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1. 发明申请

US20120266740A1 OPTICAL ELECTRIC GUITAR TRANSDUCER AND MIDI GUITAR CONTROLLER 审中-公开
标题翻译：光电吉他传感器和MIDI吉他控制器
公开(公告)号：US20120266740A1
公开(公告)日：2012-10-25
申请号：US13451124
申请日：2012-04-19
申请人： Nathan Hilbish , Afroditi Vennie Filippas , Lee Stewart , Andrew Good
发明人： Nathan Hilbish , Afroditi Vennie Filippas , Lee Stewart , Andrew Good
IPC分类号： G10H3/06 , G10H7/00
CPC分类号： G10H3/06 , G10H3/125 , G10H3/146 , G10H2220/411 , G10H2250/311
摘要： Photodiodes in combination with an amplifier of transimpedance configuration provides an optical vibration detector having a linear frequency response with a light emitter and sensor of sufficiently small size to be inserted between strings of a musical instrument in order to provide signals suitable for amplification. The frequencies of vibrating strings of a musical instrument can be converted in accordance with either of two converter embodiments to control a music synthesizer, an automatic music transcription arrangement or the like.
摘要翻译：与跨阻配置的放大器组合的光电二极管提供具有线性频率响应的光学振动检测器，其具有足够小尺寸的光发射器和传感器，以插入到乐器的弦之间，以便提供适合于放大的信号。可以根据两个转换器实施例中的任一个来转换乐器的振动弦的频率以控制音乐合成器，自动音乐转录装置等。

2. 发明申请

US20070037868A1 Macrocyclic diaminopropanes as beta-secretase inhibitors 有权
标题翻译：大环二氨基丙烷作为β-分泌酶抑制剂
公开(公告)号：US20070037868A1
公开(公告)日：2007-02-15
申请号：US11501328
申请日：2006-08-09
申请人： Lawrence Marcin , Andrew Good
发明人： Lawrence Marcin , Andrew Good
IPC分类号： A61K31/4025 , C07D413/02
CPC分类号： C07D413/04
摘要： There is provided a series of novel macrocyclic diaminopropanes of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R4, R5, n, L, Z, and as defined herein, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.
摘要翻译：提供了一系列式（I）的新型大环二氨基丙烷或立体异构体; 或其药学上可接受的盐，其中R 1，R 2，R 4，R 5，n， L，Z和如本文所定义的其药物组合物和使用方法。这些新型化合物通过β-分泌酶抑制淀粉样前体蛋白（APP）的加工，更具体地，抑制Aβ-肽的产生。本公开涉及可用于治疗与β-淀粉样蛋白产生相关的神经系统疾病的化合物，例如阿尔茨海默病和受抗淀粉样蛋白活性影响的其它病症。

3. 发明申请

US20050143316A1 Hepatitis C virus inhibitors 有权
标题翻译：丙型肝炎病毒抑制剂
公开(公告)号：US20050143316A1
公开(公告)日：2005-06-30
申请号：US10992566
申请日：2004-11-18
申请人： Yong Tu , Paul Scola , Andrew Good , Jeffrey Campbell
发明人： Yong Tu , Paul Scola , Andrew Good , Jeffrey Campbell
IPC分类号： A61K31/40 , A61K31/41 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/4709 , A61K38/00 , A61K38/05 , A61K38/21 , A61K45/06 , C07D277/04 , C07D285/08 , C07D401/00 , C07D401/12 , C07D401/14 , C07D405/00 , C07D409/14 , C07D413/14 , C07D417/14 , C07K5/06 , C12N20060101
CPC分类号： C07D409/14 , A61K38/212 , A61K45/06 , C04B35/632 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07K5/0808
摘要： Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R′, B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
摘要翻译：公开了具有以下通式的丙型肝炎病毒抑制剂：其中R 1，R 2，R 3，R'，B，Y和X 在说明书中描述。还公开了包含化合物的组合物和使用该化合物抑制HCV的方法。

