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1. 发明授权

US5296492A Certain chroman derivatives useful for treating symptoms caused by contraction of smooth muscles, circulatory diseases or epilepsy 失效
标题翻译：某些苯并二氢吡喃衍生物可用于治疗由平滑肌，循环系统疾病或癫痫的收缩引起的症状
公开(公告)号：US5296492A
公开(公告)日：1994-03-22
申请号：US893403
申请日：1992-06-03
申请人： Akira Shiozawa , Atsuro Inubushi , Kazuhisa Narita , Yukihiro Sagawa , Makoto Hosono , Masashi Iida
发明人： Akira Shiozawa , Atsuro Inubushi , Kazuhisa Narita , Yukihiro Sagawa , Makoto Hosono , Masashi Iida
IPC分类号： A61K31/35 , A61K31/353 , A61K31/44 , A61K31/4433 , A61P9/00 , A61P21/00 , C07D213/50 , C07D213/64 , C07D311/20 , C07D311/68 , C07D405/04 , C07F7/18 , C07D407/04 , C07F7/02 , A61K31/695
CPC分类号： C07D405/04 , C07F7/1856
摘要： A chroman derivative represented by the following general formula [1]: ##STR1## wherein R.sub.1 represents cyano group, nitro group, halogenomethyl group or --SO.sub.2 --X group (X represents lower alkyl group having 1-6 carbon atoms or aryl group); R.sub.2 represents hydrogen atom or OA group (A represents hydrogen atom, nitro group, lower acyl group having 1-6 carbon atoms, arylcarbonyl group, lower alkylsulfonyl group having 1-6 carbon atoms, arylsulfonyl group, arylalkyl group, tetrahydropyranyl group, lower alkoxycarbonyl group having 1-6 carbon atoms, arylalkoxycarbonyl group or silyl derivative group); R.sub.3 singly represents a hydrogen atom; or R.sub.3 forms a bond jointly with R.sub.2 ; and R.sub.4, R.sub.5, R.sub.6 and R.sub.7 each represent hydrogen atom, vinyl group, formyl group, --Y--(OA).sub.n group (Y represents straight or branched chain alkylene group having 1-6 carbon atoms or lower alkenyl group having 1-6 carbon atoms, A is as defined above, and n represents an integer of 1-3.The compound of this invention is expected to be effectively usable as an agent for treatment of various symptoms due to the contraction of smooth muscles, for treatment of the diseases of the circulatory system and for treatment of epilepsy.
摘要翻译：由下列通式（1）表示的苯并二氢吡喃衍生物：（*化学结构*）（1）其中R1表示氰基，硝基，卤代甲基或-SO2-X基（X表示具有1-6个碳原子的低级烷基原子或芳基）; R2表示氢原子或OA基（A表示氢原子，硝基，具有1-6个碳原子的低级酰基，芳基羰基，具有1-6个碳原子的低级烷基磺酰基，芳基磺酰基，芳基烷基，四氢吡喃基，低级烷氧基羰基具有1-6个碳原子的基团，芳基烷氧基羰基或甲硅烷基衍生物基团）; R3单独表示氢原子; 或R3与R2一起形成键; 和R 4，R 5，R 6和R 7各自表示氢原子，乙烯基，甲酰基，-Y-（OA）n基（Y表示具有1-6个碳原子的直链或支链亚烷基或具有1-6个碳原子的低级链烯基碳原子，A如上所定义，n表示1-3的整数。预期本发明化合物可有效地用作治疗由于平滑肌收缩引起的各种症状的药剂，用于治疗循环系统疾病和治疗癫痫。

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