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1. 发明申请

US20060189979A1 Methods and apparatus for coagulating and/or constricting hollow anatomical structures 有权
公开(公告)号：US20060189979A1
公开(公告)日：2006-08-24
申请号：US11197849
申请日：2005-08-05
申请人： Brady Esch , Bob McRae , Arthur Zikorus , Michael Mirizzi , Christopher Jones
发明人： Brady Esch , Bob McRae , Arthur Zikorus , Michael Mirizzi , Christopher Jones
IPC分类号： A61B18/14
CPC分类号： A61B18/08 , A61B18/082 , A61B18/1477 , A61B18/1492 , A61B2018/00404 , A61B2018/00791 , A61B2018/1405 , A61B2018/1425
摘要： An energy delivering probe is used for thermally coagulating and/or constricting hollow anatomical structures (HAS) including, but not limited to, blood vessels such as perforator veins. The probe includes a shaft and at least two electrodes where at least one of the electrodes has a perimeter that increases as it extends proximally.

2. 发明申请

US20080039829A1 METHOD AND APPARATUS FOR APPLYING ENERGY TO BIOLOGICAL TISSUE INCLUDING THE USE OF TUMESCENT TISSUE COMPRESSION 审中-公开
公开(公告)号：US20080039829A1
公开(公告)日：2008-02-14
申请号：US11841983
申请日：2007-08-20
申请人： Mitchel Goldman , Robert Weiss , Arthur Zikorus , James Chandler
发明人： Mitchel Goldman , Robert Weiss , Arthur Zikorus , James Chandler
IPC分类号： A61B18/04
CPC分类号： G02F1/134363 , A61B18/1492 , A61B2017/22038 , A61B2017/22051 , A61B2017/22067 , A61B2018/00214 , A61B2018/0022 , A61B2018/00404 , A61B2018/00488 , A61B2018/00589 , A61B2018/00898 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2090/3782 , A61B2218/002 , G02F1/136213 , G02F1/136259 , G02F2201/12
摘要： An electrode catheter is introduced into a hollow anatomical structure, such as a vein, and is positioned at a treatment site within the structure. Tumescent fluid is injected into the tissue surrounding the treatment site to produce tumescence of the surrounding tissue which then compresses the vein. The solution may include an anesthetic, and may further include a vasoconstrictive drug that shrinks blood vessels. The tumescent swelling in the surrounding tissue causes the hollow anatomical structure to become compressed, thereby exsanguinating the treatment site. Energy is applied by an electrode catheter in apposition with the vein wall to create a heating effect. The heating effect causes the hollow anatomical structure to become molded and durably assume the compressed dimensions caused by the tumescent technique. The electrode catheter can be moved within the structure so as to apply energy to a large section of the hollow anatomic structure. In a further aspect, the location of the electrodes is determined by impedance monitoring. Also, temperature sensors at the treatment site are averaged to determine the site temperature.

3. 发明申请

US20080039793A1 METHOD AND APPARATUS FOR APPLYING ENERGY TO BIOLOGICAL TISSUE INCLUDING THE USE OF TUMESCENT TISSUE COMPRESSION 审中-公开
标题翻译：用于将能量应用于生物组织的方法和装置，包括使用肿瘤组织压缩
公开(公告)号：US20080039793A1
公开(公告)日：2008-02-14
申请号：US11841913
申请日：2007-08-20
申请人： Mitchel Goldman , Robert Weiss , Arthur Zikorus , James Chandler
发明人： Mitchel Goldman , Robert Weiss , Arthur Zikorus , James Chandler
IPC分类号： A61B18/14
CPC分类号： G02F1/134363 , A61B18/1492 , A61B2017/22038 , A61B2017/22051 , A61B2017/22067 , A61B2018/00214 , A61B2018/0022 , A61B2018/00404 , A61B2018/00488 , A61B2018/00589 , A61B2018/00898 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2090/3782 , A61B2218/002 , G02F1/136213 , G02F1/136259 , G02F2201/12
摘要： An electrode catheter is introduced into a hollow anatomical structure, such as a vein, and is positioned at a treatment site within the structure. Tumescent fluid is injected into the tissue surrounding the treatment site to produce tumescence of the surrounding tissue which then compresses the vein. The solution may include an anesthetic, and may further include a vasoconstrictive drug that shrinks blood vessels. The tumescent swelling in the surrounding tissue causes the hollow anatomical structure to become compressed, thereby exsanguinating the treatment site. Energy is applied by an electrode catheter in apposition with the vein wall to create a heating effect. The heating effect causes the hollow anatomical structure to become molded and durably assume the compressed dimensions caused by the tumescent technique. The electrode catheter can be moved within the structure so as to apply energy to a large section of the hollow anatomic structure. In a further aspect, the location of the electrodes is determined by impedance monitoring. Also, temperature sensors at the treatment site are averaged to determine the site temperature.
摘要翻译：将电极导管引入到诸如静脉的中空解剖结构中，并且位于结构内的治疗部位。将肿胀流体注射到处理部位周围的组织中，以产生周围组织的肿胀，然后压缩静脉。溶液可以包括麻醉剂，并且还可以包括收缩血管的血管收缩药物。周围组织的肿胀肿胀导致中空的解剖结构变得压缩，从而使治疗部位脱垂。能量通过电极导管与静脉壁一起施加以产生加热效果。加热效果使得中空的解剖结构变得模制并且持久地承受由肿胀技术引起的压缩尺寸。电极导管可以在结构内移动，以将能量施加到中空解剖结构的大部分。在另一方面，通过阻抗监测确定电极的位置。此外，将处理部位的温度传感器平均以确定现场温度。

