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1. 发明申请

US20050119736A1 Bioprosthetic tissue preparation with synthetic hydrogels 有权
标题翻译：用合成水凝胶制备生物假体组织
公开(公告)号：US20050119736A1
公开(公告)日：2005-06-02
申请号：US10967365
申请日：2004-10-18
申请人： Peter Zilla , Deon Bezuidenhout , Anel Oostheysen , Paul Human
发明人： Peter Zilla , Deon Bezuidenhout , Anel Oostheysen , Paul Human
IPC分类号： A61F2/24 , A61L27/26 , A61L27/52
CPC分类号： A61L27/52 , A61L27/3687 , A61L27/507
摘要： Methods for treating xenogenic tissue for implantation into a human body including in-situ polymerization of a hydrogel polymer in tissue, and tissue treated according to those methods, where the polymerization takes place in tissue that has not been fixed with glutaraldehyde. The polymerization may only fill the tissue, bind the polymer to the tissue, or cross-link the tissue through the polymer, depending on the embodiment. One method includes free radical polymerization of a first vinylic compound, and can include cross-linking through use of a second compound having at least two vinyl groups. Another method utilizes nucleophilic addition polymerization of two compounds, one of which can include PEG and can further include hydrolytically degradable regions. In one embodiment, applicants believe the in-situ polymerization inhibits calcification, and that the polymerization of tissue un-fixed by glutaraldehyde allows for improved penetration of the polymer. The methods find one use in the treatment of porcine heart valve tissue, intended to extend the useful life of the valves by inhibiting calcification. The incorporation of degradable hydrogel regions may initially fill the tissue and reduce any initial inflammatory response, but allow for later infiltration by cells to remodel the tissue.
摘要翻译：用于治疗异种组织用于植入人体的方法，包括组织中水凝胶聚合物的原位聚合，以及根据那些方法处理的组织，其中聚合发生在未用戊二醛固定的组织中。根据实施例，聚合可以仅填充组织，将聚合物结合到组织，或者通过聚合物交联组织。一种方法包括第一乙烯基化合物的自由基聚合，并且可以包括通过使用具有至少两个乙烯基的第二化合物的交联。另一种方法利用两种化合物的亲核加成聚合，其中一种可以包括PEG，并且还可以包括水解可降解区域。在一个实施方案中，申请人认为原位聚合抑制钙化，并且由戊二醛未固定的组织的聚合允许改善聚合物的渗透性。该方法可用于治疗猪心脏瓣膜组织，旨在通过抑制钙化来延长瓣膜的使用寿命。可降解水凝胶区域的引入可以初始地填充组织并减少任何初始炎症反应，但允许细胞稍后浸润以重塑组织。

2. 发明授权

US07955788B2 Bioprosthetic tissue preparation with synthetic hydrogels 有权
标题翻译：用合成水凝胶制备生物假体组织
公开(公告)号：US07955788B2
公开(公告)日：2011-06-07
申请号：US10967365
申请日：2004-10-18
申请人： Peter Zilla , Deon Bezuidenhout , Anel Oostheysen , Paul Human
发明人： Peter Zilla , Deon Bezuidenhout , Anel Oostheysen , Paul Human
IPC分类号： A01N1/00
CPC分类号： A61L27/52 , A61L27/3687 , A61L27/507
摘要： Methods for treating xenogenic tissue for implantation into a human body including in-situ polymerization of a hydrogel polymer in tissue, and tissue treated according to those methods, where the polymerization takes place in tissue that has not been fixed with glutaraldehyde. The polymerization may only fill the tissue, bind the polymer to the tissue, or cross-link the tissue through the polymer, depending on the embodiment. One method includes free radical polymerization of a first vinylic compound, and can include cross-linking through use of a second compound having at least two vinyl groups. Another method utilizes nucleophilic addition polymerization of two compounds, one of which can include PEG and can further include hydrolytically degradable regions. In one embodiment, applicants believe the in-situ polymerization inhibits calcification, and that the polymerization of tissue un-fixed by glutaraldehyde allows for improved penetration of the polymer. The methods find one use in the treatment of porcine heart valve tissue, intended to extend the useful life of the valves by inhibiting calcification. The incorporation of degradable hydrogel regions may initially fill the tissue and reduce any initial inflammatory response, but allow for later infiltration by cells to remodel the tissue.
摘要翻译：用于治疗异种组织用于植入人体的方法，包括组织中水凝胶聚合物的原位聚合，以及根据那些方法处理的组织，其中聚合发生在未用戊二醛固定的组织中。根据实施例，聚合可以仅填充组织，将聚合物结合到组织，或者通过聚合物交联组织。一种方法包括第一乙烯基化合物的自由基聚合，并且可以包括通过使用具有至少两个乙烯基的第二化合物的交联。另一种方法利用两种化合物的亲核加成聚合，其中一种可以包括PEG，并且还可以包括水解可降解区域。在一个实施方案中，申请人认为原位聚合抑制钙化，并且由戊二醛未固定的组织的聚合允许改善聚合物的渗透性。该方法可用于治疗猪心脏瓣膜组织，旨在通过抑制钙化来延长瓣膜的使用寿命。可降解水凝胶区域的引入可以初始地填充组织并减少任何初始炎症反应，但允许细胞稍后浸润以重塑组织。

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