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1. 发明授权

US08974803B2 Injectable biomaterials 有权
标题翻译：可注射生物材料
公开(公告)号：US08974803B2
公开(公告)日：2015-03-10
申请号：US13255047
申请日：2010-03-10
申请人： Anthony Steven Weiss , Suzanne Marie Mithieux
发明人： Anthony Steven Weiss , Suzanne Marie Mithieux
IPC分类号： A61K9/14 , A61K38/39 , A61K9/00 , A61L27/20 , C07K14/78
CPC分类号： A61K38/39 , A61K9/0019 , A61L27/20 , A61L2400/06 , C07K14/78 , C08L1/02
摘要： Injectable biomaterial compositions formed from tropoelastin for tissue repair and restoration. The compositions include a coalescence-controlling agent in the form of a polysaccharide or polysaccharide derivative, in an amount effective for providing the substance with the properties of flow, enabling injection.
摘要翻译：用于组织修复和恢复的由托普弹力蛋白形成的可注射生物材料组合物。组合物包括多糖或多糖衍生物形式的聚结控制剂，其量可以有效地为物质提供流动性，从而能够注射。

2. 发明申请

US20100021440A1 USE OF TROPOELASTIN FOR REPAIR OR RESTORATION OF TISSUE 有权
标题翻译：使用TROPOELASTIN进行修复或恢复组织
公开(公告)号：US20100021440A1
公开(公告)日：2010-01-28
申请号：US12513798
申请日：2007-11-13
申请人： Anthony Steven Weiss , Suzanne Marie Mithieux
发明人： Anthony Steven Weiss , Suzanne Marie Mithieux
IPC分类号： A61K35/12 , A61K38/17 , A61K38/16
CPC分类号： A61L27/227 , A61K8/64 , A61K2800/86 , A61K2800/91 , A61L31/047 , A61Q19/08
摘要： The present invention relates to tropoelastin and to tissue repair and restoration using elastic materials. Disclosed is a process for producing an elastic material from tropoelastin including heating a solution of tropoelastin having an alkaline pH to form an elastic material from the tropoelastin in the solution. Also disclosed are elastic materials prepared according to this process and their applications.
摘要翻译：本发明涉及托普弹力素和使用弹性材料的组织修复和恢复。公开了一种由托普弹力蛋白制造弹性材料的方法，包括加热具有碱性pH的托普弹力素溶液以从溶液中的原弹药形成弹性材料。还公开了根据该方法制备的弹性材料及其应用。

3. 发明授权

US07700126B2 Tropoelastin-based protoelastin biomaterials 有权
标题翻译：基于原始弹力蛋白的原弹性蛋白生物材料
公开(公告)号：US07700126B2
公开(公告)日：2010-04-20
申请号：US11864006
申请日：2007-09-28
申请人： Martin Kean Chong Ng , Anthony Steven Weiss , Steven Garry Wise
发明人： Martin Kean Chong Ng , Anthony Steven Weiss , Steven Garry Wise
IPC分类号： A61F2/00
CPC分类号： A61K38/39 , A61L27/227 , A61L27/26 , A61L27/34 , A61L31/047 , A61L31/10
摘要： Biocompatible materials suitable for use in vascular applications have been engineered, combining human recombinant tropoelastin with other synthetic or natural biomaterials to form protoelastin. The materials can be in the form of elastin films on metal, bone, ceramic or polymer substrates, laminates of alternating polymer and elastin, blends of polymer and elastin, or elastin crosslinked with or tethered to polymer. The flexibility in engineering and design makes protoelastin biomaterials suited not only to the production of conduits but any number of other vascular applications that require blood contacting surfaces. Tropoelastin and the subsequently engineered biomaterial protoelastin provide the opportunity to satisfy a large unmet need for a biocompatible material adaptable enough to meet a range of diverse vascular uses. These are mechanically stable, elastic, strong and biocompatible (i.e., not thrombogenic and promoting adhesion of cells, especially human endothelial cells.
摘要翻译：已经设计了适用于血管应用的生物相容性材料，将人重组托拉斯特蛋白与其他合成或天然生物材料组合以形成原胶原蛋白。材料可以是金属，骨，陶瓷或聚合物基底上的弹性蛋白膜，交替聚合物和弹性蛋白的叠层，聚合物和弹性蛋白的共混物，或与聚合物交联或连接的弹性蛋白。工程和设计的灵活性使得原胶原生物材料不仅适用于导管的生产，而且也适用于需要接触血液的表面的任何数量的其他血管应用。托罗弹性蛋白和随后改良的生物材料原弹性蛋白提供了满足大量未满足的生物相容性材料需求的机会，其适应性足以满足多种血管用途的范围。这些是机械稳定的，弹性的，强的和生物相容的（即，不是血栓形成和促进细胞，特别是人内皮细胞的粘附。

