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1. 发明申请

US20080248016A1 Novel Iaccase Enzymes and Their Uses 有权
标题翻译：新型致病酶及其用途
公开(公告)号：US20080248016A1
公开(公告)日：2008-10-09
申请号：US11663424
申请日：2005-09-21
申请人： Marja Paloheimo , Terhi Puranen , Leena Valtakari , Kristiina Kruus , Jarno Kallio , Arja Mantyla , Richard Fagerstrom , Pentti Ojapalo , Jari Vehmaanpera
发明人： Marja Paloheimo , Terhi Puranen , Leena Valtakari , Kristiina Kruus , Jarno Kallio , Arja Mantyla , Richard Fagerstrom , Pentti Ojapalo , Jari Vehmaanpera
IPC分类号： A61K38/43 , C12N9/02 , C12N15/11 , C12N15/00 , A61P43/00 , C12N1/00 , C12P21/04 , D06M16/00
CPC分类号： D06M16/003 , A61K8/66 , A61Q5/00 , A61Q5/08 , C11D3/38654 , C12N9/0061 , D06L4/40 , D06P5/137 , D06P5/158 , D21C5/005 , D21H17/005
摘要： The present invention relates to novel laccase enzymes obtainable from the strains of the genus Thielavia or from the strains of the genus Chaetomium. The invention relates also to nucleic acid sequences encoding the enzymes, recombinant hosts into which the nucleic acid sequences have been introduced and to methods for the production of the enzymes in recombinant hosts. The enzymes of the invention are suitable for several applications, for example for treating denim and for strain removal.
摘要翻译：本发明涉及可从Thielavia属的菌株或Chaetomium属的菌株获得的新的漆酶。本发明还涉及编码酶的核酸序列，其中引入了核酸序列的重组宿主和在重组宿主中产生酶的方法。本发明的酶适用于几种用途，例如用于处理牛仔布和除去菌株。

2. 发明授权

US07927849B2 Laccase enzyme and use thereof 有权
标题翻译：漆酶酶及其用途
公开(公告)号：US07927849B2
公开(公告)日：2011-04-19
申请号：US11231706
申请日：2005-09-21
申请人： Marja Paloheimo , Leena Valtakari , Terhi Puranen , Kristiina Kruus , Jarno Kallio , Arja Mantyla , Richard Fagerstrom , Pentti Ojapalo , Jari Vehmaanpera
发明人： Marja Paloheimo , Leena Valtakari , Terhi Puranen , Kristiina Kruus , Jarno Kallio , Arja Mantyla , Richard Fagerstrom , Pentti Ojapalo , Jari Vehmaanpera
IPC分类号： C12N9/00 , C12N9/02
CPC分类号： A61K8/66 , A61Q5/00 , A61Q5/08 , C11D3/38654 , C12N9/0061 , D06L4/40 , D06M16/003 , D06P5/137 , D06P5/158 , D21C5/005 , D21H17/005
摘要： The present invention relates to a novel laccase enzyme obtainable from the strains of genus Thielavia. The invention relates also to the nucleic acid sequence encoding the enzyme, a recombinant host into which the nucleic acid sequence has been introduced and a method for the production of the enzyme in a recombinant host. The enzyme of the invention is suitable for several applications, in particular for increasing the lightness of denim.
摘要翻译：本发明涉及可从Thielavia属的菌株获得的新型漆酶。本发明还涉及编码该酶的核酸序列，其中引入了该核酸序列的重组宿主和在重组宿主中产生该酶的方法。本发明的酶适用于多种用途，特别是用于增加牛仔布的亮度。

3. 发明授权

US07323326B2 Cellulases, the genes encoding them and uses thereof 有权
标题翻译：纤维素酶，编码它们的基因及其用途
公开(公告)号：US07323326B2
公开(公告)日：2008-01-29
申请号：US10782002
申请日：2004-02-20
申请人： Arja Miettinen-Oinonen , John Londesborough , Jari Vehmaanpera , Heli Haakana , Arja Mantyla , Raija Lantto , Minna Elovainio , Vesa Joutsjoki , Marja Paloheimo , Pirkko Suominen
发明人： Arja Miettinen-Oinonen , John Londesborough , Jari Vehmaanpera , Heli Haakana , Arja Mantyla , Raija Lantto , Minna Elovainio , Vesa Joutsjoki , Marja Paloheimo , Pirkko Suominen
IPC分类号： C12N9/42 , D06M16/00 , C12P21/06 , C11D3/00 , C11D9/42 , C07H21/04
CPC分类号： C11D3/38645 , C12N9/2437 , C12Y302/01004
摘要： Genes encoding novel cellulases, and a gene encoding a protein that facilitates the action of such novel cellulases, the novel cellulases and a protein that facilitates the action of such cellulases, and enzyme preparations containing such proteins are described. The native hosts and the culture medium of said hosts containing said novel cellulases are also disclosed. These proteins are especially useful in the textile and detergent industry and in pulp and paper industry.
摘要翻译：编码新型纤维素酶的基因和编码促进这种新型纤维素酶作用的蛋白质的基因，新型纤维素酶和促进这种纤维素酶作用的蛋白质，以及含有这种蛋白质的酶制剂。还公开了含有所述新型纤维素酶的所述宿主的天然宿主和培养基。这些蛋白质在纺织和洗涤剂行业以及纸浆和造纸工业中特别有用。