4. 发明申请

US20070244371A1 Phlebectomy illumination device and methods 审中-公开
标题翻译： Phlebectomy照明装置及方法
公开(公告)号：US20070244371A1
公开(公告)日：2007-10-18
申请号：US11732771
申请日：2007-04-04
申请人： Hoa Nguyen , Michael Mirizzi , Brian Farley , Arthur Zikorus
发明人： Hoa Nguyen , Michael Mirizzi , Brian Farley , Arthur Zikorus
IPC分类号： A61B5/00
CPC分类号： A61B5/0084 , A61B5/0086
摘要： The disclosure relates to the use of subcutaneous illumination during phlebectomy procedures, and to devices and methods for performing hook phlebectomy while visualizing veins and surrounding tissue using light emitted subcutaneously and beneath the surgical area. An apparatus comprises, in one embodiment, a handle, an illuminator portion extending distally from the handle, the illuminator portion comprising an elongate member configured for insertion into subcutaneous tissue, the illuminator portion comprising an elongate electroluminescent device extending along the illuminator portion, the electroluminescent device being configured to generate and emit light primarily in a generally radial direction, outward and away from a longitudinal axis of the illuminator portion. Furthermore, a phlebectomy hook is provided that comprises, in one embodiment, a shaft, a bend extending generally laterally from the shaft, the bend terminating in a tip of the phlebectomy hook, and an illuminator, the illuminator configured to propagate a visible light beam near the bend, generally outward relative to a longitudinal axis of the shaft.
摘要翻译：本公开涉及在静脉切除术过程中使用皮下照射，以及使用在皮下和手术区域下方发射的光来观察静脉和周围组织进行钩静脉切除术的装置和方法。在一个实施例中，一种装置包括手柄，从手柄向远侧延伸的照明器部分，照明器部分包括构造成用于插入皮下组织的细长部件，照明器部分包括沿照射器部分延伸的细长电致发光器件，电致发光设备被配置为主要在大致径向方向上产生和发射光，其外部和远离照明器部分的纵向轴线。此外，提供了一种静脉切除术钩，其在一个实施例中包括轴，从轴大体上横向延伸的弯曲，终止于静脉切除术钩的尖端的弯曲部和照明器，所述照明器被配置成传播可见光束在弯曲附近，相对于轴的纵向轴线大致向外。

5. 发明申请

US20070088346A1 Method and apparatus for varicose vein treatment using acoustic hemostasis 审中-公开
标题翻译：使用声止血静脉曲张静脉治疗的方法和装置
公开(公告)号：US20070088346A1
公开(公告)日：2007-04-19
申请号：US11581596
申请日：2006-10-16
申请人： Michael Mirizzi , Arthur Zikorus , Brady Esch
发明人： Michael Mirizzi , Arthur Zikorus , Brady Esch
IPC分类号： A61B18/04
CPC分类号： A61N7/02 , A61B17/2251
摘要： A method of treating a perforator vein comprises applying ultrasound to the perforator vein and occluding the perforator vein with the ultrasound. An apparatus for treating blood vessels comprises an ultrasound emitter, wherein the ultrasound emitter is configured to emit ultrasound at multiple therapeutic ultrasound frequencies during a treatment cycle. The apparatus further comprises an acoustic coupler in sonic communication with the emitter, wherein the acoustic coupler has an acoustic coupling surface configured to contact a patient and facilitate delivery of ultrasound to the patient and wherein the acoustic coupler provides a conduction path for ultrasound from the emitter to the acoustic coupling surface. The apparatus further comprises an acoustic coupler containing a displaceable acoustic coupling material. The apparatus further comprises an acoustic coupler configured to vary the length of the conduction path in accordance with variation in the thickness of the acoustic coupling material disposed between the emitter and the acoustic coupling surface.
摘要翻译：治疗穿孔静脉的方法包括将超声波应用于穿孔静脉并用超声波封堵穿孔静脉。一种用于治疗血管的装置包括超声发射器，其中所述超声发射器被配置为在治疗周期期间以多个治疗超声频率发射超声波。该装置还包括与发射器声音通信的声耦合器，其中声耦合器具有被配置为接触患者并且便于将超声波传送给患者的声学耦合表面，并且其中声学耦合器提供来自发射器的超声波的传导路径到声耦合表面。该装置还包括一个包含可位移声耦合材料的声耦合器。该装置还包括声耦合器，其被配置为根据设置在发射器和声耦合表面之间的声耦合材料的厚度的变化来改变导电路径的长度。