4. 发明授权

US06277622B1 Synthetic polynucleotides 有权
标题翻译：合成多核苷酸
公开(公告)号：US06277622B1
公开(公告)日：2001-08-21
申请号：US09242095
申请日：1999-02-08
申请人： Anthony Steven Weiss
发明人： Anthony Steven Weiss
IPC分类号： C12N120
CPC分类号： C12N9/0022
摘要： This invention relates to synthetic polynucleotides which encode lysyl oxidase, lysyl oxidase like molecules or variants of these species. The synthetic polynucleotides of the invention permit the expression of functional lysyl oxidase, lysyl oxidase like molecules or variants of these species, typically in good yield. The invention also relates to recombinant DNA molecules containing these, synthetic polynucleotides, to cells containing them and to uses of the expression products.
摘要翻译：本发明涉及编码赖氨酰氧化酶，赖氨酰氧化酶样分子或这些物种的变体的合成多核苷酸。本发明的合成多核苷酸允许功能性赖氨酰氧化酶，赖氨酰氧化酶如分子或这些物种的变体的表达，通常以良好的产率。本发明还涉及含有这些，合成多核苷酸，含有它们的细胞和表达产物的用途的重组DNA分子。

5. 发明授权

US06232458B1 Synthetic polynucleotides encoding tropoelastin 失效
标题翻译：编码托普拉斯汀的合成多核苷酸
公开(公告)号：US06232458B1
公开(公告)日：2001-05-15
申请号：US08464700
申请日：1995-07-24
申请人： Anthony Steven Weiss , Stephen Lewis Martin
发明人： Anthony Steven Weiss , Stephen Lewis Martin
IPC分类号： C07H2104
CPC分类号： C07K14/78 , A61K38/00
摘要： Recombinant tropoelastins and variants of recombinant tropoelastins produced from synthetic polynucleotides, as well as the synthetic polynucleotides themselves are provided. Also provided are cross-linked elastins or elastin-like products prepared from the tropoelastins or variants.
摘要翻译：本发明提供了由合成多核苷酸产生的重组原丝原蛋白和重组原生质体的变体，以及合成的多核苷酸本身。还提供了由托拉胶弹性蛋白或变体制备的交联弹性蛋白或弹性蛋白样产物。

6. 发明授权

US07229788B1 Protease susceptibility II 有权
标题翻译：蛋白酶敏感性II
公开(公告)号：US07229788B1
公开(公告)日：2007-06-12
申请号：US09743818
申请日：1999-07-19
申请人： Anthony Steven Weiss
发明人： Anthony Steven Weiss
IPC分类号： C12N15/00 , C07K1/00 , C07K14/00
CPC分类号： C07K7/02 , A61K38/00 , C07K14/78
摘要： The present invention relates to: manipulation of the amino acid sequence of tropoelastin, particularly human tropoelastin, to modify its protease susceptibility; to tropoelastin derivatives having modified protease susceptibility; to peptidomimetic molecules which contain amino acid sequences which correspond to or incorporate the protease susceptible sequences of tropoelastin; and to uses of the tropoelastin derivatives and peptidomimetic molecules.The invention also relates to nucleic acid molecules and genetic constructs encoding the amino acid sequences of the derivatives and peptidomimetic molecules of the invention.
摘要翻译：本发明涉及：对托普弹原蛋白（特别是人类托拉斯汀）的氨基酸序列的操纵，以改变其蛋白酶敏感性; 具有改变的蛋白酶敏感性的托普拉斯汀衍生物; 含有对应于或掺入蛋白酶敏感序列的氨基酸序列的拟肽分子; 并使用托普弹力素衍生物和拟肽分子。本发明还涉及编码本发明的衍生物和拟肽分子的氨基酸序列的核酸分子和遗传构建体。

7. 发明申请

US20100174351A1 CHEMICALLY AND BIOLOGICALLY MODIFIED MEDICAL DEVICES 有权
标题翻译：化学和生物改良医疗器械
公开(公告)号：US20100174351A1
公开(公告)日：2010-07-08
申请号：US12652926
申请日：2010-01-06
申请人： Martin Kean Chong Ng , Anna Waterhouse , Anthony Steven Weiss , Steven Garry Wise
发明人： Martin Kean Chong Ng , Anna Waterhouse , Anthony Steven Weiss , Steven Garry Wise
IPC分类号： A61F2/82 , A61F2/24 , A61F2/28 , A61F2/02 , A61L33/12
CPC分类号： A61L33/128 , A61L27/04 , A61L27/08 , A61L27/34 , A61L31/022 , A61L31/024 , A61L31/10 , A61L2400/18 , C08L89/00
摘要： Biocompatible materials for use in vascular applications or for implantation have been engineered, combining human recombinant tropoelastin with other synthetic or natural biomaterials to form protoelastin. The materials can be in the form of elastin films on metal or polymer substrates, laminates of alternating polymer and elastin, blends of polymer and elastin, or elastin crosslinked with or tethered to polymer or metal. These are mechanically stable, elastic, strong and biocompatible (i.e., not thrombogenic and promoting adhesion of cells, especially human endothelial cells), not eliciting a foreign body response. Plasma polymerization of substrate is shown to enhance biocompatibility, especially when used to bind elastin or other protein to the substrate.
摘要翻译：已经设计了用于血管应用或植入的生物相容性材料，将人重组托拉斯特蛋白与其他合成或天然生物材料组合以形成原胶原蛋白。材料可以是金属或聚合物基材上的弹性蛋白膜，交替聚合物和弹性蛋白的层压材料，聚合物和弹性蛋白的共混物，或与聚合物或金属交联或连接的弹性蛋白。这些机械稳定，弹性，强力和生物相容性（即不引起血栓形成和促进细胞，特别是人内皮细胞的粘附），而不引起异物反应。显示底物的等离子体聚合增强生物相容性，特别是当用于将弹性蛋白或其它蛋白质结合到底物时。

