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    • 2. 发明申请
    • BIOSENSOR, METHOD FOR FABRICATING THE SAME, DETECTING METHOD UTILIZING THE SAME
    • 生物传感器,其制造方法,使用该方法的检测方法
    • US20100137155A1
    • 2010-06-03
    • US12376712
    • 2007-08-02
    • Yoshiroh AkagiKazuo BanKyoko SeoNaoya IchimuraAtsushi Mizusawa
    • Yoshiroh AkagiKazuo BanKyoko SeoNaoya IchimuraAtsushi Mizusawa
    • C40B30/04C40B40/10C40B50/14
    • G01N33/54353
    • A biosensor capable of highly sensitive detection of a recognition target substance while having structural stability is provided at low cost. The biosensor is for capturing and detecting a recognition target substance and includes a linker made of a hydrocarbon compound having two or more particular functional groups, a peptide serving as a molecular recognition substance directly bonded to one particular functional group of the linker, and a support directly bonded to the other particular functional group of the linker. Preferably, the particular functional groups each are a reaction product functional group of an epoxy group and an amino group. The peptide is an artificially synthesized peptide including three or more consecutive amino acid sequences, among amino acid sequences of a natural immunoglobulin, that exist in a part corresponding to a hypervariable area of the natural immunoglobulin.
    • 以低成本提供能够高度敏感地检测识别目标物质同时具有结构稳定性的生物传感器。 生物传感器用于捕获和检测识别目标物质,并且包括由具有两个或更多个特定官能团的烃化合物制成的接头,用作直接键合到接头的一个特定官能团的分子识别物质的肽,以及载体 直接键合到接头的另一个特定官能团。 优选地,特定的官能团各自为环氧基和氨基的反应产物官能团。 肽是天然免疫球蛋白的氨基酸序列中存在于对应于天然免疫球蛋白的高变区的部分中的三个或更多个连续氨基酸序列的人工合成的肽。