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1. 发明授权

US08283365B2 Indole modulators of the alpha 7 nicotinic acetylcholine receptor 失效
标题翻译： α7烟碱乙酰胆碱受体的吲哚调节剂
公开(公告)号：US08283365B2
公开(公告)日：2012-10-09
申请号：US12936408
申请日：2009-04-16
申请人： Kevin Dinnell , Andrew P Lightfoot , Howard Robert Marshall
发明人： Kevin Dinnell , Andrew P Lightfoot , Howard Robert Marshall
IPC分类号： C07D401/12 , A61K31/4439
CPC分类号： C07D401/12
摘要： This invention relates to modulation of the α7 nicotinic acetylcholine receptor (nAChR) by a compound of formula (I) or a salt thereof
摘要翻译：本发明涉及通过式（I）化合物或其盐调节α7烟碱乙酰胆碱受体（nAChR）

2. 发明授权

US06962917B2 Aminopiperidine quinolines and their azaisosteric analogues with antibacterical activity 失效
标题翻译：氨基哌啶喹啉及其具有抗菌活性的azaisosteric类似物
公开(公告)号：US06962917B2
公开(公告)日：2005-11-08
申请号：US10333829
申请日：2001-07-25
申请人： David Thomas Davies , Graham Elgin Jones , Andrew P Lightfoot , Roger Edward Markwell , Neil David Pearson
发明人： David Thomas Davies , Graham Elgin Jones , Andrew P Lightfoot , Roger Edward Markwell , Neil David Pearson
IPC分类号： C07D491/056 , A61K31/4709 , A61K31/498 , A61P31/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/04 , C07D513/04 , A61K31/4545 , C07D211/92 , C07D215/16
CPC分类号： C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/04 , C07D513/04
摘要： Aminopiperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.
摘要翻译：氨基哌啶衍生物及其药学上可接受的衍生物，其可用于哺乳动物，特别是人的细菌感染治疗方法。

3. 发明授权

US08377941B2 Indoles as modulators of nicotinic acetylcholine receptor subtype alpha-7 失效
标题翻译：吲哚作为烟碱型乙酰胆碱受体亚型α-7的调节剂
公开(公告)号：US08377941B2
公开(公告)日：2013-02-19
申请号：US12936431
申请日：2009-04-16
申请人： Kevin Dinnell , Andrew P Lightfoot , Howard Robert Marshall
发明人： Kevin Dinnell , Andrew P Lightfoot , Howard Robert Marshall
IPC分类号： C07D239/28 , A61K31/166 , A61K31/404 , A61K31/505
CPC分类号： C07D401/12
摘要： The present invention relates to modulation of the α7 nicotinic acetylcholine receptor (nAChR) by a compound of List A or a salt thereof, which may be represented, but is not limited to the compound N-[(2-Trifluoromethyl-1H-indol-5-yl)methyl]-2-(trifluoromethyl)-5-pyrimidinecarboxamide.
摘要翻译：本发明涉及通过列举A或其盐的化合物调节α7烟碱乙酰胆碱受体（nAChR），其可以表示，但不限于化合物N - [（2-三氟甲基-1H-吲哚-2-基）吡啶-5-基）甲基] -2-（三氟甲基）-5-嘧啶甲酰胺。

4. 发明申请

US20110034515A1 INDOLE MODULATORS OF THE ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR 失效
标题翻译： ALPHA 7 NICOTINIC乙酰胆碱受体的单调节剂
公开(公告)号：US20110034515A1
公开(公告)日：2011-02-10
申请号：US12936408
申请日：2009-04-16
申请人： Kevin Dinnell , Andrew P. Lightfoot , Howard Robert Marshall
发明人： Kevin Dinnell , Andrew P. Lightfoot , Howard Robert Marshall
IPC分类号： A61K31/4439 , C07D401/12 , A61P25/18
CPC分类号： C07D401/12
摘要： This invention relates to modulation of the α7 nicotinic acetylcholine receptor (nAChR) by a compound of formula (I) or a salt thereof
摘要翻译：本发明涉及通过式（I）化合物或其盐调节α7烟碱乙酰胆碱受体（nAChR）

