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1. 发明申请

US20050136002A1 Use of particulate contrast agents in diagnostic imaging for studying physiological paramaters 审中-公开
标题翻译：在诊断成像中使用颗粒造影剂来研究生理参数
公开(公告)号：US20050136002A1
公开(公告)日：2005-06-23
申请号：US10945852
申请日：2004-09-21
申请人： Sigrid Fossheim , Jo Klaveness , Atle Bjornerud , Pal Rongved , Klaes Golman , Roald Skurtveit
发明人： Sigrid Fossheim , Jo Klaveness , Atle Bjornerud , Pal Rongved , Klaes Golman , Roald Skurtveit
IPC分类号： A61K9/127 , A61B5/00 , A61B5/055 , A61B8/00 , A61K9/14 , A61K9/50 , A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , A61K51/00
CPC分类号： A61B5/01 , A61B5/055 , A61B5/416 , A61B5/4519 , A61B8/481 , A61K49/1812 , A61K49/223
摘要： The present invention relates to a method of imaging of an animate human or non-human animal body, which method comprises: administering parenterally to said body a particulate material comprising a matrix or membrane material and at least one contrast generating species, which matrix or membrane material is responsive to a pre-selected physiological parameter whereby to alter the contrast efficacy of said species in response to a change in the value of said parameter; generating image data of at least part of said body in which said species is present; and generating therefrom a signal indicative of the value or variation of said parameter in said part of said body. The invention also relates to contrast media for imaging a physioloogical parameter.
摘要翻译：本发明涉及一种对人或非动物体动物进行成像的方法，该方法包括：向所述身体肠胃外给予包含基质或膜材料和至少一种对比生成物质的颗粒材料，所述物质或基质或膜材料响应于预先选择的生理参数，从而响应于所述参数的值的变化来改变所述物种的对比效能; 生成存在所述物种的所述身体的至少一部分的图像数据; 以及由此生成指示所述身体的所述部分中的所述参数的值或变化的信号。本发明还涉及用于对生理参数进行成像的造影剂。

2. 发明申请

US20090191131A1 USE OF PARTICULATE CONTRAST AGENTS IN DIAGNOSTIC IMAGING FOR STUDYING PHYSIOLOGICAL PARAMATERS 审中-公开
标题翻译：用于研究生理参数的诊断成像中的粒子对比剂
公开(公告)号：US20090191131A1
公开(公告)日：2009-07-30
申请号：US12354275
申请日：2009-01-15
申请人： Sigrid Lise Fossheim , Jo Klaveness , Atle Bjornerud , Pal Rongved , Klaes Golman , Roald Skurtveit
发明人： Sigrid Lise Fossheim , Jo Klaveness , Atle Bjornerud , Pal Rongved , Klaes Golman , Roald Skurtveit
IPC分类号： A61K49/18 , A61K49/12
CPC分类号： A61B5/01 , A61B5/055 , A61B5/416 , A61B5/4519 , A61B8/481 , A61K49/1812 , A61K49/223
摘要： The present invention relates to a method of imaging of an animate human or non-human animal body, which method comprises: administering parenterally to said body a particulate material comprising a matrix or membrane material and at least one contrast generating species, which matrix or membrane material is responsive to a pre-selected physiological parameter whereby to alter the contrast efficacy of said species in response to a change in the value of said parameter; generating image data of at least part of said body in which said species is present; and generating therefrom a signal indicative of the value or variation of said parameter in said part of said body. The invention also relates to contrast media for imaging a physiological parameter.
摘要翻译：本发明涉及一种对人或非动物体动物进行成像的方法，该方法包括：向所述身体肠胃外给予包含基质或膜材料和至少一种对比生成物质的颗粒材料，所述物质或基质或膜材料响应于预先选择的生理参数，从而响应于所述参数的值的变化来改变所述物种的对比效能; 生成存在所述物种的所述身体的至少一部分的图像数据; 以及由此生成指示所述身体的所述部分中的所述参数的值或变化的信号。本发明还涉及用于对生理参数进行成像的造影剂。