4. 发明授权

US06878722B2 Substituted cycloalkyl P1′ hepatitis C virus inhibitors 有权
标题翻译：取代环烷基P1'丙型肝炎病毒抑制剂
公开(公告)号：US06878722B2
公开(公告)日：2005-04-12
申请号：US10441428
申请日：2003-05-20
申请人： Jeffrey Allen Campbell , Stanley D'Andrea , Andrew Good , Jianqing Li , Fiona Mcphee , Amy Ripka , Paul Michael Scola , Yong Tu
发明人： Jeffrey Allen Campbell , Stanley D'Andrea , Andrew Good , Jianqing Li , Fiona Mcphee , Amy Ripka , Paul Michael Scola , Yong Tu
IPC分类号： A61K20060101 , A61K31/47 , A61K31/4709 , A61K38/05 , A61K38/21 , A61P31/12 , C07D401/02 , C07D401/12 , C07K5/06 , C07K5/08 , C07K5/083 , C07K5/087
CPC分类号： C07K5/0827 , A61K38/21 , C07K5/0802 , C07K5/0808 , C07K5/0812 , A61K2300/00
摘要： The present invention relates to tripeptide compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. In particular, the present invention provides novel tripeptide analogs, pharmaceutical compositions containing such analogs and methods for using these analogs in the treatment of HCV infection.
摘要翻译：本发明涉及用于治疗丙型肝炎病毒（HCV）感染的三肽化合物，组合物和方法。特别地，本发明提供新颖的三肽类似物，含有这些类似物的药物组合物和使用这些类似物治疗HCV感染的方法。

5. 发明授权

US5583391A Color picture tube shadow mask having improved mask aperture pattern 失效
标题翻译：彩色显像管荫罩具有改进的面罩孔径图案
公开(公告)号：US5583391A
公开(公告)日：1996-12-10
申请号：US558314
申请日：1995-11-15
申请人： Andrew Good , Bruce G. Marks
发明人： Andrew Good , Bruce G. Marks
IPC分类号： H01J29/07 , H01J31/20 , H01J29/80
CPC分类号： H01J29/076
摘要： A color picture tube has a rectangular shadow mask mounted therein in spaced relation to a viewing screen. A major axis passes through the center of the mask and parallels the long sides thereof and a minor axis passes through the center of the mask and parallels the short sides thereof. The mask has an aperture array that includes slit-shaped apertures aligned in columns that essentially parallel the minor axis and end at a border of the aperture array. Adjacent apertures in each column are separated by tie bars in the mask that are longitudinally offset from column to adjacent column. The spacing from tie bar to tie bar in a column is the tie bar pitch at a location on the mask. A first set of the aperture columns, comprising every other column, has full length ultimate apertures at least at one end thereof, and a second set of the aperture columns, comprising every other column not in the first set, has partial length ultimate apertures at least at one end thereof. The ultimate apertures of all of the aperture columns end on smooth curved border lines. The tie bar pitch of the columns decreases from the center of the mask to the short sides thereof, with the tie bar pitch in the region of the short sides of the mask being optimized to minimize moire at the sides of the screen during tube operation. The tie bar pitch along each column varies also from the center of the mask to the long sides of the mask.
摘要翻译：彩色显象管具有安装在其中的与观看屏隔开的矩形荫罩。长轴通过掩模的中心并平行于其长边，并且短轴通过掩模的中心并平行于其短边。掩模具有孔径阵列，其包括在基本上平行于短轴并且在孔阵列的边界处终止的列中对齐的狭缝形孔。每个柱中的相邻孔由掩模中由柱相邻的柱纵向偏移的连接条分开。柱中的连杆与连杆之间的距离是在面罩上的位置处的连杆间距。包括每隔一列的第一组孔径列至少在其一端具有全长极限孔，并且包括不在第一组中的每隔一列的第二组孔列具有部分长度的极限孔，至少在一端。所有孔径柱的最终孔径在平滑的弯曲边界线上终止。柱的连接杆间距从掩模的中心减小到其短边，并且掩模的短边区域中的拉杆间距被优化以使侧面的莫尔+ E，acu + EE最小化在管操作期间的屏幕。沿着每一列的连接杆间距也从掩模的中心到掩模的长边也变化。

