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1. 发明授权

US06416756B1 Modified protease having 5 to 13 covalently coupled polymeric molecules for skin care 失效
标题翻译：具有5至13个共价偶联的用于皮肤护理的聚合物分子的改性蛋白酶
公开(公告)号：US06416756B1
公开(公告)日：2002-07-09
申请号：US09019532
申请日：1998-02-05
申请人： Arne Agerlin Olsen , Annette Prento
发明人： Arne Agerlin Olsen , Annette Prento
IPC分类号： A61K3848
CPC分类号： A61Q19/00 , A61K8/66 , A61K8/86 , A61K2800/57 , A61K2800/70 , A61Q5/02 , A61Q5/06 , A61Q5/10 , A61Q5/12 , A61Q9/02 , A61Q19/10
摘要： Modified enzymes are prepared for use in skin care products by covalently coupling to the enzymes from 4 to 70 polymeric molecules with or without a linker such as a triazine ring. Molecular weight of the polymeric molecules may be from 1 to 35 kDa and of the enzymes from 15 to 100 kDa. The number and weight of polymeric molecules coupled is balanced with the weight and/or surface area of the enzymes. Enzymes include proteases such as subtilisins, lipases and oxidoreductases such as laccases and superoxide dismutase, and polymeric molecules include polysaccharides such as dextran or pullulan and polyalkylene oxides such as polyethylene glycol. The polymeric molecules may be coupled to the enzymes at the N-terminal amino group and/or lysine residues, and preferably at a position more than 5 Å from the active site of the enzymes. A preferred modified enzyme is a protease having from 5 to 13 coupled polymeric molecules. Skin care products containing the modified enzymes have improved stability and reduced allergenicity as compared to the products containing the unmodified enzymes.
摘要翻译：通过共价偶联到具有或不具有诸如三嗪环的接头的4-70个聚合物分子的酶来制备修饰的酶用于护肤产品。聚合物分子的分子量可以是1至35kDa，且15至100kDa的酶的分子量。耦合的聚合物分子的数量和重量与酶的重量和/或表面积平衡。酶包括蛋白酶如枯草杆菌蛋白酶，脂肪酶和氧化还原酶如漆酶和超氧化物歧化酶，聚合物分子包括多糖如葡聚糖或支链淀粉以及聚环氧烷如聚乙二醇。聚合物分子可以在N末端氨基和/或赖氨酸残基处与酶的偶联，优选在离酶活性位点大于5的位置。优选的修饰酶是具有5至13个偶联聚合物分子的蛋白酶。与含有未修饰酶的产品相比，含有修饰酶的护肤品具有改善的稳定性和降低的过敏原性。

2. 发明授权

US6106828A Conjugation of polypeptides 失效
标题翻译：多肽的缀合
公开(公告)号：US6106828A
公开(公告)日：2000-08-22
申请号：US123787
申请日：1998-07-28
申请人： Henrik Bisgard-Frantzen , Arne Agerlin Olsen , Annette Prento
发明人： Henrik Bisgard-Frantzen , Arne Agerlin Olsen , Annette Prento
IPC分类号： A61K8/66 , A61K8/88 , A61Q5/02 , A61Q11/00 , A61Q19/10 , C11D3/386 , A61K38/43 , A01N37/18 , A61K38/00 , C12N11/00 , C12N11/06
CPC分类号： C11D3/386 , A61K8/66 , A61K8/88 , A61Q11/00 , A61Q19/10 , A61Q5/02 , A61K2800/57
摘要： The present invention provides polypeptide conjugates with reduced allergenicity comprising a polymeric carrier molecule having two or more polypeptide molecules coupled thereto. The invention also provides methods for producing the conjugates, compositions comprising the conjugates, and the use of the conjugates in industrial applications, including personal care products and detergent compositions.
摘要翻译：本发明提供具有降低的变应原性的多肽缀合物，其包含具有与其偶联的两个或更多个多肽分子的聚合物载体分子。本发明还提供了制备缀合物的方法，包含缀合物的组合物，以及在工业应用中使用共轭物，包括个人护理产品和洗涤剂组合物。

3. 发明授权

US5206144A Determination of glycated (glycosylated) hemoglobin in blood 失效
标题翻译：测定血液中糖化（糖基化）血红蛋白
公开(公告)号：US5206144A
公开(公告)日：1993-04-27
申请号：US607766
申请日：1990-10-30
申请人： Jesper Zeuthen , Annette Prento , Viggo Kruse
发明人： Jesper Zeuthen , Annette Prento , Viggo Kruse
IPC分类号： C07K16/18 , G01N33/72
CPC分类号： G01N33/723 , C07K16/18
摘要： The concentration of glycated hemoglobin, HbA.sub.1c, in hemoglobin from diabetic patients is regarded as a useful means of assessing the adequacy of diabetes control. This invention comprises a monoclonal antibody which, due to its specific binding of HbA.sub.1c, can be used for the determination of HbA.sub.1c in the absence of prior denaturation, in blood samples by such analytical methods as radioimmuno assay or enzyme-linked immunosorbent assay. The invention also comprises hybridoma cell lines which produce monoclonal antibodies of the invention.
摘要翻译：糖尿病患者血红蛋白中糖化血红蛋白HbA1c的浓度被认为是评估糖尿病控制适宜性的有用手段。本发明包括一种单克隆抗体，由于其具有HbA1c的特异性结合，可以通过放射免疫测定法或酶联免疫吸附测定法等分析方法在血液样品中不用先前变性来测定HbA1c。本发明还包括产生本发明的单克隆抗体的杂交瘤细胞系。

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