4. 发明申请

US20060063246A1 Novel laccase enzyme and use thereof 有权
标题翻译：新型漆酶及其用途
公开(公告)号：US20060063246A1
公开(公告)日：2006-03-23
申请号：US11231706
申请日：2005-09-21
申请人： Marja Paloheimo , Leena Valtakari , Terhi Puranen , Kristiina Kruus , Jarno Kallio , Arja Mantyla , Richard Fagerstrom , Pentti Ojapalo , Jari Vehmaanpera
发明人： Marja Paloheimo , Leena Valtakari , Terhi Puranen , Kristiina Kruus , Jarno Kallio , Arja Mantyla , Richard Fagerstrom , Pentti Ojapalo , Jari Vehmaanpera
IPC分类号： C12N9/00
CPC分类号： A61K8/66 , A61Q5/00 , A61Q5/08 , C11D3/38654 , C12N9/0061 , D06L4/40 , D06M16/003 , D06P5/137 , D06P5/158 , D21C5/005 , D21H17/005
摘要： The present invention relates to a novel laccase enzyme obtainable from the strains of genus Thielavia. The invention relates also to the nucleic acid sequence encoding the enzyme, a recombinant host into which the nucleic acid sequence has been introduced and a method for the production of the enzyme in a recombinant host. The enzyme of the invention is suitable for several applications, in particular for increasing the lightness of denim.
摘要翻译：本发明涉及可从Thielavia属的菌株获得的新型漆酶。本发明还涉及编码该酶的核酸序列，其中引入了该核酸序列的重组宿主和在重组宿主中产生该酶的方法。本发明的酶适用于多种用途，特别是用于增加牛仔布的亮度。

5. 发明授权

US5935836A Actinomadura xylanase sequences and methods of use 失效
标题翻译：放线菌木聚糖酶序列和使用方法
公开(公告)号：US5935836A
公开(公告)日：1999-08-10
申请号：US468812
申请日：1995-06-06
申请人： Jari Vehmaanpera , Arja Mantyla , Richard Fagerstrom , Raija Lantto , Marja Paloheimo , Pirkko Suominen
发明人： Jari Vehmaanpera , Arja Mantyla , Richard Fagerstrom , Raija Lantto , Marja Paloheimo , Pirkko Suominen
IPC分类号： C12N9/24 , D21C5/00 , C07K1/00 , D21C1/00 , D21C3/00
CPC分类号： C12Y302/01008 , C12N9/2482 , D21C5/005
摘要： The isolation and cloning of Actinomadura spp. xylanases having a molecular weight of 35 kDa and 50 kDa are described. These xylanases are thermostable and useful in biobleaching of wood pulp.
摘要翻译：分离和克隆Actinomadura spp。描述了分子量为35kDa和50kDa的木聚糖酶。这些木聚糖酶是热稳定的，可用于木浆的生物漂白。

