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1. 发明授权

US08321000B2 Method for detecting pathologies using cardiac activity data 有权
标题翻译：使用心脏活动数据检测病变的方法
公开(公告)号：US08321000B2
公开(公告)日：2012-11-27
申请号：US12305765
申请日：2007-07-09
申请人： Leon Glass , Claudia Lerma , Ary Goldberger
发明人： Leon Glass , Claudia Lerma , Ary Goldberger
IPC分类号： A61B5/02 , A61B5/04
CPC分类号： A61B5/0452 , A61B5/0456
摘要： The invention relates to a method for determining a pathology in a subject, said method comprising: a) correlating N-N intervals with rate dependent fluctuations of electrocardiographic parameters derived from an electrocardiogram (ECG) of said subject or other recordings reflecting cardiac activity of said subject to derive electrocardiographic parameters correlation values, wherein said pathology is determined based on said correlation values.
摘要翻译：本发明涉及一种用于确定受试者的病理学的方法，所述方法包括：a）将NN间期与所述受试者的心电图（ECG）或将所述受试者的心脏活动反映的其他记录的心电图参数的速率相关波动相关联，导出心电图参数相关值，其中基于所述相关值确定所述病理学。

2. 发明申请

US20100191130A1 METHOD FOR DETECTING PATHOLOGIES USING CARDIAC ACTIVITY DATA 有权
标题翻译：使用心脏病活动数据检测病理学的方法
公开(公告)号：US20100191130A1
公开(公告)日：2010-07-29
申请号：US12305765
申请日：2007-07-09
申请人： Leon Glass , Claudia Lerma , Ary Goldberger
发明人： Leon Glass , Claudia Lerma , Ary Goldberger
IPC分类号： A61B5/0402
CPC分类号： A61B5/0452 , A61B5/0456
摘要： The invention relates to a method for determining a pathology in a subject, said method comprising: a) correlating N-N intervals with rate dependent fluctuations of electrocardiographic parameters derived from an electrocardiogram (ECG) of said subject or other recordings reflecting cardiac activity of said subject to derive electrocardiographic parameters correlation values, wherein said pathology is determined based on said correlation values.
摘要翻译：本发明涉及一种用于确定受试者的病理学的方法，所述方法包括：a）将NN间期与所述受试者的心电图（ECG）或将所述受试者的心脏活动反映的其他记录的心电图参数的速率相关波动相关联，导出心电图参数相关值，其中基于所述相关值确定所述病理学。

3. 发明申请

US20050267362A1 Assessment of sleep quality and sleep disordered breathing based on cardiopulmonary coupling 有权
标题翻译：基于心肺耦合评估睡眠质量和睡眠呼吸障碍
公开(公告)号：US20050267362A1
公开(公告)日：2005-12-01
申请号：US11178990
申请日：2005-07-12
申请人： Joseph Mietus , Chung-Kang Peng , Robert Thomas , Ary Goldberger
发明人： Joseph Mietus , Chung-Kang Peng , Robert Thomas , Ary Goldberger
IPC分类号： A61B5/0205 , A61B5/04 , A61B5/0456 , A61B5/0476 , A61B5/0496 , A61B5/08 , A61M16/00 , A62B7/00
CPC分类号： A61B5/0472 , A61B5/0205 , A61B5/021 , A61B5/0456 , A61B5/0476 , A61B5/0496 , A61B5/0816 , A61B5/087 , A61B5/0878 , A61B5/4812 , A61B5/4815 , A61B5/4818 , A61B5/7257 , A61B5/7278 , A61B8/06 , G16H50/20 , Y02A90/26
摘要： An assessment of sleep quality and sleep disordered breathing is determined from cardiopulmonary coupling between two physiological data series. An R-R interval series is derived from an electrocardiogram (ECG) signal. The normal beats from the R-R interval series are extracted to produce a normal-to-normal interval series. The amplitude variations in the QRS complex are used to extract a surrogate respiration signal (i.e., ECG-derived respiration) associated with the NN interval series. The two series are corrected to remove outliers, and resampled. The cross-spectral power and coherence of the two resampled signals are calculated over a plurality of coherence windows. For each coherence window, the product of the coherence and cross-spectral power is used to calculate coherent cross-power. Using the appropriate thresholds for the coherent cross-power, the proportion of sleep spent in CAP, non-CAP, and wake and/or REM are determined. Coherent cross-power can be applied to differentiate obstructive from non-obstructive disease, and admixtures of the same.
摘要翻译：通过两个生理数据序列之间的心肺耦合来确定睡眠质量和睡眠呼吸紊乱的评估。从心电图（ECG）信号导出R-R间期序列。提取R-R间隔序列的正常搏动以产生正常到正常的间隔序列。 QRS复合体的振幅变化用于提取与NN间隔序列相关联的替代呼吸信号（即ECG导出的呼吸）。纠正这两个系列以消除异常值，并重新采样。在多个相干窗口上计算两个重采样信号的交叉光谱功率和相干性。对于每个相干窗口，使用相干和交叉光谱功率的乘积来计算相干交叉功率。使用相干交叉功率的适当阈值，确定在CAP，非CAP和唤醒和/或REM中花费的睡眠比例。相干交叉功能可以应用于区分阻塞性和非阻塞性疾病，以及它们的混合物。

