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    • 3. 发明申请
    • LOCAL VASCULAR DELIVERY OF mTOR INHIBITORS IN COMBINATION WITH PEROXISOME PROLIFERATORS-ACTIVATED RECEPTOR STIMULATORS
    • 与过氧化物酶体增殖物激活受体刺激物组合的mTOR抑制剂的局部血管输送
    • US20090074831A1
    • 2009-03-19
    • US11857285
    • 2007-09-18
    • Robert FaloticoAndrew Sheung-King LukTheodore L. ParkerJonathon Z. ZhaoLei Zhao
    • Robert FaloticoAndrew Sheung-King LukTheodore L. ParkerJonathon Z. ZhaoLei Zhao
    • A61K9/00A61K31/427A61K31/4439
    • A61L31/16A61L31/10A61L2300/416A61L2300/432A61L2300/45A61L2300/602
    • Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including vulnerable plaque, and atherosclerosis in type 2 diabetic patients. Therapeutic agents may also be delivered to the region of a disease site. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
    • 可以涂覆医疗装置,特别是可植入医疗装置,以最小化或基本上消除生物体对将生物体引入医疗装置的反应。 医疗装置可以涂覆任何数量的生物相容性材料。 治疗药物,药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。 这些治疗剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。 此外,这些治疗药物,药剂和/或化合物可用于促进愈合,包括预防血栓形成。 药物,药剂和/或化合物也可用于治疗2型糖尿病患者中的特定疾病,包括易损斑块和动脉粥样硬化。 治疗剂也可以递送到疾病部位的区域。 在区域递送中,液体制剂可能是期望的,以增加特定药物的功效和递送能力。 此外,可以修改装置以促进内皮化。 可以使用各种材料和涂覆方法来将药剂或化合物维持在医疗装置上,直到被输送和定位。 此外,可以修改用于递送可植入医疗装置的装置,以减少在展开期间损害可植入医疗装置的可能性。 此外,可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物,药剂和/或化合物的洗脱速率。