6. 发明申请

US20070055326A1 Method of treating a hollow anatomical structure with a thermal catheter 审中-公开
标题翻译：用热导管治疗中空解剖结构的方法
公开(公告)号：US20070055326A1
公开(公告)日：2007-03-08
申请号：US11491346
申请日：2006-07-21
申请人： Brian Farley , Russell Thompson , Arthur Zikorus , Robert McRae
发明人： Brian Farley , Russell Thompson , Arthur Zikorus , Robert McRae
IPC分类号： A61F7/00 , A61F7/12 , A61N5/06
CPC分类号： A61B18/082 , A61B18/08 , A61B18/1492 , A61B18/20 , A61B18/24 , A61B90/39 , A61B2017/00026 , A61B2017/00084 , A61B2017/00119 , A61B2017/00123 , A61B2017/00132 , A61B2018/00636 , A61B2018/00666 , A61B2018/00779 , A61B2018/00791 , A61B2018/00827 , A61B2018/046 , A61B2090/0811 , A61B2090/3925 , A61B2090/3937 , A61B2090/3945
摘要： A working end of a catheter includes at least one therapeutic element, such as a resistive heating element, usable to deliver energy for ligating, or reducing the diameter of, a hollow anatomical structure. In certain examples, the catheter includes a lumen to accommodate a guide wire or to allow fluid delivery. In certain embodiments, a balloon is inflated to place resistive element(s) into apposition with a hollow anatomical structure and to occlude the structure. Indexing devices and methods are also disclosed for successively treating portions of the hollow anatomical structure. In certain examples, marks along the catheter shaft provide visual verification to the physician of the relative position of the therapeutic element of the catheter. Embodiments of indexing devices may include pairs of rings and/or hinged arms that move a catheter a desired indexed position between successive treatments.
摘要翻译：导管的工作端包括至少一个治疗元件，例如电阻加热元件，其可用于递送用于结扎或减小中空解剖结构的直径的能量。在某些实例中，导管包括用于容纳引导线或允许流体输送的内腔。在某些实施例中，气囊被充气以将电阻元件放置成与中空解剖结构并置并阻塞结构。还公开了分级装置和方法，用于连续处理中空解剖结构的部分。在某些实例中，沿着导管轴的标记为医师提供导管治疗元件的相对位置的视觉验证。分度装置的实施例可以包括成对的环和/或铰链臂，其使导管在连续的处理之间移动期望的分度位置。

7. 发明申请

US20070016272A1 Systems and methods for treating a hollow anatomical structure 审中-公开
标题翻译：用于治疗中空解剖结构的系统和方法
公开(公告)号：US20070016272A1
公开(公告)日：2007-01-18
申请号：US11236316
申请日：2005-09-27
申请人： Russell Thompson , Arthur Zikorus , Fiona Sander , Vijay Dhaka , Brady Esch
发明人： Russell Thompson , Arthur Zikorus , Fiona Sander , Vijay Dhaka , Brady Esch
IPC分类号： A61F7/00 , A61F7/12
CPC分类号： A61B18/082 , A61B18/08 , A61B18/1492 , A61B18/20 , A61B18/24 , A61B90/39 , A61B2017/00026 , A61B2017/00084 , A61B2017/00119 , A61B2017/00123 , A61B2017/00132 , A61B2018/00636 , A61B2018/00666 , A61B2018/00779 , A61B2018/00791 , A61B2018/00827 , A61B2018/046 , A61B2090/0811 , A61B2090/3925 , A61B2090/3937 , A61B2090/3945
摘要： A catheter includes multiple primary leads to deliver energy for ligating a hollow anatomical structure. Each of the primary leads includes a resistive element located at the working end of the catheter. Separation is maintained between the leads such that each lead can individually receive power. The catheter can include a lumen to accommodate a guide wire or to allow fluid delivery. Energy is applied until the diameter of the hollow anatomical structure is reduced to the point where occlusion is achieved. In one embodiment, a balloon is inflated to place the resistive elements into apposition with a hollow anatomical structure and to occlude the structure before the application of energy. The inflated balloon impairs blood flow and facilitates the infusion of saline, or medication, to the hollow anatomical structure in order to reduce the occurrence of coagulation and to improve the heating of the structure by the catheter.
摘要翻译：导管包括多个主引线以输送用于结扎中空解剖结构的能量。每个主引线包括位于导管工作端的电阻元件。在引线之间保持分离，使得每个引线可以单独地接收电力。导管可以包括用于容纳导丝或者允许流体输送的内腔。施加能量直到中空解剖结构的直径减小到达到遮挡的程度。在一个实施例中，气囊被充气以将电阻元件与中空的解剖结构相配合并且在施加能量之前封闭结构。膨胀的气球损伤血液流动并促进将盐水或药物输注到中空解剖结构，以便减少凝血的发生并且通过导管改善结构的加热。

