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1. 发明申请

US20120258965A1 N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS 有权
标题翻译： N-羟基磺酰胺衍生物作为新生物学上有用的硝基衍生物
公开(公告)号：US20120258965A1
公开(公告)日：2012-10-11
申请号：US13531364
申请日：2012-06-22
申请人： John P. TOSCANO , Frederick Arthur Brookfield , Andrew D. Cohen , Stephen Martin Courtney , Lisa Marie Frost , Vincent Jacob Kalish
发明人： John P. TOSCANO , Frederick Arthur Brookfield , Andrew D. Cohen , Stephen Martin Courtney , Lisa Marie Frost , Vincent Jacob Kalish
IPC分类号： A61K31/381 , C07D333/38 , C07D409/06 , C07D409/04 , A61P9/10 , A61K31/4535 , A61K31/496 , A61P9/00 , A61P9/04 , C07D409/12 , A61K31/5377
CPC分类号： C07C317/48 , C07C311/48 , C07D295/155 , C07D295/16 , C07D295/192 , C07D295/26 , C07D333/26 , C07D333/36 , C07D333/38
摘要： The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.
摘要翻译：本发明涉及在生理条件下提供硝酰基（HNO）的N-羟基磺酰胺衍生物，并且可用于治疗和/或预防对硝酰病治疗有反应的疾病或病症的发作和/或发展，包括心力衰竭和缺血/再灌注伤害。新型N-羟基磺酰胺衍生物在生理条件下以控制速率释放NHO，并且通过改变N-羟基磺酰胺衍生物上官能团的性质和位置来调节HNO释放速率。

2. 发明授权

US08087058B2 HDTV subscriber verification 有权
标题翻译： HDTV用户验证
公开(公告)号：US08087058B2
公开(公告)日：2011-12-27
申请号：US10761108
申请日：2004-01-19
申请人： Andrew D. Cohen
发明人： Andrew D. Cohen
IPC分类号： H04N7/173
CPC分类号： H04N21/25825 , H04N7/17309 , H04N21/4104 , H04N21/441 , H04N21/4516 , H04N21/6582
摘要： A system for providing television (TV) service including high definition television (HDTV) service, and for providing verification that a subscriber has connected an HDTV to the system includes a TV service provider headend and a set top box (STB). The HDTV may have an HDTV digital video interface (DVI) interconnect. The STB may be electrically coupled to the headend and have an STB DVI interconnect. When the HDTV DVI interconnect is initially electrically coupled to the STB DVI interconnect, the HDTV generally presents a data signal to the STB and the STB generally presents the data signal to the headend.
摘要翻译：一种用于提供包括高分辨率电视（HDTV）服务在内的电视（TV）服务并且用于提供用户已经将HDTV连接到系统的验证的系统包括TV服务提供商头端和机顶盒（STB）。 HDTV可能具有HDTV数字视频接口（DVI）互连。 STB可以电耦合到头端并具有STB DVI互连。当HDTV DVI互连最初电耦合到STB DVI互连时，HDTV通常向STB呈现数据信号，并且STB通常将数据信号呈现给头端。

3. 发明申请

US20110306614A1 N-Hydroxylsulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors 审中-公开
标题翻译： N-羟基磺酰胺衍生物作为新的生理用途的硝基氧供体
公开(公告)号：US20110306614A1
公开(公告)日：2011-12-15
申请号：US13213480
申请日：2011-08-19
申请人： John P. Toscano , Frederick Arthur Brookfield , Andrew D. Cohen , Stephen Martin Courtney , Lisa Marie Frost , Vincent Jacob Kalish
发明人： John P. Toscano , Frederick Arthur Brookfield , Andrew D. Cohen , Stephen Martin Courtney , Lisa Marie Frost , Vincent Jacob Kalish
IPC分类号： A61K31/5377 , C07D295/135 , A61K31/185 , A61K31/5375 , A61K31/495 , A61K31/4453 , C07D307/82 , C07D333/62 , C07D215/36 , C07D235/28 , C07D277/80 , C07D263/58 , A61K31/343 , A61K31/381 , A61K31/47 , A61K31/4184 , A61K31/427 , A61K31/423 , C07D333/34 , C07D413/04 , C07D241/14 , A61K31/4965 , A61P9/00 , A61P9/04 , C07C311/48
CPC分类号： C07C311/48 , C07C317/14 , C07C323/67 , C07D213/74 , C07D231/18 , C07D261/10 , C07D263/58 , C07D285/125 , C07D295/096 , C07D307/82 , C07D309/12 , C07D317/14 , C07D333/34 , C07D333/62
摘要： The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.
摘要翻译：本发明涉及在生理条件下给予硝酰基（HNO）的N-羟基磺酰胺衍生物，并且可用于治疗和/或预防对硝酰病治疗有反应的疾病或病症的发作和/或发展，包括心力衰竭和缺血/再灌注伤害。新的N-羟基磺酰胺衍生物在生理条件下以受控的速率释放NHO，并且通过改变N-羟基磺酰胺衍生物上官能团的性质和位置来调节HNO释放速率。

