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1. 发明授权

US6025446A Stable complexes of crosslinked polyvinylpyrrolidone and iodine and method of making the same 失效
标题翻译：交联聚乙烯吡咯烷酮和碘的稳定配合物及其制备方法
公开(公告)号：US6025446A
公开(公告)日：2000-02-15
申请号：US28388
申请日：1998-02-24
申请人： Arun B. Kulkarni , Gregory R. Skover
发明人： Arun B. Kulkarni , Gregory R. Skover
IPC分类号： A61K47/32 , A61K33/18 , A61K47/48 , A61P17/00 , A61P31/00 , C08F8/22
CPC分类号： A61K47/48176
摘要： A wound treatment material which absorbs wound fluid without overdrying the wound, provides physical cushioning for the wound, and releases an antimicrobial agent (iodine) in a controlled manner to kill harmful micro-organisms without irritating the wound area or adversely affecting would healing. The wound treatment material comprises crosslinked polyvinylpyrrolidone-iodine complex which is water insoluble, but water-absorbent and water-swellable. When the complex or a wound treatment preparation containing the complex is applied to a wound, i.e., becomes hydrated, and an equilibrium is established between the complex and the wound at the wound/complex interface. Iodine is releaed from the crosslinked polyvinylpyrrolidone-iodine complex by a diffusion controlled process which responds to the reduction in concentration of free iodine in the wound fluid in equilibrium with the complex. The greater the rate of iodine depletion in the wound, the greater the rate of iodine release from the polymer-iodine complex. It has been discovered that this diffusion controlled release mechanism can be utilized to deliver antimicrobially effective amounts of iodine to the wound while maintaining the concentration of iodine below the concentration that could cause significant wound irritation or retardation of healing. It has also been found that the moist environment at the wound/complex interface and the physical protective effect (cushioning) offered by the hydrated complex can enhance wound healing.
摘要翻译：吸收伤口流体而不过度干燥伤口的伤口治疗材料为伤口提供物理缓冲，并以受控的方式释放抗微生物剂（碘）以杀伤有害微生物，而不会刺激伤口面积或不利地影响愈合。伤口处理材料包括水不溶性但是吸水和水溶胀的交联聚乙烯吡咯烷酮 - 碘络合物。当将复合物或包含复合物的伤口处理制剂施用于伤口时，即变得水合，并且在伤口/复合界面处的复合物和伤口之间建立平衡。通过扩散控制方法从交联的聚乙烯吡咯烷酮 - 碘络合物中回收碘，其响应于与络合物平衡的伤口液中游离碘浓度的降低。伤口碘消耗速率越大，聚合物碘络合物的碘释放速率就越高。已经发现，这种扩散控制释放机制可以用于向伤口递送抗微生物有效量的碘，同时保持碘浓度低于可能引起显着的伤口刺激或延缓愈合的浓度。还发现伤口/复合界面处的潮湿环境以及由水合复合物提供的物理保护作用（缓冲）可以增加伤口愈合。

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