4. 发明申请

US20070066906A1 Complexity-based dynamical analysis of a network 有权
标题翻译：网络的基于复杂度的动态分析
公开(公告)号：US20070066906A1
公开(公告)日：2007-03-22
申请号：US11483172
申请日：2006-07-10
申请人： Ary Goldberger , Chung-Kang Peng , Madalena Costa
发明人： Ary Goldberger , Chung-Kang Peng , Madalena Costa
IPC分类号： A61B5/04
CPC分类号： A61B5/0456 , A61B5/0476 , A61B5/08 , A61B5/1116 , G06F19/00
摘要： In a subject undergoing therapeutic intervention, efficacy of the therapeutic intervention is assessed based on a series of physiologic data associated with the subject. The series of physiologic data is analyzed to produce a measure of complexity. The complexity measure is then compared to a control. The efficacy of the therapeutic intervention is assessed based on the comparison of the complexity measure to the control. The control may be, for example, a complexity measure taken prior to initiation of the therapeutic intervention, a complexity measure taken from a different subject, or a predetermined threshold value. The measure of complexity is generated using, for example, a multiscale entropy measurement (MSE), a time asymmetry measurement, and/or an information-based similarity measurement. An increase in complexity indicates a positive effect of the therapeutic intervention, while a decrease in complexity indicates a negative effect of the therapeutic intervention. Stability of a non-biologic network, such as a computer network, communications network or transportation network can also be assessed.
摘要翻译：在进行治疗干预的受试者中，基于与受试者相关的一系列生理学数据来评估治疗干预的功效。分析一系列生理数据以产生复杂度。然后将复杂度测量与控件进行比较。基于复杂性测量与对照的比较来评估治疗干预的疗效。控制可以是例如在开始治疗干预之前采取的复杂性度量，从不同对象获取的复杂度度量或预定阈值。使用例如多尺度熵测量（MSE），时间不对称测量和/或基于信息的相似度测量来产生复杂度的度量。复杂性的增加表明治疗干预的积极效果，而复杂性的降低表明治疗干预的负面影响。还可以评估诸如计算机网络，通信网络或运输网络之类的非生物网络的稳定性。

5. 发明申请

US20050256418A1 Assessment of sleep quality and sleep disordered breathing based on cardiopulmonary coupling 有权
标题翻译：基于心肺耦合评估睡眠质量和睡眠呼吸障碍
公开(公告)号：US20050256418A1
公开(公告)日：2005-11-17
申请号：US10846945
申请日：2004-05-17
申请人： Joseph Mietus , Chung-Kang Peng , Robert Thomas , Ary Goldberger
发明人： Joseph Mietus , Chung-Kang Peng , Robert Thomas , Ary Goldberger
IPC分类号： A61B5/0205 , A61B5/04 , A61B5/0456 , A61B5/0476 , A61B5/0496 , A61B5/08 , A61M16/00 , A62B7/00
CPC分类号： A61B5/0456 , A61B5/0205 , A61B5/0476 , A61B5/0496 , A61B5/0816 , A61B5/4815 , A61B5/4818 , A61B5/7257 , A61B5/7278
摘要： An assessment of sleep quality and sleep disordered breathing is determined from the cardiopulmonary coupling between two physiological data series. In an embodiment, an R-R interval series is derived from an electrocardiogram (ECG) signal. The normal beats from the R-R interval series are extracted to produce a normal-to-normal (NN) interval series. The amplitude variations in the QRS complex are used to extract to a surrogate respiration signal (i.e., ECG-derived respiration (EDR)) that is associated with the NN interval series. The two series are corrected to remove outliers, and resampled. The cross-spectral power and coherence of the two resampled signals are calculated over a plurality of coherence windows. For each coherence window, the product of the coherence and cross-spectral power is used to calculate coherent cross power. Using the appropriate thresholds for the coherent cross power, the proportion of sleep spent in CAP, non-CAP, and wake and/or REM are determined.
摘要翻译：睡眠质量和睡眠呼吸紊乱的评估是从两个生理数据序列之间的心肺耦合确定的。在一个实施例中，从心电图（ECG）信号导出R-R间期序列。提取R-R间隔序列中的正常搏动以产生正常到正常（NN）的间隔序列。 QRS复合物中的幅度变化用于提取与NN间期序列相关联的替代呼吸信号（即，ECG导出的呼吸（EDR））。纠正这两个系列以消除异常值，并重新采样。在多个相干窗口上计算两个重采样信号的交叉光谱功率和相干性。对于每个相干窗口，使用相干和交叉光谱功率的乘积来计算相干交叉功率。使用相关交叉功率的适当阈值，确定在CAP，非CAP和唤醒和/或REM中花费的睡眠比例。

