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    • 3. 发明申请
    • METHOD AND SYSTEM FOR MODULATING ENERGY EXPENDITURE AND NEUROTROPHIC FACTORS
    • 调节能源支出和神经营养因子的方法和系统
    • US20080046012A1
    • 2008-02-21
    • US11851821
    • 2007-09-07
    • Alejandro CovalinJack JudyAvi Feshali
    • Alejandro CovalinJack JudyAvi Feshali
    • A61N1/00
    • A61N1/36025A61N1/36082
    • A method system for modulating the energy expenditure and/or the expressed brain-derived neurotrophic factor (BDNF) in the brain of an individual is performed by a system that includes a control device that generates a stimulation pattern from a predetermined set of stimulation parameters, and that converts the stimulation pattern into a stimulation signal. A stimulation signal delivery mechanism, configured for implantation into a selected part of the brain, receives the stimulation signal from the control device and delivers the signal to the selected part of the brain. The stimulation signal may be an electrical signal delivered by a brain-implantable electrode, or a chemical signal in the form of a drug dosage regimen delivered by an implantable micropump under the control of the control device. Modulation of the energy expenditure and/or BDNF is achieved by the stimulation of the hypothalamus, either directly or indirectly, by the stimulation signal.
    • 用于调节个体脑中能量消耗和/或表达的脑源性神经营养因子(BDNF)的方法系统由包括从预定刺激参数组产生刺激模式的控制装置的系统执行, 并将刺激模式转换为刺激信号。 被配置为植入到脑的选定部分中的刺激信号传递机构接收来自控制装置的刺激信号,并将该信号传送到脑的选定部分。 刺激信号可以是由脑可植入电极传递的电信号,或者是由控制装置的控制下由可植入的微型泵递送的药物剂量形式的化学信号。 通过刺激信号直接或间接地刺激下丘脑来实现能量消耗和/或BDNF的调节。