4. 发明申请

US20090163487A1 N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS 有权
标题翻译： N-羟基磺酰胺衍生物作为新生物学上有用的硝基衍生物
公开(公告)号：US20090163487A1
公开(公告)日：2009-06-25
申请号：US12239705
申请日：2008-09-26
申请人： John P. Toscano , Frederick Arthur Brookfield , Andrew D. Cohen , Stephen Martin Courtney , Lisa Marie Frost , Vincent Jacob Kalish
发明人： John P. Toscano , Frederick Arthur Brookfield , Andrew D. Cohen , Stephen Martin Courtney , Lisa Marie Frost , Vincent Jacob Kalish
IPC分类号： A61K31/5377 , C07C311/16 , A61K31/24 , A61K31/195 , A61K31/18 , C07D265/30 , A61K31/5375 , C07D413/12 , A61P9/04
CPC分类号： C07C317/48 , C07C311/48 , C07D295/155 , C07D295/16 , C07D295/192 , C07D295/26 , C07D333/26 , C07D333/36 , C07D333/38
摘要： The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.
摘要翻译：本发明涉及在生理条件下提供硝酰基（HNO）的N-羟基磺酰胺衍生物，并且可用于治疗和/或预防对硝酰病治疗有反应的疾病或病症的发作和/或发展，包括心力衰竭和缺血/再灌注伤害。新型N-羟基磺酰胺衍生物在生理条件下以控制速率释放NHO，并且通过改变N-羟基磺酰胺衍生物上官能团的性质和位置来调节HNO释放速率。

5. 发明授权

US08227639B2 N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors 有权
标题翻译： N-羟基磺酰胺衍生物作为新的生理有用的硝酰基供体
公开(公告)号：US08227639B2
公开(公告)日：2012-07-24
申请号：US12239705
申请日：2008-09-26
申请人： John P. Toscano , Frederick Arthur Brookfield , Andrew D. Cohen , Stephen Martin Courtney , Lisa Marie Frost , Vincent Jacob Kalish
发明人： John P. Toscano , Frederick Arthur Brookfield , Andrew D. Cohen , Stephen Martin Courtney , Lisa Marie Frost , Vincent Jacob Kalish
IPC分类号： C07C303/00
CPC分类号： C07C317/48 , C07C311/48 , C07D295/155 , C07D295/16 , C07D295/192 , C07D295/26 , C07D333/26 , C07D333/36 , C07D333/38
摘要： The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.
摘要翻译：本发明涉及在生理条件下提供硝酰基（HNO）的N-羟基磺酰胺衍生物，并且可用于治疗和/或预防对硝酰病治疗有反应的疾病或病症的发作和/或发展，包括心力衰竭和缺血/再灌注伤害。新型N-羟基磺酰胺衍生物在生理条件下以控制速率释放NHO，并且通过改变N-羟基磺酰胺衍生物上官能团的性质和位置来调节HNO释放速率。

6. 发明申请

US20120079554A1 High Definition Television Signal Compatibility Verification 有权
标题翻译：高清晰度电视信号兼容性验证
公开(公告)号：US20120079554A1
公开(公告)日：2012-03-29
申请号：US13307277
申请日：2011-11-30
申请人： Andrew D. Cohen
发明人： Andrew D. Cohen
IPC分类号： H04N21/40
CPC分类号： H04N21/25825 , H04N7/17309 , H04N21/4104 , H04N21/441 , H04N21/4516 , H04N21/6582
摘要： A system for providing television (TV) service including high definition television (HDTV) service, and for providing verification that a subscriber has connected an HDTV to the system includes a TV service provider headend and a set top box (STB). The HDTV may have an HDTV digital video interface (DVI) interconnect. The STB may be electrically coupled to the headend and have an STB DVI interconnect. When the HDTV DVI interconnect is initially electrically coupled to the STB DVI interconnect, the HDTV generally presents a data signal to the STB and the STB generally presents the data signal to the headend.
摘要翻译：一种用于提供包括高分辨率电视（HDTV）服务在内的电视（TV）服务并且用于提供用户已经将HDTV连接到系统的验证的系统包括TV服务提供商头端和机顶盒（STB）。 HDTV可能具有HDTV数字视频接口（DVI）互连。 STB可以电耦合到头端并具有STB DVI互连。当HDTV DVI互连最初电耦合到STB DVI互连时，HDTV通常向STB呈现数据信号，并且STB通常将数据信号呈现给头端。