8. 发明申请

US20060142824A1 Systems and methods for treating a hollow anatomical structure 有权
标题翻译：用于治疗中空解剖结构的系统和方法
公开(公告)号：US20060142824A1
公开(公告)日：2006-06-29
申请号：US11313512
申请日：2005-12-20
申请人： Arthur Zikorus , Robert McRae , Michael Mirizzi
发明人： Arthur Zikorus , Robert McRae , Michael Mirizzi
IPC分类号： A61F7/00 , A61F7/12
CPC分类号： A61B18/1206 , A61B18/082 , A61B18/1492 , A61B2017/00075 , A61B2018/00714 , A61B2018/00744 , A61B2018/00791 , A61B2018/00863 , A61B2218/002
摘要： A treatment system for occluding a hollow anatomical structure comprises a treatment device sized for insertion into a hollow anatomical structure. The treatment device comprises a therapeutic element configured to treat the hollow anatomical structure. The system comprises a sensor configured to sense a first treatment parameter. A controller is in communication with the treatment device and with the sensor. The controller is configured to determine a second treatment parameter based on the first treatment parameter and output the second treatment parameter.
摘要翻译：用于闭塞中空解剖结构的治疗系统包括尺寸适于插入中空解剖结构中的治疗装置。治疗装置包括构造成治疗中空解剖结构的治疗元件。该系统包括被配置为感测第一处理参数的传感器。控制器与处理装置和传感器通信。控制器被配置为基于第一处理参数确定第二处理参数并输出第二处理参数。

9. 发明申请

US20060085054A1 Methods and apparatus for treatment of hollow anatomical structures 审中-公开
标题翻译：用于治疗中空解剖结构的方法和装置
公开(公告)号：US20060085054A1
公开(公告)日：2006-04-20
申请号：US11222069
申请日：2005-09-08
申请人： Arthur Zikorus , Russell Thompson , Fiona Sander , Mark Parker
发明人： Arthur Zikorus , Russell Thompson , Fiona Sander , Mark Parker
IPC分类号： A61F7/00 , A61F7/12
CPC分类号： A61B18/08 , A61B18/1492 , A61B2018/0022 , A61B2018/00404 , A61B2018/046
摘要： One embodiment comprises an apparatus for applying energy to a hollow anatomical structure having an inner wall. The apparatus comprises an elongate shaft having a distal end and a proximal end opposite the distal end; and a capacitive treatment element located near the distal end. The capacitive treatment element is sized for insertion into the hollow anatomical structure and placement near the inner wall. The capacitive treatment element is configured to create an electric field that extends at least partially into the inner wall. Other devices and methods for treatment of hollow anatomical structures are disclosed as well.
摘要翻译：一个实施例包括用于向具有内壁的中空解剖结构施加能量的装置。该装置包括细长轴，其具有远端和与远端相对的近端; 以及位于远端附近的电容性治疗元件。电容治疗元件的尺寸适于插入中空的解剖结构并且放置在内壁附近。电容性治疗元件构造成产生至少部分延伸到内壁的电场。还公开了用于治疗中空解剖结构的其它装置和方法。

10. 发明申请

US20060030849A1 Methods and apparatus for coagulating and/or constricting hollow anatomical structures 有权
公开(公告)号：US20060030849A1
公开(公告)日：2006-02-09
申请号：US10914050
申请日：2004-08-05
申请人： Michael Mirizzi , Christopher Jones , Arthur Zikorus
发明人： Michael Mirizzi , Christopher Jones , Arthur Zikorus
IPC分类号： A61B18/14
CPC分类号： A61B18/14 , A61B18/00 , A61B2017/00084 , A61B2017/22051 , A61B2018/00095 , A61F7/123 , A61F2007/126 , A61M25/00 , A61M25/1011 , A61M2025/1072 , A61M2025/1086
摘要： An energy delivering probe is used for thermally coagulating and/or constricting hollow anatomical structures (HAS) including, but not limited to, blood vessels such as perforator veins. The probe includes a shaft and at least two electrodes where at least one of the electrodes has a generally spherical or toroidal geometry.

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