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1. 发明授权

US08759352B2 1-(4-ureidobenzoyl)piperazine derivatives 有权
标题翻译： 1-（4-脲基苯甲酰基）哌嗪衍生物
公开(公告)号：US08759352B2
公开(公告)日：2014-06-24
申请号：US13060730
申请日：2009-08-26
申请人： Andrew John Cooke , David Jonathan Bennett , Andrew Stanley Edwards , Andrew Laird Roughton , Irina Neagu , Jui-Hsiang Chan , Koc-Kan Ho , Nasrin Ansari , Michelle Lee Morris , Yajing Rong , Michael Ohlmeyer
发明人： Andrew John Cooke , David Jonathan Bennett , Andrew Stanley Edwards , Andrew Laird Roughton , Irina Neagu , Jui-Hsiang Chan , Koc-Kan Ho , Nasrin Ansari , Michelle Lee Morris , Yajing Rong , Michael Ohlmeyer
IPC分类号： A61K31/496 , C07D213/56 , C07D263/34 , C07D277/56 , C07D307/68
CPC分类号： C07D263/34 , C07D213/56 , C07D277/56 , C07D307/68 , C07D333/38
摘要： The present invention relates to 1-(4-ureidobenzoyl)piperazine derivatives having the general Formula I (We bring to your attention that formula I is not provided on this electronic version as it is provided in the abstract of the paper copy) Wherein R1 is (C1-8)alkyl, (C3-8)cycloalkyl or (C3-8)cycloalkyl(C1-3)alkyl, each of which may be substituted by hydroxy, cyano or halogen; R2 represents 1 or 2 optional halogens; R3 is (C1-6)alkyl, (C3-6)cycloalkyl or (C3-6)cycloalkyl(C1-3)alkyl, each of which may be substituted by one or more halogens; A represents a heteroaryl ring system comprising 1-3 heteroatoms selected from N, O and S, which ring system is 5- or 6-membered when X is C, and 5-membered when X is N; n is 1 or 2; or a pharmaceutically acceptable salt thereof; to pharmaceutical compositions comprising the same, and to the use of a these 1-(4-ureidobenzoyl)piperazine derivatives for the manufacture of a medicament for treating or preventing atherosclerosis and related disorders associated with cholesterol and bile acids transport and metabolism.
摘要翻译：本发明涉及具有通式I的1-（4-脲基苯甲酰基）哌嗪衍生物（我们提请您注意，该电子版本没有提供式I，如在本文摘要中提供的）。其中R1是（C 1-8）烷基，（C 3-8）环烷基或（C 3-8）环烷基（C 1-3）烷基，其各自可被羟基，氰基或卤素取代; R2表示1或2个任选的卤素; R3是（C 1-6）烷基，（C 3-6）环烷基或（C 3-6）环烷基（C 1-3）烷基，其各自可被一个或多个卤素取代; A表示包含1-3个选自N，O和S的杂原子的杂芳基环系统，当X是C时，该环系统是5-或6-元，当X是N时，该环系是5元; n为1或2; 或其药学上可接受的盐; 涉及包含其的药物组合物，以及这些1-（4-脲基苯甲酰基）哌嗪衍生物在制备用于治疗或预防动脉粥样硬化和与胆汁酸和胆汁酸运输和代谢相关的相关疾病的药物中的用途。

2. 发明授权

US07700638B2 1,5,7-trisubstituted benzimidazole derivatives and their use for modulating the GABAA receptor complex 失效
标题翻译： 1,5,7-三取代苯并咪唑衍生物及其用于调节GABA A受体复合物的用途
公开(公告)号：US07700638B2
公开(公告)日：2010-04-20
申请号：US10575380
申请日：2004-10-20
申请人： Niall Morton Hamilton , Susan Elizabeth Napier , Morag Ann MacCall Easson , Andrew John Cooke , Lene Teuber , Naheed Mirza , Frank Wätjen
发明人： Niall Morton Hamilton , Susan Elizabeth Napier , Morag Ann MacCall Easson , Andrew John Cooke , Lene Teuber , Naheed Mirza , Frank Wätjen
IPC分类号： A61K31/4184 , C07D235/04
CPC分类号： A61K31/4184 , C07D235/06 , C07D401/04 , C07D401/06 , C07D401/10 , C07D403/06 , C07D403/12 , C07D405/04
摘要： This invention relates to novel 1,5,7-trisubstituted benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith.The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex.
摘要翻译：本发明涉及新的1,5,7-三取代苯并咪唑衍生物，含有这些化合物的药物组合物及其处理方法。本发明的化合物可用于治疗对调节GABA A受体复合物有反应的中枢神经系统疾病和病症。

