12-29
申请人： Frédéric Berier , Aymeric Perchant
发明人： Frédéric Berier , Aymeric Perchant
IPC分类号： G06T5/00
CPC分类号： G06T3/4053 , G06T2207/10056 , G06T2207/30004
摘要： A method for increasing the resolution of confocal images acquired through an image guide whereof the distal end is associated with an optical head for focusing the laser beam emitted by the image guide in an observation object. For a given position of the optical head, the method includes the following steps: producing a plurality of acquisitions through the image guide, each acquisition being produced for a specific spatial shift of the distal end of the guide image relative to the optical head which remains stationary; transforming the data of each acquisition into a point cloud; registering each scatter plot relative to a point cloud taken as reference; superimposing the thus registered point clouds; and reconstructing a final image from the superimposition. Advantageously, a controlled piezoelectric tube is used arranged about the distal end of the image guide to shift the latter.
摘要翻译：一种用于增加通过其远端的图像引导获得的共焦图像的分辨率的方法，所述图像引导件与用于将由图像引导件发射的激光束聚焦在观察对象中的光学头相关联。对于光学头的给定位置，该方法包括以下步骤：通过图像引导件产生多个采集，每个采集被产生用于指导图像的远端相对于保留的光学头的特定空间位移静止的将每个采集的数据转换为点云; 将每个散点图相对于作为参考的点云注册; 叠加这样登记的点云; 并从叠加重建最终图像。有利地，使用控制压电管围绕图像引导件的远端布置以使其移动。

4. 发明申请

US20050078924A1 Confocal imaging equipment in particular for endoscope 有权
标题翻译：共焦成像设备，特别是内窥镜
公开(公告)号：US20050078924A1
公开(公告)日：2005-04-14
申请号：US10500160
申请日：2002-12-20
申请人： Bertrand Viellerobe , Magalie Genet , Frederic Berrier , Francois Lacombe , Aymeric Perchant , Georges Le Goualher , Sandra Marti , Stephane Bourriaux
发明人： Bertrand Viellerobe , Magalie Genet , Frederic Berrier , Francois Lacombe , Aymeric Perchant , Georges Le Goualher , Sandra Marti , Stephane Bourriaux
IPC分类号： G02B23/26 , A61B1/00 , A61B1/04 , A61B1/07 , G02B21/00 , G02B23/24 , G02B6/06
CPC分类号： A61B1/00188 , A61B1/00165 , A61B1/042 , A61B1/07 , A61B2562/0242 , G02B23/2469
摘要： The invention concerns an equipment comprising an image guide (1) consisting of flexible optical fibers with: on the proximal end side: a source (2), angular scanning means (3), injection means (4) in one of the fibers, means for splitting (5) the illuminating beam and the backscattered signal, means for spatial filtering (6), means for detecting (7) said signal, electronic means (8) for controlling, analyzing and digital processing of the detected signal and display; and on the distal end side: an optical head (9) for focusing the illuminating beam exiting from the illuminated fiber. The invention is characterized in that the means (3) comprise a resonant line mirror (M1) and a galvanometric field mirror (M2) with a variable frequency and two afocal optical systems adapted to conjugate the two mirrors (M1, M2) firstly in the field mirror (M2) and the injection means (4) in the image guide in a second step.
摘要翻译：本发明涉及一种包括由柔性光纤组成的图像引导件（1）的设备，其具有：在基端侧：源（2），角扫描装置（3），其中一个光纤中的注射装置（4）用于分离（5）照明光束和反向散射信号，用于空间滤波的装置（6），用于检测（7）所述信号的装置，用于控制，分析和数字处理检测到的信号和显示的电子装置（8）并且在远端侧：用于聚焦从照明光纤出射的照明光束的光学头（9）。本发明的特征在于，装置（3）包括谐振线路反射镜（M1）和具有可变频率和两个无焦光学系统的电流计镜（M2），其适于首先在两个反射镜（M1，M2）中共轭场镜（M2）和注射装置（4）在第二步骤中。