5. 发明申请

US20110028486A1 INDOLES AS MODULATORS OF NICOTICIC ACETYLCHOLINE RECEPTOR SUBTYPE ALPHA-7 失效
标题翻译：作为尼古丁乙酰胆碱受体亚型ALPHA-7的调节剂
公开(公告)号：US20110028486A1
公开(公告)日：2011-02-03
申请号：US12936431
申请日：2009-04-16
申请人： Kevin Dinnell , Andrew P. Lightfoot , Howard Robert Marshall
发明人： Kevin Dinnell , Andrew P. Lightfoot , Howard Robert Marshall
IPC分类号： A61K31/501 , C07D403/12 , A61K31/506 , A61K31/497 , C07D401/14 , C07D401/12 , A61K31/4439 , A61K31/444 , A61K31/4196 , C07D417/12 , A61K31/427 , A61K31/4155 , A61P25/18
CPC分类号： C07D401/12
摘要： The present invention relates to modulation of the α7 nicotinic acetylcholine receptor (nAChR) by a compound of List A or a salt thereof, which may be represented, but is not limited to the compound N-[(2-Trifluoromethyl-1H-indol-5-yl)methyl]-5-(trifluoromethyl)-2-pyrimidinecarboxamide.
摘要翻译：本发明涉及通过列举A或其盐的化合物调节α7烟碱乙酰胆碱受体（nAChR），其可以表示，但不限于化合物N - [（2-三氟甲基-1H-吲哚-2-基）吡啶-5-基）甲基] -5-（三氟甲基）-2-嘧啶甲酰胺。

6. 发明授权

US07534793B2 Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity 失效
标题翻译：氨基哌啶喹啉及其具有抗菌活性的azaisosteric类似物
公开(公告)号：US07534793B2
公开(公告)日：2009-05-19
申请号：US11219148
申请日：2005-09-02
申请人： David Thomas Davies , Graham Elgin Jones , Andrew P Lightfoot , Roger Edward Markwell , Neil David Pearson
发明人： David Thomas Davies , Graham Elgin Jones , Andrew P Lightfoot , Roger Edward Markwell , Neil David Pearson
IPC分类号： A61K31/4709 , C07D215/16
CPC分类号： C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/04 , C07D513/04
摘要： Aminopiperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man
摘要翻译：氨基哌啶衍生物及其药学上可接受的衍生物，其可用于哺乳动物，特别是人的细菌感染治疗方法

7. 发明授权

US07122538B2 Sulfonamide derivatives as antipsychotic agents 失效
公开(公告)号：US07122538B2
公开(公告)日：2006-10-17
申请号：US10530538
申请日：2003-10-06
申请人： Ian Thomson Forbes , Andrew Derrick Gribble , Andrew P. Lightfoot , Andrew H. Payne
发明人： Ian Thomson Forbes , Andrew Derrick Gribble , Andrew P. Lightfoot , Andrew H. Payne
IPC分类号： C07D223/16 , C07D209/44 , A61K31/55 , A61D31/4035
CPC分类号： C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The invention provides compounds of formula (I): wherein A and B represent the groups —(CH2)m— and —(CH2)n— respectively; R1 represents hydrogen or C1-6alkyl; R2 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC1-6alkyl, trifluoromethyl, trifluoromethoxy, C1-6alkyl, C1-6alkoxy, C1-6fluoroalkoxy, —(CH2)pC3-6cycloalkyl, —(CH2)pOC3-6cycloalkyl, —COC1-6alkyl, —SO2C1-6alkyl, —SOC1-6alkyl, —S—C1-6alkyl, —CO2C1-6alkyl, —CO2NR5R6, —SO2NR5R6, —(CH2)NR5R6, —(CH2)pNR5COR6, optionally substituted aryl ring, optionally substituted heteroaryl ring or optionally substituted heterocyclyl ring; R3 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC1-6alkyl, trifluoromethyl, trifluoromethoxy, C1-6alkyl, C1-6alkoxy, C1-6fluoroalkoxy, —(CH2)pC3-6cycloalkyl, —(CH2)pOC3-6cycloalkyl, —COC1-6alkyl, —SO2C1-6alkyl, —SOC1-6alkyl, —S—C1-6alkyl, —CO2C1-6alkyl, —CO2NR7R8, —SO2NR7R8, —(CH2)pNR7R8 or —(CH2)pNR7COR8; R4represents hydrogen, hydroxy, C1-6alkyl, C1-6alkoxy, C1-6fluoroalkoxy, trifluoromethyl, trifluoromethoxy, halogen, —OSO2CF3, —(CH2)pC3-6cycloalkyl, —(CH2)qOC1-6alkyl or —(CH2)pOC3-6cycloalkyl; R5 and R6 each independently represent hydrogen, C1-6alkyl or, together with the nitrogen or other atoms to which they are attached, form an azacycloalkyl ring or an oxo-substituted azacycloalkyl ring; R7 and R8 each independently represent hydrogen or C1-6alkyl; m and n independently represent an integer selected from 1 and 2; p independently represents an integer selected from 0, 1, 2 and 3; q independently represents an integer selected from 1, 2 and 3; or a pharmaceutically acceptable salt or solvate thereof, with the proviso that the compounds 8-hydroxy-3-methyl-7-phenylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine, 8-hydroxy-7-4-(hydroxyphenyl)sulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine, 7-phenylsulfonyl-1,2,3,4-tetrahydroisoquinoline and 7-phenylsulfonyl-1,2,3,4-tetrahydroisoquinoline hydrochloride are excluded. The compounds are useful in therapy, in particular as antipsychotic agents.

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