8. 发明授权

US08808365B2 Chemically and biologically modified medical devices 有权
标题翻译：化学和生物修饰的医疗器械
公开(公告)号：US08808365B2
公开(公告)日：2014-08-19
申请号：US12652926
申请日：2010-01-06
申请人： Martin Kean Chong Ng , Anna Waterhouse , Anthony Steven Weiss , Steven Garry Wise
发明人： Martin Kean Chong Ng , Anna Waterhouse , Anthony Steven Weiss , Steven Garry Wise
IPC分类号： A61F2/06 , A61K38/00
CPC分类号： A61L33/128 , A61L27/04 , A61L27/08 , A61L27/34 , A61L31/022 , A61L31/024 , A61L31/10 , A61L2400/18 , C08L89/00
摘要： Biocompatible materials for use in vascular applications or for implantation have been engineered, combining human recombinant tropoelastin with other synthetic or natural biomaterials to form protoelastin. The materials can be in the form of elastin films on metal or polymer substrates, laminates of alternating polymer and elastin, blends of polymer and elastin, or elastin crosslinked with or tethered to polymer or metal. These are mechanically stable, elastic, strong and biocompatible (i.e., not thrombogenic and promoting adhesion of cells, especially human endothelial cells), not eliciting a foreign body response. Plasma polymerization of substrate is shown to enhance biocompatibility, especially when used to bind elastin or other protein to the substrate.
摘要翻译：已经设计了用于血管应用或植入的生物相容性材料，将人重组托拉斯特蛋白与其他合成或天然生物材料组合以形成原胶原蛋白。材料可以是金属或聚合物基材上的弹性蛋白膜，交替聚合物和弹性蛋白的层压材料，聚合物和弹性蛋白的共混物，或与聚合物或金属交联或连接的弹性蛋白。这些机械稳定，弹性，强力和生物相容性（即不引起血栓形成和促进细胞，特别是人内皮细胞的粘附），而不引起异物反应。显示底物的等离子体聚合增强生物相容性，特别是当用于将弹性蛋白或其它蛋白质结合到底物时。

9. 发明授权

US08101717B2 Use of tropoelastin for repair or restoration of tissue 有权
标题翻译：使用托普拉斯汀来修复或恢复组织
公开(公告)号：US08101717B2
公开(公告)日：2012-01-24
申请号：US12513798
申请日：2007-11-13
申请人： Anthony Steven Weiss , Suzanne Marie Mithieux
发明人： Anthony Steven Weiss , Suzanne Marie Mithieux
IPC分类号： A61K38/17
CPC分类号： A61L27/227 , A61K8/64 , A61K2800/86 , A61K2800/91 , A61L31/047 , A61Q19/08
摘要： The present invention relates to tropoelastin and to tissue repair and restoration using elastic materials. Disclosed is a process for producing an elastic material from tropoelastin including heating a solution of tropoelastin having an alkaline pH to form an elastic material from the tropoelastin in the solution. Also disclosed are elastic materials prepared according to this process and their applications.
摘要翻译：本发明涉及托普弹力素和使用弹性材料的组织修复和恢复。公开了一种由托普弹力蛋白制造弹性材料的方法，包括加热具有碱性pH的托普弹力素溶液以从溶液中的原弹药形成弹性材料。还公开了根据该方法制备的弹性材料及其应用。

10. 发明申请

US20120003283A1 Injectable Biomaterials 有权
标题翻译：可注射生物材料
公开(公告)号：US20120003283A1
公开(公告)日：2012-01-05
申请号：US13255047
申请日：2010-03-10
申请人： Anthony Steven Weiss , Suzanne Marie Mithieux
发明人： Anthony Steven Weiss , Suzanne Marie Mithieux
IPC分类号： A61K9/14 , A61K38/39
CPC分类号： A61K38/39 , A61K9/0019 , A61L27/20 , A61L2400/06 , C07K14/78 , C08L1/02
摘要： Injectable biomaterial compositions formed from tropoelastin for tissue repair and restoration. The compositions include a coalescence-controlling agent in the form of a polysaccharide or polysaccharide derivative, in an amount effective for providing the substance with the properties of flow, enabling injection.
摘要翻译：用于组织修复和恢复的由托普弹力蛋白形成的可注射生物材料组合物。组合物包括多糖或多糖衍生物形式的聚结控制剂，其量可以有效地为物质提供流动性，从而能够注射。

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