6. 发明授权

US5000711A Method of making color picture tube shadow mask having improved tie bar locations 失效
标题翻译：制造具有改进的连杆位置的彩色显像管荫罩的方法
公开(公告)号：US5000711A
公开(公告)日：1991-03-19
申请号：US547004
申请日：1990-07-02
申请人： Bruce G. Marks , Andrew Good
发明人： Bruce G. Marks , Andrew Good
IPC分类号： H01J9/14
CPC分类号： H01J9/142
摘要： An improved method of making a color picture tube shadow mask includes first constructing an apertured flat mask which is formed into a domed contoured mask. The mask has a rectangular periphery with two long sides and two short sides. The mask has a major axis, which passes through the center of the mask and parallels the long sides, and a minor axis, which passes through the center of the mask and parallels said short sides. The mask includes slit-shaped apertures aligned in columns that essentially parallel the minor axis. Adjacent apertures in each column are separated by tie bars in the mask, with the spacing between tie bars in a column being the tie bar pitch at a particular location on the mask. The improvement comprises a first step of calculating the desired tie bar shadow locations at several discrete areas, for a given scan line pitch, as viewed from a distance in front of a viewing screen of a tube. The desired tie bar shadow locations are those locations that will give an optimized compromise for moire at each of the discrete areas. Next, the corresponding tie bar shadow locations on the screen are determined, taking into account the angles of the screen slope at the discrete areas. The corresponding tie bar pitches are then determined on a formed contoured shadow mask, taking into account the mask to screen spacing at each of the discrete areas. Then, the tie bar pitches on the unformed flat mask are calculated, by subtracting the stretch caused by the mask formign step. The stretch is determined by actual measurements of vertical pitch at the discrete areas on the apertured formed mask and by comparing these measurements with measurements made on the flat mask prior to forming. Finally, a least squares fitting is performed on the calculated flat mask tie bar pitches, to obtain the locations of tie bars at all areas on the flat mask.
摘要翻译：制造彩色显像管荫罩的改进方法包括首先构造形成为圆顶形轮廓掩模的有孔平面掩模。面具具有两个长边和两个短边的矩形周边。掩模具有长轴，其穿过掩模的中心并且平行于长边，并且短轴穿过掩模的中心并平行于所述短边。掩模包括在基本上平行于短轴的列中对准的狭缝状孔。每个柱中的相邻孔径由掩模中的连接条分开，柱中的连接杆之间的间距是掩模上特定位置处的连杆间距。改进包括对于给定的扫描线间距，在从管的观察屏幕前方的距离观察时，在几个离散区域处计算期望的连接条阴影位置的第一步骤。所需的连接条阴影位置是将为每个离散区域的莫尔条件提供优化折中的位置。接下来，考虑到离散区域处的屏幕斜率的角度，确定屏幕上的对应的连接条影子位置。然后在形成的轮廓的荫罩上确定对应的拉杆间距，同时考虑到每个离散区域处的屏蔽间隔。然后，通过减去由掩模形成步骤引起的拉伸来计算未形成的平面掩模上的拉杆间距。通过在孔形成的掩模上的离散区域处的垂直间距的实际测量并且通过将这些测量与在形成之前在平面掩模上进行的测量进行比较来确定拉伸。最后，对所计算的平面罩连杆杆间距进行最小二乘拟合，以获得平面罩上所有区域的连杆的位置。

7. 发明申请

US20070099825A1 Hepatitis C virus inhibitors 有权
标题翻译：丙型肝炎病毒抑制剂
公开(公告)号：US20070099825A1
公开(公告)日：2007-05-03
申请号：US11591253
申请日：2006-11-01
申请人： Stanley D'Andrea , Zhizhen Zheng , Jeffrey Campbell , Fiona McPhee , Andrew Good , Paul Scola
发明人： Stanley D'Andrea , Zhizhen Zheng , Jeffrey Campbell , Fiona McPhee , Andrew Good , Paul Scola
IPC分类号： A61K38/12 , C07K5/12
CPC分类号： A61K38/204 , A61K38/2013 , A61K38/208 , A61K38/212 , C07K5/06139 , C07K5/0804 , A61K2300/00
摘要： Macrocyclic peptides are disclosed having the general formula: wherein R′, R3, R3′, R4, R6, X, Q, and W are described. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
摘要翻译：公开了具有以下通式的大环肽：其中R'，R 3，R 3'，R 4，R 6， / SUP>，X，Q和W。还公开了包含化合物的组合物和使用该化合物抑制HCV的方法。