3. 发明申请

US20230054782A1 BICYCLIC HETEROCYCLE COMPOUNDS METHODS OF USE THEREOF FOR THE TREATMENT OF HERPES VIRUSES 有权
公开(公告)号：US20230054782A1
公开(公告)日：2023-02-23
申请号：US17783810
申请日：2020-12-17
申请人： Andrew John COOKE , Brendan M. CROWLEY , Marc A. LABROLI , Michael Aaron PLOTKIN , Izzat T. RAHEEM , Ling TONG , Deyou SHA , Merck Sharp & Dohme LLC
发明人： Andrew John Cooke , Brendan M. Crowley , Marc A. Labroli , Michael Aaron Plotkin , Izzat T. Raheem , Ling Tong , Deyou Sha
IPC分类号： C07D491/04 , C07D519/00 , C07D405/14 , C07D471/04
摘要： The present invention relates to novel Bicyclic Heterocycle Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, X, Y, Z, R1 R5, R6, and R7 are as defined herein. The present invention also relates to compositions comprising at least one Bicyclic Heterocycle Compound, and methods of using the Bicyclic Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

4. 发明授权

US09205520B2 One-hit tooling for flush mounted rotatable captive nut 有权
标题翻译：一键式工具，用于嵌入式可旋转固定螺母
公开(公告)号：US09205520B2
公开(公告)日：2015-12-08
申请号：US13348067
申请日：2012-01-11
申请人： Andrew John Cooke
发明人： Andrew John Cooke
IPC分类号： B23P19/06 , F16B37/06
CPC分类号： B23P19/062 , F16B37/062 , Y10T29/49908 , Y10T29/5343
摘要： A two-stage punch accomplishes the two-step process of sheet deformation and nut flaring to attach the nut to the sheet in a single stroke of an assembly press. The punch comprises an outer cylindrical sleeve which captivates a resiliently biased center punch. When the punch is moved downward into contact with the sheet, an embossing ring on the sleeve deforms the sheet material around an aperture in the sheet. When the punch is moved farther downward, a pointed end of the center punch extends beyond the embossing ring and into forcible contact with the nut. The nut is thereby flared capturing the sheet between flared edges of the nut and a nut flange.
摘要翻译：两级冲头完成片材变形和螺母扩口的两步过程，以在组装压力机的单次冲程中将螺母附接到片材上。该冲头包括外圆柱形套筒，该外套筒套住弹性偏置的中心冲头。当冲头向下移动以与片材接触时，套筒上的压花环使片材围绕片材中的孔变形。当冲头向下移动时，中心冲头的尖端延伸超出压花环并与螺母强制接触。螺母因此在螺母的扩口边缘和螺母法兰之间张开。

5. 发明申请

US20090264416A1 N-BENZYL,N'-ARYLCARBONYLPIPERAZINE DERIVATIVES 有权
标题翻译： N-苄基，N'-亚甲基双酚A衍生物
公开(公告)号：US20090264416A1
公开(公告)日：2009-10-22
申请号：US12194146
申请日：2008-08-19
申请人： Koc-Kan Ho , Andrew Laird Roughton , Irina Neagu , Jui-Hsiang Chan , Nasrin Ansari , Michelle Lee Morris , Yajing Rong , Michael Ohlmeyer , Andrew John Cooke , Andrew Stanley Edwards , David Jonathan Bennett
发明人： Koc-Kan Ho , Andrew Laird Roughton , Irina Neagu , Jui-Hsiang Chan , Nasrin Ansari , Michelle Lee Morris , Yajing Rong , Michael Ohlmeyer , Andrew John Cooke , Andrew Stanley Edwards , David Jonathan Bennett
IPC分类号： A61K31/551 , C07D241/04 , C07D413/12 , A61K31/496 , C07D413/14 , C07D401/12 , A61K31/5377 , A61K31/535 , C07D403/12 , C07D405/12 , C07D409/12 , A61K31/497 , C07D243/08
CPC分类号： C07D295/192 , C07D241/04 , C07D243/08 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to N-benzyl,N′-arylcarbonylpiperazine derivatives having the general formula I to pharmaceutical compositions comprising the same, and to the use of a these N-benzyl,N′-arylcarbonylpiperazine derivatives for the manufacture of a medicament for treating or preventing atherosclerosis and related disorders associated with cholesterol and bile acids transport and metabolism.
摘要翻译：本发明涉及具有通式I的N-苄基，N'-芳基羰基哌嗪衍生物，其包含其的药物组合物，以及这些N-苄基，N'-芳基羰基哌嗪衍生物在制备用于治疗或预防与胆固醇和胆汁酸运输和代谢相关的动脉粥样硬化和相关疾病。