7. 发明授权

US08832765B2 High definition television signal compatibility verification 有权
标题翻译：高分辨率电视信号兼容性验证
公开(公告)号：US08832765B2
公开(公告)日：2014-09-09
申请号：US13307277
申请日：2011-11-30
申请人： Andrew D. Cohen
发明人： Andrew D. Cohen
IPC分类号： H04N7/173 , H04N21/41 , H04N21/441
CPC分类号： H04N21/25825 , H04N7/17309 , H04N21/4104 , H04N21/441 , H04N21/4516 , H04N21/6582
摘要： A system for providing television (TV) service including high definition television (HDTV) service, and for providing verification that a subscriber has connected an HDTV to the system includes a TV service provider headend and a set top box (STB). The HDTV may have an HDTV digital video interface (DVI) interconnect. The STB may be electrically coupled to the headend and have an STB DVI interconnect. When the HDTV DVI interconnect is initially electrically coupled to the STB DVI interconnect, the HDTV generally presents a data signal to the STB and the STB generally presents the data signal to the headend.
摘要翻译：一种用于提供包括高分辨率电视（HDTV）服务在内的电视（TV）服务并且用于提供用户已经将HDTV连接到系统的验证的系统包括TV服务提供商头端和机顶盒（STB）。 HDTV可能具有HDTV数字视频接口（DVI）互连。 STB可以电耦合到头端并具有STB DVI互连。当HDTV DVI互连最初电耦合到STB DVI互连时，HDTV通常向STB呈现数据信号，并且STB通常将数据信号呈现给头端。

8. 发明授权

US08674132B2 N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors 有权
标题翻译： N-羟基磺酰胺衍生物作为新的生理有用的硝酰基供体
公开(公告)号：US08674132B2
公开(公告)日：2014-03-18
申请号：US13531364
申请日：2012-06-22
申请人： John P. Toscano , Frederick Arthur Brookfield , Andrew D. Cohen , Stephen Martin Courtney , Lisa Marie Frost , Vincent Jacob Kalish
发明人： John P. Toscano , Frederick Arthur Brookfield , Andrew D. Cohen , Stephen Martin Courtney , Lisa Marie Frost , Vincent Jacob Kalish
IPC分类号： C07C303/00
CPC分类号： C07C317/48 , C07C311/48 , C07D295/155 , C07D295/16 , C07D295/192 , C07D295/26 , C07D333/26 , C07D333/36 , C07D333/38
摘要： The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.
摘要翻译：本发明涉及在生理条件下提供硝酰基（HNO）的N-羟基磺酰胺衍生物，并且可用于治疗和/或预防对硝酰病治疗有反应的疾病或病症的发作和/或发展，包括心力衰竭和缺血/再灌注伤害。新型N-羟基磺酰胺衍生物在生理条件下以控制速率释放NHO，并且通过改变N-羟基磺酰胺衍生物上官能团的性质和位置来调节HNO释放速率。

9. 发明授权

US08030356B2 N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors 有权
标题翻译： N-羟基磺酰胺衍生物作为新的生理有用的硝酰基供体
公开(公告)号：US08030356B2
公开(公告)日：2011-10-04
申请号：US11724792
申请日：2007-03-16
申请人： John P. Toscano , Frederick Arthur Brookfield , Andrew D. Cohen , Stephen Martin Courtney , Lisa Marie Frost , Vincent Jacob Kalish
发明人： John P. Toscano , Frederick Arthur Brookfield , Andrew D. Cohen , Stephen Martin Courtney , Lisa Marie Frost , Vincent Jacob Kalish
IPC分类号： A61K31/18 , C07C311/48
CPC分类号： C07C311/48 , C07C317/14 , C07C323/67 , C07D213/74 , C07D231/18 , C07D261/10 , C07D263/58 , C07D285/125 , C07D295/096 , C07D307/82 , C07D309/12 , C07D317/14 , C07D333/34 , C07D333/62
摘要： The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.
摘要翻译：本发明涉及在生理条件下给予硝酰基（HNO）的N-羟基磺酰胺衍生物，并且可用于治疗和/或预防对硝酰病治疗有反应的疾病或病症的发作和/或发展，包括心力衰竭和缺血/再灌注伤害。新的N-羟基磺酰胺衍生物在生理条件下以受控的速率释放NHO，并且通过改变N-羟基磺酰胺衍生物上官能团的性质和位置来调节HNO释放速率。

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