6. 发明申请

US20080119747A1 Assessment of Sleep Quality and Sleep Disordered Breathing Based on Cardiopulmonary Coupling 有权
标题翻译：基于心肺耦合的睡眠质量和睡眠呼吸紊乱评估
公开(公告)号：US20080119747A1
公开(公告)日：2008-05-22
申请号：US12018768
申请日：2008-01-23
申请人： Joseph MIETUS , Chung-Kang Peng , Robert Thomas , Ary Goldberger
发明人： Joseph MIETUS , Chung-Kang Peng , Robert Thomas , Ary Goldberger
IPC分类号： A61B5/0205
CPC分类号： A61B5/0456 , A61B5/0205 , A61B5/0476 , A61B5/0496 , A61B5/0816 , A61B5/4815 , A61B5/4818 , A61B5/7257 , A61B5/7278
摘要： An assessment of sleep quality and sleep disordered breathing is determined from the cardiopulmonary coupling between two physiological data series. In an embodiment, an R-R interval series is derived from an electrocardiogram (ECG) signal. The normal beats from the R-R interval series are extracted to produce a normal-to-normal (NN) interval series. The amplitude variations in the QRS complex are used to extract to a surrogate respiration signal (i.e., ECG-derived respiration (EDR)) that is associated with the NN interval series. The two series are corrected to remove outliers, and resampled. The cross-spectral power and coherence of the two resampled signals are calculated over a plurality of coherence windows. For each coherence window, the product of the coherence and cross-spectral power is used to calculate coherent cross power. Using the appropriate thresholds for the coherent cross power, the proportion of sleep spent in CAP, non-CAP, and wake and/or REM are determined.
摘要翻译：睡眠质量和睡眠呼吸紊乱的评估是从两个生理数据序列之间的心肺耦合确定的。在一个实施例中，从心电图（ECG）信号导出R-R间期序列。提取R-R间隔序列中的正常搏动以产生正常到正常（NN）间隔序列。 QRS复合物中的幅度变化用于提取与NN间期序列相关联的替代呼吸信号（即，ECG导出的呼吸（EDR））。纠正这两个系列以消除异常值，并重新采样。在多个相干窗口上计算两个重采样信号的交叉光谱功率和相干性。对于每个相干窗口，使用相干和交叉光谱功率的乘积来计算相干交叉功率。使用相关交叉功率的适当阈值，确定在CAP，非CAP和唤醒和/或REM中花费的睡眠比例。

7. 发明申请

US20060189875A1 Complexity-based dynamical assay for assessing the toxicity and efficacy of pharmaceutical and other therapeutic interventions 失效
公开(公告)号：US20060189875A1
公开(公告)日：2006-08-24
申请号：US11356044
申请日：2006-02-17
申请人： Ary Goldberger , Chung-Kang Peng , Madalena Costa
发明人： Ary Goldberger , Chung-Kang Peng , Madalena Costa
IPC分类号： A61B5/04
CPC分类号： A61B5/0456 , A61B5/00 , A61B5/0476 , A61B5/08 , G06F19/00 , G16H50/70
摘要： In a subject undergoing therapeutic intervention, efficacy of the therapeutic intervention is assessed based on a series of physiologic data associated with the subject. The series of physiologic data is analyzed to produce a measure of complexity. The complexity measure is then compared to a control. The efficacy of the therapeutic intervention is assessed based on the comparison of the complexity measure to the control. The control may be, for example, a complexity measure taken prior to initiation of the therapeutic intervention, a complexity measure taken from a different subject, or a predetermined threshold value. The measure of complexity is generated using, for example, a multiscale entropy measurement (MSE), a time asymmetry measurement, and/or an information-based similarity measurement. An increase in complexity indicates a positive effect of the therapeutic intervention, while a decrease in complexity indicates a negative effect of the therapeutic intervention.

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