8. 发明申请

US20070015754A1 Acyl guanidines as beta-secretase inhibitors 有权
标题翻译：酰基胍作为β-分泌酶抑制剂
公开(公告)号：US20070015754A1
公开(公告)日：2007-01-18
申请号：US11471125
申请日：2006-06-20
申请人： Samuel Gerritz , Andrew Good , Lorin Thompson , Weixu Zhai , Shuhao Shi , Shirong Zhu
发明人： Samuel Gerritz , Andrew Good , Lorin Thompson , Weixu Zhai , Shuhao Shi , Shirong Zhu
IPC分类号： A61K31/5377 , A61K31/55 , A61K31/425 , A61K31/42 , A61K31/416 , A61K31/4709
CPC分类号： C07D275/03 , C07D231/14 , C07D261/18 , C07D413/12
摘要： There is provided a series of substituted acyl guanidines of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4 and R5 as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.
摘要翻译：提供一系列式（I）的取代酰基胍或立体异构体; 或其药学上可接受的盐，其中R 1，R 2，R 3，R 4和R 4，本文所定义的其药物组合物和使用方法。这些化合物通过β-分泌酶抑制淀粉样蛋白前体蛋白（APP）的加工，更具体地抑制Aβ-肽的产生。本公开涉及可用于治疗与β-淀粉样蛋白产生相关的神经系统疾病的化合物，例如阿尔茨海默病和受抗淀粉样蛋白活性影响的其它病症。

9. 发明授权

US5309189A Method for screening line screen slit mask color picture tubes 失效
标题翻译：筛选线屏幕彩色显像管的方法
公开(公告)号：US5309189A
公开(公告)日：1994-05-03
申请号：US929223
申请日：1992-08-14
申请人： Bruce G. Marks , Andrew Good , Frank R. Ragland, Jr. , Richard C. Bauder
发明人： Bruce G. Marks , Andrew Good , Frank R. Ragland, Jr. , Richard C. Bauder
IPC分类号： H01J9/227 , G03B41/00 , G03C5/00
CPC分类号： H01J9/2273
摘要： The present invention is an improvement in a method of screening a line screen slit mask color picture tube that includes coating a faceplate panel of the tube with a photosensitive material, inserting a slit shadow mask into the panel and exposing the photosensitive material by passing light from a line light source through a misregister correction lens and through the slits of the mask. The improvement comprises positioning a skew correction lens between the line light source and the misregister correction lens during exposure of the photosensitive material. The skew correction lens has a surface with a general overall cylindrical shape with deviations from the cylindrical shape being in the four corners of the skew correction lens.
摘要翻译：本发明是一种筛选线屏幕狭缝掩模彩色显像管的方法的改进，其包括用感光材料涂覆管的面板，将狭缝阴影掩模插入到面板中，并通过使来自通过不对准校正透镜和通过掩模的狭缝的线光源。该改进包括在感光材料的曝光期间在线光源和不对准校正透镜之间定位偏斜校正透镜。歪斜校正透镜具有一般整体圆柱形的表面，其偏离圆柱形状在偏斜校正透镜的四个角中。

10. 发明申请

US20160137646A1 Novel Compounds and Uses Thereof 有权
标题翻译：新型化合物及其用途
公开(公告)号：US20160137646A1
公开(公告)日：2016-05-19
申请号：US14894214
申请日：2014-05-30
申请人： Ben C. ASKEW , Andrew GOOD , Kala Pharmaceuticals, Inc.
发明人： Winston Zapanta Ong , Pawel Wojciech Nowak , Ben C. Askew , Andrew Good
IPC分类号： C07D487/04 , C07D519/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention provides novel compounds of any one of Formulae (I)-(IV), and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of any one of Formulae (I)-(IV) and pharmaceutical compositions thereof that are mucus penetrating. The invention also provides methods and kits for using the inventive compounds, and pharmaceutical compositions thereof, for treating and/or preventing diseases associated with abnormal or pathological angiogenesis and/or aberrant signaling of a growth factor signaling pathway (e.g., vascular endothelial growth factor (VEGF)), such as proliferative diseases (e.g., cancers, benign neoplasms, inflammatory diseases, autoimmune diseases) and ocular diseases (e.g., macular degeneration, glaucoma, diabetic retinopathy, retinoblastoma, edema, uveitis, dry eye, blepharitis, and post-surgical inflammation) in a subject in need thereof.
摘要翻译：本发明提供式（I） - （IV）中任一项的新化合物及其药物组合物。还提供了包含粘液穿透的式（I） - （IV）中任一项的化合物及其药物组合物的颗粒（例如纳米颗粒）。本发明还提供了用于使用本发明化合物及其药物组合物用于治疗和/或预防与生长因子信号传导途径的异常或病理性血管生成和/或异常信号传导相关的疾病的方法和试剂盒（例如，血管内皮生长因子 VEGF）），例如增殖性疾病（例如癌症，良性肿瘤，炎症性疾病，自身免疫性疾病）和眼部疾病（例如，黄斑变性，青光眼，糖尿病性视网膜病变，视网膜母细胞瘤，水肿，葡萄膜炎，干眼症，睑炎炎，手术炎症）。

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