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1. 发明申请

US20130189264A1 A NOVEL CHIMERIC PROTEIN FOR PREVENTION AND TREATMENT OF HIV INFECTION 审中-公开
标题翻译：一种用于预防和治疗艾滋病毒感染的新型CHIMERIC蛋白质
公开(公告)号：US20130189264A1
公开(公告)日：2013-07-25
申请号：US13831464
申请日：2013-03-14
申请人： The Government of the United States of America as represented by the Secretary of the Department of Health and Hu
发明人： Edward A. Berger , Christie M. Del Castillo
IPC分类号： C07K16/10
CPC分类号： C07K16/1045 , A61K39/395 , Y10S435/975
摘要： This invention relates to bispecific fusion proteins effective in viral neutralization. More specifically, such proteins have two different binding domains, an inducing-binding domain and an induced-binding domain, functionally linked by a peptide linker. Such proteins, nucleic acid molecules encoding them, and their production and use in preventing or treating viral infections are provided. One prototypical bispecific fusion protein is sCD4-SCFv(17b), in which a soluble CD4 fragment (containing domains D1 and D2) is fused to a single chain Fv portion of antibody 17b via a linker.
摘要翻译：本发明涉及在病毒中和中有效的双特异性融合蛋白。更具体地，这样的蛋白质具有两个不同的结合结构域，即通过肽接头功能连接的诱导结合结构域和诱导结合结构域。提供了这样的蛋白质，编码它们的核酸分子及其在预防或治疗病毒感染中的生产和用途。一种原型双特异性融合蛋白是sCD4-SCFv（17b），其中可溶性CD4片段（含有结构域D1和D2）通过接头与抗体17b的单链Fv部分融合。

2. 发明申请

US20060158228A1 Motion actuator 失效
标题翻译：运动执行器
公开(公告)号：US20060158228A1
公开(公告)日：2006-07-20
申请号：US10753258
申请日：2004-01-05
申请人： Ing-Shouh Hwang , Shao-Kang Hung , Cheng-Shing Tin , And Hu
发明人： Ing-Shouh Hwang , Shao-Kang Hung , Cheng-Shing Tin , And Hu
IPC分类号： G01N30/86
CPC分类号： H02N2/023
摘要： A motion actuator comprises a cylindrical movable shaft and a stage that contains an expansible/contractible device and two clamps. The expansible/contractible device can be controlled to drive the axial motion of the movable shaft, and the two clamps can be controlled to grip/release the shaft. The two clamps and the expansible/contractible device are each controlled by a bimorph structure, which comprises a cut cylindrical piezoelectric tube section in a hole enclosed by a thin wall in the stage. By sequentially activating the three piezoelectric tube sections, axial motions of the movable shaft relative to the stage in small steps are made. Each of the two clamps can be adjusted by a screw, which presses a spring structure that makes contact with the top surface of the movable shaft, so that the clamps can grip the movable shaft firmly when actuated, but not when not actuated. The flat top surface of the movable shaft is designed to inhibit the possible rotation along its axis during its axial motion. The shaft is supported by two lines at the bottom of each of the two clamps to reduce the contact area, which improves the reliability of the motion.
摘要翻译：运动致动器包括圆柱形可动轴和包含可膨胀/收缩装置和两个夹具的台架。可以控制可膨胀/收缩装置以驱动可动轴的轴向运动，并且可以控制两个夹具以夹紧/释放轴。两个夹具和可膨胀/收缩装置各自由双压电晶片结构控制，该双压电晶片结构包括在阶段中由薄壁包围的孔中的切割的圆柱形压电管部分。通过顺序地激活三个压电管部分，制造可移动轴相对于台阶的小步骤的轴向运动。两个夹具中的每一个可以通过螺钉调节，该螺钉挤压与可动轴的顶表面接触的弹簧结构，使得夹具可以在致动时牢固地夹紧可动轴，而不是在未致动时夹紧可动轴。可移动轴的平坦顶面被设计成在其轴向运动期间阻止沿其轴线的可能的旋转。轴由两个夹具每个底部的两条线支撑，以减小接触面积，从而提高了运动的可靠性。

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