6. 发明申请

US20230066268A1 INDAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF HERPES VIRUSES 有权
公开(公告)号：US20230066268A1
公开(公告)日：2023-03-02
申请号：US17784718
申请日：2020-12-15
申请人： Andrew John COOKE , Christopher D. COX , Scott D. EDMONDSON , Charles Lee JAYNE , Anilkumar NAIR , Jeffrey W. SCHUBERT , Jason W. SKUDLAREK , David M. TELLERS , De-Yi YANG , Merck Sharp & Dohme LLC
发明人： Andrew John Cooke , Christopher D. Cox , Scott D. Edmondson , Charles Lee Jayne , Anilkumar G. Nair , Jeffrey W. Schubert , Jason W. Skudlarek , David M. Tellers , De-Yi Yang
IPC分类号： A61K31/416 , A61K31/4245 , A61K31/427 , C07D231/56 , A61P31/22
摘要： The present invention relates to novel Indazole Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, X, Y, Z, R1 R5 and R6 are as defined herein. The present invention also relates to compositions comprising at least one Indazole Derivative, and methods of using the Indazole Derivatives for treating or preventing a herpesvirus infection in a patient.

7. 发明授权

US08357679B2 Hexafluoroisopropanol derivatives 有权
标题翻译：六氟异丙醇衍生物
公开(公告)号：US08357679B2
公开(公告)日：2013-01-22
申请号：US12465134
申请日：2009-05-13
申请人： Andrew John Cooke , Andrew Stanley Edwards , Fiona Elizabeth Andrews , David Jonathan Bennett , Olaf Nimz , Emma Louise Carswell
发明人： Andrew John Cooke , Andrew Stanley Edwards , Fiona Elizabeth Andrews , David Jonathan Bennett , Olaf Nimz , Emma Louise Carswell
IPC分类号： A61K31/50 , A61K31/55 , A61K31/4965 , A61K31/497 , A61K31/51 , A01N43/54 , C07D239/02 , C07D243/00 , C07D403/00 , C07D241/04 , C07D295/00
CPC分类号： C07D295/192 , C07D243/08
摘要： The present invention relates to hexafluoroisopropanol derivatives having the general formula I to pharmaceutical compositions comprising the same and to the use of these hexafluoroisopropanol derivatives in the treatment of atherosclerosis.
摘要翻译：本发明涉及具有通式I的六氟异丙醇衍生物，其含有该组合物的药物组合物以及这些六氟异丙醇衍生物用于治疗动脉粥样硬化的用途。

8. 发明申请

US20120238574A1 (1, 1, 1,3,3,3 -HEXAFLUORO-2 HYDROXYPROPAN- 2 -YL) PHENYL DERIVATIVE, PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR USE FOR THE TREATMENT OF ATHEROSCLEROSIS 有权
标题翻译：（1,1,1,3,3,3-四氢呋喃-2-羟基丙-2-炔）苯衍生物，其药物组合物及其用于治疗甲状腺功能亢进症的用途
公开(公告)号：US20120238574A1
公开(公告)日：2012-09-20
申请号：US13504209
申请日：2010-10-26
申请人： Andrew John Cooke , Emma Louise Carswell , David Jonathan Bennett
发明人： Andrew John Cooke , Emma Louise Carswell , David Jonathan Bennett
IPC分类号： A61K31/445 , C07D401/12 , A61K31/4545 , A61K31/506 , C07D405/12 , A61K31/453 , C07D413/12 , A61K31/5377 , A61K31/501 , C07D409/12 , A61P9/10 , A61P3/06 , A61P3/10 , A61P3/04 , A61K31/4535 , A61P1/16 , C07D211/46
CPC分类号： C07D295/135 , C07D211/28 , C07D213/75 , C07D237/20 , C07D239/42 , C07D261/12 , C07D295/096 , C07D295/192
摘要： The present invention relates to (1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl derivatives having the general formula (I) to pharmaceutical compositions comprising the same and to the use of these (1,1,1,3,3,3-hexafluoro-2-hydroxy-propan-2-yl)phenyl derivatives in the treatment of atherosclerosis.
摘要翻译：本发明涉及具有通式（I）的（1,1,1,3,3,3-六氟-2-羟基丙-2-基）苯基衍生物，其具有包含该化合物的药物组合物及其用途（ 1,1,1,3,3,3-六氟-2-羟基 - 丙-2-基）苯基衍生物用于治疗动脉粥样硬化。