6. 发明授权

US07348172B2 Method and DNA constructs for increasing the production level of carbohydrate degrading enzymes in filamentous fungi 有权
标题翻译：用于提高丝状真菌中碳水化合物降解酶生产水平的方法和DNA构建体
公开(公告)号：US07348172B2
公开(公告)日：2008-03-25
申请号：US11108163
申请日：2005-04-18
申请人： Marja Paloheimo , Arja Mantyla , Sanna Leskinen , Richard Fagerstrom , Jarno Kallio , Terhi Puranen , Raija Lantto , Pirkko Suominen
发明人： Marja Paloheimo , Arja Mantyla , Sanna Leskinen , Richard Fagerstrom , Jarno Kallio , Terhi Puranen , Raija Lantto , Pirkko Suominen
IPC分类号： C12P21/06 , C12N9/88 , C12N1/15 , C12N15/70 , C12N15/74 , C12Q1/68 , C07H21/04
CPC分类号： C12N9/248 , C12N15/80 , C12Y302/01008
摘要： The invention is related to a method and DNA constructs for obtaining in a filamentous fungus host a higher production level of a carbohydrate degrading (CD) enzyme, having in its original state a catalytic module (CAT) and a carbohydrate binding module (CBM) separated by a linker region. The DNA construct comprising a truncated actinomycetes, preferably Nonomuraea flexuosa (NJ) derived DNA sequence encoding a truncated form of the CD enzyme, for example Nf Xyn11A, Nf Xyn10A, and is introduced into a filamentous fungal host. Said CD enzyme contains the catalytically active region of CAT but lacks part or all of the CBM, or all of the CBM and part or all of the linker region and is expressed and secreted under the control of regulatory sequences comprising at least a signal sequence, but also promoters, terminators and DNA sequences encoding a secretable carrier protein or domains thereof, preferably originating from filamentous fungi are included. The production level obtained with DNA sequence having the shortened DNA sequence encoding the truncated form of the CD enzyme is higher than the production level obtained with DNA construct encoding the corresponding full length CD enzyme.
摘要翻译：本发明涉及一种用于在丝状真菌宿主中获得更高生产水平的降解碳水化合物（CD）酶的方法和DNA构建体，其具有在其初始状态下分离的催化模块（CAT）和碳水化合物结合模块（CBM）通过接头区域。该DNA构建体包含截短的放线菌，优选非曲霉（NJ）衍生的编码CD酶的截短形式的DNA序列，例如Nf Xyn11A，Nf Xyn10A，并被引入丝状真菌宿主中。所述CD酶含有CAT的催化活性区，但缺少部分或全部CBM，或全部CBM和部分或全部接头区，并且在包含至少一个信号序列的调控序列的控制下表达和分泌，而且还包括编码可分泌载体蛋白或其结构域的启动子，终止子和DNA序列，优选来源于丝状真菌。用缩短的编码CD酶的截短形式的DNA序列的DNA序列获得的生产水平高于用编码相应的全长CD酶的DNA构建体获得的产生水平。

7. 发明授权

US07273748B2 Cellulases, the genes encoding them and uses thereof 有权
标题翻译：纤维素酶，编码它们的基因及其用途
公开(公告)号：US07273748B2
公开(公告)日：2007-09-25
申请号：US10825378
申请日：2004-04-16
申请人： Arja Miettinen-Oinonen , John Londesborough , Jari Vehmaanpera , Heli Haakana , Arja Mantyla , Raija Lantto , Minna Elovainio , Vesa Joutsjoki , Marja Paloheimo , Pirkko Suominen
发明人： Arja Miettinen-Oinonen , John Londesborough , Jari Vehmaanpera , Heli Haakana , Arja Mantyla , Raija Lantto , Minna Elovainio , Vesa Joutsjoki , Marja Paloheimo , Pirkko Suominen
IPC分类号： D06M16/00 , C12N9/42 , C12P21/06 , C11D3/00 , C11D9/42 , C07H21/02 , C07H21/04
CPC分类号： C11D3/38645 , C12N9/2437 , C12Y302/01004
摘要： Genes encoding novel cellulases, and a gene encoding a protein that facilitates the action of such novel cellulases, the novel cellulases and a protein that facilitates the action of such cellulases, and enzyme preparations containing such proteins are described. The native hosts and the culture medium of said hosts containing said novel cellulases are also disclosed. These proteins are especially useful in the textile and detergent industry and in pulp and paper industry.
摘要翻译：编码新型纤维素酶的基因和编码促进这种新型纤维素酶作用的蛋白质的基因，新型纤维素酶和促进这种纤维素酶作用的蛋白质，以及含有这种蛋白质的酶制剂。还公开了含有所述新型纤维素酶的所述宿主的天然宿主和培养基。这些蛋白质在纺织和洗涤剂行业以及纸浆和造纸工业中特别有用。