5. 发明授权

US08718398B2 Image processing method and apparatus 有权
标题翻译：图像处理方法和装置
公开(公告)号：US08718398B2
公开(公告)日：2014-05-06
申请号：US13141991
申请日：2009-12-28
申请人： Aymeric Perchant , Nicolas Savoire
发明人： Aymeric Perchant , Nicolas Savoire
IPC分类号： G06K9/40
CPC分类号： G02B6/06 , G06T7/80 , G06T2207/10068
摘要： A method to process an image acquired through an optical-fiber guide includes acquiring a first reference image through the optical-fiber guide, acquiring a second calibration image through the optical-fiber guide, spatially identifying each fiber of the optical-fiber guide of the second calibration image in a first detection map, acquiring a recalibration image through the optical-fiber guide, determining a geometrical transformation to make the recalibration image coincide with the first reference image, deriving a new detection map spatially identifying each fiber of the optical-fiber guide of the recalibration image, wherein the new detection map is derived using the geometrical transformation and the first detection map, and individually processing zones of an acquired image corresponding to each fiber of the optical-fiber guide using the new detection map.
摘要翻译：一种处理通过光纤引导获得的图像的方法，包括：通过光纤引导获取第一参考图像，通过光纤引导获取第二校准图像，在空间上识别光纤引导件的每个光纤在第一检测图中获取第二校准图像，通过光纤引导件获取重新校准图像，确定几何变换以使重新校准图像与第一参考图像一致，导出空间上识别光纤的每个光纤的新的检测图引导重新校正图像，其中使用几何变换和第一检测图导出新的检测图，并且使用新的检测图单独处理与光纤引导件的每个光纤相对应的获取的图像的区域。

6. 发明授权

US08600134B2 Method and system for processing images acquired in real time through a medical device 有权
标题翻译：用于处理通过医疗装置实时获取的图像的方法和系统
公开(公告)号：US08600134B2
公开(公告)日：2013-12-03
申请号：US13144518
申请日：2010-01-29
申请人： Tom Vercauteren , Aymeric Perchant , Francois Lacombe , Nicolas Savoire
发明人： Tom Vercauteren , Aymeric Perchant , Francois Lacombe , Nicolas Savoire
IPC分类号： G06K9/00
CPC分类号： G06T5/50 , G06T3/4038 , G06T3/4053 , G06T2207/10068 , G06T2207/30028 , G06T2207/30104
摘要： A method for processing images acquired in real time through a medical device, said images being loaded into a buffer, comprising the steps of: stopping the loading of the images into the buffer, processing loaded images using an incremental algorithm, displaying successively intermediate results of the processing, resuming the loading and stopping the processing based on an evaluation of said intermediate results.
摘要翻译：一种用于处理通过医疗设备实时获取的图像的方法，所述图像被加载到缓冲器中，包括以下步骤：停止将图像加载到缓冲器中，使用增量算法处理加载的图像，显示连续的中间结果处理，基于所述中间结果的评估恢复加载和停止处理。

7. 发明申请

US20110261262A1 ROBUST MOSAICING METHOD, NOTABLY WITH CORRECTION OF MOTION DISTORTIONS AND TISSUE DEFORMATIONS FOR A VIVO FIBERED MICROSCOPY 有权
标题翻译：稳定的MOSAICING方法，可以修正运动失真和VIVO FIBERED MICROSCOPY的组织变形
公开(公告)号：US20110261262A1
公开(公告)日：2011-10-27
申请号：US13178688
申请日：2011-07-08
申请人： Tom Vercauteren , Aymeric Perchant , Nicholas Ayache , Xavier Pennec , Gregoire Malandain
发明人： Tom Vercauteren , Aymeric Perchant , Nicholas Ayache , Xavier Pennec , Gregoire Malandain
IPC分类号： H04N5/00
CPC分类号： G06K9/00134 , G02B21/367 , G06T3/4038 , G06T7/35 , G06T2207/10056
摘要： The present invention concerns a mosaicing method taking into account motion distortions, irregularly sampled frames and non-rigid deformations of the imaged tissue. The invention relates to a method for mosaicing frames from a video sequence acquired from a scanning device such as a scanning microscope, the method comprising the steps of: a) compensating for motion and motion distortion due to the scanning microscope, b) applying a global optimisation of inter-frame registration to align consistently the frames c) applying a construction algorithm on the registered frames to construct a mosaic, and d) applying a fine frame-to-mosaic non rigid registration. The method is based on a hierarchical framework that is able to recover a globally consistent alignment of the input frames, to compensate for the motion distortions and to capture the non-rigid deformations.
摘要翻译：本发明涉及考虑到成像组织的运动失真，不规则采样帧和非刚性变形的镶嵌方法。本发明涉及一种用于从诸如扫描显微镜的扫描装置获取的视频序列拼接帧的方法，所述方法包括以下步骤：a）补偿由扫描显微镜引起的运动和运动失真，b）应用全局框架间注册的优化以一致地对准帧c）在注册的帧上应用构造算法以构建马赛克，以及d）应用精细的帧到马赛克非刚性注册。该方法基于能够恢复输入帧的全局一致对齐的分层框架，以补偿运动失真并捕获非刚性变形。