3. 发明申请

US20080221441A1 Tumor grading from blood volume maps 有权
标题翻译：肿瘤分级从血容量图
公开(公告)号：US20080221441A1
公开(公告)日：2008-09-11
申请号：US11715529
申请日：2007-03-08
申请人： Atle Bjornerud , Kyrre Eeg Emblem
发明人： Atle Bjornerud , Kyrre Eeg Emblem
IPC分类号： A61B6/03
CPC分类号： G06T7/0012 , A61B6/501 , A61B6/507 , G06T7/11 , G06T2207/10072 , G06T2207/30016 , G06T2207/30096
摘要： An embodiment of the invention is to make possible a non-invasive grading of a tumor based on parameters determined from a frequency distribution (histogram) of values in a map representing cerebral blood volume (CBV) or cellular metabolism in the tumour. The method is especially applicable to brain tumors such as gliomas where histological grading is difficult. The invention provides a precise and consistent grading since it relies on values selected from the whole tumor (not just from hot spots); since it takes the diversity or heterogeneity of the vascularization into account by analyzing the frequency distribution (not just a mean value); and since it involves and allows for a more automated procedure wherein any subjective contributions from human operators is not critical to the resulting grading. CBV maps may be obtained by perfusion imaging using MRI or CT scanning. Cellular metabolism maps may be obtained from a glucose metabolism map obtained by positron emission tomography (PET).
摘要翻译：本发明的一个实施方案是基于根据表示肿瘤中的脑血容量（CBV）或细胞代谢的图中的值的频率分布（直方图）确定的参数，使肿瘤的非侵入性分级成为可能。该方法特别适用于组织学分级困难的脑瘤如胶质瘤。本发明提供精确和一致的分级，因为它依赖于从整个肿瘤中选择的值（不仅来自热点）; 因为通过分析频率分布（不仅仅是平均值）来考虑血管形成的多样性或异质性; 并且因为它涉及并允许更自动化的过程，其中来自人类操作者的任何主观贡献对于最终的分级不是关键的。可以通过使用MRI或CT扫描的灌注成像获得CBV图。可以从通过正电子发射断层摄影（PET）获得的葡萄糖代谢图获得细胞代谢图。

4. 发明申请

US20160058304A1 SYSTEM AND METHOD FOR VESSEL ARCHITECTURAL IMAGING 审中-公开
标题翻译：用于船舶建筑物成像的系统和方法
公开(公告)号：US20160058304A1
公开(公告)日：2016-03-03
申请号：US14773632
申请日：2014-03-10
申请人： Kyree Eeg Emblem , Gregory A. Sorensen , Rakesh K. Jain , Bruce R. Rosen , Kim Mouridsen , Atle Bjornerud
发明人： Kyree Eeg Emblem , Gregory A. Sorensen , Rakesh K. Jain , Bruce R. Rosen , Kim Mouridsen , Atle Bjornerud
IPC分类号： A61B5/02 , G01R33/56 , A61B5/00
CPC分类号： A61B5/02007 , A61B5/055 , A61B5/4842 , A61B5/4848 , A61B5/7246 , A61B5/7282 , A61B2576/02 , G01R33/5601
摘要： A system and method for generating a report regarding a vascular health status of a subject being imaged using a magnetic resonance imaging (MRI) system includes receiving a plurality of MRI datasets, each MRI dataset acquired from the a portion of the subject including a vascular structure. The process also includes analyzing the MRI datasets to identify at least one of a temporal shift and a MR signal variation between the MRI datasets, correlating the at least one of the temporal shift and the MR signal variation to a vascular health status, and generating a report indicating the vascular health status of the subject.
摘要翻译：用于产生关于使用磁共振成像（MRI）系统成像的对象的血管健康状况的报告的系统和方法包括接收多个MRI数据集，从所述对象的一部分获取的每个MRI数据集包括血管结构。该过程还包括分析MRI数据集以识别MRI数据集之间的时间偏移和MR信号变化中的至少一个，将时间偏移和MR信号变化中的至少一个与血管健康状态相关联，并且生成报告显示受试者的血管健康状况。

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