8. 发明申请

US20060014247A1 Method and DNA constructs for increasing the production level of carbohydrate degrading enzymes in filamentous fungi 有权
标题翻译：用于提高丝状真菌中碳水化合物降解酶生产水平的方法和DNA构建体
公开(公告)号：US20060014247A1
公开(公告)日：2006-01-19
申请号：US11108163
申请日：2005-04-18
申请人： Marja Paloheimo , Arja Mantyla , Sanna Leskinen , Richard Fagerstrom , Jarno Kallio , Terhi Puranen , Raija Lantto , Pirkko Suominen
发明人： Marja Paloheimo , Arja Mantyla , Sanna Leskinen , Richard Fagerstrom , Jarno Kallio , Terhi Puranen , Raija Lantto , Pirkko Suominen
IPC分类号： C12N9/88 , C12N1/16 , C12N15/74 , C07H21/04 , C12P21/06
CPC分类号： C12N9/248 , C12N15/80 , C12Y302/01008
摘要： The invention is related to a method and DNA constructs for obtaining in a filamentous fungus host a higher production level of a carbohydrate degrading (CD) enzyme, having in its original state a catalytic module (CAT) and a carbohydrate binding module (CBM) separated by a linker region. The DNA construct comprising a truncated actinomycetes, preferably Nonomuraea flexuosa (NJ) derived DNA sequence encoding a truncated form of the CD enzyme, for example Nf Xyn11A, Nf Xyn10A, and is introduced into a filamentous fungal host. Said CD enzyme contains the catalytically active region of CAT but lacks part or all of the CBM, or all of the CBM and part or all of the linker region and is expressed and secreted under the control of regulatory sequences comprising at least a signal sequence, but also promoters, terminators and DNA sequences encoding a secretable carrier protein or domains thereof, preferably originating from filamentous fungi are included. The production level obtained with DNA sequence having the shortened DNA sequence encoding the truncated form of the CD enzyme is higher than the production level obtained with DNA construct encoding the corresponding full length CD enzyme.
摘要翻译：本发明涉及一种用于在丝状真菌宿主中获得更高生产水平的降解碳水化合物（CD）酶的方法和DNA构建体，其具有在其初始状态下分离的催化模块（CAT）和碳水化合物结合模块（CBM）通过接头区域。该DNA构建体包含截短的放线菌，优选非曲霉（NJ）衍生的编码CD酶的截短形式的DNA序列，例如Nf Xyn11A，Nf Xyn10A，并被引入丝状真菌宿主中。所述CD酶含有CAT的催化活性区，但缺少部分或全部CBM，或全部CBM和部分或全部接头区，并且在包含至少一个信号序列的调控序列的控制下表达和分泌，而且还包括编码可分泌载体蛋白或其结构域的启动子，终止子和DNA序列，优选来源于丝状真菌。用缩短的编码CD酶的截短形式的DNA序列的DNA序列获得的生产水平高于用编码相应的全长CD酶的DNA构建体获得的产生水平。

9. 发明授权

US07732178B2 Laccase enzymes and their uses 有权
标题翻译：漆酶及其用途
公开(公告)号：US07732178B2
公开(公告)日：2010-06-08
申请号：US11663424
申请日：2005-09-21
申请人： Marja Paloheimo , Terhi Puranen , Leena Valtakari , Kristiina Kruus , Jarno Kallio , Arja Mantyla , Richard Fagerstrom , Pentti Ojapalo , Jari Vehmaanpera
发明人： Marja Paloheimo , Terhi Puranen , Leena Valtakari , Kristiina Kruus , Jarno Kallio , Arja Mantyla , Richard Fagerstrom , Pentti Ojapalo , Jari Vehmaanpera
IPC分类号： C12N9/02 , C12N1/20 , C12N15/00 , C12Q1/68 , C12Q1/26 , C12P21/04 , C07H21/04 , C12Q1/00
CPC分类号： D06M16/003 , A61K8/66 , A61Q5/00 , A61Q5/08 , C11D3/38654 , C12N9/0061 , D06L4/40 , D06P5/137 , D06P5/158 , D21C5/005 , D21H17/005
摘要： The present invention relates to novel laccase enzymes obtainable from the strains of the genus Thielavia or from the strains of the genus Chaetomium. The invention relates also to nucleic acid sequences encoding the enzymes, recombinant hosts into which the nucleic acid sequences have been introduced and to methods for the production of the enzymes in recombinant hosts. The enzymes of the invention are suitable for several applications, for example for treating denim and for strain removal.
摘要翻译：本发明涉及可从Thielavia属的菌株或Chaetomium属的菌株获得的新的漆酶。本发明还涉及编码酶的核酸序列，其中引入了核酸序列的重组宿主和在重组宿主中产生酶的方法。本发明的酶适用于几种用途，例如用于处理牛仔布和除去菌株。

10. 发明授权

US06635464B1 Xylanases, genes encoding them, and uses thereof 失效
标题翻译：木聚糖酶，编码它们的基因及其用途
公开(公告)号：US06635464B1
公开(公告)日：2003-10-21
申请号：US09849242
申请日：2001-05-07
申请人： Marja Paloheimo , Satu Hakola , Arja Mantyla , Jari Vehmaanpera , Raija Lantto , Tarja Lahtinen , Richard Fagerström , Pirkko Suominen
发明人： Marja Paloheimo , Satu Hakola , Arja Mantyla , Jari Vehmaanpera , Raija Lantto , Tarja Lahtinen , Richard Fagerström , Pirkko Suominen
IPC分类号： C12P2106
CPC分类号： C12Y302/01032 , A21D8/042 , A23K20/189 , A23L7/107 , C07K2319/00 , C12N9/2482 , C12N9/2485 , C12Y302/01008 , D21C5/005
摘要： DNA encoding novel xylanases, vectors containing such DNA, hosts transformed with such DNA, enzyme preparations, and the use of such preparations are described.
摘要翻译：描述了编码新型木聚糖酶的DNA，含有这种DNA的载体，用这种DNA转化的宿主，酶制剂和这些制剂的用途。

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