8. 发明授权

US07903848B2 Method for processing an image acquired through a guide consisting of a plurality of optical fibers 有权
标题翻译：用于处理通过由多根光纤构成的导向器获取的图像的方法
公开(公告)号：US07903848B2
公开(公告)日：2011-03-08
申请号：US10520917
申请日：2003-07-11
申请人： Aymeric Perchant , Georges Le Goualher , Frederic Berier
发明人： Aymeric Perchant , Georges Le Goualher , Frederic Berier
IPC分类号： G02B6/06 , G06K9/00 , G06K9/36 , H04N13/02 , H04N5/00
CPC分类号： G06T5/008 , G06T2207/10056
摘要： A method for processing an image acquired through a guide consisting of a plurality of optical fibers includes, for each optical fiber, isolating on the acquired image a zone corresponding to the optical fiber, locally processing each zone individually to correct the photon flux detected in each optical fiber, then reconstructing the acquired image by eliminating the pattern caused by the optical fiber. The method also includes a sampling process for obtaining, for each optical fiber and from a sampling image, a sample injection rate which can be used for reconstructing the acquired images. The method also includes a prior step which consists in detecting the fibers from a target.
摘要翻译：用于处理通过由多根光纤组成的导向器获取的图像的方法包括：对于每个光纤，在所获取的图像上隔离与光纤对应的区域，分别对每个区域进行局部处理，以校正每个光纤中检测到的光子通量光纤，然后通过消除由光纤引起的图案来重构获取的图像。该方法还包括用于从每个光纤和采样图像获得可用于重建获取的图像的样本注入速率的采样处理。该方法还包括一个前期步骤，其中包括从目标物中检测纤维。

9. 发明授权

US07911590B2 Method and system for measuring the speed of blood flow 有权
标题翻译：测量血流速度的方法和系统
公开(公告)号：US07911590B2
公开(公告)日：2011-03-22
申请号：US11547197
申请日：2005-03-25
申请人： Francois Lacombe , Georges Le Goualher , Aymeric Perchant , Nicholas Ayache
发明人： Francois Lacombe , Georges Le Goualher , Aymeric Perchant , Nicholas Ayache
IPC分类号： G01P3/36
CPC分类号： A61B3/1241 , A61B3/1025 , G01F1/7086 , G01N15/147 , G01N15/1475 , G01N2015/1075 , G01N2015/145 , G02B21/0028 , G02B21/0084
摘要： The invention relates to a method for measuring the speed of a particle such as a red blood cell moving inside a flow such as a flow of the blood, using a light scanning microscope. The inventive method comprises the following steps: acquisition of an image by x and y light scanning on a plane containing the object; detection on the plane (x, y) of a mark on the plane (x, y); estimation of the speed vg of the object from the gradient thus determined.
摘要翻译：本发明涉及一种使用光扫描显微镜测量诸如血液流动之类的流动中移动的红细胞等粒子的速度的方法。本发明的方法包括以下步骤：在包含对象的平面上通过x和y光扫描获取图像; 在平面上的标记（x，y）上的检测（x，y）; 从如此确定的梯度估计对象的速度vg。

10. 发明授权

US07646938B2 Method and system for super-resolution of confocal images acquired through an image guide, and device used for implementing such a method 有权
标题翻译：通过图像引导获取的共焦图像的超分辨率的方法和系统，以及用于实现这种方法的装置
公开(公告)号：US07646938B2
公开(公告)日：2010-01-12
申请号：US10585083
申请日：2004-12-29
申请人： Frédéric Berier , Aymeric Perchant
发明人： Frédéric Berier , Aymeric Perchant
IPC分类号： G06K9/32 , G06F15/00
CPC分类号： G06T3/4053 , G06T2207/10056 , G06T2207/30004
摘要： A method for increasing the resolution of confocal images acquired through an image guide whereof the distal end is associated with an optical head for focusing the laser beam emitted by the image guide in an observation object. For a given position of the optical head, the method includes the following steps: producing a plurality of acquisitions through the image guide, each acquisition being produced for a specific spatial shift of the distal end of the guide image relative to the optical head which remains stationary; transforming the data of each acquisition into a point cloud; registering each scatter plot relative to a point cloud taken as reference; superimposing the thus registered point clouds; and reconstructing a final image from the superimposition. Advantageously, a controlled piezoelectric tube is used arranged about the distal end of the image guide to shift the latter.
摘要翻译：一种用于增加通过其远端的图像引导获得的共焦图像的分辨率的方法，所述图像引导件与用于将由图像引导件发射的激光束聚焦在观察对象中的光学头相关联。对于光学头的给定位置，该方法包括以下步骤：通过图像引导件产生多个采集，每个采集被产生用于指导图像的远端相对于保留的光学头的特定空间位移静止的将每个采集的数据转化为点云; 将每个散点图相对于作为参考的点云注册; 叠加这样登记的点云; 并从叠加重建最终图像。有利地，使用控制压电管围绕图像引导件的远端布置以使其移动。

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