9. 发明申请

US20120015958A1 1-(4-UREIDOBENZOYL)PIPERAZINE DERIVATIVES 有权
标题翻译： 1-（4-羟基苯甲酰基）哌嗪衍生物
公开(公告)号：US20120015958A1
公开(公告)日：2012-01-19
申请号：US13060730
申请日：2009-08-26
申请人： Andrew John Cooke , David Jonathan Bennett , Andrew Stanley Edwards , Andrew Laird Roughton , Irina Neagu , Jui-Hsiang Chan , Koc Kan Ho , Nasrin Ansari , Michelle Lee Morris , Yajing Rong , Michael Ohlmeyer
发明人： Andrew John Cooke , David Jonathan Bennett , Andrew Stanley Edwards , Andrew Laird Roughton , Irina Neagu , Jui-Hsiang Chan , Koc Kan Ho , Nasrin Ansari , Michelle Lee Morris , Yajing Rong , Michael Ohlmeyer
IPC分类号： A61K31/496 , C07D417/06 , C07D405/06 , C07D409/06 , C07D403/06 , A61P3/04 , A61P9/10 , A61P7/00 , A61P1/00 , A61P3/06 , A61P3/10 , C07D413/06 , C07D401/06
CPC分类号： C07D263/34 , C07D213/56 , C07D277/56 , C07D307/68 , C07D333/38
摘要： The present invention relates to 1-(4-ureidobenzoyl)piperazine derivatives having the general Formula I (We bring to your attention that formula I is not provided on this electronic version as it is provided in the abstract of the paper copy) Wherein R1 is (C1-8)alkyl, (C3-8)cycloalkyl or (C3-8)cycloalkyl(C1-3)alkyl, each of which may be substituted by hydroxy, cyano or halogen; R2 represents 1 or 2 optional halogens; R3 is (C1-6)alkyl, (C3-6)cycloalkyl or (C3-6)cycloalkyl(C1-3)alkyl, each of which may be substituted by one or more halogens; A represents a heteroaryl ring system comprising 1-3 heteroatoms selected from N, O and S, which ring system is 5- or 6-membered when X is C, and 5-membered when X is N; n is 1 or 2; or a pharmaceutically acceptable salt thereof; to pharmaceutical compositions comprising the same, and to the use of a these 1-(4-ureidobenzoyl)piperazine derivatives for the manufacture of a medicament for treating or preventing atherosclerosis and related disorders associated with cholesterol and bile acids transport and metabolism.
摘要翻译：本发明涉及具有通式I的1-（4-脲基苯甲酰基）哌嗪衍生物（我们提请您注意，该电子版本没有提供式I，如在本文摘要中提供的）。其中R1是（C 1-8）烷基，（C 3-8）环烷基或（C 3-8）环烷基（C 1-3）烷基，其各自可被羟基，氰基或卤素取代; R2表示1或2个任选的卤素; R3是（C 1-6）烷基，（C 3-6）环烷基或（C 3-6）环烷基（C 1-3）烷基，其各自可被一个或多个卤素取代; A表示包含1-3个选自N，O和S的杂原子的杂芳基环系统，当X是C时，该环系统是5-或6-元，当X是N时，该环系是5元; n为1或2; 或其药学上可接受的盐; 涉及包含其的药物组合物，以及这些1-（4-脲基苯甲酰基）哌嗪衍生物在制备用于治疗或预防动脉粥样硬化和与胆汁酸和胆汁酸运输和代谢相关的相关疾病的药物中的用途。

10. 发明申请

US20150320733A1 INDAZOLE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS 有权
标题翻译：作为醛固酮合成酶抑制剂的INDAZOLE化合物
公开(公告)号：US20150320733A1
公开(公告)日：2015-11-12
申请号：US14651491
申请日：2013-12-17
申请人： Scott B. HOYT , Jerry Andrew TAYLOR , Clare LONDON , Yusheng XIONG , Andrew John COOKE , MERCK SHARP & DOHME CORP.
发明人： Scott B. Hoyt , Jerry Andrew Taylor , Clare London , Yusheng Xiong , Andrew John Cooke
IPC分类号： A61K31/4439 , A61K31/497 , C07D403/14 , C07D401/04 , A61K31/4725
CPC分类号： A61K31/4439 , A61K31/4725 , A61K31/497 , C07D401/04 , C07D403/04 , C07D403/14
摘要： This invention relates to indazole compounds of the structural formula: (structure represented) or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment or amelioration of conditions that could be treated by inhibiting aldosterone synthase.
摘要翻译：本发明涉及结构式为（结构式）的吲唑化合物或其药学上可接受的盐，其中该变量在本文中定义。本发明化合物选择性地抑制醛固酮合酶。本发明还提供包含式I化合物或其盐的药物组合物，以及可能用于治疗或改善可通过抑制醛固酮合酶治疗的病症的方法。

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